A recording of this webinar can be found at https://youtu.be/IqG3j5b-CXQ Keeping databases up-to-date is a significant challenge with the rate at which many data sources are growing. Open PHACTS and Big Data Europe organised this webinar to hold an open, informal discussion around keeping databases updated – from user needs, to the challenges of automation, to potential technical approaches underpinning key data sources. Joining our panel are Dr Evan Bolton, who manages the PubChem project at NCBI, and Professor Chris Evelo, Co-Founder and Director at WikiPathways.