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Name: Bui Bich Phuong
Class: E2



                           VIETNAM NATIONAL UNIVERSITY, HANOI
                               University of languages and international
                                                                   studies
                               Faculty of English Languages and Teacher
                                                              Education
                                                     Fast Tract Division




                        READING PORTFOLIO



                               Student: Bui Bich Phuong
                                     Class: 11E2




                               Hanoi, 2012


                           Table of contents
   We          Topic                 Tittle               Source
  ek

READING PORTFOLIO                                                    Page 1
Name: Bui Bich Phuong
Class: E2

    2        Literature               Mart Twain                webside
    3        Nutrition        Diet and nutrion for women        webside
    4        Physiology       Do Teens Need Less Shut-          TIME
                                Eye than We Think?              magazine
    5        Fashion         Paris Fashion Week: Roland         FASTION
                             Mouret autumn/winter 2012          magazine
    6        Psychology       Three Things That Maintain        Psychologytoda
                                      Anxiety               y
                                                                magazine
    7        Science                                            FORENSIC
                               GSR: How Do You Know             magazine
                                  You're Right?

    9        Business           Recipe for a Successful         TIME
                                     Business:                  Magazine
                                  Growing success

   10        Neuroscienc     Scientists Uncover Clue to         SCIENCEDAIL
         e                 Preventing, and Possibly         Y
                           Reversing, Rare Childhood            magazine
                           Genetic Disease

   11        Oceanogragh      Widespread Adaptability           SCIENCEDAIL
         y                   Coral Reefs May Be Able to
                                                            Y Magazine:
                           Adapt to Climate Change With
                                  Help from Algae
   12        Engineering           Brian’s bridges             BOOK “Don’t
                                                            throw this away!
                                                            The civil
                                                            engineering life”
   13        Dedicine         Discovery Provide Blueprint      SCIENCEDAIL
                           for New Drugs That Can Inhibit   Y
                                  Hepatitis C Virut            magazine

   14        Marketing            Marketing in china            FINANCE
                                                                Magazine




                        WEEK 2- LITERATURE
READING PORTFOLIO                                                       Page 2
Name: Bui Bich Phuong
Class: E2


                                 Mark Twain
                  Source: www.the famouspeople.com/profiles/mark-twain.

     Famous as                    Author and Humorist
      Born on                     30 November 1835 in Florida, Missouri
      Died on                     21 April 1910
      Nationality                 United States
  Samuel Langhorne Clemens, better known by his pen name Mark Twain, was
an American author, essayist, lecturer and humorist who wrote a series of
famous books including Adventures of Huckleberry Finn and The Adventures of
Tom Sawyer. Mark's first important work, The Celebrated Jumping Frog of
Calaveras County was first published in the New York Saturday Press and
became a bestseller within a short span of time. He also wrote a series of
travelogues including the bestselling The Innocents Abroad- that came in 1869-
and notable short stories such as Advice for Little Girls and The Celebrated
Jumping Frogs of Calaveras County which earned him the worldwide fame and
appreciation as a writer. Most of all, the author is known for his notable and
insightful satires that gained him reverence from both critics as well as his
contemporaries who call him the 'father of the English literature'.
  Childhood & Early Life
  Samuel Langhorne Clemens was born on November 30, 1835 in Florida,
Missouri in the United States. He was the sixth of seven children of his father, a
country merchant John Marshall Clemens and mother Jane Lampton Clemens
and only three of his siblings could survive into their adulthood. At age four, Mark
along with his family, moved to a port town Hannibal, situated on the bank of
world’s second largest river Mississippi.
  Mark’s father John Clemens died of pneumonia in 1847, and the family was
left in financial upheaval. An eleven year old Mark took a job of typesetter in
1851, to aid the family during its hard pressed finance and began contributing
articles and humorous sketches for the Hannibal Journal a newspaper run by his

READING PORTFOLIO                                                             Page 3
Name: Bui Bich Phuong
Class: E2

brother Orion. At age 18, Mark twain left this job and became a printer in New
York City.
  As a child, Mark Twain received no formal schooling, but a keen learner, he
widened his circle of knowledge by finding information in public libraries. It was
his traveling to New Orleans in 1857, that he grew immensely fascinated with the
steamboats and became an apprentice cub river pilot, earning his license in
1858. While working as a successful river pilot, he developed a huge attachment
for the river, which would become a subject of his books in later life. He lost his
brother Henry in 1858, who was also working with him on the boat.
  Travels and Early Career
  With the outbreak of Civil War in 1861, route on the Mississippi was blocked
and he had to move to the silver mining town of the Carson City with his brother
Orion. They traveled to the Rocky Mountains and many places including the
Mormon community in Salt Lake City and ending at the silver mining town of
Virginia City, Nevada. Here Mark experimented with the work of mining but failed
miserably and finally got a job at a Virginia City newspaper, the Territorial
Enterprise. In year 1863, Mark wrote the first humorous account of his travel.
  Mark next journeyed to San Francisco, where he began to work as a journalist
and lecturer. In 1867, he traveled to Europe and the Middle East and wrote a
collection of travel letters in 1869, which became known as The Innocents
Abroad. He wrote some notable short stories during this period including Advice
for Little Girls and The Celebrated Jumping Frogs of Calaveras County.
  Mark Twain as a Writer
  Twain as a writer initiated with humorous and light verse but embarked on
more serious and harsh subjects in his later career. His one of the important
works in this category was Huckleberry Finn, which combined humor and social
criticism. Aside from this, he wrote several travelogues and lectures. A Tramp
Abroad(1880), his first travelogue and a satirical account of his travels to


READING PORTFOLIO                                                            Page 4
Name: Bui Bich Phuong
Class: E2

Germany, Italy and the Alps, was a sequel to his early work Innocent abroad and
was next followed by The Prince and the Pauper in 1882. Mark wrote his first
important work, The Celebrated Jumping Frog of Calaveras County In year 1865,
which was first published in the New York Saturday Press and became a
bestseller within a short span of time. Yet many of his work were suppressed,
censored or banned in America for various reasons. In 1888, Mark Twain was
awarded the Master of Art degree from Yale University.
  Later Life
  Towards the end of his life, Mark Twain traveled and lectured actively. During
this period he lost money in many bad investment schemes like mining and
printing machines thus acquiring a huge debt. In 1895, he set off on a world tour
to Australia, Canada, India and New Zealand and only returned when he was
able to pay off the debt. Though he suffered from many losses in his personal
life, he never lost his sense of humor and talent as a writer. Meanwhile, he had
written the famous series Tom Sawyer Abroad in 1894 followed by Tom Sawyer,
Detective in 1896. Mark suffered from yet another emotional set back when his
daughter Susy died of meningitis in 1896. Olivia’s death in 1904 and Jean’s
death in 1909 further deepened his pain and left him in the depth of despair.
  In 1901, Yale University awarded him an honorary Doctor of Letters degree for
his literary efforts and he received the same award from Oxford University in
1907. The same year, he published two books- A Horse’s Tale and Christian
Science. Now a celebrated novelist and much more admired author, he enjoyed
a huge section of followers and wrote around thirty books, essays and short
stories. He was also a guest of the then American president Theodore Roosevelt
at the White House. After the death of his wife and daughter Susy, Mark moved
to his home in Redding, Connecticut in 1908.
  Death
  Mark Twain died of a heart attack on 21 April 1910 in Redding in Connecticut


READING PORTFOLIO                                                           Page 5
Name: Bui Bich Phuong
Class: E2

and now rests at the Woodlawn Cemetery in Elmira, New York, where his wife
and other children were buried. He was survived by his daughter Clara.
                                            *****


  I. The reflection on the article
  This article is very excellent, I think, because the writer shows quite enough
interesting and exact information about one of the famous authour on literature - Mark
Twain: his life from the childhood to adutlhood until death, his career, his family and his
achievements. The article’s instruction is very clear with 5 main ideas: Childhood &
Early Life, Travels and Early Career,Mark Twain as a Writer , Later Life , Death.
The reporter gives quite many examples to make clear the achievements of Mark
Twain. He makes reader feel so interested and attracted in the article. Moreover, he
presents information very clear that helps readers can understand and reach the main
content of each paragraph as well as the whole article. He uses a large range of
vocabulary and sentence structure. I can learn so much from his idiosyncrasy, for
instane how to present information about a famous person and how to make impression
on reader.



  II. Vocabulary and structure:
  1. pen name (n): a name used by a writer instead of their real name.
  ex. he’s better known by his pen-name Mark Twain
  2. bestseller(n): a product, usually a book, which is bought by large number
of people.
  ex. it has been on the New York Times best-seller list for thirty-seven weeks.
  3. notable (adj): deserving to be noticed or to receive attention; important
  ex. with a few noable exceptions, everyone gave something.
  4. be known for sth (n): be famous for sth
  insightful (adj): showing a clear understanding of a person or situation.
  ex. one particular author seems to be more insightful than the rest.

READING PORTFOLIO                                                                   Page 6
Name: Bui Bich Phuong
Class: E2

   5. satire(n): a way of criticizing a person, an idea or an institution in which
you use humour to show their faults or weaknessesl a piece of writing that uses
this type of criticism.
   ex. the novel is stinging satire on American politic.
   6.   comtemporary (adj): belong to the same time
   ex. we have no comtemporary account of the battle.
   7. merchant (n): a person who beys or sells goods in large quantities,
especially one who imports and exports goods/ a person who likes a particular
activity.
   ex. - he is a speed merchant
   -    Venice was once a city of rich merchants.
   8. port town (n): a town with a harbour, especially one where ships load and
unload goods.
   ex. He lived in a port town.
   9. pneumonia (n): a serious illness affecting one or both lungs that makes
breathing difficult.
   ex. He died of pneumonia.
   10. be left in financial upheaval ( mất khả năng tài chính): a big change in
finance that causes a lot of confusion, worry and problem.
   ex. after his father had died, his family was left in finacial upheaval.
   11. immensely (= extremly, very much) fascinated (= very interested)
   ex. I’ve always been immensely fascinated by his ideas.
   12. apprentice (n): a young person who works for an employer for a fixed
period of time in order to learn the particular skills needed in their job.
                       (v): to make sth an apprentice.
   ex. has was apprenticed to his uncle as a carpenter.
   13. travelogue (n): a movie/ film, broadcast or piece if writing about travel.
   ex. he has just published a travelogue


READING PORTFOLIO                                                              Page 7
Name: Bui Bich Phuong
Class: E2

  14. censor (v): to remove the parts of a book, film/ movie. etc. that are
considered to be offensive, immoral or a political threat.
  ex. the news reports had been heavily censored.
  15. sequel (n): a book. film/ movie, play, etc. that continues the story of an
earlier one.
  ex. A sequel to the hit movie “ Madagascar” will be published next time.
  16. to died of sth = died because of (a reason)
  17. meningitis (n): a serious disease in which the tissues surrounding the
brain become infected and swollen, causing severe headache, fever ad
sometimes death.
  ex. his is suffering from viral meningitis.
  18. despair (n): the feeling of having lost all hope.
  idom: be the depair of sb: yo make sb worried or unhappy, because they can
not help.
  ex. my handwriting was the despair of my teachers
  19. embarked on/ upon sth: to start to do sth new or difficult
  ex. she is about to embark on a diplomatic career.




                        WEEK 3 - NUTRITION
                  Diet and nutrion for women
  Source:
http://www.helpguide.org/life/healthy_eating_women_nutrition.htm


  Tip 1: Eat to control cravings and boost energy


READING PORTFOLIO                                                            Page 8
Name: Bui Bich Phuong
Class: E2

  Your diet has a major effect on your food cravings, your stress levels, and your
energy throughout the day. By making smart food choices and developing
healthy eating habits, you’ll find it much easier to stay slim, control cravings, and
feel energetic all day long.
  •   Eat breakfast. Get your metabolism going in the morning by eating a
healthy breakfast. Studies show that people who eat breakfast tend to weigh less
than those who skip it. A solid breakfast provides energy for the day.
  •   Eat regularly. Going too long between meals can make you feel irritable
and tired, so aim to eat something at least every 3-4 hours. Support your body’s
natural cycle of energy by eating a substantial breakfast, a nutritious lunch, a
snack around 2 pm (to compensate for the body’s natural low point that occurs
around 3 each afternoon), and a light early dinner.
  •   Cut the junk. The ups and downs that
come with eating sugary snacks and simple
carbohydrates cause extreme swings in energy
level and mood. Cutting out these foods can be
tough, but if you can resist for several days,
your cravings will subside.
  •   Focus on complex carbohydrates.




READING PORTFOLIO                                                              Page 9
Name: Bui Bich Phuong
Class: E2

  such as baked potatoes, whole-wheat pasta, brown rice, oatmeal, whole grain
breads, and bananas boost your “feel-good” serotonin levels without a crash.
They also provide plenty of fiber, so you feel full much longer.


  Tip 2: Get plenty of good carbs
  You may think that they key to losing weight or avoiding weight gain is cutting
out carbohydrates. But carbs, like fats, are a vital part of a healthy diet. They give
you the fuel you need to get through your day, fight fatigue, and stay feeling full.
The key is to choose
  Complex carbohydrates—the “good carbs”—have not been stripped of their
fiber and nutrients. Because they’re rich in fiber, they keep you full longer and
help with weight control. Good sources of complex carbs include whole grains
such as whole grain brown rice, stone ground whole wheat, millet, or quinoa, as
well as beans, other legumes, fruit, and vegetables.
  Simple carbohydrates—the “bad carbs”—have been stripped of their fiber and
many of their nutrients. Simple carbs lead to a dramatic spike in your blood
sugar, followed by a rapid crash. These carbs are much less efficient at filling
you up and keeping you energized. Simple carbs include white flour, white rice,
and sugary foods.
  Complex carbohydrates:
  •   Leave you full and satisfied
  •   Are packed with nutrients
  •   Provide long-lasting energy
  Simple carbohydrates:
  •   Leave you hungry for more
  •   Are mostly empty calories
  •   Provide only short-lived energy



READING PORTFOLIO                                                             Page 10
Name: Bui Bich Phuong
Class: E2

  Tip 3: Don’t cut out the fat!
  Many women have been led to believe that dietary fat is unhealthy and will
contribute to weight gain. But fats are a necessary part of a healthy diet. What
really matters are the types of fat you eat.
  Women need healthy fats in their diet to look and feel great
  •   Healthy fats boost your brain power and mood. Fats are essential to
healthy brain function. They put you in a good mood and keep you mentally
sharp.
  •   Healthy fats promote healthy pregnancies. When you’re pregnant, both
you and your growing baby need healthy fat to feel your best. Fat is especially
important to your baby’s developing brain and nervous system.
  •   Healthy fats contribute to lifelong beauty. Fats are essential for vibrant,
glowing skin, hair, and nails. A lack of healthy fats in your diet can lead to dull,
flaky skin, brittle nails, and dry or easily-damaged hair.
  •   Healthy fats help control cravings. Because fat is so dense in calories, a
little goes a long way in making you feel full. Small amounts of good fats like nuts
or seeds make great satisfying snacks.
  •   Fats lower the glycemic index of foods, easing the spike in blood sugar
that results from eating carbohydrates.
  •   You need fat in order to absorb certain vitamins. Many important
vitamins—including vitamins A, D, E, and K—are fat-soluble, meaning you need
fat in your system in order to absorb them.
                                          *****


  I. The reflection on the article
  This article provides us with useful advices about diet and nutrition for women
which help them keep the fit and have a perfect body. This article talk about the
tips of diet anf nutrition for women.

READING PORTFOLIO                                                            Page 11
Name: Bui Bich Phuong
Class: E2

  - Tip 1: eat to control cravings and boost energy.
  - Tip 2: eat plenty of good crads
  - Tip 3: don’t cut to fat
  To make each tip clearer, he gives some supporting ideas and examples. After
reading this article, I get more knowledge and know how to keep fit in right way
and what a food nutrion is . I realise that I have had incorrect opinion about diet
nutrion. I think, like me, many people, especially women feel interested in it
because of its value.
  Bases on the article, you can see that the writer has a clear range of
knowledge about nutrition


  II. Vocabulary
  1. metabolism (n) : a chemical processes in living things that change food,
etc. into energy and meterials growth ( sự trao đổi chất)
  ex: The body’s metabolism is slowed down by extreme cold.
  2. serotonin (n): a chemical in the brain that affects how messages are sent
from the brain to the body, and also affects how a person feel. ( C12H22N20).
  3. fiber (n): the part of food that help to keep a person heathy by keeping the
bowels working and moving other food quickly through the body
  ex: Dried fruits are especially high in fiber.
  4. quinoa : a South American plant, grown for its seeds, uses as food and to
make alcoholic drinks, the seeds of the quinoa plant.
  ex. Quinoa is a plant that are growth a lots in Andes area.
  5. craving (n):a strong desire for sth
  ex: He has a craving to see the world.
                                          *****




READING PORTFOLIO                                                           Page 12
Name: Bui Bich Phuong
Class: E2


                        WEEK 4 - PHYSIOLOGY
  Do Teens Need Less Shut-Eye than We Think?
                                                         - By Alexandra Sifferlin -
                                                      Source: TIME magazine,
                                                              Date: Feb 21th 2012


  Between extracurricular activities, homework and late-night Facebooking,
many teens aren’t catching the nightly sleep’s hours they need. Or are they?
  Although national guidelines recommend that teens get at least 8.5 hours of
sleep a night — a bar that few teens actually meet — a new study suggests that
they may not require as much shut-eye as we thought, at least not if performance
on standardized tests is any measure.
  In their report published in the current issue
of the Eastern Economics Journal, researchers
from Brigham Young University analyzed a
nationally representative sample of 1,724
students and compared the amount of sleep
they reported getting to their standardized test
scores. Sixteen-year-olds scored best on only
7 hours of sleep a night, it turns out. For 12-
year-olds, the optimal amount of sleep was
slightly over 8 hours, and for 10-year-olds it
was about 9 hours.
  “If your kid’s not getting nine hours of sleep, maybe you don’t have to worry so
much,” study author and Brigham Young University economist Mark Showalter
told MSNBC, especially if he’s not actually sleep deprived.
  MORE: 10 Risky Behaviors More Common in Sleepy Teens

READING PORTFOLIO                                                           Page 13
Name: Bui Bich Phuong
Class: E2

  So where does the nine-hours standard come from? The researchers believe
the current sleep recommendations date back to a 1970s Stanford University
study of teens and their sleep patterns. In that study, teens were brought to a lab
a few days a year for three years and told to sleep as long as they wanted. But,
of course, how much teens want to sleep and how much they need to sleep are
two different things.
  “We couldn’t find much scientific empirical backing for the common
recommendations,” Showalter told MSNBC. His findings fall in line with a
separate study published in Pediatrics last week that looked more than 100 years
of reported sleep duration in kids. That study concluded that no matter how much
sleep kids have historically gotten, it was always assumed that they weren’t
getting enough. The study also found that sleep recommendations have always
been pretty subjective.
  Healthland’s Bonnie Rochman reported:
  In reality, there is almost no evidence about how much sleep kids truly need to
function their best. “We think for no particularly good reason that kids need more
sleep than they’re getting,” says [senior author Tim Olds, a professor of health
sciences at the University of South Australia in Adelaide]. “Every so often a group
of blokes get together and say, What do you recommend, boys? Should we push
it up to 9 hours, 15 minutes? It really is like that, honestly. It’s an arbitrary public-
health line in the sand that people draw.”
  MORE: A History of Kids and Sleep: Why They Never Get Enough
  That being said, it’s entirely likely that teens aren’t getting enough sleep — it’s
just that there isn’t good scientific evidence of that. But while chronic lack of
sleep has been tied to many ill health effects, including increased risks of
depression and weight gain, it looks like getting less than a full 9 hours shouldn’t
hinder test scores. No more excuses, teens.
  I. The reflection on the article

READING PORTFOLIO                                                                Page 14
Name: Bui Bich Phuong
Class: E2

  Nowadays, most of teens don’t spend enough time on sleeping, although they
know it’s useful for their health . This article gives us much useful information
about sleep. For instance, Chronic lack of sleep has been tied to many ill health
effects. It helps us know more about importance of getting enough sleep that is
very neccesary for teens. After reading this article, I see that it’s necessary for
myself to spend at least a half of hour sleeping in the noon as well as sleeping
gets enough 8 hours per day to good for my health. The reporter persuades
reader with many examples, evidences ( particular figures, quotations),
especially, quotation     the ideas   opinion of both   researchers, scientists and
teens. However, I think the main ideas of this article are not very clear which
make reader feel confused to realize main content of each part.


