7. ORIGIN SURFACE
EPITHELIAL
CELLS
GERM CELLS SEX CORD-
STROMAL
CELLS
OVERALL
FREQUENCY
65-70% 15-20% 5-10%
PROPORTION
OF MALIGNANT
OVARIAN
TUMORS
90% 3-5% 2-3%
AGE GROUP
AFFECTED
>20 YEARS <25 YEARS ALL AGES
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
19.
20.
21.
22.
23.
24.
25.
26.
27.
28.
29.
30. PATHOPHYSIOLOGY
• Modifiable Risk factors:
• Being overweight or obese
• Never being pregnant
• Using of Hormone
Replacement Therapy
• Using of talcum powder
• Smoking
• Non - modifiable
Risk factors:
• Age, most cases
develop after
menopause
• A family history of
ovarian cancer
• Inherited gene
mutation
- BRCA-1/BRCA-
2
Increase number
of cells in tissue
DNA damage in
the ovary cell
Failure of DNA
repair
Cellular genes
mutation
Unregulated
Growth and
Differentiation
31. Benign Malignant
Ovarian cancer
formation
• Pelvic
pressure
• Change in
bowel habits
• Lower
abdominal
pain Metastasis
Pelvic organs
• Pelvic pain
• Pain during sex
• Nausea and
vomiting
Peritoneal Cavity
• Abdominal Bloating
• Feeling full quickly
when eating
• Loss of appetite
3 Common Sites
• Epithelial cells
• Germ Cells
• Sex-cord stromal
Cell
Lungs, liver,
lymph nodes and
other organs