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Charles Modlin, M.D., MBA
                         Overview & Examples
                         Health Disparities in
•   Staff Urologist      Racial/ Ethnic Minority
•   Kidney Transplant    Populations
    Surgeon
                         Discuss Causes of
•   Founder &            Health Disparities
    Director, Minority
    Men’s Health         Health Disparities
    Center               Prevention
•   Cleveland Clinic
                         Highlight Cleveland
                         Clinic Programs
                         Designed to Address
                         Multifaceted Health
                         Disparities
Disclosures

•   I do not have any significant financial
    interest or other relationship with the
    manufacturers of any products or
    providers of services I intend to
    discuss.
•
Cleveland Clinic
Minority Men’s Health Center
Cleveland Clinic Minority Men’s
   Health Center/ Health Fair
       Established 2003
    Special Health Concerns in
          Minority Males
Health
•   In 1947, The World Health Organization
    defined health as:
•   “a state of complete
     - physical,
     - mental, and
     - social well-being and
     - not merely the absence of disease and
       infirmity”
U.S. Minorities Increasing in
    Numbers & Percentage Population

•   Minorities:
     - African Americans (Blacks), AA
     - Hispanic/ Latinos, H/L
     - Asian, A
     - Native American, (American Indians), NA
     - Pacific Islander, PI
•   1970: All U.S. Minorities 12.3% population
•   2003: All U.S. Minorities 25%
•   2006: All U.S. Minorities 30%
•   2050: Projected 50%
Population of the United States by Race and
 Hispanic/Latino Origin, Census 2000 and 2010
                                                   Census                         Census
                                                   2010,               Percent of 2000,                    Percent of
Race and Hispanic/Latino origin                    population          population population               population

Total Population                                     308,745,538         100.0%         281,421,906           100.0%

Single race

White                                                196,817,552           63.7         211,460,626             75.1

Black or African American                              37,685,848          12.2          34,658,190             12.3

American Indian and Alaska Native                       2,247,098            .7           2,475,956             0.9

Asian                                                  14,465,124           4.7          10,242,998             3.6

 Native Hawaiian and other Pacific
                                                           481,576         0.15            398,835              0.1
Islander

Two or more races                                       5,966,481           1.9           6,826,228             2.4

Some other race                                            604,265          .2           15,359,073             5.5

Hispanic or Latino                                     50,477,594          16.3          35,305,818             12.5
NOTE: Percentages do not add up to 100% due to rounding and because Hispanics may be of any race and are therefore counted
under more than one category.
Source: U.S. Census Bureau: National Population Estimates; Decennial Census.
Read more: Population of the United States by Race and Hispanic/Latino Origin, Census 2000
and July 1, 2005 — Infoplease.com http://www.infoplease.com/ipa/A0762156.html#ixzz1yins01sM
Race in Medicine & Research

•   Active debate about meaning, importance
•   Possibility of improving prevention and
    treatment of diseases by predicting hard-to-
    ascertain factors on the basis of more easily
    ascertained characteristics

•   Race: surrogate marker of increased
    likelihood of certain medical conditions
Health Disparities in AA’s
• Compared to general
  population, each year:
• 44% more AA’s die from cancer
• 30% more die from heart
  disease
• 180% more die from stroke
http://www.cdc.gov/cancer/dcpc/data/race.htm
http://www.kff.org/minorityhealth/index.cfm
African Americans Life
             Expectancies
•   AA’s 6-8 year shorter life expectancy
    than whites
•   AA’s have not benefited equally from
    medical advances
•   AAs economically advantaged do not
    enjoy in equal measure with whites
    expected +++ influence of affluence on
    their health.
Life Expectancy at Birth (in
years), by Race/Ethnicity, 2007

              U.S.   Ohio

      White   78.7   78.0

      AA      74.3   73.3

      H/L     83.5   80.4

      Asian   87.3   83.4

      NA      75.1   NSD
Life Expectancy at Birth Among Black and White Males and Females in the
         United States and the Black-White Life Expectancy Gap, 1975-2003




Harper, S. et al. JAMA 2007;0:297.11.1224-1232.

   Copyright restrictions may apply.
Number of Deaths per 100,000
    Population by Race/Ethnicity,
                       2005

    United States             Ohio
•   White      785.3          White 850.4
•   Black    1,016.6          Black 1,078.1
•   Other      476.5          Other 291.2
                       2008
    United States             Ohio
    White     750.3           White 828.0
    Black     934.9           Black 1,029.2
    Other     445.8           Other 325.7
Infant Mortality Rate (Deaths per 1,000 Live
         Births) by Race/Ethnicity
                 2003-2005

•   United States                              Ohio
•   Non-Hispanic White      5.7                 6.4
•   Non-Hispanic Black     13.6                15.6
•   Hispanic                5.6                 6.5



•   2007            Non-HW NH-Black Hispanic
•   United States   5.7     13.4     5.5
•   Ohio            6.4     15.3     6.6
Number of Deaths Due to Firearms
       per 100,000 Population by
         Race/Ethnicity, 2005
•   United States                                   Ohio
•   White 8.9                                       White                7.7
•   Black   19.4                                    Black                22.3
•   Other   4.1                                     Other                NSD




http://www.statehealthfacts.org/comparebar.jsp?ind=115&cat=2&sub=32&yr=63&typ=3
High Blood Pressure Levels Vary
     by Race and Ethnicity
  Race of Ethnic              Men         Women
      Group                   (%)          (%)
 African
                              43.0             45.7
 Americans
 Mexican
                              27.8             28.9
 Americans
 Whites                       33.9             31.3
 All                          34.1             32.7


  http://www.cdc.gov/bloodpressure/facts.htm
Hypertension
         African Americans

•   HTN risk factor for:
    - Kidney, eye, heart, vascular disease
    - 7.5 million Blacks
    - High salt diets, urban living, poverty,
      psychosocial factors: stress, genetic
      predisposition
    - Greater likelihood of being untreated
Cardiovascular Disease and
       Heart Failure in AA’s
•   CVD leading cause of death in all U.S.
    pts.
•   Greater incidence in AA’s
•   Race and ethnicity influence a patient's
    chance of receiving many specific
    procedures and treatments:
    - AA 13% less likely to have coronary
      angiography, 1/3 less to have bypass
Screening & Treatment
    Differences by Race & Gender
•   Blacks are less       Paula A. Johnson, MD,
    likely to receive       MPH
    major procedures      Brigham and Women’s Hospital
    diagnosing and
    treating coronary
                          Sources: Schulman KA et al,
    heart disease than      N Engl J Med 1999;340(8);
    whites                  Ayanian JZ et al, JAMA,
•   Black women are         1993;269,20; Giles et al,
    the least likely to     Arch Intern Med
    have such               1995;155(3); Johnson PA
    procedures              et al, Ann Intern Med
    recommended             1993;119(8))
Heart Disease in AA

•   Heart failure from HTN is > in Blacks (40%) than
    Whites (7%).
•   Major risk factors: smoking, HTN, high
    cholesterol, physical inactivity.