       II. Vocabulary and sentence structure
  1.         extracurricular (adj): not part of the usual course of work or studies
at a school or college.
  Ex. Schools and colleges often hold extracutticular activities to help students
enlarge their knowledge.
  2.         shut-eye (n): sleep ( imformal)
  Ex: According to reporter, teens may not require as much shut-eye as we
thought.
  3.         standardized (v): to make objects or activities of the same type
have the same features or qualities, to make sth standard.
  Ex: Teacher should give students standardized lesson to make them better.
  4.         optimal = optimum (adj): the best possible, producing the best
possible result.
  Ex: we aim for optimal efficiency in all our operations.
  5.         bloke = man (n)
  Ex: He seems like a nice bloke.

READING PORTFOLIO                                                           Page 15
Name: Bui Bich Phuong
Class: E2

  6.        chronic (Adj): having had a disease for a long time
  7.        duration (n): the length of time that sth lasts or continues
  Ex: His house was used as a hospital for the duration of the war.
  8.        arbitrary (adj): (of an action, decision, etc): not seeming to     be
based on reason, system or plan and sometimes seeming unfair.
  Ex: The choice of players for the team seemed to be completely arbitrary.




                        WEEK 5 - FASHION
READING PORTFOLIO                                                          Page 16
Name: Bui Bich Phuong
Class: E2


           Paris Fashion Week: Roland Mouret
                  autumn/winter 2012
                                                                 - Lisa Armstrong -
                                                   Source: FASHION magazine
                                                         Date: March 2nd 2012


   Mouret debuted his first line of shoes at his Paris Fashion Week show today.
                              In order to qualify as a global fashion brand, a label
                           must sell more than clothes. Accessories are a given.
                           After more than ten years in the business, Roland
                           Mouret, the British based designer who brought us the
                           Galaxy and Moon dresses, as worn by every celebrity
                           from Rachel Weisz and Keira Knightley to Cameron
                           Diaz, revealed his own world of shoes in Paris today.
                              "I know how to drape fabric but I had to learn a
                           whole new subject in the form of engineering," said
                           Mouret backstage.
  "One of the hardest things is finding good factories. The best are in Italy and
France, but often working at full capacity for big names".
       Mouret's shoes are being manufactured by Robert Clergerie, a middling
sized French shoe label that enjoyed considerable success in the 1980s doing
masculine-styled shoes for women, but which waned recently, as shoes became
higher and sexier.
      Earlier this year Clergerie announced its new designer: Roland Mouret. His
first collection for the brand, with a strong 1940s feel, but with contemporary
proportions (i.e. lots of height) will arrive in stores in late summer. The
partnership also enables him finally to have a separate shoe collection, under his


READING PORTFOLIO                                                            Page 17
Name: Bui Bich Phuong
Class: E2

own name - also high, also with (concealed) platforms, and with a heel shape
and last that spell out the initial R when viewed from the side.
  But can an ingenue bring anything new to footwear?
  "Comfort," he retorts, "It's to do with balance, the angle of the last - not just the
heel. I've spent a lot of time listening to what women want," he says, "and they're
not giving up on heels any time soon. But they're tired of suffering".
          The other step towards brandifation is to hire a lavish venue - and
transform it. Mouret did that too as he clad the ornately gilded walls of the Hotel
Intercontinental's ballroom with rough wooden planks.
  "It's supposed to evoke what you do to a precious building when you want to
protect it in a war,' he explained.
       If it looked more like a Club Med ski chalet , that suited the first few outfits
perfectly, since they featured faint tracings of reindeer or fawn prints and came in
an icy blue shade which could have been Wallis Simpson blue, but which Mouret
said was Dior blue (don't say he's auditioning for that job too).
        Mouret's silhouette has loosened considerably since the suction-packed
hourglass of the Galaxy and Moon, but it's still tailored and intensely feminine,
with loving attention paid to a woman's rear. "You have to be really confident
about your tush to wear that", observed one front rower as a Dior blue dress, with
a zip right up the back, sashayed past. Either that or invest in Spanx.
                                          *****



  I. The reflection on the article
  Roland Mouret, the British based designer who brought us the Galaxy and
Moon dresses, debuted his first line of shoes at his Paris Fashion Week show.
The article talk about Mouret’s shoes, its history and features. This article gives
reader more information about designer Mouret and his shoes label in New York
fashion week. After reading this artcle, I get more interesting information about

READING PORTFOLIO                                                              Page 18
Name: Bui Bich Phuong
Class: E2

fashion in the world which I have seemed to care of before. I think, readers,
especially women will feel so interested in this article because it mentions about
fashion which is a popular and interesting topic. However, I don’t like it so miuch
because the writer’s expression is not very good, it’s not have clear ideas. There
fore, it’s hard for me to find the main ideas of each paragraph.



  II. Vocabulary and structure:
  1. manufactured (v) : to make goods in large quatities, using machinery
  ex: this company manufactures the equipments use to make contact lenses.
  2. brand (n): a type of product made by a particular company.
  Ex. Which brand of toothpaste do you use?
  3. drape (v) to cover or decorate sth/sb with metarial/
  4. fabric (n): a material made by weaving wool, cotton. Silk,etc, used for
making curtain, clothes, etc. and for covering furniture.
  Ex. Some silk fabric will drape beautifully.
  5. masculine (adj): having qualities or appearance considered to be typical
of men, connected with or like men
  ex. He was handsome, strong and very masculine.
  6. contemporary (Adj): belonging to the same time.
  Ex. He was contemporary with the dramatist Congreve
  7. proportion (n): the relationship of one thing to another in size, amount,
etc.
  ex.
  8. platform (n): the flat surface raised above the level of ground or floor,
used by public speakers or performers so that the audiences can see them.
  Ex. Coming onto the platform now is tonight’s conductor, Bich Phuong
  9. initial (adj): happen at the beginning, first.
  Ex. In the initial stage (= at the beginning) of the campaign

READING PORTFOLIO                                                           Page 19
Name: Bui Bich Phuong
Class: E2

  10. retort (v): to reply quickly to a comment, in an angry, offended or
humorous way.
  Ex. Sam retorted that it’s my fault as much as his.
  11. ingenue (v): an innocent young woman, especially in a film or play.
  Ex. Can an ingenue bring anything new to footwear?
  12. gilded (adj): cover with a thin layer or gold or gold paint
  ex. He bought a gilded picture frame.
  13. lavish (adj): large in amount, impressive, usually costing a lot of money.
  Ex. They live in a lavish lifestyle.
  14. venue (n): a place where people meet for              an organized event, for
example, a concert, sporting event or conference.
  Ex. The band will be playing in 20 different venues in UK
  15. fawn (adj) : light yellowish-brown in color.
  Ex. Chicken’s feather is fawn.
  16. silhouette (n): a shape of a person’s body or of an object
  ex. The dress is fitted to give you a fattering silhouette.
  17. intense (adj): having or showing very strong feeling.
  Ex. She is intense about everything.
  18. arrive in stores: phân phối đến các cửa hàng
  ex. Pizza is arrives in stores in my town from factory.
  19. evoke (adj): bring a feeling, a memory or an image into your mind.
  Ex. This song evoked the memories of her youngth.
  20. sashay: to walk in a very confident but relaxed way , especially in order to
be noticed.
  Ex. I watched her as she sashayed across the room.




READING PORTFOLIO                                                           Page 20
Name: Bui Bich Phuong
Class: E2


                        WEEK 6 – PSYCHOLOGY
                    Simple strategies for handling anxiety and stress
                                           Source: Psychologytoday Magazine
                                                            Date: March 19, 2012

           Three Things That Maintain Anxiety
                                                    - Patrick B. McGrath, Ph.D.-
  How many times have you had the same conversation with someone over and
over again, and then became frustrated again and again because they did not
follow your advice? I hear about this happening all of the time actually. I hear
about it from therapists that I train who tell me how frustrating it is to work with
anxious patients.
  Now, I will agree that it can be frustrating to work with some anxious patients,
but it does not have to be. In fact, some of the best therapy in the world was
designed to treat anxiety disorders. So, treating stressed and anxious people is
not all that difficult if you know what you are doing.
  So, I am going to let you all in on a little secret - I am going to tell you what to
do to overcome your stress and anxiety. It is just a few simple steps and you will
be able to make great strides in helping yourself to overcome your fears. And, if
you need any extra help from a therapist, that is fine too, as I will also tell you
where to find good help.
  Instead of talking about what is stressful or what is leading you to feel anxious,
you would be better off stopping these three behaviors:
  1.     Avoidance: If you avoid what it is you fear, you will teach yourself that
the only way to be safe is to avoid what you fear. This is a recipe for disaster,
because you will just avoid more and more things over time instead of learning
how to handle what it is that bothers you.


READING PORTFOLIO                                                              Page 21
Name: Bui Bich Phuong
Class: E2

  2.      Reassurance Seeking: If all you do is ask everyone you know if
everything will be OK, you will never learn how to handle things on your own.
This is also a tricky scheme, because if someone tells you that everything will be
OK, and then it turns out not to be, you can blame them for it not turning out well
because they lied to you and told you that everything will be OK.
  3.      Distraction: If you do have to face whatever it is you fear and you
distract yourself from it, then you never actually learn how to handle it and you
maintain your fear and convince yourself that the only reason you are safe is
because of the distraction that you did.
  These three things are actually called safety seeking behaviors, and they are
all performed in order to feel good right now instead of feeling good later on. That
may sound like a good thing, but it really is a very poor way of coping because
people soon become so reliant on these coping strategies that they live only to
feel good in the moment and do not do what they need to do to be well in the
long run. In future posts we will break the safety seeking behaviors down more in
depth and talk about how to overcome them.
  If you are in need of help with stress, or are seeing someone and do not feel
that you are making progress, I suggest looking at the "Find A Therapist".
                                           ***


  I. The inflection on the article:
  This article discusses about the simple strategies for handling anxiety and
stress. Writter didn’t directly tell about how to handle, on the other hand, he
pointed    three wrong behaviors of almost people, these are avoidance ,
reassurance seeking and distraction. With each behavior, he gives interesting
supporting ideas. From those points, he advices readers should avoid those
things. According to me, this article is a good one. I enjoy the way that reporter
shows his ideas which is quite clearly and makes article be coherent. However,

READING PORTFOLIO                                                            Page 22
Name: Bui Bich Phuong
Class: E2

the range of vocabulary is not very varied. I think it would be better if writer chose
words more careful to make it more interesting.


  II. Vocabulary and structure
  1. therapy = psychotherapy (n): the treatment of metal illness by discussing
sb’s problem with them rather than by giving them some drugs.
                                 The treatment of a physical proplem or an illness.
  Ex. I went to therapy because my doctor suggested it.
  2. Reassurance (n): the fact of giving advices or helps that takes away a
person’s fears or doubts
  Ex. Teenagers need love, encouragement and reassurance from their parents.
  3. recipe for sth: a method or an idea that seems likely to have a particular
result.
  Ex. What is her recipe for success.
          His plan are a recipe for disaster.
  4. seek (v): to look for sth/sb/ try to obtain or achieve sth.
  Ex. People who are unemployed and actively seeking work.
  5. reliant (adj): needing sth/ sb in order to survice, be successful, etc.
  Ex. The survice has become heavily reliant on government supports




READING PORTFOLIO                                                              Page 23
Name: Bui Bich Phuong
Class: E2


                           WEEK 7 – SCIENCE
                               Issac Newton
  Source: http://www.universetoday.com/82052/issac-newton-inventions/


  Sir Issac Newton is best know for his laws of motion. Many people’s
knowledge of his scientific contributions stops there. Issac Newtons inventions
contributed a great deal to our current understanding of subjects from optics to
theology and how early scientists were able to view their world.


                                       In mathematics Issac Newton inventions
                                    included     laying   the   ground   work    for
                                    differential and integral calculus. His work
                                    was based on his insight that the integration
                                    of a function is merely the inverse procedure
                                    to differentiating it. Taking differentiation as
                                    the basic operation, he produced simple
                                    analytical      methods that unified many
                                    separate techniques previously developed to
                                    solve apparently unrelated problems such
                                    as finding areas, tangents, the lengths of
                                    curves and the maxima and minima of
        Sir Issac Newton        functions.
  Issac Newton inventions in mechanics and gravitation were summarized the
Principia. His discoveries in terrestrial and celestial mechanics showed how
universal gravitation provided an explanation of falling bodies on Earth and of the
motions of planets, comets, and other bodies in the heavens. He explained a
wide range of then unrelated phenomena: the eccentric orbits of comets, the

READING PORTFOLIO                                                            Page 24
Name: Bui Bich Phuong
Class: E2

tides and their variations, the precession of the Earth’s axis, and motion of the
Moon as perturbed by the gravity of the Sun. This work includes Newton’s three
famous laws of motion, fluid motion, and an explanation of Kepler’s laws of
planetary motion.
  Issac Newton inventions in optics included his observation that white light
could be separated by a prism into a spectrum of different colors, each
characterized by a unique refractivity. He proposed the corpuscular theory of
light. He was the first person to understand the rainbow. He was the first person
to use a curved mirror in a telescope to prevent light form being broken up into
unwanted colors.
  Isaac Newton inventions and contributions to science were many and varied.
They covered revolutionary ideas and practical inventions. His works in physics,
mathematics and astronomy are still important today. His contributions in any
one of these fields would have made him famous; taken as a whole, they make
him truly outstanding.
                                         .***


  I. The reflection on the article:
  Here’s an article about Issac Newton – one of the most famous scientists in
the world, who had contributed variety of inventions to science fields such as
mathematics, physics and astronomy. The article introduces achievements which
Newton attemted and their significances to science and life. They help people
totally sees the world, explains strange phenomenons which no one could do
before. According to me, this is a good article because it provide reader with total
knowledge about Newton’s inventions. That shows large knowledge, especially
on science field. I like the way which writter presents his ideas, they are quite
unity and make paragraphs coherent. What’s more, range of vocabulary and
structures are varied so that make article be more interesting.

READING PORTFOLIO                                                            Page 25
Name: Bui Bich Phuong
Class: E2

        II. Vocabulary       and sentence structure

      1. theology (n): study of religion and beliefs
      2. tangent (n): a straigh line that touches the outside of a curve but not cross
it.
      Ex. The distance between the centre of a curve and its tangent is as far as its
radius.
      3. terrestrial (adj): connected with the planet Earth.
      Ex. Terrestrial life is very varied.
      4. celestial (adj): of the sky or of heaven.
      Ex. The Sun, Moon and stars are celestial.
      5. crepuscular (adj): related to the period of the evening when the sun had
just gone down but there is still some light in the sky
         ex. I like crepuscular time
      6. telescope (n): a piece of equipment shaped like a tube that you look
through to make objects that are far away appear larger and nearer.
      Ex. We can look at the stars through the telescope.
      7. the eccentric orbits of comets
      8. tide (n): a regular of rise or fall in the level of the sea, caused by the full of
the Sun and the Moon; the flow of water that happens as the sea rises and falls.
      Ex. Is the tides coming in or going out?
      9. perturb (v): to make an obstacle with motion of an object.
      Ex. Moon as perturbed by the gravity of the Sun
      10. spectrum (n): a range of sound waves or several other types of waves.
      Ex. Red and violet are at opposite ends of the spectrum




READING PORTFOLIO                                                                  Page 26
Name: Bui Bich Phuong
Class: E2




         GSR: How Do You Know You're Right?
                                                 - By Timothy J. Drake, Ph.D. -
                                                            Magazine: Forensic
                                                        Date: October 18, 2011

  Using integrated SEM-EDX technology to provide automatic, rapid, and
validated results.

  As the volume of cases grows and forensic crime labs’ budgets shrink, lab
operations management, technicians, and litigators are all looking for answers
related to gunshot residue (GSR) detection, identification, and characterization.
Lab operations need high throughput solutions that require little oversight or
expertise, yet maintain a high degree of reliability. Lab technicians need easy to
use platforms that generate accurate results and reporting that provides
information and knowledge, not reams of data. And, above all, litigators need
validation of that reporting and those results to give them the confidence they
need to go to court and to ensure that those results will stand up under cross
examination at trial. Integrated scanning electronmicroscopes with energy X-ray
dispersive Spectrometers (SEM-EDX) offer platforms that not only provide GSR
results, but further validate those results through a series of checks and
balances; offering the answer that all three audiences are looking for.

  SEM Technology and GSR

  SEM-EDX systems are commonly used for imaging comparison and X-ray
microanalysis of trace evidence samples including tool marks, ink, paper, fibers,
hair, and paint coatings. Back in the late 60s forensic laboratories in London

READING PORTFOLIO                                                          Page 27
Name: Bui Bich Phuong
Class: E2

started to use Scanning ElectronMicroscopes (SEM) for the manual detection
and analysis of Gun Shot Residue particles on a routine basis.


                                              Forty years later, SEMs are still
                                           used in laboratories worldwide for the
                                           detection     of      GSR         particles.
                                           Technological      advances,      including
                                           the integration of Energy Dispersive
                                           Spectrometers for elemental analysis
                                           (EDX) and a software platform for
                                           automated       detection,       relocation,
                                           confirmation, and reporting, have
                                           made this the go-to technology for
                                           EDX     analysis    and      imaging      of
                                           samples     collected     from     suspect
                                           shooters.

