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Unit: Genetics – Block 1 <br />Introduction• Lesson topic: Meiosis and Gene Linkages• Length of Lesson: 45 min lesson; 30 min lab• VA Standards of Learning: 6.a – 6.ac – Students will investigate and understand cell growth and division, gamete formation, and cell specialization<br />Cognitive Objectives• SWBAT understand that all living cells come from other living cells. During mitosis, the nucleus of the cell divides, forming two nuclei with identical genetic information• SWBAT understand that many organisms are capable of combining genetic information from two parents to produce offspring. Sex cells are produced through meiosis. This allows sexually reproducing organisms to produce genetically differing offspring.• SWBAT understand that many body cells of an organism can be specialized to perform different functions, even though they are all descended from a single cell and contain essentially the same genetic information<br />Materials and Advanced Preparation<br />• Miller and Levine’s Biology textbook (Miller & Joseph, 2008): Chapter 11.4 – 11.5• PowerPoint lecture with accompanying fill-in-the-blank handout• Grading rubric for mutations lab• Life cycle diagrams for° Rhizopus ° A moss° A fern° An animal, such as a human° Chlamydomonas or Ulva ° Nitella <br />Teaching and Learning Sequence<br />• Introduction/Anticipatory Set° Begin with an oral overview of what was taught the day before, answering questions as needed° Write Sperm, Eggs, and Why is Sexual Reproduction Important on the poster board. Have the students work in groups and go around “Carousel” style and fill in what they read the night before pertains to each section (PREPARATION)° After discussing the above, ask who can describe the difference between plant and animal cells, mitosis vs. meiosis and the purpose of DNA<br />• Lesson Development (ASSISTANCE)° Quick overview of mitosis° Discuss the differences between haploid and diploid cells° Discuss each phase of meiosis, having the students draw a representative figures and act out each phase° Explain the difference between male and female gamete formation° Show examples of gene linkage and gene maps<br />• Closure° Ask students: are meiosis and mitosis the same? How are they different? Who knows the phases of mitosis? What are the chromosomes and what difference do they play in meiosis vs. mitosis? (REFLECTION)° Review the handouts on life cycles of various organisms and begin the Meiosis lab (Virginia Department of Education, 2010)° Discuss questions #2 under introduction; give groups their assignment for the mutation lab day (Cystic Fibrosis, Sickle Cell Disease, Down Syndrome, Color Blindness, Hemophilia, Duchenne Muscular Dystrophy, Turner’s Syndrome and Klinefelter’s Syndrome)° Assign chapter 11.1 thru 11.3 to read for homework in preparation of the next day’s lesson; have students review diagrams of life cycle charts in preparation of the next day’s lab; mutations lab<br />Homework• Assign chapter 11.1 thru 11.3 to read for homework in preparation of the next day’s lesson; have students review diagrams of life cycle charts in preparation of the next day’s lab; mutations lab<br />Assessment• Formative – Asking the students questions during the lesson to re-enforce the segment being taught• Summative – After completion of the lab, students will be evaluated on their data sheet, which incorporates the lesson<br />References<br />Miller, K., & Joseph, L. (2008). Biology. Pearson Prentice Hall.<br />Virginia Department of Education. (2010). Science: Biology: Scope and Sequence. Retrieved August 31, 2010, from Virginia Department of Education: http://www.doe.virginia.gov/testing/sol/scope_sequence/science_scope_sequence/scopeseq_science_biology.pdf<br />Appended Materials• Instructional Content and Strategies Organizer• Curriculum Framework Document• Grading Rubric for Mutations Lab<br />Instructional Content and Strategies Organizer<br />,[object Object],Mutations Lab Project<br />With your group, you will research the mutation of your choice.  <br />You will need a one-page handout for the class listing the following facts:<br />,[object Object]
When was the mutation discovered?
How common is the mutation?
What causes the mutation?
Is the mutation recessive, dominant, incompletely dominant, codominant, sex-linked, or environmental?
