The report presents the market potential of seven major pipeline drugs meant for the treatment of migraine. These seven drugs that fall in the various categories of Ergotamines, Anti 5-HT Receptor Agonists and Anti-CGRPs by mechanism of action have been recognized as being clinically effective in migraine treatment. Expected to be launched in the market within the next 4-5 years, these seven potential drugs are likely to bring about major changes in the way migraine is treated globally.
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Migraine Pipeline Drugs Market Assessment– Forecast to 2022
1. (c) AZOTH Analytics
Migraine Pipeline Drugs Market Assessment: Industry
Analysis, Pipeline Review, Clinical Trials, Market Potential –
Forecast to 2022
• Global Migraine Pipeline Drugs Assessment –
Review, Potential, Clinical Trials
• Global Migraine Drugs Share By Type – Acute and
Prophylaxis
• Company Analysis
January 2018
2. (c) AZOTH Analytics
Global Migraine Pipeline Drugs
Assessment
Global Migraine Drugs Market
(2012-2016), By Value
Global Migraine Drugs Market
(2017-2022), By Value
Breakdown-By Type - Acute and
Prophylaxis)
Global Migraine Drugs Market
(2012-16), By Value
Global Migraine Drugs Market
(2017-22), By Value
Global Coverage Country Coverage
Migraine Pipeline Drugs Market Assessment: Industry Analysis, Pipeline Review, Clinical Trials, Market
Potential – Forecast to 2022
Migraine Drugs Market, By Value
(2012-2016)
Migraine Drugs Market, By Value
(2017-2022)
United States
United Kingdom
Japan
France
Italy
Germany
Pipeline Drugs Coverage
Migraine Drugs Market Forecast -
By Value (2018-2022)
Drug X-1
Drug X-2
Drug X-3
Drug X-4
Drug X-5
Drug X-6
Drug X-7
Company Coverage
Product Benchmarking
Policy and Regulatory Landscape
Financial Analysis
Sales
EBITDA
Business Strategy
Amgen
Allergan
Eli Lilly
Alder Pharmaceuticals
Teva Pharmaceuticals
Vernalis
Pfizer
Impax Laboratories
Glaxo Smithkline
Global Coverage
Country Coverage
Scope of the Study Migraine Pipeline Drugs Assessment
Global Migraine Drugs Market – By Type (Acute and Prophylaxis)
2
3. (c) AZOTH Analytics
Table of Content
3
S.No Particulars Page No.
1. Research Methodology 16
2. Executive Summary 17
3. Migraine - An Overview 18
3.1 Symptoms of migraine 18
3.2 Stages of Migraine 19
3.3 Types of Migraine 20
3.4 Types of migraine on the basis of frequency of occurrence 24
4. Treatment of Migraine 25
4.1 Goal of Migraine Treatment 26
4.2 Treatment of Migraine – Pharmacological and Non-Pharmacological 26
4.2.1 Pharmacological treatment of migraine 27
4.2.2 Pharmacological - Abortive 28
4.2.3 Pharmacological - Preventive 30
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Table of Content
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S.No Particulars Page No.
4.2.4 Non-Pharmacological Treatment of Migraine 33
4.2.5 Non- Pharmacological - Surgical 34
4.2.6 Non- Pharmacological – Non-Surgical 35
5. Anti Migraine Pipeline Drugs 38
5.1 Anti-Migraine Pipeline Drugs (According to Mechanism of Working) 39
5.2 Anti Migraine Pipeline Drugs (Ergotamine) – Drug X-1 40
5.2.1 Description 41
5.2.2 Regulatory Milestones 42
5.2.3 Advantages & Disadvantages 43
5.2.4 Product Profile & Expected Launch 44
5.2.5 Clinical Trials and Status 45
5.2.6 Pivotal Clinical Trials and Results 46
5.2.7 Drug X-1 – Global Market Potential 48
5.2.8 Drug X-1 - 7Ps Analysis 50
5. (c) AZOTH Analytics
Table of Content
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S.No Particulars Page No.
5.3 Anti Migraine Pipeline Drugs (Anti-5HT Receptor Agonist) – Drug X-2 51
5.3.1 Description 52
5.3.2 Regulatory Milestones 53
5.3.3 Advantages & Disadvantages 54
5.3.4 Product Profile & Expected Launch 55
5.3.5 Clinical Trials and Status 56
5.3.6 Pivotal Clinical Trials and Results 58
5.3.7 Drug X-2 – Global Market Potential 60
5.3.8 Drug X-2 – 7Ps Analysis 62
5.4 Anti Migraine Pipeline Drugs (Anti CGRPs) 63
5.5 Anti Migraine Pipeline Drugs (Anti CGRPs) – By Drug 66
5.6 Anti Migraine Pipeline Drugs (CGRP Antagonist) - Drug X-3 67
5.6.1 Description 68
5.6.2 Regulatory Milestones 69
5.6.3 Advantages & Disadvantages 70
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S.No Particulars Page No.