  Typically,GSR particles (Figure 1) are composed of lead (Pb), barium(Ba), and
antimony (Sb), and commonly range in size from0.5 to 10microns.They have
varying morphologies and surface textures, but the vast majority are generally
spherical in shape. Ammunition can also be manufactured without lead. Lead-
free ammunition is becoming more prevalent as manufacturers use lead-free or
low-lead propellants to avoid the toxicity of lead .Aluminum(Al) and strontium(Sr)
are often used in lead free cartridges. In addition, Sintox® GSR particles are
characterized by spheroidal particles mainly consisting of titanium(Ti) and zinc
(Zn).




READING PORTFOLIO                                                              Page 28
Name: Bui Bich Phuong
Class: E2




  I. The inflection on the article
  Based on the tittle, reader can see that this article points that Using integrated
SEM-EDX technology is helpful for forensic science, provide automatic,
rapid, and validated results. After reading it, I know more terms of science
as well as enlarge the range of vocabulary and get more knowledge about
them. However, the writer uses so many vocabularies and term of science so it
is quite difficult to understand or event thought I look for new words in dictionary
and know the definition of them as well, I seem to no see what the meaning of
whole sentence is in the first time to read. So I had to spend more time reading
and understanding.


  II. Vocabulary and sentence structures
  1. litigate (v): to take a claim or disagreement to court.
    Litigator : a person who litigate
    Ex. Litigate in two different european countries.
  2. Residue (n): is a small amount of something that is left behind. (noun)
  Ex. When you peel off a tag but there is some sticky stuff left, the sticky stuff is
an example ofresidue.
  3. Reliability (n): Variant of reliable that can be relied on; dependable;
trustworthy
  Ex. The reliability of these results has been questioned.
  4. Validation (n): Variant of validate
         1. to make binding under the law; give legal force to; declare legally
      valid

READING PORTFOLIO                                                             Page 29
Name: Bui Bich Phuong
Class: E2

         2. to prove to be valid; confirm the validity of; verify
  Ex. They didn’t receive any validation of court.
  5. reams of sth (n): a large quantities of sth
  Ex. He writes reams in the essay.
  6. dispersive (adj): describes something that spreads or scatters.
  Ex. An example of dispersive equipment is a device used for spreading seeds
in a garden.
     7. Spectrometer (n): an instrument used for measuring spectral
wavelengths
  Ex. Spectrometer for the detection and quantification of trace compounds in
exhaled breath in real time
  8. platforms:  a raised horizontal surface of wood, stone, or metal; specif.,
                          1.       a raised stage or flooring beside railroad tracks or
                        the like
                          2.       a raised flooring     or stage    for performers,
                        speakers, etc.
                 a statement of principles and policies, esp. of a political party
  Ex. It aims to tackle the needs of the uk's science, engineering and technology
industry and to create a unified platform and voice.
  9. trial (n): a formal examination of evidence in court by judge and often a jury,
to decide if sb accused of a crime guilty or not.
  Ex. He is on trial for murder.
  10. morphology (n): Morphology refers to the study of how animals and
plants are formed.
  Ex. In order to determine the surface morphology and orientation texture of
the films, scanning electron microscopy, sem, was performed.
  11. spherical (adj): shaped like spheres
  Ex. The eye is a roughly spherical organ built a bit like a football.


READING PORTFOLIO                                                              Page 30
Name: Bui Bich Phuong
Class: E2



  12. Ammunition (n): is something that you can use against another person to
get him or her to do something for you or to do what you want.
  Ex. An example of ammunition is when you know your little brother snuck in
late and you threaten to tell on him if he doesn't make you breakfast.
  13. prevalent (adj): ~ among sb / ~ in sb/sth : that exists or is very common
at a particular time or in a particular place.
  Ex. The concentration on bebop did seem disproportionately prevalent in all
forms of education, however.
  14. toxicity of lead (n): The quality or condition of being toxic/ The degree to
which a substance is toxic.
  Ex. Minor toxicities of this drug include nausea and vomitting.
  15. propellants (n): a thing or substance that probels sth, for example the
fuel that fires a rocket.
  Ex. Until solid propellants were developed for such big rockets, this was a
universal problem.
     16. shrink (v): to become or to make sth smaller in size or amount
     Ex. The market for their products is shrinking




READING PORTFOLIO                                                          Page 31
Name: Bui Bich Phuong
Class: E2




                   WEEK 9- BUSINESS
              Recipe for a Successful Business:
                           Growing success
                                                   Magazine: TIME
                                                       Date:: December 3, 2007

        For many entrepreneurs, starting a business is the culmination of many
years of dreaming and planning. So it is understood that every small business
owner wants their business to flourish and be productive - and that is the reason
that they usually concentrate on growth.
  But what many small business owners forget is that the recipe for creating a
successful business is a gradual process in which each stage needs to be
crossed before reaching the next one.
  Think Differently
  As a small business owner, your main ambition is to grow your company. So,
you want to usher in momentum - and to bring in this momentum into your
business, you need to think differently. You might be chasing success, but what
you may be forgetting is that it is the small successes in between that make way
for larger ones.
  Having said that, it is better to redirect your energies towards smaller
successes that will not only move your business ahead, but will motivate you at
the same time.
  Believe and Concentrate



READING PORTFOLIO                                                         Page 32
Name: Bui Bich Phuong
Class: E2

  As an entrepreneur, the success of your business depends largely on you.
That's why you need to learn to have a solid belief in the opportunity that you
have taken to start your business and in your industry as well. Your small
business is only going to work for you if you are ambitious enough to take charge
of your destiny.
  You should not look at your business as just another activity. You should also
take it more seriously than a hobby, or a project that you have taken on as a trial
to see if it will work.
  Treat your business as your full-time job where failure isn't an option. Really
concentrate on making it successful.
  Have a Viable Business Plan
  You can start your business on the path to success by creating a business
plan. You should meticulously create a business plan that explains the objectives
of your business, the tactics that you are going to use, the formulas that you want
to apply, the targets that you want to achieve and the monetary figure that you
desire to earn.
  All these points should be stated clearly and you should put in your best efforts
to achieve them.
  Ingredients of a Business Plan
  Your business plan should have a professional summary that will define your
target market. It should include the legal details of your business, which is your
contact address and description of your business - whether it is a partnership,
corporation or some other form. You should also mention in the plan how you are
going to meet your targets and how you are going to beat the competition in the
market.
  You should also include a thorough market analysis in your business plan.
This shows that you have studied the market carefully before getting into the
business. Here, you can mention the present trends in your industry and what the


READING PORTFOLIO                                                           Page 33
Name: Bui Bich Phuong
Class: E2

demand is for your products and services. Then you can include the prices of
your competitors and how your prices will compete with them.
  An important part of your business plan is the financial section, in which you
note the personal funds you have, the capital that you need and how you plan to
repay your debts, if you have any. The financial section should also include your
balance sheet, financial worksheet, and annual income.
  Another important aspect of your business that needs to be mentioned in the
business plan is your team - you as the owner, and any partners or associates
that you have and their credentials.
  Growing a successful business takes time, hard work and dedication. If you
believe in yourself and the business from the beginning, you will be successful in
short order.
                                        *****
  I. The inflection on the article
   The topic of article mentions the proplem that many people care of: how
to be successful. In the article, reporter supports 4 main tips to be successful
in business, including: Think Differently, Believe and Concentrate, Ingredients of
a Business Plan, Have a Viable Business Plan. These are useful advices for
people who want to be successful in business but don’t know how to do.
According to him, to success, it’s essensial to have goal and a particular plan
that how you get the target. When reading this article, I feel very interested
in the recipes which reporter supported, especially the forth tip:
ingrediences in you business plan which inclues a professional summary
that will define your target market, a thorough market analysis in your business
plan, the financial section, your team. I also like the way that he shows the
ideas is quite clear. Sentence structures, range of vocabulary are quite
good. Thanks to this article, I know more about recipes to be successful. It
may be helpful and essencial for me in the future.

READING PORTFOLIO                                                          Page 34
Name: Bui Bich Phuong
Class: E2




  II. Vocabulary and sentence structures
  1. entrepreneur (n): a person who makes money by starting or running
businesses, especially when this involves taking financial risks!
  Ex. A creative entreprenur, he was continually dreaming up new projects
  2. culmination (n): the highest point or end of sth, usually happening after a
long time.
  Ex. A decision will be taken at the culmination of the research.
  3. to usher in sth: to be the beginning of sht or to make sth new begin
  Ex. The change of management ushered in fresh ideas or policies.
  4. momentum (n): the ability to keep increasing or developing
  ex. The campaign for change now has considerable momentum.
  5. chase (v): to try to achieve sth like work or success.
  Ex. Too many people are chasing too few jobs nowadays.
  6. destiny (n): what happen to sh or what ill happen in the future, can not
change or avoid.
  Ex. You can not change your destiny.
  7. meticulous (adj): paying carefully attention to every detail.
   ~ in sth/ ~ doing sth / ~ about sth
  Ex. She is meticulous about her appearance beforeg going out.
  8. monetary (adj): connected with money , especially all the money in the
country.
  Ex. The sculptures were of little monetary value.
  9. credentials (n): (~ as/ for sb): the qualities, the training or experience that
make you suitable to do sth / a document such as letters prove you that you
are who claim to you and can therefore be trusted
  ex. He has all the credentials for the job.

READING PORTFOLIO                                                            Page 35
Name: Bui Bich Phuong
Class: E2

  10. flourish (adj): to develop quickly and be successful or common
    Ex. There was a flourishing black market.

                      WEEK 10: NEUROSCIENCE
           Scientists Uncover Clue to Preventing,
                   and Possibly Reversing,
               Rare Childhood Genetic Disease
                                                        Magazine: SCIENCEDAILY
                                                          Published: April 1st , 2012

  Scientists think they have found a way to prevent and possibly reverse the
most debilitating symptoms of a rare, progressive childhood degenerative
disease that leaves children with slurred speech, unable to walk, and in a
wheelchair before they reach adolescence.
  In the April 1 online edition of Nature
Medicine, Karl Herrup, chair of the
Department      of    Cell   Biology   and
Neuroscience in the School of Arts and
Sciences provides new information on
why this genetic disease attacks the
cerebellum -- a part of the brain that
controls      movement        coordination,
equilibrium, and muscle tone -- and
other regions of the brain.
                                                Karl Herrup, chair of Cell Biology
  Using mouse and human brain
                                              and    Neuroscience     at    Rutgers
tissue     studies,    Herrup    and    his
                                              University. (Credit: Nick Romanenko)
colleagues at Rutgers found that in the



READING PORTFOLIO                                                             Page 36
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Class: E2

  brain tissue of young adults who died from axtaxia-telangiectasia, or A-T
disease, a protein known as HDAC4 was in the wrong place. HDAC4 is known to
regulate bone and muscle development, but it is also found in the nerve cells of
the brain
  The protein that is defective in A-T, they discovered, plays a critical role in
keeping HDAC4 from ending up in the nucleus of the nerve cell instead of in the
cytoplasm where it belongs. In a properly working nerve cell, the HDAC4 in the
cytoplasm helps to prevent nerve cell degeneration; however, in the brain tissue
of young adults who had died from A-T disease, the protein was in the nucleus
where it attacked the histones -- the small proteins that coat and protect the
DNA.
  "What we have found is a double-edged sword," said Herrup. "While the
HDAC4 protein protected a neuron's function when it was in the cytoplasm, it was
lethal in the nucleus."
  To prove this point, Rutgers scientists analyzed mice, genetically engineered
with the defective protein found in children with A-T, as well as wild mice. The
animals were tested on a rotating rod to measure their motor coordination. While
the normal mice were able to stay on the rod without any problems for five to six
minutes, the mutant mice fell off within 15 to 20 seconds.
  After being treated with trichostation A (TSA), a chemical compound that
inhibits the ability of HDAC4 to modify proteins, they found that the mutant mice
were able to stay on the rotating rod without falling off -- almost as long as the
normal mice.
  Although the behavioral symptoms and brain cell loss in the engineered mice
are not as severe as in humans, all of the biochemical signs of cell stress were
reversed and the motor skills improved dramatically in the mice treated with TSA.
This outcome proves that brain cell function could be restored, Herrup said.




READING PORTFOLIO                                                          Page 37
Name: Bui Bich Phuong
Class: E2

  "The caveat here is that we have fixed a mouse brain with less devastation
and fewer problems than seen in a child with A-T disease," said Herrup. "But
what this mouse data says is that we can take existing cells that are on their way
to death and restore their function."
  Neurological degeneration is not the only life-threatening effect associated with
this genetic disease. A-T disease -- which occurs in an estimated 1 in 40,000
births -- causes the immune system to break down and leaves children extremely
susceptible to cancers such as leukemia or lymphoma. There is no known cure
and most die in their teens or early 20s. According to the AT Children's Project,
many of those who die at a young age might not have been properly diagnosed,
which may, in fact, make the disease even more common.
  Herrup says although this discovery does not address all of the related
medical conditions associated with the disease, saving existing brain cells even
those that are close to death -- and restoring life-altering neurological functions
would make a tremendous improvement in the lives of these children.
  "We can never replace cells that are lost," said Herrup. "But what these mouse
studies indicate is that we can take the cells that remain in the brains of these
children and make them work better. This could improve the quality of life for
these kids by unimaginable amounts."
  Additionally, Herrup says, the research might provide insight into other
neurodegenerative diseases. "If this is found to be true, then the work we've
done on this rare disease of childhood may have a much wider application in
helping to treat other diseases of the nervous system, even those that affect the
elderly, like Alzheimer's," he said.
                                        *****



  I. The inflection on the article


READING PORTFOLIO                                                           Page 38
Name: Bui Bich Phuong
Class: E2

  This article talks about NEUROSCIENCE that is a new item in Science. It’s
clear with 3 main ideas in the title: Scientists Uncover Clue to Preventing,
Possibly Reversing, and Rare Childhood Genetic Disease.
  In this article, reporter uses many technical terms in neuroscience so that it’s
quite difficult to understand clearly the content of the article. He shows a large
knowledge, widen range of vocabulary. To explain and make clearly topic, the
writer gives supportings as well as particular examples and quotes the idea of
some scientists. I think this is a good article. Based on it, people can get more
information and knowledge about the new topic of science field. After reading
this article, I enlarge my knowledge about Neuroscience that I never care of
before. Beside, I’ve learnt a lot of good new words in the field of neuroscience.


  II. Vocabulary and sentence structure:


  1. debilitating (adj): making sb’s body or mind weaker.
  Ex. She found the heat debilitating.
  2. symptom (n) : a sigh that sth exists, especially sth bad
  ex. If symptom persists, consult your doctor.
  3. rare (Adj) : existing in small numbers, therefore valuable or interesting
  ex. This pieces is extremely rare.
  4. degenerative (adj): (of an illness) : getting or likely to get worse as time
passes
  ex. The degenerative diseases such as arthritis
  5. slurry (n): a thick liquid consisting of water mixed with animal waste, coal
dust or clay.
  Ex.
  6. adolescence (n): the time in na person’s life when she or he develops
from a child into an adult.

READING PORTFOLIO                                                           Page 39
Name: Bui Bich Phuong
Class: E2

  Ex. Adolesence brights about major changes in a young person’s body.
  7. equilibrium (n): a state of balance, especially between opposing forces or
influences.
  Ex. He can’t maintain enough equilibrium to rade a bike
  8. plays a critical role in doing
  9. nucleus (n): a central part of some cells.
  10. nerve (n): any of a long thread that can be carry messages between brain
and parts of the body (dây thần kinh)
  - nerve cell: Tế bào thần kinh
  ex. At the last minute she almost lost her nerve
  11. cytoplasm (n): all the living material in a cell, not including nucleus.
  Ex. Tế bào chất
  12. histone : 1 loại protein có trong chất tế bào
  13. double-edged sword
  14. lethal (adj): causing or able to cause o lot of harm or damage.
  Ex. He has been sentenced to death by lethal injection.
  15. rotating rod
  16. caveat (n): a waring that particular things need to be considered before
sth can be done.
  Ex. Any dicussion of legal action must be preceded by a caveat on costs.
  17. devastation (n): great instruction or damage, especially over a wide area.
  Ex. The bomb caused widespread devastation.
  18. immune (adj): ~ to sth: that can not catch or be affected by a particular
disease or illness.
  Ex. Adults are often immune to German measles
  19. susceptible (adj): ~ to sb/sth : very likely to be influenced, harmed or
affected by sth/sb
  ex. Some of these plants are more susceptible to frost damage than others


READING PORTFOLIO                                                                Page 40
Name: Bui Bich Phuong
Class: E2

  20. leukaemia (n): a serious disease in which too many white blood cells are
produced, causing weakness, and sometimes death.
  - Bệnh bạch hầu
  Ex. Leukaemia is one of the most serious diseases.
  21. lymphoma (n): cancer of the lymph nodes
  - ung thư hệ bạch huyết
  ex. She diesd because of lymphoma
  22. tremendous (Adj): very great/ extremely good
  ex. It was a tremendous experience.
  23. neuroscience (n): a science that deal with the structure and function of
the brain and nervous system.
  - Khoa hoc nghiên cứu về hệ thần kinh.
  24. neurodegenerative (Adj): ảnh hưởng xấu đến hệ thành kinh.
  Ex. I think that accident will be neurodegenerative.




READING PORTFOLIO                                                         Page 41
Name: Bui Bich Phuong
Class: E2




                WEEK 11: OCEANOGRAPHY
                        Widespread Adaptability
   Coral Reefs May Be Able to Adapt to Climate
               Change With Help from Algae
                                                      Magazine: Science Daily
                                                          Date: Aprial. 11, 2012
  A new study by scientists at the University of Miami's Rosenstial School of
Marine & Atmospheric Science suggests that many species of reef-building
corals may be able to adapt to warming waters by relying on their closest aquatic
partners - algae. The corals' ability to host a variety of algal types, each with
different sensitivities to environmental stress, could offer a much-needed lifeline
in the face of global climate change.