•   AA’s:
     - less knowledge about risk factors than whites,
       even per age and education.
•   AA diet consumption of meat, fried foods, high in
    cholesterol and saturated fats.
•   Physician Decision-making
Cerebrovascular Disease in AA
•   Blacks higher incidence of and
    >>mortality from stroke than whites
    - Blacks more hemorrhagic vs.
      ischemic (Stroke 1991^22:299-304)
•   Race and ethnicity influence a patient's
    chance of receiving many specific
    procedures and treatments.
2005 Stroke Death Rates per
     100,000 population
           (Kaiser Family Foundation)

United States            Ohio
Rate

White                    White
44.7                     48.2

Black                    Black
65.2                     60.3

Other                    Other
38                       31.9
Cancer in African Americans

•   Cancer 2nd leading cause of U.S.
    deaths
•   AA’s highest death rates in U.S.
•   Contributing factors: Tob,
    occupations, diet, knowledge, attitudes
    and practices, health/medical
    resources, biological factors,
    socioeconomic status.
Smoking in African
               Americans
•   AA tend to start smoking later in life
    and fewer cigarettes/day than Whites
•   More likely smoke Tar and Nicotine
    brands, 55% AA use only mentholated
    form
•   AA less likely than Whites to quit
•   AA 30% higher Nicotine intake per
    cigarette and differ in metabolism
•   Clin Immunol Immunopathol. 1991 May;59(2):187-200.
Cancer in AA
 By Race, AA more likely develop and
 die of the 4 most common cancers:

   Breast,
   Prostate,
   Colon,
   Lung—
       Cancer Incidence and Death Rates* by Site, Race, and
        Ethnicity†, US, 2004-2008. American Cancer Society. Cancer
        Facts & Figures 2012. Atlanta: American Cancer Society;
        2012.
Cancer Incidence Rates by Race
          (Kaiser Family Foundation)
        2004 Rate Age-Adjusted per 100,000
        • United States             Ohio
        • White 455.4               White    426.1
        • Black 469.6               Black    453.6
        • Hispanic 356.5            Hispanic     403.7


                                         0.0 - 471.7
United States            Rate

White                           462.5
Black                           471.7
Hispanic•                       350.1
        •
            2007
Number of Cancer Deaths per
          100,000 Population by
       Race/Ethnicity, 2005 & 2007


U.S.    2005 2007     Ohio 2005 2007
White 182.6   174.7   Whites 194.2   190.5
Black 222.7   209.1   Blacks 249.2   238.1
Other 112.4   108.5   Other   66.0    91.3
Cancer Mortality Trends Among
Men by Race/Ethnicity: Progress
Among white men in the           •   Among black men in the
  United States from 1999 to         United States from 1999 to
  2008, deaths from—                 2008, deaths from—
   - Colorectal cancer                - Colorectal cancer
     decreased significantly            decreased significantly
     by 3.0% per year.                  by 1.9% per year.

   -   Lung cancer decreased         -   Lung cancer decreased
       significantly by 2.0%             significantly by 2.8%
       per year.                         per year.

   -   Prostate cancer               -   Prostate cancer
       decreased significantly           decreased significantly
       by 3.4% per year.                 by 3.7% per year.

   -   Melanoma of the skin          -   Melanoma of the skin
       increased significantly           remained level.
       by 1.0% per year.
Five-year relative survival by stage at diagnosis for
                            total cancers
          in adults 20 years and older by race and gender
                      Source: SEER 1992-2001


                                        Stage at
diagnosis             Local        Regional             Distant           All Stages
Distant All stages
Gender Race Diagnosed % Survival %Diagnosed % Survival % Diagnosed % Survival % Survival %
Men     Black    54           92   20          31          26        16         56
        White    58           95   20          43          22        20         64

Women Black      40           83   33          50          27        15         51
      White      50           92   28          61          22        21         64

Local
Lung Cancer Deaths
Total Population
                                       Rate per 100,000
 TOTAL                                        57.6
 Race and ethnicity
 American Indian or Alaska Native             38.2
 Asian or Pacific Islander                    29.3
 Asian                                        DNC
 Native Hawaiian and other Pacific Islander   DNC
 Black or African American                    66.7
 White                                        57.5
 Hispanic or Latino                           22.7
Prostate Cancer Deaths
     Males                                  Rate per 100,000

     TOTAL                                        32.0
     Race and ethnicity
     American Indian or Alaska Native             15.9
     Asian or Pacific Islander                    12.4
     Asian                                        DNC
     Native Hawaiian and other Pacific Islander   DNC
     Black or African American                    68.7

     White                                        29.4
     Hispanic or Latino                           20.9


Data source: National Vital Statistics System (NVSS), CDC, NCHS.
Number of Diabetes Deaths per
        100,000 Population by
        Race/Ethnicity, 2005

    United States   Ohio
•   White 22.5      White   28.4
•   Black    47.0   Black   58.3
•   Other    20.5   Other   NSD
Kidney Disease and
            African Americans

•   The incidence of ESRD in AA is 4 times
    greater than in whites.
•   HTN and DM are the most commonly
    identified causes of kidney failure

•   National chronic kidney disease fact sheet, 2007.
    http://www.cdc.gov/diabetes/pubs/factsheets/kidney.htm
New Cases of End-Stage
Total Population
                                       Renal Disease
                                      Rate per Million
TOTAL                                             289
Race and ethnicity
American Indian or Alaska Native                  586
Asian or Pacific Islander                         344
Asian                                            DNC
Native Hawaiian and other Pacific Islander       DNC
Black or African American                        873
White                                            218
Gender
Female                                            242
Male                                              348

                     Data source: U.S. Renal Data System (USRDS), NIH, NIDDK.
Renal Transplantation:
                 Disparities
•   Currently approx.
    - 100,000 pts. on Kidney Tx
      Waiting list
       •35% AA; 19%H/L
       •But AA’s only 12% U.S.
           population; H/L 16%
       •   NIH News
           http://www.nih.gov/news/health/mar2012/niddk-08.htm

       • AA only get 26% of Deceased
           Donor Kidney Tx
Renal Transplantation:
               Disparities

•   Among Appropriate Candidates for Tx, Blacks
    are less likely: (UNOS Scientific Registry)
     - referred for evaluation
     - listed for Tx (account for only 28% new
       listing)
     - receive Tx
     - Post Tx have higher rejection rates (50%
       higher), lower patient and graft survival

    Blacks wait 2-4 times as long as whites
Why Healthcare Disparities?
•   Reasons:
•   Multifactorial
     •   Patient and Provider Factors
          •  Culture/ Culture Competency/ Communication
          •  Education/ Health Literacy
          •  Historical Factors/ Distrust/ Racism/ Stereotyping/ Bias
          •  Socio-Economic
               • Lack of health insurance
               • Lack of Access
               • Environment/ Nutrition
     •   Lack of Diverse Healthcare Workforce
     •   Genetics/ Biologic/ Diff. Response to Medications
     •   Lack of Minority Patients in Research Trials
     •   Sub-specialization in Medicine & Lack of Awareness of
         Disparities
Health Disparities Solutions:
        Multifaceted

 - Based upon our Cleveland
   Clinic MMHC Observations
   and Research
 - Examples of our Cleveland
   Clinic Innovative Solutions/
   Programs
Solutions: Step 1

Health Provider Recognition,
Acknowledgment of Existence,
Causes & Impact of Health Disparities
in Minority Populations
Doctors on Disparities in Medical
                 Care
•   Doctors less likely than public to say
    disparities are happening “very often”
    or “somewhat often.”

