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 Ontology-­‐based	
  
services	
  and	
  knowledge	
  management	
  in	
  the	
  
Agronomic	
  Domain	
  
Pierre	
  Larmande	
  
Ins-tute	
  of	
  Research	
  for	
  Development	
  (IRD)	
  
Head	
  of	
  data	
  integra-on	
  group	
  at	
  the	
  Ins-tute	
  of	
  Computa-onal	
  Biology	
  
pierre.larmande@ird.fr	
  
	
  
Outline
•  Data integration challenges in the Life Sciences
•  Ontologies/ Semantic Web Technologies
•  AgroPortal a proposition for ontology-based services in the
agronomic domain
•  Agronomic Linked Data project
Data landscape in the Life Sciences
•  The availability of biological data has increased
•  Advancements in:
•  computational biology
•  genome sequencing
•  high-throughput technologies
•  Integrative approaches are necessary to understand
the functioning of biological systems
•  Lack of effective approaches to integrate data that
has created a gap between data and knowledge
•  Need for an effective method to bridge gap between
data and underlying meaning
•  Harvest the power of
overlaying different data sets
Data integration challenges
Semantic Web Technology
•  An extension of the current Web technologies.
•  Enables navigation and meaningful use of digital
resources.
•  Support aggregation and integration of information
from diverse sources.
•  Based on common and standard formats.
Resource Description Framework (RDF)
•  Framework for representing information about resources
on the Web
•  Provides a labeled connection between two resources
•  Uses Unique Resource Identifiers (URI)
•  Statements take the form of triples:


Subject	
   Predicate	
   Object	
  
<Gene_A>	
   <codes_for>	
   <Protein_A>	
  
RDF	
  Triple	
  
•  Combining the triples results in a directed, labeled
graph.
<Gene_A>	
  
<Protein_A>	
  
<has_funcFon>	
  
<BP_A>	
  
<MF_A>	
  
<Gene_X>	
  
<regulates>	
  
7	
  
AgroPortal	
  
	
  a	
  proposi(on	
  for	
  ontology-­‐based	
  
services	
  in	
  the	
  agronomic	
  domain	
  
Clément	
  Jonquet,	
  	
  
Esther	
  Dzalé-­‐Yeumo,	
  
	
  Elizabeth	
  Arnaud,	
  
	
  Pierre	
  Larmande	
  
	
  
ObjecFves	
  of	
  AgroPortal	
  project	
  
•  Develop	
  and	
  support	
  a	
  reference	
  ontology	
  repository	
  
for	
  the	
  agronomic	
  domain	
  
–  One-­‐stop-­‐shop	
  for	
  plant/agronomic	
  related	
  ontologies	
  	
  
–  Primary	
  focus	
  on	
  the	
  agronomic	
  &	
  plant	
  domain	
  
•  Reusing	
  the	
  NCBO	
  BioPortal	
  technology	
  
–  Avoid	
  to	
  re-­‐implement	
  what	
  has	
  been	
  done	
  
–  Facilitate	
  interoperability	
  
–  Reusing	
  the	
  scien-fic	
  outcomes,	
  experience	
  &	
  methods	
  
of	
  the	
  biomedical	
  domain	
  	
  
•  Enable	
  straighUorward	
  use	
  of	
  agronomic	
  related	
  
ontologies	
  
–  Respect	
  the	
  requirements	
  of	
  the	
  agronomic	
  community	
  	
  
–  Fully	
  seman-c	
  web	
  compliant	
  infrastructure	
  
9	
  
HOW	
  DOES	
  IT	
  LOOKS?	
  
10	
  
11	
  
12	
  
Available	
  ontologies	
  
•  Already	
  29	
  ontologies…	
  and	
  we	
  expect	
  around	
  40	
  soon.	
  
–  (half	
  are	
  not	
  included	
  in	
  the	
  NCBO	
  BioPortal)	
  
•  Ontologies	
  are	
  organized	
  in	
  Groups	
  and	
  Categories	
  
13	
  
14	
  
15	
  
Recommender	
  
16	
  
Mappings	
  
17	
  
Community	
  based	
  func-onali-es	
  
Atelier	
  InOvive	
  2015	
  –	
  Rennes	
  –	
  29	
  juin	
  
2015	
  
18	
  
REST	
  Web	
  Service	
  API:	
  
hhp://data.agroportal.lirmm.fr/documenta-on	
  	
  
Atelier	
  InOvive	
  2015	
  –	
  Rennes	
  –	
  29	
  juin	
  
2015	
  
19	
  
SPARQL	
  endpoint:	
  
hhp://sparql.agroportal.lirmm.fr	
  	
  
20	
  
AN	
  ONTOLOGY	
  REPOSITORY…	
  
WHO’S	
  GONNA	
  USE	
  IT?	
  