READING PORTFOLIO                                                           Page 42
Name: Bui Bich Phuong
Class: E2

  Using a highly sensitive genetic technique,
Ph.D. student Rachel Silverstein analyzed 39
coral species from DNA collected in the Indo-
Pacific and Caribbean collected over the last 15
years. Most of these species had not previously
been thought capable of hosting more than one
type of the single-celled symbiotic algae, called
zooxanthellae, which live inside the coral and         A new study suggests that many
help to supply them with energy.                    species of reef-building corals may
  Silverstein's results revealed that at least one be able to adapt to warming waters
colony of all 39 species tested had at least two by relying on their closest aquatic
                                                    partners – algae.
varieties of algae, including one thought to be

  heat tolerant. Over half of the species were found to associate with all four of
the major types of algae found in corals.
  "This study shows that more coral species are able to host multiple algal
symbionts than we previously thought," said Andrew Baker, associate professor
at UM's Rosenstiel School and co-author of the study. "The fact that they all
seem to be capable of hosting symbionts that might help them survive warmer
temperatures suggests they have hidden potential that was once thought to be
confined to just a few special species."
  More than 10 years ago, Baker was one of the first scientists to suggest that
the ability of corals to associate with diverse algal symbionts may be one
mechanism by which they are able to rapidly respond to environmental changes,
such as increased ocean temperatures due to climate change.
  "Although our study shows that different coral species do tend to have
preferences in their algal partners, the fact that these preferences are not
absolutely rigid means that we cannot ignore the possibility that most corals



READING PORTFOLIO                                                               Page 43
Name: Bui Bich Phuong
Class: E2

might change partners in response to environmental changes in the future," said
Silverstein.
  Globally, reefs have lost more than 70 percent of their corals as a result of
pollution, disease, overfishing, and climate change. Increased temperatures
cause coral "bleaching," in which corals expel their algal partners, turn pale, and
often die. However, some symbionts can resist bleaching in warmer waters and
may help the corals survive during stress. The ability to host multiple symbionts
may help save coral reefs from future losses during expected ocean
temperatures increases of 2-4 degrees Celsius (3-7 degrees Fahrenheit) by
2100.
  "These new findings should encourage us to find better ways to protect coral
reef ecosystems from overfishing, pollution and habitat destruction, and buy us
some time to avoid the worst climate change scenarios," said Baker, who is also
a research associate of the Wildlife Conservation Society in New York.
  The study was published in the online edition of the journal Proceedings of the
Royal Society B. Adrienne Correa, a former UM Rosenstiel School student of
Baker's and a current postdoc at Oregon State University, is a co-author on the
study, as well. The U.S. National Science Foundation, the Wildlife Conservation
Society, the Lenfest Ocean Program and Pew Fellows Program in Marine
Conservation funded the study.
                                         *****


  I. The reflection on the article
  The article reports a new study by scientists at the University of Miami's
Rosenstial School of Marine & Atmospheric Science about coral reef. Based on
the result of study, the writer provides reader with useful information about this
special kind of animal. I can learn more about the corals' ability to host a variety
of algal types and more coral species are able to host multiple algal symbiont

READING PORTFOLIO                                                            Page 44
Name: Bui Bich Phuong
Class: E2

than we previously thought. Additionally, The status of coral caused of pollution
and increasing of temperature. From that, it’s necessary to protect them.
Reporter supports ideas with opinion of researchers so that it makes article be
clear and belief. Not only help us enlarge knowledge and open the         mind, this
article but also teach us how to present a topic, make it clear and help reader
understand. I can also learn many vocabularies that related to Oceanography.
However, I think it will be better if reporter makes main ideas more clear by
putting topic sentences is the first sentence of paragraph.



  II. Vocabulary & Sentence Structure:

  1. Coral reef (n) : a long line of a hard substance that is red, pink or white in
colour, and that forms on the bottom of the sea from the bones of very small
creatures. ( rặng san hô )
  Ex. Halong bay is famous for colourful coral reef.
  2. algae (n): very simple plants that have no real leaves, stems, roots, and
that grow in or near water. (tảo)
  Algal (adj) + only before noun
  Ex. Algae is the simplest plant.
  3. Zooxanthellae: tảo cộng sinh, vàng lục
  4. single-celled (adj): only one cell – the smallest unit of living matter that
can exist on its own. (đơn bào)
  ex. Algae is a single-celled plant.
  5. hosting symbiont (n): an animal or a plant on which another animal or
plant lives and feed. ( vật chủ)
  symbiont / symbiosis (n) : the relationshio between two different living
creatures that live close together and depend on each other in particular ways,
each getting particular benefits from the other. (sinh vật cộng sinh)

READING PORTFOLIO                                                            Page 45
Name: Bui Bich Phuong
Class: E2

  Ex.The birds live in symbiosis with the cattle, pichking insects fromm their skin
to eat.
  6. to associate with sth/ sb: to make a connection between people or things
in your mind. ( lien kết)
  Ex. I always associate the smell of baking with my childhood.
  7. multiple (adj): many in number, involving many different people or
things. (nhiều)
  Ex. This study shows that more coral species are able to host multiple algal
symbionts than we previously thought
  8. mechanism (n): a system of parts in a living thing that together perform a
particular function
  Ex. The body das defence mechanism against many diseases.
  9. Rigid (adj): difficult to change
  Ex. They offer rigid principle.
  10. Ignore (v) : to pay no attention to sth
  Ex. I made a suggestion but they chose to ignore it, as a result their campaing
was collapsed.
  11. Overfishing (n): a process of taking so many fish from the sea, a river,
etc. that the number of fish in it becomes very low. (sự khai thác, đánh cạn cá)
  Ex. A shortage of tuna, caused of overfishing.
  12. Bleach (v): to become white or pale by a chemical process or by the
effect of light from the sun; to make sth white or pale in this way. ( tẩy trắng)
  Ex. His hair was bleached by the sun.
  13. Pale (adj): light in color; containing a lot of white; having skin that is almost
white because of illness; strongly emotion, etc.( tái nhợt, xanh xao)
  Ex. You look pale. Are you OK?
  14. expel (~ sth from sth) (v): to force air or water out of a part of the body or
from a container ( tống ra)


READING PORTFOLIO                                                              Page 46
Name: Bui Bich Phuong
Class: E2

  ex. Try to expel water from the belly.
  15. Ecosystem (n): all the plants and living creatures in a particular area
considered in relation to their physical environment . ( Hệ sinh thái)
  Ex. Islands often support delicate ecosystems that evolved without any need
for defence.




                  WEEK 12 – ENGINEERING
                 Genetic Engineering
          How to Use Light to Control the Brain
                                                          - By Stephen Dougherty -
                                                   Magazine: Scientific American
                                                             Date: March 27, 2012
  LIGHT: Scientists can use light to switch on a neuron Image: iStock / kertlis
  In the film Amèlie, the main character is a young eccentric woman who
attempts to change the lives of those around her for the better. One day Amèlie
finds an old rusty tin box of childhood mementoes in her apartment, hidden by a
boy decades earlier. After tracking down Bretodeau, the owner, she lures him to
a phone booth where he discovers the box. Upon opening the box and seeing a
few marbles, a sudden flash of vivid images come flooding into his mind. Next

READING PORTFOLIO                                                          Page 47
Name: Bui Bich Phuong
Class: E2

thing you know, Bretodeau is transported to a time when he was in the
schoolyard scrambling to stuff his pockets with hundreds of marbles while a
teacher is yelling at him to hurry up.
  We    have      all   experienced   this:    a
seemingly insignificant trigger, a scent, a
song, or an old photograph transports us
to another time and place. Now a group of
neuroscientists     have    investigated      the
fascinating question: Can a few neurons
trigger a full memory?

  In a new study, published in Nature, a group of researchers from MIT showed
for the first time that it is possible to activate a memory on demand, by
stimulating only a few neurons with light, using a technique known as
optogenetics. Optogenetics is a powerful technology that enables researchers to
control genetically modified neurons with a brief pulse of light.
  To artificially turn on a memory, researchers first set out to identify the
neurons that are activated when a mouse is making a new memory. To
accomplish this, they focused on a part of the brain called the hippocampus,
known for its role in learning and memory, especially for discriminating places.
Then they inserted a gene that codes for a light-sensitive protein into
hippocampal neurons, enabling them to use light to control the neurons.
  With the light-sensitive proteins in place, the researchers gave the mouse a
new memory. They put the animal in an environment where it received a mild
foot shock, eliciting the normal fear behavior in mice: freezing in place. The
mouse learned to associate a particular environment with the shock.
  Next, the researchers attempted to answer the big question: Could they
artificially activate the fear memory? They directed light on the hippocampus,
activating a portion of the neurons involved in the memory, and the animals

READING PORTFOLIO                                                         Page 48
Name: Bui Bich Phuong
Class: E2

showed a clear freezing response. Stimulating the neurons appears to have
triggered the entire memory.
  The researchers performed several key tests to confirm that it was really the
original memory recalled. They tested mice with the same light-sensitive protein
but without the shock; they tested mice without the light-sensitive protein; and
they tested mice in a different environment not associated with fear. None of
these tests yielded the freezing response, reinforcing the conclusion that the
pulse of light indeed activated the old fear memory.
  In 2010, optogenetics was named the scientific Method of the Year by the
journal Nature Methods. The technology was introduced in 2004 by a research
group at Stanford University led by Karl Deisseroth, a collaborator on this
research. The critical advantage that optogenetics provides over traditional
neuroscience techniques, like electrical stimulation or chemical agents, is speed
and precision. Electrical stimulation and chemicals can only be used to alter
neural activity in nonspecific ways and without precise timing. Light stimulation
enables control over a small subset of neurons on a millisecond time scale.
  Over the last several years, optogenetics has provided powerful insights into
the neural underpinnings of brain disorders like depression, Parkinson’s disease,
anxiety, and schizophrenia. Now, in the context of memory research, this study
shows that it is possible to artificially stimulate a few neurons to activate an old
memory, controlling an animals’ behavior without any sensory input. This is
significant because it provides a new approach to understand how complex
memories are formed in the first place.
  Lest ye worry about implanted memories and mind control, this technology is
still a long way from reaching any human brains. Nevertheless, the first small
steps towards the clinical application of optogenetics have already begun. A
group at Brown University, for example, is working on a wireless optical electrode
that can deliver light to neurons in the human brain. Who knows, someday,


READING PORTFOLIO                                                            Page 49
Name: Bui Bich Phuong
Class: E2

instead of new technology enabling us to erase memories á la Eternal Sunshine
of the Spotless Mind, we may actually undergo memory enhancement therapy
with a brief session under the lights.
                                           *****



  I. The reflection on the article

  This article shows many information about genetic engineering – one of new
engineering fields. Based on many studies in renown universities and groups ,
reporter provides interesting knowledge as scientific researchers. He uses a wide
range of scientific terms that make readers feel difficult to understand. To make
it clear, he presents a new study, published in Nature, a group of researchers
from MIT. For example, reader can know more about optogenetics is a powerful
technology that enables researchers to control genetically modified neurons with
a brief pulse of light. I’m interested in this article, not only because of its content,
but also manner of expessing of the writer. It’s really impressive. In addition,
introduction part is quite attracting and interesting. What’s more, the article gives
me a lot of good new words in the field of engineering


  II. Vocabulary & Sentence Structure
         1.   eccentric (adj): considered by other people to be strange or
       unusual.
  ex. The old lady was getting very eccentric.
  2.   to lures sb to sth: to persuade or trick sb to go somewhere or to do sth
by promising them a reward.
  Ex. The woman that had lured him to his death.
  3. to come flooding into/ in sth: to arrive or go mind in a large number.
  Ex. Telephone calls came flooding in from all over the country.

READING PORTFOLIO                                                               Page 50
Name: Bui Bich Phuong
Class: E2

   4. to yell at sb to do sth: to shout loudly, for example, when you’re angry,
excited, frighten or in pain.
   Ex. She yelled at the child to get down from the wall.
   5. marble (n): a small ball of colored glass that children roll along a ground
in a game.
   Ex. Three boys are playing marbles.
   6. scent (n): the pleasant smell that sth has (flower, perfume, etc.).
   Ex. The air is filled with the scent of wild flowers.
   7. fascinating (adj): extremely interesting and attractive.
   Ex. The end of this story makes fascinating reading.
   8. optogenetic: is a powerful technology that enables researchers to control
genetically modified neurons with a brief pulse of light.
   9. pulse of light : a single short increase in the amount of light produced by
a machine.
   Ex. The pulse of light is influent to control the brain.
   10. To artificially turn on a memory: created by people, not happening
naturally, not real
   11. hippocampus: (n): either of the two areas of the brain thought to be the
centre of emotion or memory. ( đồi hải mã – thuộc não bộ)
   12. discriminating (adj): able to judge the good quality of sth. (sáng suốt, có
nhận thức đúng đắn)
   Ex. They are very discriminating about what restaurants they go to.
       You should be discriminating about the order to do the project.
   13. to elicit sth from sb: to get information or a reaction from sb, often with
difficulty.
   Ex. The police could elicit evidence from him.
   14. to reinforce sth (v): to make a feeling, an idea, a theory, etc. stronger.
   Ex. The experience reinforced my sense of loss.


READING PORTFOLIO                                                             Page 51
Name: Bui Bich Phuong
Class: E2

  15. a collaborator on sth: a person who works with another person to create
or produce sth suck as book.
  Ex. I need a good collaborator on this project.
  16. precision (n): a quality of being exact, accurate, or careful.
  Ex. You can choose your target with grater precision.
  17. underpin (v): support or form the basic of an argument , a claim, etc.
  ex. This report was inderpinned
  18. schizophrenia (n): a metal illness in which a person becomes unable to
link thought, emotion, and behavior (chứng phân liệt tâm thần)
  ex. His grandfather has been had the schizophenia.
  19. sensory (adj): connected with your physical senses.
  Ex. Nose is one of five sensory organs on the body.
  20. to enhance sth (v): to increase or further improve the good quality, value
or status of sb/ sth.
  Ex. The images should be enhanced using digital technology.

                                     *****
                               Brian’s bridges
      Source: BOOK “Don’t throw this away! The civil engineering life”
                                                             -   By Brian Brenner-


        It appeared that I was a budding engineer, so my mother wrote to the
governor and got tickets to the opening ceremony of the Verrazano Bridge. A big
crowd gathered at the Staten Island toll plaza on a bright and sunny November
day for long speeches and pontification. Most of the participants didn’t have
much to do with the bridge’s design and construction, other than to show up for
the dedication. Robert Moses, the chairman of the Triborough Bridge and Tunnel


READING PORTFOLIO                                                           Page 52
Name: Bui Bich Phuong
Class: E2

Authority, pointed to the chief engineer, Othmar Amman, but didn’t mention him
by name. This was as close as the speakers got to acknowledging the engineers,
since Amman himself was not invited to the podium. I still have the Opening Day
brochure and commemorative stamps in my bridge scrapbook. My mother wrote
on the front of the scrapbook, “Brian’s bridges.”
      A great bridge is the product of the imagination and sweat of hundreds of
people. Maybe this is why a bridge is not easily identified with individuals and
why a bridge’s creation and birth seem anonymous. Very few of the structures
are named in honor of the people who created them. In fact, most bridge names
honor people who had nothing to do with the work. In the case of the Verrazano
Bridge, naming the structure after its creators would have required a very long
name. Society expects that engineers and constructors will fade into the
background, like the bridges. The builders can be proud of their creations but
must be satisfied that the symbolic act of naming, the official recognition of the
creation, will be transferred to someone else.
       In March 2003, my father visited Boston. It was a warm afternoon after a
long, bitter winter. We went to visit the Zakim Bridge, just days before the first
part of its staged opening. The Zakim Bridge stood tall and sleek in the middle of
dowdy, old downtown Boston. Hundreds of thousands had watched the structure
appear from nothing, with its futuristic concrete pylons and slender cables strung
to the deck one piece at a time. Upon completion, the structure quickly became
an infrastructure icon for the city, with its image appearing on bank
advertisements, at the beginning of newscasts, and in dozens of unrelated
publications. On the fourth of July, the blue tower lights were supplemented by a
red glow at night, so with the white cables, the bridge was patriotic, a giant cable-
stayed American flag.
  We stood by the bridge. I had little direct involvement with this bridge design,
but I said to my father:


READING PORTFOLIO                                                             Page 53
Name: Bui Bich Phuong
Class: E2

      “What do you think of my bridge, Dad?”
      “Nice job,” he replied.
                                          *****


  I. The reflection on the article
  This is a part of a story I read. The authour talks true story that he known.
This passage tells about a Bridge – called Zakim. The Zakim Bridge stood tall
and sleek in the middle of dowdy, old downtown Boston. It is a great bridge is the
product of the imagination and sweat of hundreds of people I can get some
interesting and useful information of the Zakim Bridge: its structure, its history,
ect. If having free time, I suggest you enjoying it.



  II. Vocabulary and structures:
  .
  1. pontificate: to give your opinions about something in a way that shows that
you think you are right.
  Ex: She is good at pontificating.
  2. dedication: a ceremony that is held to show that a building or an object
has a special purpose or is special to the memory of a particular person.
  Ex: They are preparing for the dedication.
  3. podium: a small platform that a person stands on when giving a speech or
conducting an orchestra.
  4. bugging: beginning to develop or become successful.
  Ex: The budding young star is now hot property in Hollywood
  5. commemorative: intended to help people remember and respect an
important person or event in the past.
  Ex: A commemorative plaque on the bridge records the name of the engineer.


READING PORTFOLIO                                                           Page 54
Name: Bui Bich Phuong
Class: E2

  6.   scrapbook: a book with empty pages where you can stick pictures,
newspaper articles, etc..
  Ex: He bought a scrapbook to his son as a birthday present.
  7. anonymous: with a name that is not known or that is not made public.
  Ex: The money was donated by a local businessman who wishes to remain
anonymous.
  8. to fade into something: to disappear gradually.
  Ex: Spring was fading into summer.
  9. bitter: (of weather conditions) extremely cold and unpleasant.
  Ex: It's really bitter out today.
  10. sleek: smooth and shiny.
  Ex: She has got sleek black hair.
  11. dowdy: dull or boring and not attractive.
  Ex: The dress seems to be dowdy.
  12. futuristic: extremely modern and unusual in appearance, as if belonging
to a future time.
  Ex: My house has a futuristic design.
  13. concrete: building material that is made by mixing together cement, sand,
small stones and water.
  Ex: The pathway is formed from large pebbles set in concrete.
  14. pylon: a tall metal structure that is used for carrying electricity wires high
above the ground.
  Ex: There are too many pylons here.
  15. deck: a wooden floor that is built outside the back of a house where you
can sit and relax.
  Ex. After dinner, We sat out on the deck to relax.




READING PORTFOLIO                                                            Page 55
Name: Bui Bich Phuong
Class: E2

  16. infrastructure: the basic systems and services that are necessary for a
country or an organization to run smoothly, for example buildings, transport and
water and power supplies.
  17. glow: a dull steady light, especially from a fire that has stopped producing
flames.
  Ex: There was no light except for the occasional glow of a cigarette.
  18. patriotic: having or expressing a great love of your country.
  Ex: He really was a patriotic man.




                    WEEK 13 – MEDICINE
    Discovery Provides Blueprint for New Drugs
        That Can Inhibit Hepatitis C Virus

                                                      Magazine: ScienceDaily
                                                          Date: Mar. 19th, 2012
  ScienceDaily (Mar. 19, 2012) — Chemists at the University of California, San
Diego have produced the first high resolution structure of a molecule that when
attached to the genetic material of the hepatitis C virus prevents it from
reproducing.



