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COVID-19 Vaccination:
Current status and
Challenges
DR. BHUSHAN KAMBLE,
ASST. PROFESSOR, DEPT. OF CM & FM
1
Contents
Introduction
Current status of vaccination
COVID-19 Vaccines approved in India
Vaccine sequencing
Vaccination in pregnancy and lactation
Vaccination for children
Challenges in vaccination
2
Introduction
Launched on 16th Jan 2021 in phase
wise manner pan-India
Phase-I 1cr HCWs & 1cr FLWs
Co-WIN App developed by UNDP.
Free of cost
COVISHIELD and COVAXIN Vaccine
3
Date Beneficiary
16th Jan 21 Health Care Workers
(HCWs)
1st Feb 21 Front Line Workers
(FLWs)
1st Mar 21 Geriatric population age
>60 years and
Between 45-59 years
with co-morbidities
1st Apr 21 All people ≥45 years
1st May 21 All >18 years of age
Current status of COVID-19 VACCINATION
Availability of more vaccines,
Advance visibility of vaccine
availability to States and UTs
Providing them COVID
Vaccines free of cost.(75%)
4
VACCINE
DOSES
(As on 16
August 2021)
SUPPLIED 56,81,14,630
CONSUMPTI
ON
54,22,75,723
BALANCE
AVAILABLE
2,89,47,890
The new phase of universalization of COVID-19
vaccination has commenced from 21st June, 2021.
Cumulative Vaccine
Dose Coverage
On 16th August 2021
Total 55,85,834 vaccine doses given on 16th :
1st Dose: 43,18,152
2nd Dose: 12,67,682.
Cumulative vaccine doses 55,14,89,821
1st Dose: 428426418 (31.7%)
2nd Dose: 123063403 (9.1%)
5
Healthcare workers
1st Dose: 103518482nd Dose: 8114959.
Frontline workers
1st Dose: 18283967 2nd Dose: 12226514
People Aged 18-44 Years
1st Dose: 200068334
2nd Dose: 15935853
People Aged ≥ 45 Years
1st Dose: 118223789 2nd Dose: 46231673
. People Aged ≥ 60 Years 1st Dose:
81498480 2nd Dose: 40554404
Statewise Covid-19 vaccination status
Five States namely Madhya Pradesh, Gujarat, Rajasthan, Maharashtra and Uttar
Pradesh: have administered more than 1 Crore Cumulative Doses of COVID-19 Vaccine in
the age group 18-44 years.
Highest doses are given by UP (5,74,28,780), Maharashtra(4,91,99,401), Gujrat
(3,98,45,089), Madhypradesh (3,98,45,089) and Rajsthan (3,75,16,981)
Maharashtra and UP are vaccinating daily approx. 10 lakh dosages and GJ, RJ and Bihar
are vaccinating around 5 lakh people.
Telangana: Total vaccination: 1,62,25,901 (1,64,339), 1st dose:1,20,73,758 2nd
dose:41,52,143
6
Vaccination Coverage
7
COVID-19 Vaccines approved in India
DCGI has given approval for following 5 COVID-19 vaccines for restricted use in
emergency situation till 16th Aug 2021
8
• COVISHIELD
• COVAXIN
Jan
21
Sputnik
V
Apr
21
Moderna
Jun
21
Johnson
&
Johnson
Aug
21
COVID-19 Vaccines approved in India
Vaccine
Type of Vaccine No of
doses
Time gap
between 2 dose Vaccine
Efficacy
Effectivene
ss against
Delta
Variant
Covishield Viral Vector 2 12-16 weeks 70.4%
82.4%*
63%
Covaxin Inactivated virus 2 4 weeks 77.8% 65.2%
Sputnik V Viral Vector 2 3 weeks 91.6% 83%
Moderna mRNA 2 4 weeks 94.1% 76%
Johnson &
Johnson
Viral Vector 1 NA 92.4% 71%
9
*At 4 weeks interval
ZyCov-D
DNA
3 ID2856
Corbevax
Bio E
Protein
subunit
2IM28
Novovax
SII
Protein
subunitIM2
1days
Children and Vaccination
The development of the COVID-19 vaccine for
children is in the advanced stages of clinical trials
AIIMS has started the second dose trial of
COVAXIN in 2-6 year old Children.