21	
  
4	
  Driving	
  Agronomic	
  Use	
  Cases	
  
•  IBC	
  Rice	
  Genomics	
  
–  data	
  integra-on	
  and	
  knowledge	
  management	
  
related	
  to	
  rice	
  
	
  
•  RDA	
  Wheat	
  Data	
  Interoperability	
  working	
  group	
  
–  common	
  framework	
  for	
  describing,	
  represen-ng,	
  
linking	
  and	
  publishing	
  wheat	
  data	
  with	
  respect	
  to	
  
open	
  standards	
  
•  INRA	
  Linked	
  Open	
  Vocabularies,	
  LovInra	
  
–  publish	
  vocabularies	
  produced	
  or	
  co-­‐produced	
  by	
  
INRA	
  scien-sts	
  and	
  foster	
  their	
  reuse	
  beyond	
  the	
  
original	
  researchers	
  
•  The	
  Crop	
  Ontology	
  project	
  
–  publishes	
  ontologies	
  required	
  for	
  describing	
  crop	
  
germplasm,	
  traits	
  and	
  evalua-on	
  trials.	
  
22	
  
Each	
  use	
  case	
  has	
  a	
  specific	
  group	
  in	
  
AgroPortal	
  
•  Feature	
  to	
  come:	
  slices	
  
– Specific	
  “entry”	
  in	
  the	
  AgroPortal	
  
23	
  
AgroLD	
  
	
  The	
  Agronomic Linked
Data project
Aravind	
  Venkatensan,	
  
Gildas	
  Tagny,	
  
Nordine	
  El	
  Hassouni,	
  
Manuel	
  Ruiz,	
  
	
  Pierre	
  Larmande	
  
	
  
Agronomic Linked Data (AgroLD)
•  Semantic web based system that integrates data from
South Green Bioinformatics node
•  Aim:
•  Capability to answer complex real life questions
•  Efficient information integration / retrieval.
•  Easy extensibility.
•  Aid in holistic understanding of domain
AgroLD
•  AgroLD will be developed in phases –
•  Website: www.agrold.org
•  Phase I: includes data on:
•  Rice (Oryza spp).
•  Oryza barthi
•  Oryza brachyantha
•  Oryza Sativa
•  Oryza glaberimma
•  Arabidopsis thaliana
•  Sorghum (Sorghum bicolor)
•  Maize/Corn (Zea mays)
•  Wheat
•  Triticum astivum
•  Triticum urartu
Data	
  sources	
  in	
  AgroLD	
  
Ontologies	
  in	
  AgroLD	
  
Knowledge in AgroLD
AgroLD	
  
Ontologies	
  
www.agrold.org
Search	
  and	
  browse	
  AgroLD	
  
Plant	
  height	
  
Sparql	
  query	
  editor	
  
Sparql	
  query	
  editor	
  
Results	
  are	
  annotated	
  with	
  evidence_code	
  	
  
hhp://geneontology.org/page/guide-­‐go-­‐evidence-­‐codes	
  
VisualisaFon	
  of	
  queries	
  
Advanced	
  form-­‐based	
  search	
  
Results	
  are	
  combined	
  with	
  external	
  services	
  	
  
Please	
  send	
  us	
  your	
  Feedback!	
  
Your	
  answers	
  will	
  help	
  us	
  to	
  
improve	
  the	
  applicaton	
  
Acknowledgements	
  
Elizabeth	
  Arnaud,	
  	
  
Leo	
  Valee,	
  	
  
Marie-­‐Angelique	
  Laporte,	
  	
  
Julian	
  Pietragalla	
  
Manuel	
  Ruiz,	
  
Nordine	
  El	
  Hassouni	
  
Aravind	
  Venkatesan,	
  
Gildas	
  Tagny	
  
Esther	
  Dzalé-­‐Yeumo,	
  
Cyril	
  Pommier	
  
Patrick	
  Valduriez	
  
Clement	
  Jonquet	
  
Pierre	
  Larmande	
  
Contact:	
  pierre.larmande@ird.fr	
  

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Ontology-Based Services and Knowledge Management in the Agricultural Domain, by Pierre Larmande