READING PORTFOLIO                                                          Page 56
Name: Bui Bich Phuong
Class: E2

  Hepatitis C is a chronic infectious disease that affects some 170 million people
worldwide and causes chronic liver disease and liver cancer. According to the
Centers for Disease Control and Prevention, hepatitis C now kills more
Americans each year than HIV.
  The structure of the molecule, which was published in a paper in this week's
early online edition of the journal Proceedings of the National Academy of
Sciences, provides a detailed blueprint for the design of drugs that can inhibit the
replication of the hepatitis C virus, which proliferates by hijacking the cellular
machinery in humans to manufacture duplicate viral particles..
  Finding a way to stop that process
could effectively treat viral infections
of hepatitis C, for which no vaccine is
currently available. But until now
scientists        have    identified   few
inhibiting compounds that directly act
on the virus's ribonucleic acid (RNA)
                                                The molecule prompts the Hepatitis
genome       --    the    organism's   full
                                              C’s viral RNA to open up a portion of its
complement of genetic material.
                                              hinge-like structure and encapsulate the
  "This lack of detailed information
                                              inhibitor like a perfectly fit glove. (Credit:
on how inhibitors lock onto the viral
                                              Image courtesy of University of California
genome target has hampered the
                                              - San Diego)
development of better drugs," said
Thomas       Hermann,      an    associate
professor         of     chemistry     and
biochemistry at UC San Diego who
headed the research team, which
also included scientists from San
Diego State University.


READING PORTFOLIO                                                                   Page 57
Name: Bui Bich Phuong
Class: E2

     The team detailed the structure of a molecule that induces the viral RNA to
open up a portion of its hinge-like structure and encapsulate the inhibitor like a
perfectly fit glove, blocking the ability of the hepatitis C virus to replicate.
  The molecule is from a class of compounds called benzimidazoles, known to
stop the production of viral proteins in infected human cells. Its three-dimensional
atomic structure was determined by X-ray crystallography, a method of mapping
the arrangement of atoms within a crystal, in which a beam of X-rays strikes a
crystal and causes the beam of light to spread. The angles and intensities of the
light beams allowed the scientists to calculate the structure of the viral RNA-
inhibitor complex.
  "This structure will guide approaches to rationally design better drug
candidates and improve the known benzimidazole inhibitors," said Hermann.
"Also, the crystal structure demonstrates that the binding pocket for the inhibitors
in the hepatitis C virus RNA resembles drug-binding pockets in proteins. This is
important to help overcome the notion that RNA targets are so unlike traditional
protein targets that drug discovery approaches with small molecule inhibitors are
difficult to achieve for RNA."
  The study was supported by the National Institutes of Health and National
Science Foundation.
                                            *****


  I. The reflection on the article:
  After reading tittle of this article, reader can see the main idea: Discovery Provides
Blueprint for New Drugs That Can Inhibit Hepatitis C Virus
  It’s quite difficult to understand the content of this article because it talks about
a new field relating to science so using to many scientic terms as well as range of
new words is quite hard to know axactly what the meaning is. However, it’s clear
that the article provides reader with new knowledge which is attractive at people

READING PORTFOLIO                                                                  Page 58
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Portfolio - Reading Articles