Zydus Cadila's ZyCOV-D has already submitted
data for approval children over 12 to 18 years.
Conducted trial in 50 centers over 28,000
participants and having efficacy of 66.6% against
symptomatic covid
Moderna vaccine already got emergency use
authorization in USA for 12 to 17 years children
and claimed full protection.
10
COVID vaccination for pregnant & lactating mothers
DCGI didn’t give license for Pregnant and lactating mother women due to lack of
trial data.
FIGO, RCOG and FOGSI emphasized vaccination these women despite of limited
availability of data as the risk of getting COVID-19 in pregnancy and its resulting
morbidity is much more than the theoretical risks from the vaccine
Supported by interim recommendation of WHO for use of Covishield vaccine
(ChAdOx1-S) during pregnancy and lactation.
NTAGI, MoHFW approved the vaccination against COVID-19 on 19th May for all
lactating mother and for pregnant women on 2nd July 2021.
 Pregnant women can get Covishield, Covaxin or Sputnik V any time during
pregnancy
If already infected with COVID during pregnancy then she can get vaccine after
delivery.
Till 30 July only 2.3 lakh pregnant women received their Jab. TN, AP, Odisha, MP,
Karala and Karnataka are leading.
11
Challenges in COVID Vaccination
COVID
Vaccination
Vaccine
Hesitancy
Vaccine
Wastage
Vaccine
Shortage
Online
Registration
Crowd
Manageme
nt
Effect on
RI
12
 Many states such as JH (37.3%), CG(30.2%), TN(15.5%)
J&K (10.8%) and MP(10.7%) reported much higher
wastage than national average (6.3%)
 Due to vaccine supply shortage many beneficiaries could
not receive their 2nd Dose on time
 Frequent change in policy and update in Co-Win portal.
 Diversions from Vaccine sequencing at many places
 Fear of derailing other Immunisation Programmes
 Vaccine hesitancy reduces vaccine uptake and
compromises herd immunity
Vaccine Hesitancy and solutions
Vaccine hesitancy refers to delaying or refusing vaccines despite the availability of vaccine services.
Concerns about vaccine safety, adverse effects, toxicity, Perceptions of low risk , worry about unforeseen future
negative effects or lack of information and support
Possible ways to overcome: Awareness programmes, Dialogue-based interventions, CSR Activities, Training
healthcare professionals, Partner with diverse stakeholders
 WHO Based increasing vaccination model
At the heart of this model is motivation
to be vaccinated. Motivation can be captured by
concepts like readiness, willingness, or intention
13
Upcoming Challenges in Covid Vaccination
COVID-19 vaccine breakthrough infections
Variants of Concern: Delta Plus(K417N)
 Vaccine Escape
Duration of protection: 3months to 8 months
Booster doses
14
16

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Covid 19 vaccination [autosaved]

  • 1. COVID-19 Vaccination: Current status and Challenges DR. BHUSHAN KAMBLE, ASST. PROFESSOR, DEPT. OF CM & FM 1
  • 2. Contents Introduction Current status of vaccination COVID-19 Vaccines approved in India Vaccine sequencing Vaccination in pregnancy and lactation Vaccination for children Challenges in vaccination 2
  • 3. Introduction Launched on 16th Jan 2021 in phase wise manner pan-India Phase-I 1cr HCWs & 1cr FLWs Co-WIN App developed by UNDP. Free of cost COVISHIELD and COVAXIN Vaccine 3 Date Beneficiary 16th Jan 21 Health Care Workers (HCWs) 1st Feb 21 Front Line Workers (FLWs) 1st Mar 21 Geriatric population age >60 years and Between 45-59 years with co-morbidities 1st Apr 21 All people ≥45 years 1st May 21 All >18 years of age
  • 4. Current status of COVID-19 VACCINATION Availability of more vaccines, Advance visibility of vaccine availability to States and UTs Providing them COVID Vaccines free of cost.(75%) 4 VACCINE DOSES (As on 16 August 2021) SUPPLIED 56,81,14,630 CONSUMPTI ON 54,22,75,723 BALANCE AVAILABLE 2,89,47,890 The new phase of universalization of COVID-19 vaccination has commenced from 21st June, 2021.