Does the mutation cause a phenotypic change, genotypic change, or both?

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Meiosis Block 1

  • 1.
  • 2. When was the mutation discovered?
  • 3. How common is the mutation?
  • 4. What causes the mutation?
  • 5. Is the mutation recessive, dominant, incompletely dominant, codominant, sex-linked, or environmental?
  • 6. Does the mutation cause a phenotypic change, genotypic change, or both?
  • 7. Are there medications the people have to take, what are they?
  • 8. Are there lifestyle changes the people have to make, what are they?
  • 9. What is the common life span of someone with the mutation?
  • 10. Are they able to reproduce? If not, why is that important to survival of the human race?You will also need a visual. This can be a poster, a PowerPoint presentation, a home-made video, or something else pre-approved by me <br />You will give a 10 min oral presentation. Everyone in your group must speak. If you choose a video, that can take up no more than 3 min of your presentation time.<br />You will be given time in class to discuss with your group where you are in the research. Plan ahead wisely. You may want to assign different jobs for people in the group: the handout, the visual, and perhaps a script for the presentation. <br />All information in the handout and presentation must be cited using approved format for class! Remember: you need at least 5 journal articles; no Wikipedia; no unaccredited websites (only information from websites that end in .edu or .gov)<br />Extra Credit: Discuss in handout or presentation how the media has portrayed the mutation. This can include celebrities with the mutation, movies, songs, newscasts, myths, etc. For this section ONLY you may use Wikipedia and unaccredited websites, as necessary.<br />This will count as a test grade.<br />Good luck!<br />Meiosis and Gene Linkage Lecture Notes<br />Chromosome Number<br />A cell that contains _________ sets of homologues chromosomes is said to be diploid<br />Homologous chromosomes are when the chromosomes that come from male <br />parent have a corresponding chromosome from the female parent<br />The _____________ of sexually reproducing organisms are haploid, because they only have ______ set of chromosomes<br />Phases of Meiosis<br />Meiosis is a process of ______________division in which the number ______________ per cell is cut in __________through the separation of homologous chromosomes in a diploid cell<br />By the end of meiosis II, the diploid cell that entered meiosis has become _________ haploid cells<br />Meiosis I: Prophase<br />Each chromosome pairs with its corresponding homologous chromosome to form a structure called a ___________; therefore, there are four _______________in a tetrad<br />As they form the tetrads, they exchange portions of their chromatids in a process called _____________________<br />Meiosis I: Metaphase<br />_________________________ attach to the chromosomes<br />Meiosis I: Anaphase<br />The fibers pull the homologous chromosomes toward ______________ ends of the cell<br />Meiosis I: Telophase and Cytokinesis<br />___________________________ form. The cell separates into ________ cells<br />These two cells enter Meiosis II<br />Meiosis II: Prophase<br />Unlike the first division, neither cell goes through a round of chromosome ________________ before entering meiosis II<br />Each of the cell’s chromosomes has 2 chromatids<br />Meiosis II: Metaphase<br />Chromosomes line up in the ____________ of each cell<br />Meiosis II: Anaphase<br />The paired chromatids separate and move toward ________________ ends of the cell<br />Meiosis II: Telophase and Cytokinesis<br />Each cell separates into two cells - meaning __________ haploid cells all together<br />Gamete Formation<br />In __________ animals, meiosis produces four haploid sperm cells<br /> However, the cell divisions at the end of meiosis are uneven in females, so that only a _____________ cell receives most of the cytoplasm<br />Mitosis vs. Meiosis<br />Mitosis results in the production of two genetically ______________ diploid cells<br />Meiosis produces four genetically ______________ haploid cells<br />Gene Linkage<br />It is the __________________ that assort independently, not the individual genes<br />Each chromosome is a group of linked genes<br />Gene Maps<br />Crossing-over during meiosis sometimes separates ___________ that had been on the same chromosomes onto homologous chromosomes, producing new combinations of _____________<br />