  • 1. Name: Bui Bich Phuong Class: E2 VIETNAM NATIONAL UNIVERSITY, HANOI University of languages and international studies Faculty of English Languages and Teacher Education Fast Tract Division READING PORTFOLIO Student: Bui Bich Phuong Class: 11E2 Hanoi, 2012 Table of contents We Topic Tittle Source ek READING PORTFOLIO Page 1
  • 2. Name: Bui Bich Phuong Class: E2 2 Literature Mart Twain webside 3 Nutrition Diet and nutrion for women webside 4 Physiology Do Teens Need Less Shut- TIME Eye than We Think? magazine 5 Fashion Paris Fashion Week: Roland FASTION Mouret autumn/winter 2012 magazine 6 Psychology Three Things That Maintain Psychologytoda Anxiety y magazine 7 Science FORENSIC GSR: How Do You Know magazine You're Right? 9 Business Recipe for a Successful TIME Business: Magazine Growing success 10 Neuroscienc Scientists Uncover Clue to SCIENCEDAIL e Preventing, and Possibly Y Reversing, Rare Childhood magazine Genetic Disease 11 Oceanogragh Widespread Adaptability SCIENCEDAIL y Coral Reefs May Be Able to Y Magazine: Adapt to Climate Change With Help from Algae 12 Engineering Brian’s bridges BOOK “Don’t throw this away! The civil engineering life” 13 Dedicine Discovery Provide Blueprint SCIENCEDAIL for New Drugs That Can Inhibit Y Hepatitis C Virut magazine 14 Marketing Marketing in china FINANCE Magazine WEEK 2- LITERATURE READING PORTFOLIO Page 2
  • 3. Name: Bui Bich Phuong Class: E2 Mark Twain Source: www.the famouspeople.com/profiles/mark-twain. Famous as Author and Humorist Born on 30 November 1835 in Florida, Missouri Died on 21 April 1910 Nationality United States Samuel Langhorne Clemens, better known by his pen name Mark Twain, was an American author, essayist, lecturer and humorist who wrote a series of famous books including Adventures of Huckleberry Finn and The Adventures of Tom Sawyer. Mark's first important work, The Celebrated Jumping Frog of Calaveras County was first published in the New York Saturday Press and became a bestseller within a short span of time. He also wrote a series of travelogues including the bestselling The Innocents Abroad- that came in 1869- and notable short stories such as Advice for Little Girls and The Celebrated Jumping Frogs of Calaveras County which earned him the worldwide fame and appreciation as a writer. Most of all, the author is known for his notable and insightful satires that gained him reverence from both critics as well as his contemporaries who call him the 'father of the English literature'. Childhood & Early Life Samuel Langhorne Clemens was born on November 30, 1835 in Florida, Missouri in the United States. He was the sixth of seven children of his father, a country merchant John Marshall Clemens and mother Jane Lampton Clemens and only three of his siblings could survive into their adulthood. At age four, Mark along with his family, moved to a port town Hannibal, situated on the bank of world’s second largest river Mississippi. Mark’s father John Clemens died of pneumonia in 1847, and the family was left in financial upheaval. An eleven year old Mark took a job of typesetter in 1851, to aid the family during its hard pressed finance and began contributing articles and humorous sketches for the Hannibal Journal a newspaper run by his READING PORTFOLIO Page 3
  • 4. Name: Bui Bich Phuong Class: E2 brother Orion. At age 18, Mark twain left this job and became a printer in New York City. As a child, Mark Twain received no formal schooling, but a keen learner, he widened his circle of knowledge by finding information in public libraries. It was his traveling to New Orleans in 1857, that he grew immensely fascinated with the steamboats and became an apprentice cub river pilot, earning his license in 1858. While working as a successful river pilot, he developed a huge attachment for the river, which would become a subject of his books in later life. He lost his brother Henry in 1858, who was also working with him on the boat. Travels and Early Career With the outbreak of Civil War in 1861, route on the Mississippi was blocked and he had to move to the silver mining town of the Carson City with his brother Orion. They traveled to the Rocky Mountains and many places including the Mormon community in Salt Lake City and ending at the silver mining town of Virginia City, Nevada. Here Mark experimented with the work of mining but failed miserably and finally got a job at a Virginia City newspaper, the Territorial Enterprise. In year 1863, Mark wrote the first humorous account of his travel. Mark next journeyed to San Francisco, where he began to work as a journalist and lecturer. In 1867, he traveled to Europe and the Middle East and wrote a collection of travel letters in 1869, which became known as The Innocents Abroad. He wrote some notable short stories during this period including Advice for Little Girls and The Celebrated Jumping Frogs of Calaveras County. Mark Twain as a Writer Twain as a writer initiated with humorous and light verse but embarked on more serious and harsh subjects in his later career. His one of the important works in this category was Huckleberry Finn, which combined humor and social criticism. Aside from this, he wrote several travelogues and lectures. A Tramp Abroad(1880), his first travelogue and a satirical account of his travels to READING PORTFOLIO Page 4
  • 5. Name: Bui Bich Phuong Class: E2 Germany, Italy and the Alps, was a sequel to his early work Innocent abroad and was next followed by The Prince and the Pauper in 1882. Mark wrote his first important work, The Celebrated Jumping Frog of Calaveras County In year 1865, which was first published in the New York Saturday Press and became a bestseller within a short span of time. Yet many of his work were suppressed, censored or banned in America for various reasons. In 1888, Mark Twain was awarded the Master of Art degree from Yale University. Later Life Towards the end of his life, Mark Twain traveled and lectured actively. During this period he lost money in many bad investment schemes like mining and printing machines thus acquiring a huge debt. In 1895, he set off on a world tour to Australia, Canada, India and New Zealand and only returned when he was able to pay off the debt. Though he suffered from many losses in his personal life, he never lost his sense of humor and talent as a writer. Meanwhile, he had written the famous series Tom Sawyer Abroad in 1894 followed by Tom Sawyer, Detective in 1896. Mark suffered from yet another emotional set back when his daughter Susy died of meningitis in 1896. Olivia’s death in 1904 and Jean’s death in 1909 further deepened his pain and left him in the depth of despair. In 1901, Yale University awarded him an honorary Doctor of Letters degree for his literary efforts and he received the same award from Oxford University in 1907. The same year, he published two books- A Horse’s Tale and Christian Science. Now a celebrated novelist and much more admired author, he enjoyed a huge section of followers and wrote around thirty books, essays and short stories. He was also a guest of the then American president Theodore Roosevelt at the White House. After the death of his wife and daughter Susy, Mark moved to his home in Redding, Connecticut in 1908. Death Mark Twain died of a heart attack on 21 April 1910 in Redding in Connecticut READING PORTFOLIO Page 5
  • 6. Name: Bui Bich Phuong Class: E2 and now rests at the Woodlawn Cemetery in Elmira, New York, where his wife and other children were buried. He was survived by his daughter Clara. ***** I. The reflection on the article This article is very excellent, I think, because the writer shows quite enough interesting and exact information about one of the famous authour on literature - Mark Twain: his life from the childhood to adutlhood until death, his career, his family and his achievements. The article’s instruction is very clear with 5 main ideas: Childhood & Early Life, Travels and Early Career,Mark Twain as a Writer , Later Life , Death. The reporter gives quite many examples to make clear the achievements of Mark Twain. He makes reader feel so interested and attracted in the article. Moreover, he presents information very clear that helps readers can understand and reach the main content of each paragraph as well as the whole article. He uses a large range of vocabulary and sentence structure. I can learn so much from his idiosyncrasy, for instane how to present information about a famous person and how to make impression on reader. II. Vocabulary and structure: 1. pen name (n): a name used by a writer instead of their real name. ex. he’s better known by his pen-name Mark Twain 2. bestseller(n): a product, usually a book, which is bought by large number of people. ex. it has been on the New York Times best-seller list for thirty-seven weeks. 3. notable (adj): deserving to be noticed or to receive attention; important ex. with a few noable exceptions, everyone gave something. 4. be known for sth (n): be famous for sth insightful (adj): showing a clear understanding of a person or situation. ex. one particular author seems to be more insightful than the rest. READING PORTFOLIO Page 6
  • 7. Name: Bui Bich Phuong Class: E2 5. satire(n): a way of criticizing a person, an idea or an institution in which you use humour to show their faults or weaknessesl a piece of writing that uses this type of criticism. ex. the novel is stinging satire on American politic. 6. comtemporary (adj): belong to the same time ex. we have no comtemporary account of the battle. 7. merchant (n): a person who beys or sells goods in large quantities, especially one who imports and exports goods/ a person who likes a particular activity. ex. - he is a speed merchant - Venice was once a city of rich merchants. 8. port town (n): a town with a harbour, especially one where ships load and unload goods. ex. He lived in a port town. 9. pneumonia (n): a serious illness affecting one or both lungs that makes breathing difficult. ex. He died of pneumonia. 10. be left in financial upheaval ( mất khả năng tài chính): a big change in finance that causes a lot of confusion, worry and problem. ex. after his father had died, his family was left in finacial upheaval. 11. immensely (= extremly, very much) fascinated (= very interested) ex. I’ve always been immensely fascinated by his ideas. 12. apprentice (n): a young person who works for an employer for a fixed period of time in order to learn the particular skills needed in their job. (v): to make sth an apprentice. ex. has was apprenticed to his uncle as a carpenter. 13. travelogue (n): a movie/ film, broadcast or piece if writing about travel. ex. he has just published a travelogue READING PORTFOLIO Page 7
  • 8. Name: Bui Bich Phuong Class: E2 14. censor (v): to remove the parts of a book, film/ movie. etc. that are considered to be offensive, immoral or a political threat. ex. the news reports had been heavily censored. 15. sequel (n): a book. film/ movie, play, etc. that continues the story of an earlier one. ex. A sequel to the hit movie “ Madagascar” will be published next time. 16. to died of sth = died because of (a reason) 17. meningitis (n): a serious disease in which the tissues surrounding the brain become infected and swollen, causing severe headache, fever ad sometimes death. ex. his is suffering from viral meningitis. 18. despair (n): the feeling of having lost all hope. idom: be the depair of sb: yo make sb worried or unhappy, because they can not help. ex. my handwriting was the despair of my teachers 19. embarked on/ upon sth: to start to do sth new or difficult ex. she is about to embark on a diplomatic career. WEEK 3 - NUTRITION Diet and nutrion for women Source: http://www.helpguide.org/life/healthy_eating_women_nutrition.htm Tip 1: Eat to control cravings and boost energy READING PORTFOLIO Page 8
  • 9. Name: Bui Bich Phuong Class: E2 Your diet has a major effect on your food cravings, your stress levels, and your energy throughout the day. By making smart food choices and developing healthy eating habits, you’ll find it much easier to stay slim, control cravings, and feel energetic all day long. • Eat breakfast. Get your metabolism going in the morning by eating a healthy breakfast. Studies show that people who eat breakfast tend to weigh less than those who skip it. A solid breakfast provides energy for the day. • Eat regularly. Going too long between meals can make you feel irritable and tired, so aim to eat something at least every 3-4 hours. Support your body’s natural cycle of energy by eating a substantial breakfast, a nutritious lunch, a snack around 2 pm (to compensate for the body’s natural low point that occurs around 3 each afternoon), and a light early dinner. • Cut the junk. The ups and downs that come with eating sugary snacks and simple carbohydrates cause extreme swings in energy level and mood. Cutting out these foods can be tough, but if you can resist for several days, your cravings will subside. • Focus on complex carbohydrates. READING PORTFOLIO Page 9
  • 10. Name: Bui Bich Phuong Class: E2 such as baked potatoes, whole-wheat pasta, brown rice, oatmeal, whole grain breads, and bananas boost your “feel-good” serotonin levels without a crash. They also provide plenty of fiber, so you feel full much longer. Tip 2: Get plenty of good carbs You may think that they key to losing weight or avoiding weight gain is cutting out carbohydrates. But carbs, like fats, are a vital part of a healthy diet. They give you the fuel you need to get through your day, fight fatigue, and stay feeling full. The key is to choose Complex carbohydrates—the “good carbs”—have not been stripped of their fiber and nutrients. Because they’re rich in fiber, they keep you full longer and help with weight control. Good sources of complex carbs include whole grains such as whole grain brown rice, stone ground whole wheat, millet, or quinoa, as well as beans, other legumes, fruit, and vegetables. Simple carbohydrates—the “bad carbs”—have been stripped of their fiber and many of their nutrients. Simple carbs lead to a dramatic spike in your blood sugar, followed by a rapid crash. These carbs are much less efficient at filling you up and keeping you energized. Simple carbs include white flour, white rice, and sugary foods. Complex carbohydrates: • Leave you full and satisfied • Are packed with nutrients • Provide long-lasting energy Simple carbohydrates: • Leave you hungry for more • Are mostly empty calories • Provide only short-lived energy READING PORTFOLIO Page 10
  • 11. Name: Bui Bich Phuong Class: E2 Tip 3: Don’t cut out the fat! Many women have been led to believe that dietary fat is unhealthy and will contribute to weight gain. But fats are a necessary part of a healthy diet. What really matters are the types of fat you eat. Women need healthy fats in their diet to look and feel great • Healthy fats boost your brain power and mood. Fats are essential to healthy brain function. They put you in a good mood and keep you mentally sharp. • Healthy fats promote healthy pregnancies. When you’re pregnant, both you and your growing baby need healthy fat to feel your best. Fat is especially important to your baby’s developing brain and nervous system. • Healthy fats contribute to lifelong beauty. Fats are essential for vibrant, glowing skin, hair, and nails. A lack of healthy fats in your diet can lead to dull, flaky skin, brittle nails, and dry or easily-damaged hair. • Healthy fats help control cravings. Because fat is so dense in calories, a little goes a long way in making you feel full. Small amounts of good fats like nuts or seeds make great satisfying snacks. • Fats lower the glycemic index of foods, easing the spike in blood sugar that results from eating carbohydrates. • You need fat in order to absorb certain vitamins. Many important vitamins—including vitamins A, D, E, and K—are fat-soluble, meaning you need fat in your system in order to absorb them. ***** I. The reflection on the article This article provides us with useful advices about diet and nutrition for women which help them keep the fit and have a perfect body. This article talk about the tips of diet anf nutrition for women. READING PORTFOLIO Page 11
  • 12. Name: Bui Bich Phuong Class: E2 - Tip 1: eat to control cravings and boost energy. - Tip 2: eat plenty of good crads - Tip 3: don’t cut to fat To make each tip clearer, he gives some supporting ideas and examples. After reading this article, I get more knowledge and know how to keep fit in right way and what a food nutrion is . I realise that I have had incorrect opinion about diet nutrion. I think, like me, many people, especially women feel interested in it because of its value. Bases on the article, you can see that the writer has a clear range of knowledge about nutrition II. Vocabulary 1. metabolism (n) : a chemical processes in living things that change food, etc. into energy and meterials growth ( sự trao đổi chất) ex: The body’s metabolism is slowed down by extreme cold. 2. serotonin (n): a chemical in the brain that affects how messages are sent from the brain to the body, and also affects how a person feel. ( C12H22N20). 3. fiber (n): the part of food that help to keep a person heathy by keeping the bowels working and moving other food quickly through the body ex: Dried fruits are especially high in fiber. 4. quinoa : a South American plant, grown for its seeds, uses as food and to make alcoholic drinks, the seeds of the quinoa plant. ex. Quinoa is a plant that are growth a lots in Andes area. 5. craving (n):a strong desire for sth ex: He has a craving to see the world. ***** READING PORTFOLIO Page 12
  • 13. Name: Bui Bich Phuong Class: E2 WEEK 4 - PHYSIOLOGY Do Teens Need Less Shut-Eye than We Think? - By Alexandra Sifferlin - Source: TIME magazine, Date: Feb 21th 2012 Between extracurricular activities, homework and late-night Facebooking, many teens aren’t catching the nightly sleep’s hours they need. Or are they? Although national guidelines recommend that teens get at least 8.5 hours of sleep a night — a bar that few teens actually meet — a new study suggests that they may not require as much shut-eye as we thought, at least not if performance on standardized tests is any measure. In their report published in the current issue of the Eastern Economics Journal, researchers from Brigham Young University analyzed a nationally representative sample of 1,724 students and compared the amount of sleep they reported getting to their standardized test scores. Sixteen-year-olds scored best on only 7 hours of sleep a night, it turns out. For 12- year-olds, the optimal amount of sleep was slightly over 8 hours, and for 10-year-olds it was about 9 hours. “If your kid’s not getting nine hours of sleep, maybe you don’t have to worry so much,” study author and Brigham Young University economist Mark Showalter told MSNBC, especially if he’s not actually sleep deprived. MORE: 10 Risky Behaviors More Common in Sleepy Teens READING PORTFOLIO Page 13
  • 14. Name: Bui Bich Phuong Class: E2 So where does the nine-hours standard come from? The researchers believe the current sleep recommendations date back to a 1970s Stanford University study of teens and their sleep patterns. In that study, teens were brought to a lab a few days a year for three years and told to sleep as long as they wanted. But, of course, how much teens want to sleep and how much they need to sleep are two different things. “We couldn’t find much scientific empirical backing for the common recommendations,” Showalter told MSNBC. His findings fall in line with a separate study published in Pediatrics last week that looked more than 100 years of reported sleep duration in kids. That study concluded that no matter how much sleep kids have historically gotten, it was always assumed that they weren’t getting enough. The study also found that sleep recommendations have always been pretty subjective. Healthland’s Bonnie Rochman reported: In reality, there is almost no evidence about how much sleep kids truly need to function their best. “We think for no particularly good reason that kids need more sleep than they’re getting,” says [senior author Tim Olds, a professor of health sciences at the University of South Australia in Adelaide]. “Every so often a group of blokes get together and say, What do you recommend, boys? Should we push it up to 9 hours, 15 minutes? It really is like that, honestly. It’s an arbitrary public- health line in the sand that people draw.” MORE: A History of Kids and Sleep: Why They Never Get Enough That being said, it’s entirely likely that teens aren’t getting enough sleep — it’s just that there isn’t good scientific evidence of that. But while chronic lack of sleep has been tied to many ill health effects, including increased risks of depression and weight gain, it looks like getting less than a full 9 hours shouldn’t hinder test scores. No more excuses, teens. I. The reflection on the article READING PORTFOLIO Page 14
  • 15. Name: Bui Bich Phuong Class: E2 Nowadays, most of teens don’t spend enough time on sleeping, although they know it’s useful for their health . This article gives us much useful information about sleep. For instance, Chronic lack of sleep has been tied to many ill health effects. It helps us know more about importance of getting enough sleep that is very neccesary for teens. After reading this article, I see that it’s necessary for myself to spend at least a half of hour sleeping in the noon as well as sleeping gets enough 8 hours per day to good for my health. The reporter persuades reader with many examples, evidences ( particular figures, quotations), especially, quotation the ideas opinion of both researchers, scientists and teens. However, I think the main ideas of this article are not very clear which make reader feel confused to realize main content of each part. II. Vocabulary and sentence structure 1. extracurricular (adj): not part of the usual course of work or studies at a school or college. Ex. Schools and colleges often hold extracutticular activities to help students enlarge their knowledge. 2. shut-eye (n): sleep ( imformal) Ex: According to reporter, teens may not require as much shut-eye as we thought. 3. standardized (v): to make objects or activities of the same type have the same features or qualities, to make sth standard. Ex: Teacher should give students standardized lesson to make them better. 4. optimal = optimum (adj): the best possible, producing the best possible result. Ex: we aim for optimal efficiency in all our operations. 5. bloke = man (n) Ex: He seems like a nice bloke. READING PORTFOLIO Page 15
  • 16. Name: Bui Bich Phuong Class: E2 6. chronic (Adj): having had a disease for a long time 7. duration (n): the length of time that sth lasts or continues Ex: His house was used as a hospital for the duration of the war. 8. arbitrary (adj): (of an action, decision, etc): not seeming to be based on reason, system or plan and sometimes seeming unfair. Ex: The choice of players for the team seemed to be completely arbitrary. WEEK 5 - FASHION READING PORTFOLIO Page 16
  • 17. Name: Bui Bich Phuong Class: E2 Paris Fashion Week: Roland Mouret autumn/winter 2012 - Lisa Armstrong - Source: FASHION magazine Date: March 2nd 2012 Mouret debuted his first line of shoes at his Paris Fashion Week show today. In order to qualify as a global fashion brand, a label must sell more than clothes. Accessories are a given. After more than ten years in the business, Roland Mouret, the British based designer who brought us the Galaxy and Moon dresses, as worn by every celebrity from Rachel Weisz and Keira Knightley to Cameron Diaz, revealed his own world of shoes in Paris today. "I know how to drape fabric but I had to learn a whole new subject in the form of engineering," said Mouret backstage. "One of the hardest things is finding good factories. The best are in Italy and France, but often working at full capacity for big names". Mouret's shoes are being manufactured by Robert Clergerie, a middling sized French shoe label that enjoyed considerable success in the 1980s doing masculine-styled shoes for women, but which waned recently, as shoes became higher and sexier. Earlier this year Clergerie announced its new designer: Roland Mouret. His first collection for the brand, with a strong 1940s feel, but with contemporary proportions (i.e. lots of height) will arrive in stores in late summer. The partnership also enables him finally to have a separate shoe collection, under his READING PORTFOLIO Page 17
  • 18. Name: Bui Bich Phuong Class: E2 own name - also high, also with (concealed) platforms, and with a heel shape and last that spell out the initial R when viewed from the side. But can an ingenue bring anything new to footwear? "Comfort," he retorts, "It's to do with balance, the angle of the last - not just the heel. I've spent a lot of time listening to what women want," he says, "and they're not giving up on heels any time soon. But they're tired of suffering". The other step towards brandifation is to hire a lavish venue - and transform it. Mouret did that too as he clad the ornately gilded walls of the Hotel Intercontinental's ballroom with rough wooden planks. "It's supposed to evoke what you do to a precious building when you want to protect it in a war,' he explained. If it looked more like a Club Med ski chalet , that suited the first few outfits perfectly, since they featured faint tracings of reindeer or fawn prints and came in an icy blue shade which could have been Wallis Simpson blue, but which Mouret said was Dior blue (don't say he's auditioning for that job too). Mouret's silhouette has loosened considerably since the suction-packed hourglass of the Galaxy and Moon, but it's still tailored and intensely feminine, with loving attention paid to a woman's rear. "You have to be really confident about your tush to wear that", observed one front rower as a Dior blue dress, with a zip right up the back, sashayed past. Either that or invest in Spanx. ***** I. The reflection on the article Roland Mouret, the British based designer who brought us the Galaxy and Moon dresses, debuted his first line of shoes at his Paris Fashion Week show. The article talk about Mouret’s shoes, its history and features. This article gives reader more information about designer Mouret and his shoes label in New York fashion week. After reading this artcle, I get more interesting information about READING PORTFOLIO Page 18
  • 19. Name: Bui Bich Phuong Class: E2 fashion in the world which I have seemed to care of before. I think, readers, especially women will feel so interested in this article because it mentions about fashion which is a popular and interesting topic. However, I don’t like it so miuch because the writer’s expression is not very good, it’s not have clear ideas. There fore, it’s hard for me to find the main ideas of each paragraph. II. Vocabulary and structure: 1. manufactured (v) : to make goods in large quatities, using machinery ex: this company manufactures the equipments use to make contact lenses. 2. brand (n): a type of product made by a particular company. Ex. Which brand of toothpaste do you use? 3. drape (v) to cover or decorate sth/sb with metarial/ 4. fabric (n): a material made by weaving wool, cotton. Silk,etc, used for making curtain, clothes, etc. and for covering furniture. Ex. Some silk fabric will drape beautifully. 5. masculine (adj): having qualities or appearance considered to be typical of men, connected with or like men ex. He was handsome, strong and very masculine. 6. contemporary (Adj): belonging to the same time. Ex. He was contemporary with the dramatist Congreve 7. proportion (n): the relationship of one thing to another in size, amount, etc. ex. 8. platform (n): the flat surface raised above the level of ground or floor, used by public speakers or performers so that the audiences can see them. Ex. Coming onto the platform now is tonight’s conductor, Bich Phuong 9. initial (adj): happen at the beginning, first. Ex. In the initial stage (= at the beginning) of the campaign READING PORTFOLIO Page 19
  • 20. Name: Bui Bich Phuong Class: E2 10. retort (v): to reply quickly to a comment, in an angry, offended or humorous way. Ex. Sam retorted that it’s my fault as much as his. 11. ingenue (v): an innocent young woman, especially in a film or play. Ex. Can an ingenue bring anything new to footwear? 12. gilded (adj): cover with a thin layer or gold or gold paint ex. He bought a gilded picture frame. 13. lavish (adj): large in amount, impressive, usually costing a lot of money. Ex. They live in a lavish lifestyle. 14. venue (n): a place where people meet for an organized event, for example, a concert, sporting event or conference. Ex. The band will be playing in 20 different venues in UK 15. fawn (adj) : light yellowish-brown in color. Ex. Chicken’s feather is fawn. 16. silhouette (n): a shape of a person’s body or of an object ex. The dress is fitted to give you a fattering silhouette. 17. intense (adj): having or showing very strong feeling. Ex. She is intense about everything. 18. arrive in stores: phân phối đến các cửa hàng ex. Pizza is arrives in stores in my town from factory. 19. evoke (adj): bring a feeling, a memory or an image into your mind. Ex. This song evoked the memories of her youngth. 20. sashay: to walk in a very confident but relaxed way , especially in order to be noticed. Ex. I watched her as she sashayed across the room. READING PORTFOLIO Page 20