  • 5. Cumulative Vaccine Dose Coverage On 16th August 2021 Total 55,85,834 vaccine doses given on 16th : 1st Dose: 43,18,152 2nd Dose: 12,67,682. Cumulative vaccine doses 55,14,89,821 1st Dose: 428426418 (31.7%) 2nd Dose: 123063403 (9.1%) 5 Healthcare workers 1st Dose: 103518482nd Dose: 8114959. Frontline workers 1st Dose: 18283967 2nd Dose: 12226514 People Aged 18-44 Years 1st Dose: 200068334 2nd Dose: 15935853 People Aged ≥ 45 Years 1st Dose: 118223789 2nd Dose: 46231673 . People Aged ≥ 60 Years 1st Dose: 81498480 2nd Dose: 40554404
  • 6. Statewise Covid-19 vaccination status Five States namely Madhya Pradesh, Gujarat, Rajasthan, Maharashtra and Uttar Pradesh: have administered more than 1 Crore Cumulative Doses of COVID-19 Vaccine in the age group 18-44 years. Highest doses are given by UP (5,74,28,780), Maharashtra(4,91,99,401), Gujrat (3,98,45,089), Madhypradesh (3,98,45,089) and Rajsthan (3,75,16,981) Maharashtra and UP are vaccinating daily approx. 10 lakh dosages and GJ, RJ and Bihar are vaccinating around 5 lakh people. Telangana: Total vaccination: 1,62,25,901 (1,64,339), 1st dose:1,20,73,758 2nd dose:41,52,143 6
  • 8. COVID-19 Vaccines approved in India DCGI has given approval for following 5 COVID-19 vaccines for restricted use in emergency situation till 16th Aug 2021 8 • COVISHIELD • COVAXIN Jan 21 Sputnik V Apr 21 Moderna Jun 21 Johnson & Johnson Aug 21
  • 9. COVID-19 Vaccines approved in India Vaccine Type of Vaccine No of doses Time gap between 2 dose Vaccine Efficacy Effectivene ss against Delta Variant Covishield Viral Vector 2 12-16 weeks 70.4% 82.4%* 63% Covaxin Inactivated virus 2 4 weeks 77.8% 65.2% Sputnik V Viral Vector 2 3 weeks 91.6% 83% Moderna mRNA 2 4 weeks 94.1% 76% Johnson & Johnson Viral Vector 1 NA 92.4% 71% 9 *At 4 weeks interval ZyCov-D DNA 3 ID2856 Corbevax Bio E Protein subunit 2IM28 Novovax SII Protein subunitIM2 1days
  • 10. Children and Vaccination The development of the COVID-19 vaccine for children is in the advanced stages of clinical trials AIIMS has started the second dose trial of COVAXIN in 2-6 year old Children. Zydus Cadila's ZyCOV-D has already submitted data for approval children over 12 to 18 years. Conducted trial in 50 centers over 28,000 participants and having efficacy of 66.6% against symptomatic covid Moderna vaccine already got emergency use authorization in USA for 12 to 17 years children and claimed full protection. 10
  • 11. COVID vaccination for pregnant & lactating mothers DCGI didn’t give license for Pregnant and lactating mother women due to lack of trial data. FIGO, RCOG and FOGSI emphasized vaccination these women despite of limited availability of data as the risk of getting COVID-19 in pregnancy and its resulting morbidity is much more than the theoretical risks from the vaccine Supported by interim recommendation of WHO for use of Covishield vaccine (ChAdOx1-S) during pregnancy and lactation. NTAGI, MoHFW approved the vaccination against COVID-19 on 19th May for all lactating mother and for pregnant women on 2nd July 2021.  Pregnant women can get Covishield, Covaxin or Sputnik V any time during pregnancy If already infected with COVID during pregnancy then she can get vaccine after delivery. Till 30 July only 2.3 lakh pregnant women received their Jab. TN, AP, Odisha, MP, Karala and Karnataka are leading. 11