•   Kaiser Family Foundation Survey, March
    2002. http://www.kff.org/minorityhealth/20020321a-index.cfm
Health Provider Education

• Regarding:
 - Existence and Impact of
   Health Disparities in
   Minority Populations
Congressman Louis Stokes
Health Equity Lecture Forum,
      Established 2006
Cleveland Clinic Journal Medicine
       Special Series 2012:
Addressing Disparities in Health Care
      Guest Editor: Charles Modlin, MD, MBA

                         •   Modlin CS.
                             Addressing
                             Disparities in Health
                             Care Cleveland Clinic
                             Journal of Medicine
                             January 2012 vol. 79
                             (1): 44-45.
Disparities in prostate cancer in African American
    men: what primary care physicians can do.
Wu I, Modlin C. Cleveland Clinic Journal of Medicine
              May 2012 vol. 79 5 313-320
SOLUTION: Step 2
      Vision & Commitment
Institutional/Self-Belief that You
     Can Make A Difference
Solutions: Step 3:
Health Provider Cultural Competency &
              Sensitivity

•   All providers need to become sensitive
    to traditions, values, attitudes of ethnic
    groups
     - Mandated in some states, i.e. New
       Jersey first state
•   Cultural sensitiveness indicates how
    culture can strongly influence the amount
    and type of communication between
    patients and their health providers
The African American Barber Shop, Beauty Salon
             and Church Initiative
 A Tool in Development of Medical & Nursing
          Student & Health Provider
       Cultural Competency/Sensitivity
Step 4: Community Trust-Building


• Key Lesson:
 Initiative
                   Barbershop, Salon, Church



• Trust is single most important
 prerequisite necessary for healthcare
 providers to have success in promoting
 health in AA communities.
Solutions: Step 5
African American Physician Leadership,
        Visibility & Availability:
 Very Important To The African American Community
Become Part of the Community:
 Build Trusting Relationships
Become Part of the Community:
 Build Trusting Relationships
TEAMWORK & VOLUNTEERISM:
             Step 6
•   Dept. Urology
•   Dept. Nephrology
•   Medicine Institute
•   Cleveland Clinic
    Interdepartmental Clinical
    Collaborations
•   Wellness Institute
•   Dept. Pastoral Care Services
•   Dept. Social Work
•   Pharmacy
•   Division of Nursing
•   Nutrition Services
•   Institutional Services (Pt.
    Education, OPSA, Sponsored
    Research, etc.)
•   Corporate Communications
•   Governmental & Community
    Relations
•   Diversity
•   Bioethics
•   Biostatistics
•   Cleveland Clinic Lerner College
    of Medicine
•   Lerner Research Institute
Community & Corporate
Partners and Sponsors: Step 7
Solutions: Step 8

•   Facilitated Patient Access
•   Financial/ Charity Assistance Programs
Cleveland Clinic
      Financial Assistance Program

•   Under Ohio Hospital Care Assurance Program (HCAP)
    Cleveland Clinic offers basic, medically necessary
    hospital-level services free of charge to individuals who
    are residents of Ohio, and who are currently eligible
    recipients of the General Assistance or the Disability
    Assistance Programs or whose income is at or below the
    Federal Poverty Income Guidelines.


•   In addition, Cleveland Clinic provides financial
    assistance on a sliding scale to patients who do not have
    insurance at family income levels up to four (4) times the
    Federal Poverty Income Guidelines, and to all patients,
    including patients with insurance coverage, if there are
    exceptional circumstances.
Financial Assistance Program
                     Family Size   HCAP 2008      CC Financial
                                   Federal        Assistance

•   2008 Federal                   Poverty
                                   Income Level
                                                  Program
                                                  (Family Income
                                                  up to 400% of
    Poverty Income                                Federal Poverty
                                                  Level)
    Guidelines
                     1             $10,400        $41,600

                     2             $14,000        $56,000

                     3             $17,600        $70,400

                     4             $21,200        $84,800

                     5             $24,800        $99,200

                     6             $28,400        $113,600

                     7             $32,000        $128,000

                     8             $35,600        $142,400
Facilitated Patient Access:
   Step 9: Preventive Health
Screenings & Health Education
“Every Life Deserves World Class Care”
10th Annual Minority Men’s
        Health Fair
Health Fair Video
•   Courtesy Mr. Greg Lockhart
     - Frame By Frame Video
        Productions
     http://www.youtube.com/watch?v=3L4zEnecs9M
Health Screenings: Identification of
 Diseases in Early Treatable States
MMHC Health Fair Screenings 2007


       600




       500


                                                                                                422      439
                                                                                        400
       400




e
l
t
i
T      300
s
i

                                                                    217
x
A


                                                    200
       200
                                     153
                   120
       100




         0
            Dental Screenings   Blood Pressure     Stress         Urinalysis       Reviewed     DRE   Blood draws
             & Oral Hygiene        Screening     Management                       Medications
               Instruction
    Series1        120               153            200             217                 400     422      439
Solutions: Step 10: Dedicated
     Health Literacy Education

•   Health Education/ Outreach
    to Promote/ Improve Health
                                 •   Health Literacy
    Literacy
                                     Saves Lives
     - Increase awareness of
        preventive health
     - Increase health
        screenings
     - Promote healthy
        lifestyles
     - Promote participation
        in clinical trials by
        minorities
     - Promote awareness of
        family medical history
Minority Men’s Health Center
         Health Fair

  Health Information You Need To
               Know!
  (With Pre & Post Test Options)
Kidney Disease and Kidney
         Transplantation

•   Diabetes and high-blood pressure
    cause most kidney disease and kidney
    failure.
•   Control of your blood pressure and
    blood sugar may prevent kidney
    disease.
•   Kidney transplantation is a way to treat
    kidney failure. More AA are needed to
    donate their kidneys while living or
    after death.
Diabetes

•   Risk factors for diabetes are:
    - Genetics
    - Obesity
    - Lack of exercise
    - Other predisposing factors
Solution: Step 11:
                Communications
    Health Disparities Public Media Campaign


•   TV Media/ News
•   Print Media
Media Awareness
Solutions: Step 12


Patient Compliance:
 How To Improve It
Solutions: Step 13
  Community Empowerment:
Cleveland Clergy Ambassadors
  Health Education Program
2012 Minority Men’s Health Center
     Health Advocates
Solutions: Step 14
Translational Medicine to Benefit
  Health Disparity Populations
Solutions: Step 15
Encourage Minority Patient
 Participation in Clinical
     Research Trials
Response to Medications
            African Americans
•   Differences in genetics, environmental and cultural
    factors may lead to racial differences in response to
    medications.
•   Studies and Examples:
•   AA respond better to Calcium Antagonists
    -   Whites respond better to ACE and B-Blockers
    -   BiDil—New Med to treat CHF in AA

    - RACE-BASED MEDICINE
    -   Immunosuppressive Medications in AA
Etiology of Heart Failure
                  in Black Patients
                            HTN                             CAD


                     LVH                                             MI


                                           HF
    More common cause                                            More common cause of
    of HF cases in blacks                                         HF cases in whites



LVH=left ventricular hypertrophy.
Adapted from Yancy CW. J Card Fail. 2003;9(suppl 5):S210-S215.
A-HeFT: Additional 43% Reduction in Mortality Beyond Current
                           Standard Therapies

                          100

                                                                BiDil + Standard Therapies
                          95
           Survival (%)




                          90        Placebo + Standard Therapies                             Event rate=6.2%

                                                                                     43% Reduction*
                                                                                     P=.012 by Log-Rank Test

                          85                                                                 Event rate=10.2%

                                0        100     200       300          400   500      600
                                                       Time (days)
     BiDil, n = 518                      463     407        360         314   253       16
  Placebo, n = 532                       466     401        340         285   233       25
*Reduction refers to relative risk in mortality 1 – (hazard ratio) =1 – 0.57 =0.43. Reduction represents full length
 of follow-up.
BiDil [prescribing information]. Lexington, MA: NitroMed, Inc.; 2005.
Solutions:
Step 16: Mentorship: Developing
   Future Healthcare Leaders
Increasing Diversity of Health
     Provider Workforce
Solutions: Step 17:
Develop Community Partnerships
Community Leadership &
Celebrity Endorsement of
     MMHC: Step 18
Bill Cobbs: Hollywood Actor
        on Disease Prevention & Early Detection


