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ORIGIN SURFACE
EPITHELIAL
CELLS
GERM CELLS SEX CORD-
STROMAL
CELLS
OVERALL
FREQUENCY
65-70% 15-20% 5-10%
PROPORTION
OF MALIGNANT
OVARIAN
TUMORS
90% 3-5% 2-3%
AGE GROUP
AFFECTED
>20 YEARS <25 YEARS ALL AGES
PATHOPHYSIOLOGY
• Modifiable Risk factors:
• Being overweight or obese
• Never being pregnant
• Using of Hormone
Replacement Therapy
• Using of talcum powder
• Smoking
• Non - modifiable
Risk factors:
• Age, most cases
develop after
menopause
• A family history of
ovarian cancer
• Inherited gene
mutation
- BRCA-1/BRCA-
2
Increase number
of cells in tissue
DNA damage in
the ovary cell
Failure of DNA
repair
Cellular genes
mutation
Unregulated
Growth and
Differentiation
Benign Malignant
Ovarian cancer
formation
• Pelvic
pressure
• Change in
bowel habits
• Lower
abdominal
pain Metastasis
Pelvic organs
• Pelvic pain
• Pain during sex
• Nausea and
vomiting
Peritoneal Cavity
• Abdominal Bloating
• Feeling full quickly
when eating
• Loss of appetite
3 Common Sites
• Epithelial cells
• Germ Cells
• Sex-cord stromal
Cell
Lungs, liver,
lymph nodes and
other organs
Ovarian cancer.pptx
Ovarian cancer.pptx
Ovarian cancer.pptx
Ovarian cancer.pptx
Ovarian cancer.pptx
Ovarian cancer.pptx
Ovarian cancer.pptx
Ovarian cancer.pptx
Ovarian cancer.pptx
Ovarian cancer.pptx
Ovarian cancer.pptx
Ovarian cancer.pptx
Ovarian cancer.pptx
Ovarian cancer.pptx
Ovarian cancer.pptx
Ovarian cancer.pptx
Ovarian cancer.pptx
Ovarian cancer.pptx
Ovarian cancer.pptx
Ovarian cancer.pptx
Ovarian cancer.pptx
Ovarian cancer.pptx
Ovarian cancer.pptx

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Ovarian cancer.pptx

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  • 7. ORIGIN SURFACE EPITHELIAL CELLS GERM CELLS SEX CORD- STROMAL CELLS OVERALL FREQUENCY 65-70% 15-20% 5-10% PROPORTION OF MALIGNANT OVARIAN TUMORS 90% 3-5% 2-3% AGE GROUP AFFECTED >20 YEARS <25 YEARS ALL AGES
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  • 30. PATHOPHYSIOLOGY • Modifiable Risk factors: • Being overweight or obese • Never being pregnant • Using of Hormone Replacement Therapy • Using of talcum powder • Smoking • Non - modifiable Risk factors: • Age, most cases develop after menopause • A family history of ovarian cancer • Inherited gene mutation - BRCA-1/BRCA- 2 Increase number of cells in tissue DNA damage in the ovary cell Failure of DNA repair Cellular genes mutation Unregulated Growth and Differentiation
  • 31. Benign Malignant Ovarian cancer formation • Pelvic pressure • Change in bowel habits • Lower abdominal pain Metastasis Pelvic organs • Pelvic pain • Pain during sex • Nausea and vomiting Peritoneal Cavity • Abdominal Bloating • Feeling full quickly when eating • Loss of appetite 3 Common Sites • Epithelial cells • Germ Cells • Sex-cord stromal Cell Lungs, liver, lymph nodes and other organs