  • 21. Name: Bui Bich Phuong Class: E2 WEEK 6 – PSYCHOLOGY Simple strategies for handling anxiety and stress Source: Psychologytoday Magazine Date: March 19, 2012 Three Things That Maintain Anxiety - Patrick B. McGrath, Ph.D.- How many times have you had the same conversation with someone over and over again, and then became frustrated again and again because they did not follow your advice? I hear about this happening all of the time actually. I hear about it from therapists that I train who tell me how frustrating it is to work with anxious patients. Now, I will agree that it can be frustrating to work with some anxious patients, but it does not have to be. In fact, some of the best therapy in the world was designed to treat anxiety disorders. So, treating stressed and anxious people is not all that difficult if you know what you are doing. So, I am going to let you all in on a little secret - I am going to tell you what to do to overcome your stress and anxiety. It is just a few simple steps and you will be able to make great strides in helping yourself to overcome your fears. And, if you need any extra help from a therapist, that is fine too, as I will also tell you where to find good help. Instead of talking about what is stressful or what is leading you to feel anxious, you would be better off stopping these three behaviors: 1. Avoidance: If you avoid what it is you fear, you will teach yourself that the only way to be safe is to avoid what you fear. This is a recipe for disaster, because you will just avoid more and more things over time instead of learning how to handle what it is that bothers you. READING PORTFOLIO Page 21
  • 22. Name: Bui Bich Phuong Class: E2 2. Reassurance Seeking: If all you do is ask everyone you know if everything will be OK, you will never learn how to handle things on your own. This is also a tricky scheme, because if someone tells you that everything will be OK, and then it turns out not to be, you can blame them for it not turning out well because they lied to you and told you that everything will be OK. 3. Distraction: If you do have to face whatever it is you fear and you distract yourself from it, then you never actually learn how to handle it and you maintain your fear and convince yourself that the only reason you are safe is because of the distraction that you did. These three things are actually called safety seeking behaviors, and they are all performed in order to feel good right now instead of feeling good later on. That may sound like a good thing, but it really is a very poor way of coping because people soon become so reliant on these coping strategies that they live only to feel good in the moment and do not do what they need to do to be well in the long run. In future posts we will break the safety seeking behaviors down more in depth and talk about how to overcome them. If you are in need of help with stress, or are seeing someone and do not feel that you are making progress, I suggest looking at the "Find A Therapist". *** I. The inflection on the article: This article discusses about the simple strategies for handling anxiety and stress. Writter didn’t directly tell about how to handle, on the other hand, he pointed three wrong behaviors of almost people, these are avoidance , reassurance seeking and distraction. With each behavior, he gives interesting supporting ideas. From those points, he advices readers should avoid those things. According to me, this article is a good one. I enjoy the way that reporter shows his ideas which is quite clearly and makes article be coherent. However, READING PORTFOLIO Page 22
  • 23. Name: Bui Bich Phuong Class: E2 the range of vocabulary is not very varied. I think it would be better if writer chose words more careful to make it more interesting. II. Vocabulary and structure 1. therapy = psychotherapy (n): the treatment of metal illness by discussing sb’s problem with them rather than by giving them some drugs. The treatment of a physical proplem or an illness. Ex. I went to therapy because my doctor suggested it. 2. Reassurance (n): the fact of giving advices or helps that takes away a person’s fears or doubts Ex. Teenagers need love, encouragement and reassurance from their parents. 3. recipe for sth: a method or an idea that seems likely to have a particular result. Ex. What is her recipe for success. His plan are a recipe for disaster. 4. seek (v): to look for sth/sb/ try to obtain or achieve sth. Ex. People who are unemployed and actively seeking work. 5. reliant (adj): needing sth/ sb in order to survice, be successful, etc. Ex. The survice has become heavily reliant on government supports READING PORTFOLIO Page 23
  • 24. Name: Bui Bich Phuong Class: E2 WEEK 7 – SCIENCE Issac Newton Source: http://www.universetoday.com/82052/issac-newton-inventions/ Sir Issac Newton is best know for his laws of motion. Many people’s knowledge of his scientific contributions stops there. Issac Newtons inventions contributed a great deal to our current understanding of subjects from optics to theology and how early scientists were able to view their world. In mathematics Issac Newton inventions included laying the ground work for differential and integral calculus. His work was based on his insight that the integration of a function is merely the inverse procedure to differentiating it. Taking differentiation as the basic operation, he produced simple analytical methods that unified many separate techniques previously developed to solve apparently unrelated problems such as finding areas, tangents, the lengths of curves and the maxima and minima of Sir Issac Newton functions. Issac Newton inventions in mechanics and gravitation were summarized the Principia. His discoveries in terrestrial and celestial mechanics showed how universal gravitation provided an explanation of falling bodies on Earth and of the motions of planets, comets, and other bodies in the heavens. He explained a wide range of then unrelated phenomena: the eccentric orbits of comets, the READING PORTFOLIO Page 24
  • 25. Name: Bui Bich Phuong Class: E2 tides and their variations, the precession of the Earth’s axis, and motion of the Moon as perturbed by the gravity of the Sun. This work includes Newton’s three famous laws of motion, fluid motion, and an explanation of Kepler’s laws of planetary motion. Issac Newton inventions in optics included his observation that white light could be separated by a prism into a spectrum of different colors, each characterized by a unique refractivity. He proposed the corpuscular theory of light. He was the first person to understand the rainbow. He was the first person to use a curved mirror in a telescope to prevent light form being broken up into unwanted colors. Isaac Newton inventions and contributions to science were many and varied. They covered revolutionary ideas and practical inventions. His works in physics, mathematics and astronomy are still important today. His contributions in any one of these fields would have made him famous; taken as a whole, they make him truly outstanding. .*** I. The reflection on the article: Here’s an article about Issac Newton – one of the most famous scientists in the world, who had contributed variety of inventions to science fields such as mathematics, physics and astronomy. The article introduces achievements which Newton attemted and their significances to science and life. They help people totally sees the world, explains strange phenomenons which no one could do before. According to me, this is a good article because it provide reader with total knowledge about Newton’s inventions. That shows large knowledge, especially on science field. I like the way which writter presents his ideas, they are quite unity and make paragraphs coherent. What’s more, range of vocabulary and structures are varied so that make article be more interesting. READING PORTFOLIO Page 25
  • 26. Name: Bui Bich Phuong Class: E2 II. Vocabulary and sentence structure 1. theology (n): study of religion and beliefs 2. tangent (n): a straigh line that touches the outside of a curve but not cross it. Ex. The distance between the centre of a curve and its tangent is as far as its radius. 3. terrestrial (adj): connected with the planet Earth. Ex. Terrestrial life is very varied. 4. celestial (adj): of the sky or of heaven. Ex. The Sun, Moon and stars are celestial. 5. crepuscular (adj): related to the period of the evening when the sun had just gone down but there is still some light in the sky ex. I like crepuscular time 6. telescope (n): a piece of equipment shaped like a tube that you look through to make objects that are far away appear larger and nearer. Ex. We can look at the stars through the telescope. 7. the eccentric orbits of comets 8. tide (n): a regular of rise or fall in the level of the sea, caused by the full of the Sun and the Moon; the flow of water that happens as the sea rises and falls. Ex. Is the tides coming in or going out? 9. perturb (v): to make an obstacle with motion of an object. Ex. Moon as perturbed by the gravity of the Sun 10. spectrum (n): a range of sound waves or several other types of waves. Ex. Red and violet are at opposite ends of the spectrum READING PORTFOLIO Page 26
  • 27. Name: Bui Bich Phuong Class: E2 GSR: How Do You Know You're Right? - By Timothy J. Drake, Ph.D. - Magazine: Forensic Date: October 18, 2011 Using integrated SEM-EDX technology to provide automatic, rapid, and validated results. As the volume of cases grows and forensic crime labs’ budgets shrink, lab operations management, technicians, and litigators are all looking for answers related to gunshot residue (GSR) detection, identification, and characterization. Lab operations need high throughput solutions that require little oversight or expertise, yet maintain a high degree of reliability. Lab technicians need easy to use platforms that generate accurate results and reporting that provides information and knowledge, not reams of data. And, above all, litigators need validation of that reporting and those results to give them the confidence they need to go to court and to ensure that those results will stand up under cross examination at trial. Integrated scanning electronmicroscopes with energy X-ray dispersive Spectrometers (SEM-EDX) offer platforms that not only provide GSR results, but further validate those results through a series of checks and balances; offering the answer that all three audiences are looking for. SEM Technology and GSR SEM-EDX systems are commonly used for imaging comparison and X-ray microanalysis of trace evidence samples including tool marks, ink, paper, fibers, hair, and paint coatings. Back in the late 60s forensic laboratories in London READING PORTFOLIO Page 27
  • 28. Name: Bui Bich Phuong Class: E2 started to use Scanning ElectronMicroscopes (SEM) for the manual detection and analysis of Gun Shot Residue particles on a routine basis. Forty years later, SEMs are still used in laboratories worldwide for the detection of GSR particles. Technological advances, including the integration of Energy Dispersive Spectrometers for elemental analysis (EDX) and a software platform for automated detection, relocation, confirmation, and reporting, have made this the go-to technology for EDX analysis and imaging of samples collected from suspect shooters. Typically,GSR particles (Figure 1) are composed of lead (Pb), barium(Ba), and antimony (Sb), and commonly range in size from0.5 to 10microns.They have varying morphologies and surface textures, but the vast majority are generally spherical in shape. Ammunition can also be manufactured without lead. Lead- free ammunition is becoming more prevalent as manufacturers use lead-free or low-lead propellants to avoid the toxicity of lead .Aluminum(Al) and strontium(Sr) are often used in lead free cartridges. In addition, Sintox® GSR particles are characterized by spheroidal particles mainly consisting of titanium(Ti) and zinc (Zn). READING PORTFOLIO Page 28
  • 29. Name: Bui Bich Phuong Class: E2 I. The inflection on the article Based on the tittle, reader can see that this article points that Using integrated SEM-EDX technology is helpful for forensic science, provide automatic, rapid, and validated results. After reading it, I know more terms of science as well as enlarge the range of vocabulary and get more knowledge about them. However, the writer uses so many vocabularies and term of science so it is quite difficult to understand or event thought I look for new words in dictionary and know the definition of them as well, I seem to no see what the meaning of whole sentence is in the first time to read. So I had to spend more time reading and understanding. II. Vocabulary and sentence structures 1. litigate (v): to take a claim or disagreement to court. Litigator : a person who litigate Ex. Litigate in two different european countries. 2. Residue (n): is a small amount of something that is left behind. (noun) Ex. When you peel off a tag but there is some sticky stuff left, the sticky stuff is an example ofresidue. 3. Reliability (n): Variant of reliable that can be relied on; dependable; trustworthy Ex. The reliability of these results has been questioned. 4. Validation (n): Variant of validate 1. to make binding under the law; give legal force to; declare legally valid READING PORTFOLIO Page 29
  • 30. Name: Bui Bich Phuong Class: E2 2. to prove to be valid; confirm the validity of; verify Ex. They didn’t receive any validation of court. 5. reams of sth (n): a large quantities of sth Ex. He writes reams in the essay. 6. dispersive (adj): describes something that spreads or scatters. Ex. An example of dispersive equipment is a device used for spreading seeds in a garden. 7. Spectrometer (n): an instrument used for measuring spectral wavelengths Ex. Spectrometer for the detection and quantification of trace compounds in exhaled breath in real time 8. platforms:  a raised horizontal surface of wood, stone, or metal; specif., 1. a raised stage or flooring beside railroad tracks or the like 2. a raised flooring or stage for performers, speakers, etc.  a statement of principles and policies, esp. of a political party Ex. It aims to tackle the needs of the uk's science, engineering and technology industry and to create a unified platform and voice. 9. trial (n): a formal examination of evidence in court by judge and often a jury, to decide if sb accused of a crime guilty or not. Ex. He is on trial for murder. 10. morphology (n): Morphology refers to the study of how animals and plants are formed. Ex. In order to determine the surface morphology and orientation texture of the films, scanning electron microscopy, sem, was performed. 11. spherical (adj): shaped like spheres Ex. The eye is a roughly spherical organ built a bit like a football. READING PORTFOLIO Page 30
  • 31. Name: Bui Bich Phuong Class: E2 12. Ammunition (n): is something that you can use against another person to get him or her to do something for you or to do what you want. Ex. An example of ammunition is when you know your little brother snuck in late and you threaten to tell on him if he doesn't make you breakfast. 13. prevalent (adj): ~ among sb / ~ in sb/sth : that exists or is very common at a particular time or in a particular place. Ex. The concentration on bebop did seem disproportionately prevalent in all forms of education, however. 14. toxicity of lead (n): The quality or condition of being toxic/ The degree to which a substance is toxic. Ex. Minor toxicities of this drug include nausea and vomitting. 15. propellants (n): a thing or substance that probels sth, for example the fuel that fires a rocket. Ex. Until solid propellants were developed for such big rockets, this was a universal problem. 16. shrink (v): to become or to make sth smaller in size or amount Ex. The market for their products is shrinking READING PORTFOLIO Page 31
  • 32. Name: Bui Bich Phuong Class: E2 WEEK 9- BUSINESS Recipe for a Successful Business: Growing success Magazine: TIME Date:: December 3, 2007 For many entrepreneurs, starting a business is the culmination of many years of dreaming and planning. So it is understood that every small business owner wants their business to flourish and be productive - and that is the reason that they usually concentrate on growth. But what many small business owners forget is that the recipe for creating a successful business is a gradual process in which each stage needs to be crossed before reaching the next one. Think Differently As a small business owner, your main ambition is to grow your company. So, you want to usher in momentum - and to bring in this momentum into your business, you need to think differently. You might be chasing success, but what you may be forgetting is that it is the small successes in between that make way for larger ones. Having said that, it is better to redirect your energies towards smaller successes that will not only move your business ahead, but will motivate you at the same time. Believe and Concentrate READING PORTFOLIO Page 32
  • 33. Name: Bui Bich Phuong Class: E2 As an entrepreneur, the success of your business depends largely on you. That's why you need to learn to have a solid belief in the opportunity that you have taken to start your business and in your industry as well. Your small business is only going to work for you if you are ambitious enough to take charge of your destiny. You should not look at your business as just another activity. You should also take it more seriously than a hobby, or a project that you have taken on as a trial to see if it will work. Treat your business as your full-time job where failure isn't an option. Really concentrate on making it successful. Have a Viable Business Plan You can start your business on the path to success by creating a business plan. You should meticulously create a business plan that explains the objectives of your business, the tactics that you are going to use, the formulas that you want to apply, the targets that you want to achieve and the monetary figure that you desire to earn. All these points should be stated clearly and you should put in your best efforts to achieve them. Ingredients of a Business Plan Your business plan should have a professional summary that will define your target market. It should include the legal details of your business, which is your contact address and description of your business - whether it is a partnership, corporation or some other form. You should also mention in the plan how you are going to meet your targets and how you are going to beat the competition in the market. You should also include a thorough market analysis in your business plan. This shows that you have studied the market carefully before getting into the business. Here, you can mention the present trends in your industry and what the READING PORTFOLIO Page 33
  • 34. Name: Bui Bich Phuong Class: E2 demand is for your products and services. Then you can include the prices of your competitors and how your prices will compete with them. An important part of your business plan is the financial section, in which you note the personal funds you have, the capital that you need and how you plan to repay your debts, if you have any. The financial section should also include your balance sheet, financial worksheet, and annual income. Another important aspect of your business that needs to be mentioned in the business plan is your team - you as the owner, and any partners or associates that you have and their credentials. Growing a successful business takes time, hard work and dedication. If you believe in yourself and the business from the beginning, you will be successful in short order. ***** I. The inflection on the article The topic of article mentions the proplem that many people care of: how to be successful. In the article, reporter supports 4 main tips to be successful in business, including: Think Differently, Believe and Concentrate, Ingredients of a Business Plan, Have a Viable Business Plan. These are useful advices for people who want to be successful in business but don’t know how to do. According to him, to success, it’s essensial to have goal and a particular plan that how you get the target. When reading this article, I feel very interested in the recipes which reporter supported, especially the forth tip: ingrediences in you business plan which inclues a professional summary that will define your target market, a thorough market analysis in your business plan, the financial section, your team. I also like the way that he shows the ideas is quite clear. Sentence structures, range of vocabulary are quite good. Thanks to this article, I know more about recipes to be successful. It may be helpful and essencial for me in the future. READING PORTFOLIO Page 34
  • 35. Name: Bui Bich Phuong Class: E2 II. Vocabulary and sentence structures 1. entrepreneur (n): a person who makes money by starting or running businesses, especially when this involves taking financial risks! Ex. A creative entreprenur, he was continually dreaming up new projects 2. culmination (n): the highest point or end of sth, usually happening after a long time. Ex. A decision will be taken at the culmination of the research. 3. to usher in sth: to be the beginning of sht or to make sth new begin Ex. The change of management ushered in fresh ideas or policies. 4. momentum (n): the ability to keep increasing or developing ex. The campaign for change now has considerable momentum. 5. chase (v): to try to achieve sth like work or success. Ex. Too many people are chasing too few jobs nowadays. 6. destiny (n): what happen to sh or what ill happen in the future, can not change or avoid. Ex. You can not change your destiny. 7. meticulous (adj): paying carefully attention to every detail. ~ in sth/ ~ doing sth / ~ about sth Ex. She is meticulous about her appearance beforeg going out. 8. monetary (adj): connected with money , especially all the money in the country. Ex. The sculptures were of little monetary value. 9. credentials (n): (~ as/ for sb): the qualities, the training or experience that make you suitable to do sth / a document such as letters prove you that you are who claim to you and can therefore be trusted ex. He has all the credentials for the job. READING PORTFOLIO Page 35
  • 36. Name: Bui Bich Phuong Class: E2 10. flourish (adj): to develop quickly and be successful or common Ex. There was a flourishing black market. WEEK 10: NEUROSCIENCE Scientists Uncover Clue to Preventing, and Possibly Reversing, Rare Childhood Genetic Disease Magazine: SCIENCEDAILY Published: April 1st , 2012 Scientists think they have found a way to prevent and possibly reverse the most debilitating symptoms of a rare, progressive childhood degenerative disease that leaves children with slurred speech, unable to walk, and in a wheelchair before they reach adolescence. In the April 1 online edition of Nature Medicine, Karl Herrup, chair of the Department of Cell Biology and Neuroscience in the School of Arts and Sciences provides new information on why this genetic disease attacks the cerebellum -- a part of the brain that controls movement coordination, equilibrium, and muscle tone -- and other regions of the brain. Karl Herrup, chair of Cell Biology Using mouse and human brain and Neuroscience at Rutgers tissue studies, Herrup and his University. (Credit: Nick Romanenko) colleagues at Rutgers found that in the READING PORTFOLIO Page 36
  • 37. Name: Bui Bich Phuong Class: E2 brain tissue of young adults who died from axtaxia-telangiectasia, or A-T disease, a protein known as HDAC4 was in the wrong place. HDAC4 is known to regulate bone and muscle development, but it is also found in the nerve cells of the brain The protein that is defective in A-T, they discovered, plays a critical role in keeping HDAC4 from ending up in the nucleus of the nerve cell instead of in the cytoplasm where it belongs. In a properly working nerve cell, the HDAC4 in the cytoplasm helps to prevent nerve cell degeneration; however, in the brain tissue of young adults who had died from A-T disease, the protein was in the nucleus where it attacked the histones -- the small proteins that coat and protect the DNA. "What we have found is a double-edged sword," said Herrup. "While the HDAC4 protein protected a neuron's function when it was in the cytoplasm, it was lethal in the nucleus." To prove this point, Rutgers scientists analyzed mice, genetically engineered with the defective protein found in children with A-T, as well as wild mice. The animals were tested on a rotating rod to measure their motor coordination. While the normal mice were able to stay on the rod without any problems for five to six minutes, the mutant mice fell off within 15 to 20 seconds. After being treated with trichostation A (TSA), a chemical compound that inhibits the ability of HDAC4 to modify proteins, they found that the mutant mice were able to stay on the rotating rod without falling off -- almost as long as the normal mice. Although the behavioral symptoms and brain cell loss in the engineered mice are not as severe as in humans, all of the biochemical signs of cell stress were reversed and the motor skills improved dramatically in the mice treated with TSA. This outcome proves that brain cell function could be restored, Herrup said. READING PORTFOLIO Page 37
  • 38. Name: Bui Bich Phuong Class: E2 "The caveat here is that we have fixed a mouse brain with less devastation and fewer problems than seen in a child with A-T disease," said Herrup. "But what this mouse data says is that we can take existing cells that are on their way to death and restore their function." Neurological degeneration is not the only life-threatening effect associated with this genetic disease. A-T disease -- which occurs in an estimated 1 in 40,000 births -- causes the immune system to break down and leaves children extremely susceptible to cancers such as leukemia or lymphoma. There is no known cure and most die in their teens or early 20s. According to the AT Children's Project, many of those who die at a young age might not have been properly diagnosed, which may, in fact, make the disease even more common. Herrup says although this discovery does not address all of the related medical conditions associated with the disease, saving existing brain cells even those that are close to death -- and restoring life-altering neurological functions would make a tremendous improvement in the lives of these children. "We can never replace cells that are lost," said Herrup. "But what these mouse studies indicate is that we can take the cells that remain in the brains of these children and make them work better. This could improve the quality of life for these kids by unimaginable amounts." Additionally, Herrup says, the research might provide insight into other neurodegenerative diseases. "If this is found to be true, then the work we've done on this rare disease of childhood may have a much wider application in helping to treat other diseases of the nervous system, even those that affect the elderly, like Alzheimer's," he said. ***** I. The inflection on the article READING PORTFOLIO Page 38
  • 39. Name: Bui Bich Phuong Class: E2 This article talks about NEUROSCIENCE that is a new item in Science. It’s clear with 3 main ideas in the title: Scientists Uncover Clue to Preventing, Possibly Reversing, and Rare Childhood Genetic Disease. In this article, reporter uses many technical terms in neuroscience so that it’s quite difficult to understand clearly the content of the article. He shows a large knowledge, widen range of vocabulary. To explain and make clearly topic, the writer gives supportings as well as particular examples and quotes the idea of some scientists. I think this is a good article. Based on it, people can get more information and knowledge about the new topic of science field. After reading this article, I enlarge my knowledge about Neuroscience that I never care of before. Beside, I’ve learnt a lot of good new words in the field of neuroscience. II. Vocabulary and sentence structure: 1. debilitating (adj): making sb’s body or mind weaker. Ex. She found the heat debilitating. 2. symptom (n) : a sigh that sth exists, especially sth bad ex. If symptom persists, consult your doctor. 3. rare (Adj) : existing in small numbers, therefore valuable or interesting ex. This pieces is extremely rare. 4. degenerative (adj): (of an illness) : getting or likely to get worse as time passes ex. The degenerative diseases such as arthritis 5. slurry (n): a thick liquid consisting of water mixed with animal waste, coal dust or clay. Ex. 6. adolescence (n): the time in na person’s life when she or he develops from a child into an adult. READING PORTFOLIO Page 39