•   http://www.youtube.com/watch?v=-HE7I_J-q98&featu
Health Policy Advocacy:
                Step 19:
United States Congressional Black Caucus,
            U.S. Capital,
           Washington, D.C.
Healthy People 2000: Priority Areas

•   1. Physical Activity and Fitness
    2. Nutrition
    3. Tobacco
    4. Substance Abuse: Alcohol and Other Drugs
    5. Family Planning
    6. Mental Health and Mental Disorders
    7. Violent and Abusive Behavior
    8. Educational and Community-Based Programs
    9. Unintentional Injuries
    10. Occupational Safety and Health
    11. Environmental Health
    12. Food and Drug Safety
    13. Oral Health
    14. Maternal and Infant Health
    15. Heart Disease and Stroke
    16. Cancer
    17. Diabetes and Chronic Disabling Conditions
    18. HIV Infection
    19. Sexually Transmitted Diseases
    20. Immunization and Infectious Diseases
    21. Clinical Preventive Services
    22. Surveillance and Data Systems
Healthy People 2010

•   Healthy People 2010 challenges individuals, communities,
    professionals, and institutions—all of us— to take specific
    steps to ensure that good health, as well as long life, are
    enjoyed by all.
•
    Healthy People is managed by the
    Office of Disease Prevention and Health Promotion,
    U.S. Department of Health and Human Services
Step 20:Promotion of & Celebration
  of Family Support Systems and
Awareness of Family Medical History
Solutions: Step 21
        Outcomes Research

•   Look at health outcomes in your own
    practice and at your own institution
•   Know how you are doing
•   Develop strategies to improve your
    outcomes
Analysis of Disparities in Kidney
  Transplantation by Race at
      Cleveland Clinic

Section of Renal Transplantation
 Minority Men’s Health Center


 C. Modlin, C. Zaramo, J. Alster, L. Zhou, D.
           Goldfarb, S. Flechner,
               and A. Novick
Health Disparities in Renal Graph
     Survival in Tx Patients by Race and
             Source of Allograft

Cadaveric (CAD)               Living Related (LR)
Dialysis 1st Week Post-Tx
Significant Disparities in Dialysis following the First
Week of Post Renal Transplantations (Post-Tx, p<0.001*)

                    100

                                        *p< 0.0001
   Percentage (%)




                     80

                               52.14%
                     60


                     40                              15%


                     20                                         8.16%         5.14%


                      0
                             African          Caucasian      African      Caucasian (L)
                          American (CAD)       (CAD)       American (L)

                                               Race/ Ethnicity
Post-Tx Serum Creatinine (CAD)
Creatinine Levels from Cadaveric Donors, Significant Difference at 7
                              Days
  (p<0.0001), 1 month (p=0.005) and 2 Months (1 Year ) (p< 0.004)



        *
 7
                                               African American (CAD)
             p=0.0001
                                               White (CAD
 6


 5
                                           P<.0001 @ 7 days
                                           P<.008 @ 12 mos.
 4


 3
                      *   p=0.005

 2


 1
                                                *   p=0.004

 0
     Day 7        1            3       6       12         36
                                    Time
STEP 22:
   Putting it all together:
  Develop and Implement
  Multifaceted Innovative
Programs to Address Health
         Disparities
•   Transplantation
    Proceedings
    Volume 40, Issue 4 ,
    Pages 1001-1004, May
    2008
Culturally Sensitive & Competent Team to
Promote Organ Donor Registration
Expanding Organ Donation
Acceptance and Transplant
Rates in African Americans
            AND
Promotion of Prevention of
 Kidney Disease in African
        Americans
Solution: Promotion of Living
 Kidney Donation in African
          Americans
Living Unrelated Renal
           Transplantation




• http://www.youtube.com/watch?v=jy0CsHLL8YE
Living Related Renal
  Transplantation
Standard Surgical Techniques
 for Kidney Transplantation
Renal Allograft
Solutions:
   Innovations in Healthcare:
Look to see how you can innovate
      to improve outcomes
•   Utilization of Expanded Criteria Donor Kidneys for
    Transplantation:
     - Single Pediatric Deceased Donor Allografts
     - Pediatric Enbloc Deceased Donor Allografts
     - Kidneys with multiple arteries
     - Dual Deceased Donor Allografts
     - Kidneys with capsular injuries
     - Kidneys with renal artery aneurysms
Expanded Criteria Donor
Kidneys for Transplantation

              •   Modlin CS,
                  Goldfarb DA, Novick
                   AC. The use of
                  expanded criteria
                  cadaver and live
                  donor kidneys for
                  transplantation. Urol
                  transplantation
                  Clin North Am. 2001
                  Nov;28(4):687-707.
Issues and Techniques Available to Expand
     the Pool of Kidneys Available For
         Transplantation. MODLIN

                     •   Chapter 10. In Kidney
                         and Pancreas
                         Transplantation: A
                         Practice Guide.
Multiple Renal Arteries
End-To-Side Arterial
   Anastamosis
Dual Mate Kidney with 3 Arteries
Dual Mate Kidney with 4 Arteries
Dual Deceased Donor Allograft
Pediatric Deceased Donor
     Kidneys For Transplantation

•   Modlin C, Novick AC, Goormastic M, Hodge E,
    Mastrioanni B, Myles J. Long-term results with single
    pediatric donor kidney transplants in adult recipients. J
    Urol 1996 Sep;156(3):890-895.


•   Hobart MG, Modlin CS, Kapoor A, Boparai N, Mastroianni
    B, Papajcik D, Flechner SM, Goldfarb DA, Fischer R,
    O'Malley KJ, Novick AC. Transplantation of pediatric
    enbloc cadaver kidneys into adult recipients.
    Transplantation 1998 Dec 27;66(12):1689-1694.
Pediatric Enbloc Allografts
Pediatric Enbloc Kidneys
Pediatric Enbloc Kidney
       Allografts
Pediatric Enbloc Allografts
Pediatric Enbloc Post Perfusion
Capsular Repair Vicryl Mesh
Capsular Repair
Renal Capsular Repair

•   J Natl Med Assoc.
    2012;104:199-201
Renal Angiomyolipoma
in Living Donor Kidney
Living Donor Kidney with
 Renal Artery Aneurysm
Dr. charles modlin nma new orleans urology presentation july 30 2012
Dr. charles modlin nma new orleans urology presentation july 30 2012
Dr. charles modlin nma new orleans urology presentation july 30 2012
Dr. charles modlin nma new orleans urology presentation july 30 2012

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Dr. charles modlin nma new orleans urology presentation july 30 2012

