Network pharmacology: From BioAssay Response Data to Network

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Network pharmacology, comparing protein pharmacology networks built from Ligand based approach (Similarity Ensemble Approach) with those built from BioAssay response data.

Technologie Gesundheit & Medizin

Network Pharmacology: From
BioAssay Response Data to Network

Bin Chen, Nikil Wale, Kevin McConnell
and Eric Gifford

Cite: Bin Chen, Kevin McConnell, Nikil Wale, David Wild, Eric Gifford, Comparing Bioassay Response and
Similarity Ensemble Approaches to Probing Protein Pharmacology, Bioinformatics

Network of top 2% most highly correlated pairs by BARD using Spearman (Node presents assay, two nodes are linked if their similarity reaches certain
threshold. Node is colored by gene family. Solid edges indicate common edges between two networks. Some non obvious links are highlighted in dashed
red oval.

Network of top 2% most highly correlated pairs by BARD using SEA (Node presents assay, two nodes are linked if their similarity reaches certain
threshold. Node is colored by gene family. Solid edges indicate common edges between two networks. Some non obvious links are highlighted in dashed
red oval.

5-HT7 & D1
common active 536
spearman 0.571
TC=0.84
SEA: 1.2e-25

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Network pharmacology: From BioAssay Response Data to Network

1. Network Pharmacology: From BioAssay Response Data to Network Bin Chen, Nikil Wale, Kevin McConnell and Eric Gifford Cite: Bin Chen, Kevin McConnell, Nikil Wale, David Wild, Eric Gifford, Comparing Bioassay Response and Similarity Ensemble Approaches to Probing Protein Pharmacology, Bioinformatics

9. Network of top 2% most highly correlated pairs by BARD using Spearman (Node presents assay, two nodes are linked if their similarity reaches certain threshold. Node is colored by gene family. Solid edges indicate common edges between two networks. Some non obvious links are highlighted in dashed red oval.

10. Network of top 2% most highly correlated pairs by BARD using SEA (Node presents assay, two nodes are linked if their similarity reaches certain threshold. Node is colored by gene family. Solid edges indicate common edges between two networks. Some non obvious links are highlighted in dashed red oval.

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18. 5-HT7 & D1 common active 536 spearman 0.571 TC=0.84 SEA: 1.2e-25

Network pharmacology: From BioAssay Response Data to Network

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