  • 12. Challenges in COVID Vaccination COVID Vaccination Vaccine Hesitancy Vaccine Wastage Vaccine Shortage Online Registration Crowd Manageme nt Effect on RI 12  Many states such as JH (37.3%), CG(30.2%), TN(15.5%) J&K (10.8%) and MP(10.7%) reported much higher wastage than national average (6.3%)  Due to vaccine supply shortage many beneficiaries could not receive their 2nd Dose on time  Frequent change in policy and update in Co-Win portal.  Diversions from Vaccine sequencing at many places  Fear of derailing other Immunisation Programmes  Vaccine hesitancy reduces vaccine uptake and compromises herd immunity
  • 13. Vaccine Hesitancy and solutions Vaccine hesitancy refers to delaying or refusing vaccines despite the availability of vaccine services. Concerns about vaccine safety, adverse effects, toxicity, Perceptions of low risk , worry about unforeseen future negative effects or lack of information and support Possible ways to overcome: Awareness programmes, Dialogue-based interventions, CSR Activities, Training healthcare professionals, Partner with diverse stakeholders  WHO Based increasing vaccination model At the heart of this model is motivation to be vaccinated. Motivation can be captured by concepts like readiness, willingness, or intention 13
  • 14. Upcoming Challenges in Covid Vaccination COVID-19 vaccine breakthrough infections Variants of Concern: Delta Plus(K417N)  Vaccine Escape Duration of protection: 3months to 8 months Booster doses 14
  • 15. 16

Hinweis der Redaktion

  1. Globally 2nd dose 23.5% 1st dose: 31.2% US: 1st dose 60% 2nd dose 46% Uk: 1st dose75% 2nd dose 65% UAE, Qatar: 100% France: 76% 54%
  2. J&J –Duration-8months Dr. Pramod Kumar Garg THS and Technology Institute, FBD studied 3687 and 5163 controls Bharat Biotech Phase 3 data on July 2 revealed 77.8%, ICMR study in august showed 1.5 reduction in titre against delta strain Covaxin data submitted to WHO for International autharorization on 9July Johnson & Johnson has announced that it is collaborating with Telangana-based Biological E to produce its 'Janssen COVID-19 vaccine' in India.
  3. Pfizer two dose vaccine approved for children 12 to 19 years by USFDA Sputnik V also conducting trial on children 12-19 in Moscow
  4. Mortality among pregnant 2-3times up Europe, US already started vaccination
  5. Vaccine hesitancy refers to delaying or refusing vaccines despite the availability of vaccine services; it is complex and context-specific, varying across time, location, and vaccine type, and includes factors such as complacency, convenience, and confidence Vaccine hesitancy reduces vaccine uptake and compromises herd immunity. When herd immunity is compromised, disease outbreaks among the unvaccinated population are likely. For example, in 2017, measles was eliminated in the UK; however, the elimination status was lost in 2019, as a marked increase in measles cases occurred owing to sub-optimal uptake of the MMR vaccine in the population​. Vaccine hesitancy, therefore undermines the effectiveness and success of immunisationprogrammes.  
  6. it is complex and context-specific, varying across time, location, and vaccine type, and includes factors such as complacency, convenience, and confidence.
  7. It is defined as the detection of SARS-CoV-2 RNA or antigen in a respiratory specimen collected from a person ≥14 days after they have completed all recommended doses of authorized COVID-19 vaccine