  • 1. Charles Modlin, M.D., MBA Overview & Examples Health Disparities in • Staff Urologist Racial/ Ethnic Minority • Kidney Transplant Populations Surgeon Discuss Causes of • Founder & Health Disparities Director, Minority Men’s Health Health Disparities Center Prevention • Cleveland Clinic Highlight Cleveland Clinic Programs Designed to Address Multifaceted Health Disparities
  • 2. Disclosures • I do not have any significant financial interest or other relationship with the manufacturers of any products or providers of services I intend to discuss. •
  • 4. Cleveland Clinic Minority Men’s Health Center/ Health Fair Established 2003 Special Health Concerns in Minority Males
  • 5. Health • In 1947, The World Health Organization defined health as: • “a state of complete - physical, - mental, and - social well-being and - not merely the absence of disease and infirmity”
  • 6. U.S. Minorities Increasing in Numbers & Percentage Population • Minorities: - African Americans (Blacks), AA - Hispanic/ Latinos, H/L - Asian, A - Native American, (American Indians), NA - Pacific Islander, PI • 1970: All U.S. Minorities 12.3% population • 2003: All U.S. Minorities 25% • 2006: All U.S. Minorities 30% • 2050: Projected 50%
  • 7. Population of the United States by Race and Hispanic/Latino Origin, Census 2000 and 2010 Census Census 2010, Percent of 2000, Percent of Race and Hispanic/Latino origin population population population population Total Population 308,745,538 100.0% 281,421,906 100.0% Single race White 196,817,552 63.7 211,460,626 75.1 Black or African American 37,685,848 12.2 34,658,190 12.3 American Indian and Alaska Native 2,247,098 .7 2,475,956 0.9 Asian 14,465,124 4.7 10,242,998 3.6 Native Hawaiian and other Pacific 481,576 0.15 398,835 0.1 Islander Two or more races 5,966,481 1.9 6,826,228 2.4 Some other race 604,265 .2 15,359,073 5.5 Hispanic or Latino 50,477,594 16.3 35,305,818 12.5 NOTE: Percentages do not add up to 100% due to rounding and because Hispanics may be of any race and are therefore counted under more than one category. Source: U.S. Census Bureau: National Population Estimates; Decennial Census. Read more: Population of the United States by Race and Hispanic/Latino Origin, Census 2000 and July 1, 2005 — Infoplease.com http://www.infoplease.com/ipa/A0762156.html#ixzz1yins01sM
  • 8. Race in Medicine & Research • Active debate about meaning, importance • Possibility of improving prevention and treatment of diseases by predicting hard-to- ascertain factors on the basis of more easily ascertained characteristics • Race: surrogate marker of increased likelihood of certain medical conditions
  • 9. Health Disparities in AA’s • Compared to general population, each year: • 44% more AA’s die from cancer • 30% more die from heart disease • 180% more die from stroke http://www.cdc.gov/cancer/dcpc/data/race.htm http://www.kff.org/minorityhealth/index.cfm
  • 10. African Americans Life Expectancies • AA’s 6-8 year shorter life expectancy than whites • AA’s have not benefited equally from medical advances • AAs economically advantaged do not enjoy in equal measure with whites expected +++ influence of affluence on their health.
  • 11. Life Expectancy at Birth (in years), by Race/Ethnicity, 2007 U.S. Ohio White 78.7 78.0 AA 74.3 73.3 H/L 83.5 80.4 Asian 87.3 83.4 NA 75.1 NSD
  • 12. Life Expectancy at Birth Among Black and White Males and Females in the United States and the Black-White Life Expectancy Gap, 1975-2003 Harper, S. et al. JAMA 2007;0:297.11.1224-1232. Copyright restrictions may apply.
  • 13. Number of Deaths per 100,000 Population by Race/Ethnicity, 2005 United States Ohio • White 785.3 White 850.4 • Black 1,016.6 Black 1,078.1 • Other 476.5 Other 291.2 2008 United States Ohio White 750.3 White 828.0 Black 934.9 Black 1,029.2 Other 445.8 Other 325.7
  • 14. Infant Mortality Rate (Deaths per 1,000 Live Births) by Race/Ethnicity 2003-2005 • United States Ohio • Non-Hispanic White 5.7 6.4 • Non-Hispanic Black 13.6 15.6 • Hispanic 5.6 6.5 • 2007 Non-HW NH-Black Hispanic • United States 5.7 13.4 5.5 • Ohio 6.4 15.3 6.6
  • 15. Number of Deaths Due to Firearms per 100,000 Population by Race/Ethnicity, 2005 • United States Ohio • White 8.9 White 7.7 • Black 19.4 Black 22.3 • Other 4.1 Other NSD http://www.statehealthfacts.org/comparebar.jsp?ind=115&cat=2&sub=32&yr=63&typ=3
  • 16. High Blood Pressure Levels Vary by Race and Ethnicity Race of Ethnic Men Women Group (%) (%) African 43.0 45.7 Americans Mexican 27.8 28.9 Americans Whites 33.9 31.3 All 34.1 32.7 http://www.cdc.gov/bloodpressure/facts.htm
  • 17. Hypertension African Americans • HTN risk factor for: - Kidney, eye, heart, vascular disease - 7.5 million Blacks - High salt diets, urban living, poverty, psychosocial factors: stress, genetic predisposition - Greater likelihood of being untreated
  • 18. Cardiovascular Disease and Heart Failure in AA’s • CVD leading cause of death in all U.S. pts. • Greater incidence in AA’s • Race and ethnicity influence a patient's chance of receiving many specific procedures and treatments: - AA 13% less likely to have coronary angiography, 1/3 less to have bypass
  • 19. Screening & Treatment Differences by Race & Gender • Blacks are less Paula A. Johnson, MD, likely to receive MPH major procedures Brigham and Women’s Hospital diagnosing and treating coronary Sources: Schulman KA et al, heart disease than N Engl J Med 1999;340(8); whites Ayanian JZ et al, JAMA, • Black women are 1993;269,20; Giles et al, the least likely to Arch Intern Med have such 1995;155(3); Johnson PA procedures et al, Ann Intern Med recommended 1993;119(8))
  • 20. Heart Disease in AA • Heart failure from HTN is > in Blacks (40%) than Whites (7%). • Major risk factors: smoking, HTN, high cholesterol, physical inactivity. • AA’s: - less knowledge about risk factors than whites, even per age and education. • AA diet consumption of meat, fried foods, high in cholesterol and saturated fats. • Physician Decision-making
  • 21. Cerebrovascular Disease in AA • Blacks higher incidence of and >>mortality from stroke than whites - Blacks more hemorrhagic vs. ischemic (Stroke 1991^22:299-304) • Race and ethnicity influence a patient's chance of receiving many specific procedures and treatments.
  • 22. 2005 Stroke Death Rates per 100,000 population (Kaiser Family Foundation) United States Ohio Rate White White 44.7 48.2 Black Black 65.2 60.3 Other Other 38 31.9
  • 23. Cancer in African Americans • Cancer 2nd leading cause of U.S. deaths • AA’s highest death rates in U.S. • Contributing factors: Tob, occupations, diet, knowledge, attitudes and practices, health/medical resources, biological factors, socioeconomic status.
  • 24. Smoking in African Americans • AA tend to start smoking later in life and fewer cigarettes/day than Whites • More likely smoke Tar and Nicotine brands, 55% AA use only mentholated form • AA less likely than Whites to quit • AA 30% higher Nicotine intake per cigarette and differ in metabolism • Clin Immunol Immunopathol. 1991 May;59(2):187-200.
  • 25. Cancer in AA  By Race, AA more likely develop and die of the 4 most common cancers:  Breast,  Prostate,  Colon,  Lung—  Cancer Incidence and Death Rates* by Site, Race, and Ethnicity†, US, 2004-2008. American Cancer Society. Cancer Facts & Figures 2012. Atlanta: American Cancer Society; 2012.
  • 26. Cancer Incidence Rates by Race (Kaiser Family Foundation) 2004 Rate Age-Adjusted per 100,000 • United States Ohio • White 455.4 White 426.1 • Black 469.6 Black 453.6 • Hispanic 356.5 Hispanic 403.7 0.0 - 471.7 United States Rate White 462.5 Black 471.7 Hispanic• 350.1 • 2007
  • 27. Number of Cancer Deaths per 100,000 Population by Race/Ethnicity, 2005 & 2007 U.S. 2005 2007 Ohio 2005 2007 White 182.6 174.7 Whites 194.2 190.5 Black 222.7 209.1 Blacks 249.2 238.1 Other 112.4 108.5 Other 66.0 91.3
