Sage Bionetworks is a non-profit organization that supports open and collaborative biomedical research across organizations through various consortiums and partnerships. Some of its initiatives include the TCGA Pan-Cancer Consortium involving analysis of 12 tumor types, the CommonMind Consortium involving collection and analysis of brain tissue samples for schizophrenia research, and the Accelerating Medicines Partnership, a public-private partnership focused on diseases such as Alzheimer's. Sage Bionetworks also supports data challenges and the development of collaborative research platforms.
biomedical research in an increasingly digital world
1. brian m. bot | principal scientist |
2016 april 18
sage bionetworks
pnw life science executive forum
biomedical research in an increasingly digital world
opportunities when problems are bigger than
a single organization
3. sage bionetworks
a non-profit organization which pilots a
variety of components that are necessary
to build a scientific research commons
focused on a world where biomedical research
will fundamentally change to be
more open and collaborative
supports communities of researchers
working collaboratively across disciplines
our approach
10. CommonMind Consortium
large public / private partnership
phase I: prefrontal cortex
~300 SCZ, 300 control, 60 BD
processing pipelines developed in collaboration
between sage and mssm
30. Columbia Professor Dimitris Anastassiou
MPEG-2 compression of digital audio and video signals
Modules of co-expressed genes shared across cancers
Belief that these ‘attractors’ represent underlying biological
mechanisms (bioinformatic ‘hallmarks of cancer’1)
1D. Hanahan, R. A. Weinberg. Hallmarks of cancer: The next generation. Cell 144, 646–674 (2011)
DREAM Challenges
34. 34
48,104 downloads from app store - first six months
16,585 participants consented
14,684 participants enrolled
9,520 agreed to ‘share broadly’
1,087 self reported a professional diagnosis of Parkinson
mPower
38. democratization of research
de-coupling of data collection and analysis
cloud infrastructure
gov’t agencies and public pushing for > sharing
increasingly decentralized research ecosystem