  • 1.  Ontology-­‐based   services  and  knowledge  management  in  the   Agronomic  Domain   Pierre  Larmande   Ins-tute  of  Research  for  Development  (IRD)   Head  of  data  integra-on  group  at  the  Ins-tute  of  Computa-onal  Biology   pierre.larmande@ird.fr    
  • 2. Outline •  Data integration challenges in the Life Sciences •  Ontologies/ Semantic Web Technologies •  AgroPortal a proposition for ontology-based services in the agronomic domain •  Agronomic Linked Data project
  • 3. Data landscape in the Life Sciences •  The availability of biological data has increased •  Advancements in: •  computational biology •  genome sequencing •  high-throughput technologies •  Integrative approaches are necessary to understand the functioning of biological systems
  • 4. •  Lack of effective approaches to integrate data that has created a gap between data and knowledge •  Need for an effective method to bridge gap between data and underlying meaning •  Harvest the power of overlaying different data sets Data integration challenges
  • 5. Semantic Web Technology •  An extension of the current Web technologies. •  Enables navigation and meaningful use of digital resources. •  Support aggregation and integration of information from diverse sources. •  Based on common and standard formats.
  • 6. Resource Description Framework (RDF) •  Framework for representing information about resources on the Web •  Provides a labeled connection between two resources •  Uses Unique Resource Identifiers (URI) •  Statements take the form of triples: 
 Subject   Predicate   Object   <Gene_A>   <codes_for>   <Protein_A>   RDF  Triple  
  • 7. •  Combining the triples results in a directed, labeled graph. <Gene_A>   <Protein_A>   <has_funcFon>   <BP_A>   <MF_A>   <Gene_X>   <regulates>   7  
  • 8. AgroPortal    a  proposi(on  for  ontology-­‐based   services  in  the  agronomic  domain   Clément  Jonquet,     Esther  Dzalé-­‐Yeumo,    Elizabeth  Arnaud,    Pierre  Larmande    
  • 9. ObjecFves  of  AgroPortal  project   •  Develop  and  support  a  reference  ontology  repository   for  the  agronomic  domain   –  One-­‐stop-­‐shop  for  plant/agronomic  related  ontologies     –  Primary  focus  on  the  agronomic  &  plant  domain   •  Reusing  the  NCBO  BioPortal  technology   –  Avoid  to  re-­‐implement  what  has  been  done   –  Facilitate  interoperability   –  Reusing  the  scien-fic  outcomes,  experience  &  methods   of  the  biomedical  domain     •  Enable  straighUorward  use  of  agronomic  related   ontologies   –  Respect  the  requirements  of  the  agronomic  community     –  Fully  seman-c  web  compliant  infrastructure   9  
  • 10. HOW  DOES  IT  LOOKS?   10  
  • 11. 11  
  • 12. 12  
  • 13. Available  ontologies   •  Already  29  ontologies…  and  we  expect  around  40  soon.   –  (half  are  not  included  in  the  NCBO  BioPortal)   •  Ontologies  are  organized  in  Groups  and  Categories   13  
  • 14. 14  
  • 15. 15  
  • 18. Community  based  func-onali-es   Atelier  InOvive  2015  –  Rennes  –  29  juin   2015   18  
  • 19. REST  Web  Service  API:   hhp://data.agroportal.lirmm.fr/documenta-on     Atelier  InOvive  2015  –  Rennes  –  29  juin   2015   19  
  • 21. AN  ONTOLOGY  REPOSITORY…   WHO’S  GONNA  USE  IT?   21  
  • 22. 4  Driving  Agronomic  Use  Cases   •  IBC  Rice  Genomics   –  data  integra-on  and  knowledge  management   related  to  rice     •  RDA  Wheat  Data  Interoperability  working  group   –  common  framework  for  describing,  represen-ng,   linking  and  publishing  wheat  data  with  respect  to   open  standards   •  INRA  Linked  Open  Vocabularies,  LovInra   –  publish  vocabularies  produced  or  co-­‐produced  by   INRA  scien-sts  and  foster  their  reuse  beyond  the   original  researchers   •  The  Crop  Ontology  project   –  publishes  ontologies  required  for  describing  crop   germplasm,  traits  and  evalua-on  trials.   22  
  • 23. Each  use  case  has  a  specific  group  in   AgroPortal   •  Feature  to  come:  slices   – Specific  “entry”  in  the  AgroPortal   23  
  • 24. AgroLD    The  Agronomic Linked Data project Aravind  Venkatensan,   Gildas  Tagny,   Nordine  El  Hassouni,   Manuel  Ruiz,    Pierre  Larmande    
  • 25. Agronomic Linked Data (AgroLD) •  Semantic web based system that integrates data from South Green Bioinformatics node •  Aim: •  Capability to answer complex real life questions •  Efficient information integration / retrieval. •  Easy extensibility. •  Aid in holistic understanding of domain
  • 26. AgroLD •  AgroLD will be developed in phases – •  Website: www.agrold.org •  Phase I: includes data on: •  Rice (Oryza spp). •  Oryza barthi •  Oryza brachyantha •  Oryza Sativa •  Oryza glaberimma •  Arabidopsis thaliana •  Sorghum (Sorghum bicolor) •  Maize/Corn (Zea mays) •  Wheat •  Triticum astivum •  Triticum urartu
  • 27. Data  sources  in  AgroLD  
  • 29. Knowledge in AgroLD AgroLD   Ontologies  
  • 31. Search  and  browse  AgroLD   Plant  height  
  • 34. Results  are  annotated  with  evidence_code     hhp://geneontology.org/page/guide-­‐go-­‐evidence-­‐codes  
  • 37. Results  are  combined  with  external  services    
  • 38. Please  send  us  your  Feedback!   Your  answers  will  help  us  to   improve  the  applicaton  
  • 39. Acknowledgements   Elizabeth  Arnaud,     Leo  Valee,     Marie-­‐Angelique  Laporte,     Julian  Pietragalla   Manuel  Ruiz,   Nordine  El  Hassouni   Aravind  Venkatesan,   Gildas  Tagny   Esther  Dzalé-­‐Yeumo,   Cyril  Pommier   Patrick  Valduriez   Clement  Jonquet   Pierre  Larmande   Contact:  pierre.larmande@ird.fr