  • 28. Cancer Mortality Trends Among Men by Race/Ethnicity: Progress Among white men in the • Among black men in the United States from 1999 to United States from 1999 to 2008, deaths from— 2008, deaths from— - Colorectal cancer - Colorectal cancer decreased significantly decreased significantly by 3.0% per year. by 1.9% per year. - Lung cancer decreased - Lung cancer decreased significantly by 2.0% significantly by 2.8% per year. per year. - Prostate cancer - Prostate cancer decreased significantly decreased significantly by 3.4% per year. by 3.7% per year. - Melanoma of the skin - Melanoma of the skin increased significantly remained level. by 1.0% per year.
  • 29. Five-year relative survival by stage at diagnosis for total cancers in adults 20 years and older by race and gender Source: SEER 1992-2001 Stage at diagnosis Local Regional Distant All Stages Distant All stages Gender Race Diagnosed % Survival %Diagnosed % Survival % Diagnosed % Survival % Survival % Men Black 54 92 20 31 26 16 56 White 58 95 20 43 22 20 64 Women Black 40 83 33 50 27 15 51 White 50 92 28 61 22 21 64 Local
  • 30.
  • 31. Lung Cancer Deaths Total Population Rate per 100,000 TOTAL 57.6 Race and ethnicity American Indian or Alaska Native 38.2 Asian or Pacific Islander 29.3 Asian DNC Native Hawaiian and other Pacific Islander DNC Black or African American 66.7 White 57.5 Hispanic or Latino 22.7
  • 32. Prostate Cancer Deaths Males Rate per 100,000 TOTAL 32.0 Race and ethnicity American Indian or Alaska Native 15.9 Asian or Pacific Islander 12.4 Asian DNC Native Hawaiian and other Pacific Islander DNC Black or African American 68.7 White 29.4 Hispanic or Latino 20.9 Data source: National Vital Statistics System (NVSS), CDC, NCHS.
  • 33. Number of Diabetes Deaths per 100,000 Population by Race/Ethnicity, 2005 United States Ohio • White 22.5 White 28.4 • Black 47.0 Black 58.3 • Other 20.5 Other NSD
  • 34. Kidney Disease and African Americans • The incidence of ESRD in AA is 4 times greater than in whites. • HTN and DM are the most commonly identified causes of kidney failure • National chronic kidney disease fact sheet, 2007. http://www.cdc.gov/diabetes/pubs/factsheets/kidney.htm
  • 35. New Cases of End-Stage Total Population Renal Disease Rate per Million TOTAL 289 Race and ethnicity American Indian or Alaska Native 586 Asian or Pacific Islander 344 Asian DNC Native Hawaiian and other Pacific Islander DNC Black or African American 873 White 218 Gender Female 242 Male 348 Data source: U.S. Renal Data System (USRDS), NIH, NIDDK.
  • 36. Renal Transplantation: Disparities • Currently approx. - 100,000 pts. on Kidney Tx Waiting list •35% AA; 19%H/L •But AA’s only 12% U.S. population; H/L 16% • NIH News http://www.nih.gov/news/health/mar2012/niddk-08.htm • AA only get 26% of Deceased Donor Kidney Tx
  • 37. Renal Transplantation: Disparities • Among Appropriate Candidates for Tx, Blacks are less likely: (UNOS Scientific Registry) - referred for evaluation - listed for Tx (account for only 28% new listing) - receive Tx - Post Tx have higher rejection rates (50% higher), lower patient and graft survival Blacks wait 2-4 times as long as whites
  • 38. Why Healthcare Disparities? • Reasons: • Multifactorial • Patient and Provider Factors • Culture/ Culture Competency/ Communication • Education/ Health Literacy • Historical Factors/ Distrust/ Racism/ Stereotyping/ Bias • Socio-Economic • Lack of health insurance • Lack of Access • Environment/ Nutrition • Lack of Diverse Healthcare Workforce • Genetics/ Biologic/ Diff. Response to Medications • Lack of Minority Patients in Research Trials • Sub-specialization in Medicine & Lack of Awareness of Disparities
  • 39. Health Disparities Solutions: Multifaceted - Based upon our Cleveland Clinic MMHC Observations and Research - Examples of our Cleveland Clinic Innovative Solutions/ Programs
  • 40. Solutions: Step 1 Health Provider Recognition, Acknowledgment of Existence, Causes & Impact of Health Disparities in Minority Populations
  • 41. Doctors on Disparities in Medical Care • Doctors less likely than public to say disparities are happening “very often” or “somewhat often.” • Kaiser Family Foundation Survey, March 2002. http://www.kff.org/minorityhealth/20020321a-index.cfm
  • 42. Health Provider Education • Regarding: - Existence and Impact of Health Disparities in Minority Populations
  • 43. Congressman Louis Stokes Health Equity Lecture Forum, Established 2006
  • 44. Cleveland Clinic Journal Medicine Special Series 2012: Addressing Disparities in Health Care Guest Editor: Charles Modlin, MD, MBA • Modlin CS. Addressing Disparities in Health Care Cleveland Clinic Journal of Medicine January 2012 vol. 79 (1): 44-45.
  • 45. Disparities in prostate cancer in African American men: what primary care physicians can do. Wu I, Modlin C. Cleveland Clinic Journal of Medicine May 2012 vol. 79 5 313-320
  • 46. SOLUTION: Step 2 Vision & Commitment Institutional/Self-Belief that You Can Make A Difference
  • 47. Solutions: Step 3: Health Provider Cultural Competency & Sensitivity • All providers need to become sensitive to traditions, values, attitudes of ethnic groups - Mandated in some states, i.e. New Jersey first state • Cultural sensitiveness indicates how culture can strongly influence the amount and type of communication between patients and their health providers
  • 48. The African American Barber Shop, Beauty Salon and Church Initiative A Tool in Development of Medical & Nursing Student & Health Provider Cultural Competency/Sensitivity
  • 49.
  • 50. Step 4: Community Trust-Building • Key Lesson: Initiative Barbershop, Salon, Church • Trust is single most important prerequisite necessary for healthcare providers to have success in promoting health in AA communities.
  • 51. Solutions: Step 5 African American Physician Leadership, Visibility & Availability: Very Important To The African American Community
  • 52. Become Part of the Community: Build Trusting Relationships
  • 53. Become Part of the Community: Build Trusting Relationships
  • 54. TEAMWORK & VOLUNTEERISM: Step 6 • Dept. Urology • Dept. Nephrology • Medicine Institute • Cleveland Clinic Interdepartmental Clinical Collaborations • Wellness Institute • Dept. Pastoral Care Services • Dept. Social Work • Pharmacy • Division of Nursing • Nutrition Services • Institutional Services (Pt. Education, OPSA, Sponsored Research, etc.) • Corporate Communications • Governmental & Community Relations • Diversity • Bioethics • Biostatistics • Cleveland Clinic Lerner College of Medicine • Lerner Research Institute
  • 55. Community & Corporate Partners and Sponsors: Step 7
  • 56. Solutions: Step 8 • Facilitated Patient Access • Financial/ Charity Assistance Programs
  • 57. Cleveland Clinic Financial Assistance Program • Under Ohio Hospital Care Assurance Program (HCAP) Cleveland Clinic offers basic, medically necessary hospital-level services free of charge to individuals who are residents of Ohio, and who are currently eligible recipients of the General Assistance or the Disability Assistance Programs or whose income is at or below the Federal Poverty Income Guidelines. • In addition, Cleveland Clinic provides financial assistance on a sliding scale to patients who do not have insurance at family income levels up to four (4) times the Federal Poverty Income Guidelines, and to all patients, including patients with insurance coverage, if there are exceptional circumstances.
  • 58. Financial Assistance Program Family Size HCAP 2008 CC Financial Federal Assistance • 2008 Federal Poverty Income Level Program (Family Income up to 400% of Poverty Income Federal Poverty Level) Guidelines 1 $10,400 $41,600 2 $14,000 $56,000 3 $17,600 $70,400 4 $21,200 $84,800 5 $24,800 $99,200 6 $28,400 $113,600 7 $32,000 $128,000 8 $35,600 $142,400
  • 59. Facilitated Patient Access: Step 9: Preventive Health Screenings & Health Education
  • 60. “Every Life Deserves World Class Care”
  • 61. 10th Annual Minority Men’s Health Fair
  • 62. Health Fair Video • Courtesy Mr. Greg Lockhart - Frame By Frame Video Productions http://www.youtube.com/watch?v=3L4zEnecs9M
  • 63.
  • 64. Health Screenings: Identification of Diseases in Early Treatable States
  • 65. MMHC Health Fair Screenings 2007 600 500 422 439 400 400 e l t i T 300 s i 217 x A 200 200 153 120 100 0 Dental Screenings Blood Pressure Stress Urinalysis Reviewed DRE Blood draws & Oral Hygiene Screening Management Medications Instruction Series1 120 153 200 217 400 422 439
