The document discusses how addiction affects the brain. Genetics account for 40-60% of addiction risk, with low dopamine levels increasing risk. Addictive drugs increase dopamine levels in the brain's reward centers beyond normal levels. All addictions impact the lower central brain regions controlling automatic functions and the cortex. The brain's structure and chemistry can be permanently altered by addiction, though recovery is possible over many years as the brain heals.

1. Addiction and the Brain An in depth look at how brain activity is directly connected with addictions