This article is shared by BOC Sciences.

1. High-throughput Screening
BOC Sciences provides high-quality, customized, high-throughput drug
screening services based on experimental methods at the molecular and
cellular levels. To ensure the reliability of the service, we are equipped
with a high capacity chemical library, automated operating system, high
sensitivity detection system, efficient data processing system and highly
specific drug screening model. In the process of high throughput
screening, BOC Sciences can carry out quality control, information
tracking and data storage for all key steps according to customers'
requirements and industry standards, to ensure the safety of all outputs.
High-throughput screening technology is a method for screening drug
candidates that interact with targets from a sample pool by using
microplates containing molecules (such as enzymes and receptors) and
cells as carriers. Drug candidates are screened for the effect on the
biological activity of the target or cells. In the process of high-throughput
screening, multiple disciplines are closely combined, such as
pharmaceutical chemistry, molecular biology, cell biology, mathematics,
microbiology and computer science. With the rapid development of
high-throughput screening technology, it has become an important way
to discover new drugs.

2. Below is a list of our High-throughput screening process:
Preparation of samples and composite libraries
Screening facilities usually store their composite library collections in
so-called “inventory discs”. The chopping board was not used directly in
the experiment. Instead, when necessary, the compound from the
storage plate is “copied” to the analytical plate through the liquid transfer
station.

3. The establishment of a method suitable for laboratory automation
Configuration of robot workstations
Data acquisition and processing
We make use of our experience in pharmaceutical chemistry to identify
new drug candidates and accelerate towards clinical research,
effectively helping our customers control the cost of new drug
development.
Our Methods
 Optical detection technology
 Radioactive detection technology
 Fluorescence detection technology
 Multifunctional microplate detection system
Our Advantages
 Large high-throughput screening compound library
 High specificity
 Continuous update of compound library
Our expertise is from industrial and academic backgrounds. We can
provide a wide range of screenings on multiple platforms and advice for
development and analysis from initial stage of the development to
project completion.
References
1. Bajorath, J. (2002). Integration of virtual and high-throughput
screening. Nature Reviews Drug Discovery, 1(11), 882.
2. Gao, H., Korn, J. M., Ferretti, S., Monahan, J. E., Wang, Y., Singh, M., ... &
Balbin, O. A. (2015). High-throughput screening using patient-derived
tumor xenografts to predict clinical trial drug response. Nature
medicine, 21(11), 1318.