  • 66.
  • 67.
  • 68.
  • 69.
  • 70. Solutions: Step 10: Dedicated Health Literacy Education • Health Education/ Outreach to Promote/ Improve Health • Health Literacy Literacy Saves Lives - Increase awareness of preventive health - Increase health screenings - Promote healthy lifestyles - Promote participation in clinical trials by minorities - Promote awareness of family medical history
  • 71. Minority Men’s Health Center Health Fair Health Information You Need To Know! (With Pre & Post Test Options)
  • 72. Kidney Disease and Kidney Transplantation • Diabetes and high-blood pressure cause most kidney disease and kidney failure. • Control of your blood pressure and blood sugar may prevent kidney disease. • Kidney transplantation is a way to treat kidney failure. More AA are needed to donate their kidneys while living or after death.
  • 73. Diabetes • Risk factors for diabetes are: - Genetics - Obesity - Lack of exercise - Other predisposing factors
  • 74. Solution: Step 11: Communications Health Disparities Public Media Campaign • TV Media/ News • Print Media
  • 76. Solutions: Step 12 Patient Compliance: How To Improve It
  • 77.
  • 78. Solutions: Step 13 Community Empowerment: Cleveland Clergy Ambassadors Health Education Program
  • 79. 2012 Minority Men’s Health Center Health Advocates
  • 80. Solutions: Step 14 Translational Medicine to Benefit Health Disparity Populations
  • 81. Solutions: Step 15 Encourage Minority Patient Participation in Clinical Research Trials
  • 82. Response to Medications African Americans • Differences in genetics, environmental and cultural factors may lead to racial differences in response to medications. • Studies and Examples: • AA respond better to Calcium Antagonists - Whites respond better to ACE and B-Blockers - BiDil—New Med to treat CHF in AA - RACE-BASED MEDICINE - Immunosuppressive Medications in AA
  • 83. Etiology of Heart Failure in Black Patients HTN CAD LVH MI HF More common cause More common cause of of HF cases in blacks HF cases in whites LVH=left ventricular hypertrophy. Adapted from Yancy CW. J Card Fail. 2003;9(suppl 5):S210-S215.
  • 84. A-HeFT: Additional 43% Reduction in Mortality Beyond Current Standard Therapies 100 BiDil + Standard Therapies 95 Survival (%) 90 Placebo + Standard Therapies Event rate=6.2% 43% Reduction* P=.012 by Log-Rank Test 85 Event rate=10.2% 0 100 200 300 400 500 600 Time (days) BiDil, n = 518 463 407 360 314 253 16 Placebo, n = 532 466 401 340 285 233 25 *Reduction refers to relative risk in mortality 1 – (hazard ratio) =1 – 0.57 =0.43. Reduction represents full length of follow-up. BiDil [prescribing information]. Lexington, MA: NitroMed, Inc.; 2005.
  • 85. Solutions: Step 16: Mentorship: Developing Future Healthcare Leaders
  • 86. Increasing Diversity of Health Provider Workforce
  • 87. Solutions: Step 17: Develop Community Partnerships
  • 88. Community Leadership & Celebrity Endorsement of MMHC: Step 18
  • 89. Bill Cobbs: Hollywood Actor on Disease Prevention & Early Detection • http://www.youtube.com/watch?v=-HE7I_J-q98&featu
  • 90. Health Policy Advocacy: Step 19: United States Congressional Black Caucus, U.S. Capital, Washington, D.C.
  • 91. Healthy People 2000: Priority Areas • 1. Physical Activity and Fitness 2. Nutrition 3. Tobacco 4. Substance Abuse: Alcohol and Other Drugs 5. Family Planning 6. Mental Health and Mental Disorders 7. Violent and Abusive Behavior 8. Educational and Community-Based Programs 9. Unintentional Injuries 10. Occupational Safety and Health 11. Environmental Health 12. Food and Drug Safety 13. Oral Health 14. Maternal and Infant Health 15. Heart Disease and Stroke 16. Cancer 17. Diabetes and Chronic Disabling Conditions 18. HIV Infection 19. Sexually Transmitted Diseases 20. Immunization and Infectious Diseases 21. Clinical Preventive Services 22. Surveillance and Data Systems
  • 92. Healthy People 2010 • Healthy People 2010 challenges individuals, communities, professionals, and institutions—all of us— to take specific steps to ensure that good health, as well as long life, are enjoyed by all. • Healthy People is managed by the Office of Disease Prevention and Health Promotion, U.S. Department of Health and Human Services
  • 93. Step 20:Promotion of & Celebration of Family Support Systems and Awareness of Family Medical History
  • 94. Solutions: Step 21 Outcomes Research • Look at health outcomes in your own practice and at your own institution • Know how you are doing • Develop strategies to improve your outcomes
  • 95. Analysis of Disparities in Kidney Transplantation by Race at Cleveland Clinic Section of Renal Transplantation Minority Men’s Health Center C. Modlin, C. Zaramo, J. Alster, L. Zhou, D. Goldfarb, S. Flechner, and A. Novick
  • 96. Health Disparities in Renal Graph Survival in Tx Patients by Race and Source of Allograft Cadaveric (CAD) Living Related (LR)
  • 97. Dialysis 1st Week Post-Tx Significant Disparities in Dialysis following the First Week of Post Renal Transplantations (Post-Tx, p<0.001*) 100 *p< 0.0001 Percentage (%) 80 52.14% 60 40 15% 20 8.16% 5.14% 0 African Caucasian African Caucasian (L) American (CAD) (CAD) American (L) Race/ Ethnicity
  • 98. Post-Tx Serum Creatinine (CAD) Creatinine Levels from Cadaveric Donors, Significant Difference at 7 Days (p<0.0001), 1 month (p=0.005) and 2 Months (1 Year ) (p< 0.004) * 7 African American (CAD) p=0.0001 White (CAD 6 5 P<.0001 @ 7 days P<.008 @ 12 mos. 4 3 * p=0.005 2 1 * p=0.004 0 Day 7 1 3 6 12 36 Time
  • 99. STEP 22: Putting it all together: Develop and Implement Multifaceted Innovative Programs to Address Health Disparities
  • 100. Transplantation Proceedings Volume 40, Issue 4 , Pages 1001-1004, May 2008
  • 101. Culturally Sensitive & Competent Team to Promote Organ Donor Registration
  • 102. Expanding Organ Donation Acceptance and Transplant Rates in African Americans AND Promotion of Prevention of Kidney Disease in African Americans
  • 103. Solution: Promotion of Living Kidney Donation in African Americans
  • 104. Living Unrelated Renal Transplantation • http://www.youtube.com/watch?v=jy0CsHLL8YE
  • 105. Living Related Renal Transplantation
  • 106. Standard Surgical Techniques for Kidney Transplantation
  • 107.
  • 108.
  • 110.
  • 111. Solutions: Innovations in Healthcare: Look to see how you can innovate to improve outcomes • Utilization of Expanded Criteria Donor Kidneys for Transplantation: - Single Pediatric Deceased Donor Allografts - Pediatric Enbloc Deceased Donor Allografts - Kidneys with multiple arteries - Dual Deceased Donor Allografts - Kidneys with capsular injuries - Kidneys with renal artery aneurysms
  • 112. Expanded Criteria Donor Kidneys for Transplantation • Modlin CS, Goldfarb DA, Novick AC. The use of expanded criteria cadaver and live donor kidneys for transplantation. Urol transplantation Clin North Am. 2001 Nov;28(4):687-707.
  • 113. Issues and Techniques Available to Expand the Pool of Kidneys Available For Transplantation. MODLIN • Chapter 10. In Kidney and Pancreas Transplantation: A Practice Guide.
  • 114.
  • 116. End-To-Side Arterial Anastamosis
  • 117. Dual Mate Kidney with 3 Arteries
  • 118. Dual Mate Kidney with 4 Arteries
  • 119. Dual Deceased Donor Allograft
  • 120.
  • 121. Pediatric Deceased Donor Kidneys For Transplantation • Modlin C, Novick AC, Goormastic M, Hodge E, Mastrioanni B, Myles J. Long-term results with single pediatric donor kidney transplants in adult recipients. J Urol 1996 Sep;156(3):890-895. • Hobart MG, Modlin CS, Kapoor A, Boparai N, Mastroianni B, Papajcik D, Flechner SM, Goldfarb DA, Fischer R, O'Malley KJ, Novick AC. Transplantation of pediatric enbloc cadaver kidneys into adult recipients. Transplantation 1998 Dec 27;66(12):1689-1694.
  • 124.
  • 125.
  • 126. Pediatric Enbloc Kidney Allografts
  • 128. Pediatric Enbloc Post Perfusion
  • 131. Renal Capsular Repair • J Natl Med Assoc. 2012;104:199-201
  • 133. Living Donor Kidney with Renal Artery Aneurysm