  • 40. Name: Bui Bich Phuong Class: E2 Ex. Adolesence brights about major changes in a young person’s body. 7. equilibrium (n): a state of balance, especially between opposing forces or influences. Ex. He can’t maintain enough equilibrium to rade a bike 8. plays a critical role in doing 9. nucleus (n): a central part of some cells. 10. nerve (n): any of a long thread that can be carry messages between brain and parts of the body (dây thần kinh) - nerve cell: Tế bào thần kinh ex. At the last minute she almost lost her nerve 11. cytoplasm (n): all the living material in a cell, not including nucleus. Ex. Tế bào chất 12. histone : 1 loại protein có trong chất tế bào 13. double-edged sword 14. lethal (adj): causing or able to cause o lot of harm or damage. Ex. He has been sentenced to death by lethal injection. 15. rotating rod 16. caveat (n): a waring that particular things need to be considered before sth can be done. Ex. Any dicussion of legal action must be preceded by a caveat on costs. 17. devastation (n): great instruction or damage, especially over a wide area. Ex. The bomb caused widespread devastation. 18. immune (adj): ~ to sth: that can not catch or be affected by a particular disease or illness. Ex. Adults are often immune to German measles 19. susceptible (adj): ~ to sb/sth : very likely to be influenced, harmed or affected by sth/sb ex. Some of these plants are more susceptible to frost damage than others READING PORTFOLIO Page 40
  • 41. Name: Bui Bich Phuong Class: E2 20. leukaemia (n): a serious disease in which too many white blood cells are produced, causing weakness, and sometimes death. - Bệnh bạch hầu Ex. Leukaemia is one of the most serious diseases. 21. lymphoma (n): cancer of the lymph nodes - ung thư hệ bạch huyết ex. She diesd because of lymphoma 22. tremendous (Adj): very great/ extremely good ex. It was a tremendous experience. 23. neuroscience (n): a science that deal with the structure and function of the brain and nervous system. - Khoa hoc nghiên cứu về hệ thần kinh. 24. neurodegenerative (Adj): ảnh hưởng xấu đến hệ thành kinh. Ex. I think that accident will be neurodegenerative. READING PORTFOLIO Page 41
  • 42. Name: Bui Bich Phuong Class: E2 WEEK 11: OCEANOGRAPHY Widespread Adaptability Coral Reefs May Be Able to Adapt to Climate Change With Help from Algae Magazine: Science Daily Date: Aprial. 11, 2012 A new study by scientists at the University of Miami's Rosenstial School of Marine & Atmospheric Science suggests that many species of reef-building corals may be able to adapt to warming waters by relying on their closest aquatic partners - algae. The corals' ability to host a variety of algal types, each with different sensitivities to environmental stress, could offer a much-needed lifeline in the face of global climate change. READING PORTFOLIO Page 42
  • 43. Name: Bui Bich Phuong Class: E2 Using a highly sensitive genetic technique, Ph.D. student Rachel Silverstein analyzed 39 coral species from DNA collected in the Indo- Pacific and Caribbean collected over the last 15 years. Most of these species had not previously been thought capable of hosting more than one type of the single-celled symbiotic algae, called zooxanthellae, which live inside the coral and A new study suggests that many help to supply them with energy. species of reef-building corals may Silverstein's results revealed that at least one be able to adapt to warming waters colony of all 39 species tested had at least two by relying on their closest aquatic partners – algae. varieties of algae, including one thought to be heat tolerant. Over half of the species were found to associate with all four of the major types of algae found in corals. "This study shows that more coral species are able to host multiple algal symbionts than we previously thought," said Andrew Baker, associate professor at UM's Rosenstiel School and co-author of the study. "The fact that they all seem to be capable of hosting symbionts that might help them survive warmer temperatures suggests they have hidden potential that was once thought to be confined to just a few special species." More than 10 years ago, Baker was one of the first scientists to suggest that the ability of corals to associate with diverse algal symbionts may be one mechanism by which they are able to rapidly respond to environmental changes, such as increased ocean temperatures due to climate change. "Although our study shows that different coral species do tend to have preferences in their algal partners, the fact that these preferences are not absolutely rigid means that we cannot ignore the possibility that most corals READING PORTFOLIO Page 43
  • 44. Name: Bui Bich Phuong Class: E2 might change partners in response to environmental changes in the future," said Silverstein. Globally, reefs have lost more than 70 percent of their corals as a result of pollution, disease, overfishing, and climate change. Increased temperatures cause coral "bleaching," in which corals expel their algal partners, turn pale, and often die. However, some symbionts can resist bleaching in warmer waters and may help the corals survive during stress. The ability to host multiple symbionts may help save coral reefs from future losses during expected ocean temperatures increases of 2-4 degrees Celsius (3-7 degrees Fahrenheit) by 2100. "These new findings should encourage us to find better ways to protect coral reef ecosystems from overfishing, pollution and habitat destruction, and buy us some time to avoid the worst climate change scenarios," said Baker, who is also a research associate of the Wildlife Conservation Society in New York. The study was published in the online edition of the journal Proceedings of the Royal Society B. Adrienne Correa, a former UM Rosenstiel School student of Baker's and a current postdoc at Oregon State University, is a co-author on the study, as well. The U.S. National Science Foundation, the Wildlife Conservation Society, the Lenfest Ocean Program and Pew Fellows Program in Marine Conservation funded the study. ***** I. The reflection on the article The article reports a new study by scientists at the University of Miami's Rosenstial School of Marine & Atmospheric Science about coral reef. Based on the result of study, the writer provides reader with useful information about this special kind of animal. I can learn more about the corals' ability to host a variety of algal types and more coral species are able to host multiple algal symbiont READING PORTFOLIO Page 44
  • 45. Name: Bui Bich Phuong Class: E2 than we previously thought. Additionally, The status of coral caused of pollution and increasing of temperature. From that, it’s necessary to protect them. Reporter supports ideas with opinion of researchers so that it makes article be clear and belief. Not only help us enlarge knowledge and open the mind, this article but also teach us how to present a topic, make it clear and help reader understand. I can also learn many vocabularies that related to Oceanography. However, I think it will be better if reporter makes main ideas more clear by putting topic sentences is the first sentence of paragraph. II. Vocabulary & Sentence Structure: 1. Coral reef (n) : a long line of a hard substance that is red, pink or white in colour, and that forms on the bottom of the sea from the bones of very small creatures. ( rặng san hô ) Ex. Halong bay is famous for colourful coral reef. 2. algae (n): very simple plants that have no real leaves, stems, roots, and that grow in or near water. (tảo) Algal (adj) + only before noun Ex. Algae is the simplest plant. 3. Zooxanthellae: tảo cộng sinh, vàng lục 4. single-celled (adj): only one cell – the smallest unit of living matter that can exist on its own. (đơn bào) ex. Algae is a single-celled plant. 5. hosting symbiont (n): an animal or a plant on which another animal or plant lives and feed. ( vật chủ) symbiont / symbiosis (n) : the relationshio between two different living creatures that live close together and depend on each other in particular ways, each getting particular benefits from the other. (sinh vật cộng sinh) READING PORTFOLIO Page 45
  • 46. Name: Bui Bich Phuong Class: E2 Ex.The birds live in symbiosis with the cattle, pichking insects fromm their skin to eat. 6. to associate with sth/ sb: to make a connection between people or things in your mind. ( lien kết) Ex. I always associate the smell of baking with my childhood. 7. multiple (adj): many in number, involving many different people or things. (nhiều) Ex. This study shows that more coral species are able to host multiple algal symbionts than we previously thought 8. mechanism (n): a system of parts in a living thing that together perform a particular function Ex. The body das defence mechanism against many diseases. 9. Rigid (adj): difficult to change Ex. They offer rigid principle. 10. Ignore (v) : to pay no attention to sth Ex. I made a suggestion but they chose to ignore it, as a result their campaing was collapsed. 11. Overfishing (n): a process of taking so many fish from the sea, a river, etc. that the number of fish in it becomes very low. (sự khai thác, đánh cạn cá) Ex. A shortage of tuna, caused of overfishing. 12. Bleach (v): to become white or pale by a chemical process or by the effect of light from the sun; to make sth white or pale in this way. ( tẩy trắng) Ex. His hair was bleached by the sun. 13. Pale (adj): light in color; containing a lot of white; having skin that is almost white because of illness; strongly emotion, etc.( tái nhợt, xanh xao) Ex. You look pale. Are you OK? 14. expel (~ sth from sth) (v): to force air or water out of a part of the body or from a container ( tống ra) READING PORTFOLIO Page 46
  • 47. Name: Bui Bich Phuong Class: E2 ex. Try to expel water from the belly. 15. Ecosystem (n): all the plants and living creatures in a particular area considered in relation to their physical environment . ( Hệ sinh thái) Ex. Islands often support delicate ecosystems that evolved without any need for defence. WEEK 12 – ENGINEERING Genetic Engineering How to Use Light to Control the Brain - By Stephen Dougherty - Magazine: Scientific American Date: March 27, 2012 LIGHT: Scientists can use light to switch on a neuron Image: iStock / kertlis In the film Amèlie, the main character is a young eccentric woman who attempts to change the lives of those around her for the better. One day Amèlie finds an old rusty tin box of childhood mementoes in her apartment, hidden by a boy decades earlier. After tracking down Bretodeau, the owner, she lures him to a phone booth where he discovers the box. Upon opening the box and seeing a few marbles, a sudden flash of vivid images come flooding into his mind. Next READING PORTFOLIO Page 47
  • 48. Name: Bui Bich Phuong Class: E2 thing you know, Bretodeau is transported to a time when he was in the schoolyard scrambling to stuff his pockets with hundreds of marbles while a teacher is yelling at him to hurry up. We have all experienced this: a seemingly insignificant trigger, a scent, a song, or an old photograph transports us to another time and place. Now a group of neuroscientists have investigated the fascinating question: Can a few neurons trigger a full memory? In a new study, published in Nature, a group of researchers from MIT showed for the first time that it is possible to activate a memory on demand, by stimulating only a few neurons with light, using a technique known as optogenetics. Optogenetics is a powerful technology that enables researchers to control genetically modified neurons with a brief pulse of light. To artificially turn on a memory, researchers first set out to identify the neurons that are activated when a mouse is making a new memory. To accomplish this, they focused on a part of the brain called the hippocampus, known for its role in learning and memory, especially for discriminating places. Then they inserted a gene that codes for a light-sensitive protein into hippocampal neurons, enabling them to use light to control the neurons. With the light-sensitive proteins in place, the researchers gave the mouse a new memory. They put the animal in an environment where it received a mild foot shock, eliciting the normal fear behavior in mice: freezing in place. The mouse learned to associate a particular environment with the shock. Next, the researchers attempted to answer the big question: Could they artificially activate the fear memory? They directed light on the hippocampus, activating a portion of the neurons involved in the memory, and the animals READING PORTFOLIO Page 48
  • 49. Name: Bui Bich Phuong Class: E2 showed a clear freezing response. Stimulating the neurons appears to have triggered the entire memory. The researchers performed several key tests to confirm that it was really the original memory recalled. They tested mice with the same light-sensitive protein but without the shock; they tested mice without the light-sensitive protein; and they tested mice in a different environment not associated with fear. None of these tests yielded the freezing response, reinforcing the conclusion that the pulse of light indeed activated the old fear memory. In 2010, optogenetics was named the scientific Method of the Year by the journal Nature Methods. The technology was introduced in 2004 by a research group at Stanford University led by Karl Deisseroth, a collaborator on this research. The critical advantage that optogenetics provides over traditional neuroscience techniques, like electrical stimulation or chemical agents, is speed and precision. Electrical stimulation and chemicals can only be used to alter neural activity in nonspecific ways and without precise timing. Light stimulation enables control over a small subset of neurons on a millisecond time scale. Over the last several years, optogenetics has provided powerful insights into the neural underpinnings of brain disorders like depression, Parkinson’s disease, anxiety, and schizophrenia. Now, in the context of memory research, this study shows that it is possible to artificially stimulate a few neurons to activate an old memory, controlling an animals’ behavior without any sensory input. This is significant because it provides a new approach to understand how complex memories are formed in the first place. Lest ye worry about implanted memories and mind control, this technology is still a long way from reaching any human brains. Nevertheless, the first small steps towards the clinical application of optogenetics have already begun. A group at Brown University, for example, is working on a wireless optical electrode that can deliver light to neurons in the human brain. Who knows, someday, READING PORTFOLIO Page 49
  • 50. Name: Bui Bich Phuong Class: E2 instead of new technology enabling us to erase memories á la Eternal Sunshine of the Spotless Mind, we may actually undergo memory enhancement therapy with a brief session under the lights. ***** I. The reflection on the article This article shows many information about genetic engineering – one of new engineering fields. Based on many studies in renown universities and groups , reporter provides interesting knowledge as scientific researchers. He uses a wide range of scientific terms that make readers feel difficult to understand. To make it clear, he presents a new study, published in Nature, a group of researchers from MIT. For example, reader can know more about optogenetics is a powerful technology that enables researchers to control genetically modified neurons with a brief pulse of light. I’m interested in this article, not only because of its content, but also manner of expessing of the writer. It’s really impressive. In addition, introduction part is quite attracting and interesting. What’s more, the article gives me a lot of good new words in the field of engineering II. Vocabulary & Sentence Structure 1. eccentric (adj): considered by other people to be strange or unusual. ex. The old lady was getting very eccentric. 2. to lures sb to sth: to persuade or trick sb to go somewhere or to do sth by promising them a reward. Ex. The woman that had lured him to his death. 3. to come flooding into/ in sth: to arrive or go mind in a large number. Ex. Telephone calls came flooding in from all over the country. READING PORTFOLIO Page 50
  • 51. Name: Bui Bich Phuong Class: E2 4. to yell at sb to do sth: to shout loudly, for example, when you’re angry, excited, frighten or in pain. Ex. She yelled at the child to get down from the wall. 5. marble (n): a small ball of colored glass that children roll along a ground in a game. Ex. Three boys are playing marbles. 6. scent (n): the pleasant smell that sth has (flower, perfume, etc.). Ex. The air is filled with the scent of wild flowers. 7. fascinating (adj): extremely interesting and attractive. Ex. The end of this story makes fascinating reading. 8. optogenetic: is a powerful technology that enables researchers to control genetically modified neurons with a brief pulse of light. 9. pulse of light : a single short increase in the amount of light produced by a machine. Ex. The pulse of light is influent to control the brain. 10. To artificially turn on a memory: created by people, not happening naturally, not real 11. hippocampus: (n): either of the two areas of the brain thought to be the centre of emotion or memory. ( đồi hải mã – thuộc não bộ) 12. discriminating (adj): able to judge the good quality of sth. (sáng suốt, có nhận thức đúng đắn) Ex. They are very discriminating about what restaurants they go to. You should be discriminating about the order to do the project. 13. to elicit sth from sb: to get information or a reaction from sb, often with difficulty. Ex. The police could elicit evidence from him. 14. to reinforce sth (v): to make a feeling, an idea, a theory, etc. stronger. Ex. The experience reinforced my sense of loss. READING PORTFOLIO Page 51
  • 52. Name: Bui Bich Phuong Class: E2 15. a collaborator on sth: a person who works with another person to create or produce sth suck as book. Ex. I need a good collaborator on this project. 16. precision (n): a quality of being exact, accurate, or careful. Ex. You can choose your target with grater precision. 17. underpin (v): support or form the basic of an argument , a claim, etc. ex. This report was inderpinned 18. schizophrenia (n): a metal illness in which a person becomes unable to link thought, emotion, and behavior (chứng phân liệt tâm thần) ex. His grandfather has been had the schizophenia. 19. sensory (adj): connected with your physical senses. Ex. Nose is one of five sensory organs on the body. 20. to enhance sth (v): to increase or further improve the good quality, value or status of sb/ sth. Ex. The images should be enhanced using digital technology. ***** Brian’s bridges Source: BOOK “Don’t throw this away! The civil engineering life” - By Brian Brenner- It appeared that I was a budding engineer, so my mother wrote to the governor and got tickets to the opening ceremony of the Verrazano Bridge. A big crowd gathered at the Staten Island toll plaza on a bright and sunny November day for long speeches and pontification. Most of the participants didn’t have much to do with the bridge’s design and construction, other than to show up for the dedication. Robert Moses, the chairman of the Triborough Bridge and Tunnel READING PORTFOLIO Page 52
  • 53. Name: Bui Bich Phuong Class: E2 Authority, pointed to the chief engineer, Othmar Amman, but didn’t mention him by name. This was as close as the speakers got to acknowledging the engineers, since Amman himself was not invited to the podium. I still have the Opening Day brochure and commemorative stamps in my bridge scrapbook. My mother wrote on the front of the scrapbook, “Brian’s bridges.” A great bridge is the product of the imagination and sweat of hundreds of people. Maybe this is why a bridge is not easily identified with individuals and why a bridge’s creation and birth seem anonymous. Very few of the structures are named in honor of the people who created them. In fact, most bridge names honor people who had nothing to do with the work. In the case of the Verrazano Bridge, naming the structure after its creators would have required a very long name. Society expects that engineers and constructors will fade into the background, like the bridges. The builders can be proud of their creations but must be satisfied that the symbolic act of naming, the official recognition of the creation, will be transferred to someone else. In March 2003, my father visited Boston. It was a warm afternoon after a long, bitter winter. We went to visit the Zakim Bridge, just days before the first part of its staged opening. The Zakim Bridge stood tall and sleek in the middle of dowdy, old downtown Boston. Hundreds of thousands had watched the structure appear from nothing, with its futuristic concrete pylons and slender cables strung to the deck one piece at a time. Upon completion, the structure quickly became an infrastructure icon for the city, with its image appearing on bank advertisements, at the beginning of newscasts, and in dozens of unrelated publications. On the fourth of July, the blue tower lights were supplemented by a red glow at night, so with the white cables, the bridge was patriotic, a giant cable- stayed American flag. We stood by the bridge. I had little direct involvement with this bridge design, but I said to my father: READING PORTFOLIO Page 53
  • 54. Name: Bui Bich Phuong Class: E2 “What do you think of my bridge, Dad?” “Nice job,” he replied. ***** I. The reflection on the article This is a part of a story I read. The authour talks true story that he known. This passage tells about a Bridge – called Zakim. The Zakim Bridge stood tall and sleek in the middle of dowdy, old downtown Boston. It is a great bridge is the product of the imagination and sweat of hundreds of people I can get some interesting and useful information of the Zakim Bridge: its structure, its history, ect. If having free time, I suggest you enjoying it. II. Vocabulary and structures: . 1. pontificate: to give your opinions about something in a way that shows that you think you are right. Ex: She is good at pontificating. 2. dedication: a ceremony that is held to show that a building or an object has a special purpose or is special to the memory of a particular person. Ex: They are preparing for the dedication. 3. podium: a small platform that a person stands on when giving a speech or conducting an orchestra. 4. bugging: beginning to develop or become successful. Ex: The budding young star is now hot property in Hollywood 5. commemorative: intended to help people remember and respect an important person or event in the past. Ex: A commemorative plaque on the bridge records the name of the engineer. READING PORTFOLIO Page 54
  • 55. Name: Bui Bich Phuong Class: E2 6. scrapbook: a book with empty pages where you can stick pictures, newspaper articles, etc.. Ex: He bought a scrapbook to his son as a birthday present. 7. anonymous: with a name that is not known or that is not made public. Ex: The money was donated by a local businessman who wishes to remain anonymous. 8. to fade into something: to disappear gradually. Ex: Spring was fading into summer. 9. bitter: (of weather conditions) extremely cold and unpleasant. Ex: It's really bitter out today. 10. sleek: smooth and shiny. Ex: She has got sleek black hair. 11. dowdy: dull or boring and not attractive. Ex: The dress seems to be dowdy. 12. futuristic: extremely modern and unusual in appearance, as if belonging to a future time. Ex: My house has a futuristic design. 13. concrete: building material that is made by mixing together cement, sand, small stones and water. Ex: The pathway is formed from large pebbles set in concrete. 14. pylon: a tall metal structure that is used for carrying electricity wires high above the ground. Ex: There are too many pylons here. 15. deck: a wooden floor that is built outside the back of a house where you can sit and relax. Ex. After dinner, We sat out on the deck to relax. READING PORTFOLIO Page 55
  • 56. Name: Bui Bich Phuong Class: E2 16. infrastructure: the basic systems and services that are necessary for a country or an organization to run smoothly, for example buildings, transport and water and power supplies. 17. glow: a dull steady light, especially from a fire that has stopped producing flames. Ex: There was no light except for the occasional glow of a cigarette. 18. patriotic: having or expressing a great love of your country. Ex: He really was a patriotic man. WEEK 13 – MEDICINE Discovery Provides Blueprint for New Drugs That Can Inhibit Hepatitis C Virus Magazine: ScienceDaily Date: Mar. 19th, 2012 ScienceDaily (Mar. 19, 2012) — Chemists at the University of California, San Diego have produced the first high resolution structure of a molecule that when attached to the genetic material of the hepatitis C virus prevents it from reproducing. READING PORTFOLIO Page 56
  • 57. Name: Bui Bich Phuong Class: E2 Hepatitis C is a chronic infectious disease that affects some 170 million people worldwide and causes chronic liver disease and liver cancer. According to the Centers for Disease Control and Prevention, hepatitis C now kills more Americans each year than HIV. The structure of the molecule, which was published in a paper in this week's early online edition of the journal Proceedings of the National Academy of Sciences, provides a detailed blueprint for the design of drugs that can inhibit the replication of the hepatitis C virus, which proliferates by hijacking the cellular machinery in humans to manufacture duplicate viral particles.. Finding a way to stop that process could effectively treat viral infections of hepatitis C, for which no vaccine is currently available. But until now scientists have identified few inhibiting compounds that directly act on the virus's ribonucleic acid (RNA) The molecule prompts the Hepatitis genome -- the organism's full C’s viral RNA to open up a portion of its complement of genetic material. hinge-like structure and encapsulate the "This lack of detailed information inhibitor like a perfectly fit glove. (Credit: on how inhibitors lock onto the viral Image courtesy of University of California genome target has hampered the - San Diego) development of better drugs," said Thomas Hermann, an associate professor of chemistry and biochemistry at UC San Diego who headed the research team, which also included scientists from San Diego State University. READING PORTFOLIO Page 57
  • 58. Name: Bui Bich Phuong Class: E2 The team detailed the structure of a molecule that induces the viral RNA to open up a portion of its hinge-like structure and encapsulate the inhibitor like a perfectly fit glove, blocking the ability of the hepatitis C virus to replicate. The molecule is from a class of compounds called benzimidazoles, known to stop the production of viral proteins in infected human cells. Its three-dimensional atomic structure was determined by X-ray crystallography, a method of mapping the arrangement of atoms within a crystal, in which a beam of X-rays strikes a crystal and causes the beam of light to spread. The angles and intensities of the light beams allowed the scientists to calculate the structure of the viral RNA- inhibitor complex. "This structure will guide approaches to rationally design better drug candidates and improve the known benzimidazole inhibitors," said Hermann. "Also, the crystal structure demonstrates that the binding pocket for the inhibitors in the hepatitis C virus RNA resembles drug-binding pockets in proteins. This is important to help overcome the notion that RNA targets are so unlike traditional protein targets that drug discovery approaches with small molecule inhibitors are difficult to achieve for RNA." The study was supported by the National Institutes of Health and National Science Foundation. ***** I. The reflection on the article: After reading tittle of this article, reader can see the main idea: Discovery Provides Blueprint for New Drugs That Can Inhibit Hepatitis C Virus It’s quite difficult to understand the content of this article because it talks about a new field relating to science so using to many scientic terms as well as range of new words is quite hard to know axactly what the meaning is. However, it’s clear that the article provides reader with new knowledge which is attractive at people READING PORTFOLIO Page 58