Hinweis der Redaktion

  1. This definition implies that health is a complex mechanism involving more components than freedom from physical disease and pain. It is an evolving process involving social, spiritual, emotional, physical and intellectual considerations.
  2. Black Americans who are economically advantaged do not enjoy in equal measure with whites the expected positive influence of affluence on their health. One possible explanation relates to the high stress levels that middle class AA’s experience (relative to whites). Prolonged High-effort mental coping mechanisms among African Americans who succeed in white-collar work environments contributes to hypertension and increased heart rate.
  3. Heart disease. Race and ethnicity influence a patient&apos;s chance of receiving many specific procedures and treatments. African Americans are 13 percent less likely to undergo coronary angioplasty and one-third less likely to undergo bypass surgery than are whites. Heart failure due to hypertension is more common in Blacks (40%) than whites (7%). The major risk factors are smoking, htn, high cholesterol, and physical inactivity. AA’s have less knowledge about risk factors than do whites, even when taking age and education into consideration. The AA diet stresses the consumption of meat, esp. pork, fried foods and eggs, and is high in cholesterol and saturated fats. Physician Decisionmaking A small study of physicians&apos; decisions about whether to refer patients for cardiac catheterization, a diagnostic procedure for heart disease, provides supportive evidence that factors other than insurance and income can influence the quality of care people get. This study, which used actors portraying similar economic backgrounds, found that black women were significantly less likely than white men to be recommended for referral, despite reporting the same symptoms.
  4. Some risk factors for stroke—age, male sex, black race and family history of stroke, are non-modifiable. Hypertension is the most important modifiable risk factor in all populations. Other important modifiable factors include diabetes, afib, tia, alcoholism, smoking, obesity, low physical exercise, poor nutrition, hypercoagulable states, and use of illicit drugs, oral contraceptives and hormone replacement therapy.
  5. Cancer is the 2 nd leading cause of death in the U.S. and significant burden to AA’s, who have the highest death rates. The incidence of cervical cancer in AA is double that of whites. Contributing factors: tobacco, occupations, diet, knowledge, attitudes and practices, health/medical resources, biological factors, and socioeconomic status. 55% of deaths in AA are caused by smoking-related diseases.
  6. The prevalence of smoking among young black males doubled from 14.2 to 28.2% from 1991-1997. A smoking cessation study examined the effects of physician recommendation to quit smoking and noted that people who were told by physicians to stop smoking did so twice as often successfully as those not told by a physician.
  7. More research is needed on the identification, prevention, treatment, and care cancer in the minority population.
  8. Approx. 37% of all internal cancers diagnosed in AA men are prostate cancer. This translates to about 225 per 100,000 new AA cases of cancer, which is more than the combined projections for the next 5 leading cancer sites. The incidence of prostate cancer in the age group 45-49 for blacks is 12.6/100,000 compared to whites 7.4/100,000
  9. The incidence of ESRD in AA is 4 times greater than in whites. HTN and DM are the most commonly identified causes of kidney failure, but regardless of the diagnosis, AA are at greater risk than whites of requiring dialysis or transplantation.
  10. The number of cadaveric transplants is roughly 4 per 100 dialysis patient-years among white men, 3 per 100 dialysis years among white women and black men and 2 per 100 dialysis years among black women. The demand for organs has outpaced supply. Whites are more than 2 times as likely as blacks to be wait-listed before dialysis. Factors believe to account for some of the disparities: AA once referred do not advance through the process as quickly: some reasons are related to place of recidence, educational level, functionality on dialysis, and associated medical comorbidity.
  11. Poverty is the most important factor and affects the ability to afford preventive and routine health services. Other barriers to health are: transportation, long waiting times, inconvenient hours of service and confusion at the clinic or hospital atmosphere and other factors. These barriers cause AA’s to revert to public medical facilities with distant appointments, contribute to the advancement of illnesses and the high use of costly ER services. Limited education and illiteracy obstruct the ability to interpret and comprehend health-related information. The persistent association between race and lack of health care utilization, even with the same socioeconomic stratum, suggests that discrimination and physician bias is still a plausible explanation.
  12. Many white health care professionals have difficulties understanding the African American culture, beliefs, and expectations. The body language between African Americans and Whites can also be a barrier. Most providers are not educated and trained to be culturally sensitive. The cultural barriers are built into the very fabric of the U.S. health system model, which emphasizes isolating and treating different ailments through specialized practitioners, rather than a holistic approach. Beware, not all African Americans think or act or react the same way. The provider needs to interact with each patient to develop his/her holistic, culturally competent plan of care. With this approach, quality is maximized, and outcomes are more successful.
  13. Etiology of Heart Failure in Black Patients Retrospective analyses of V-HeFT-I, V-HeFT-II, SOLVD, US Carvedilol, BEST, and MERIT-HF have reported subgroup data demonstrating that black patients have a higher incidence of HTN as a cause of LVD than do non-blacks. HF in non-black patients is more likely to be caused by CAD than by HTN. 40%-80% of HF cases in blacks are caused by HTN. 50%-80% of HF cases in whites are caused by CAD. Reference Yancy CW. Heart failure in African Americans: pathophysiology and treatment. J Card Fail. 2003;9(suppl 5):S210-S215.
  14. A-HeFT: Additional 43% Reduction in Mortality Beyond Current Standard Therapies This Kaplan-Meier curve shows an additional 43% decrease in mortality among those patients treated with BiDil plus standard therapies. This result led to the Data Safety and Monitoring Board’s recommendation to terminate the trial early. Reference BiDil [prescribing information]. Lexington, MA: NitroMed, Inc.; 2005.