5.6.4 Product Profile & Expected Launch 71
5.6.5 Clinical Trials and Status 72
5.6.6 Pivotal Clinical Trials and Results 73
5.6.7 Drug X-3 – Global Market Potential 75
5.6.8 Drug X-3 – 7Ps Analysis 77
5.7 Anti Migraine Pipeline Drugs (Anti-CGRP Mab) - Drug X-4 80
5.7.1 Description 81
5.7.2 Regulatory Milestones 82
5.7.3 Advantages & Disadvantages 83
5.7.4 Product Profile & Expected Launch 84
5.7.5 Clinical Trials and Status 85
5.7.6 Pivotal Clinical Trials and Results 86
5.7.7 Drug X-4 – Global Market Potential 90
5.7.8 Drug X-4 – 7Ps Analysis 92
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Table of Content
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S.No Particulars Page No.
5.8 Anti Migraine Pipeline Drugs (Anti-CGRP Mab) - Drug X-5 93
5.8.1 Description 94
5.8.2 Regulatory Milestones 95
5.8.3 Advantages & Disadvantages 96
5.8.4 Product Profile & Expected Launch 97
5.8.5 Clinical Trials and Status 98
5.8.6 Pivotal Clinical Trials and Results 100
5.8.7 Drug X-5 – Global Market Potential 103
5.8.8 Drug X-5 – 7Ps Analysis 105
5.9 Anti Migraine Pipeline Drugs (Anti-CGRP Mab) - Drug X-6 106
5.9.1 Description 107
5.9.2 Regulatory Milestones 108
5.9.3 Advantages & Disadvantages 109
5.9.4 Product Profile & Expected Launch 110
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S.No Particulars Page No.
5.9.5 Clinical Trials and Status 111
5.9.6 Pivotal Clinical Trials and Results 113
5.9.7 Drug X-6 – Global Market Potential 115
5.9.8 Drug X-6 – 7Ps Analysis 117
5.10 Anti Migraine Pipeline Drugs (Anti-CGRP Mab) - Drug X-7 118
5.10.1 Description 119
5.10.2 Regulatory Milestones 120
5.10.3 Advantages & Disadvantages 121
5.10.4 Product Profile & Expected Launch 122
5.10.5 Clinical Trials and Status 123
5.10.6 Pivotal Clinical Trials and Results 125
5.10.7 Drug X-7 – Global Market Potential 127
5.10.8 Drug X-7 – 7Ps Analysis 129
9. (c) AZOTH Analytics
Table of Content
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S.No Particulars Page No.
6. Global Migraine Drugs Market: Growth and Forecast 130
6.1 By Value (2012-2016) 131
6.2 By Value (2017-2022) 132
7. Global Migraine Drugs Market-By Type 135
7.1 Global Migraine Drugs Market, By Type : Breakdown (%) 135
7.1.1 Global Migraine Drugs Market- By Type: 2016 (%) 136
7.1.2 Global Migraine Drugs Market – By Type: 2022 (%) 137
7.2 Global Migraine Drugs Market- By Acute 139
7.2.1 By Value (2012-2016) 139
7.2.2 By Value (2017-2022) 139
7.3 Global Migraine Drugs Market- By Prophylaxis 140
7.3.1 By Value (2012-2016) 140
7.3.2 By Value (2017-2022) 140
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8. Global Migraine Drugs Market: Country Analysis (U.S, U.K, Japan, France, Italy, Germany, ROW) 141
8.1 U.S. Migraine Drugs Market, By Value (2012-2022) 142
8.2 U.K. Migraine Drugs Market, By Value (2012-2022) 144
8.3 Japan Migraine Drugs Market, By Value (2012-2022) 146
8.4 France Migraine Drugs Market, By Value (2012-2022) 148
8.5 Italy Migraine Drugs Market, By Value (2012-2022) 150
8.6 Germany Migraine Drugs Market, By Value (2012-2022) 152
8.7 ROW Migraine Drugs Market, By Value (2012-2022) 154
9. Market Dynamics 155
9.1 Migraine Drug Market Drivers 156
9.2 Migraine Drug Market Challenges 160
10. Company Profile 162
10.1. Amgen 163
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12. (c) AZOTH Analytics
List of Figures
Figure No. Figure Title Page No.
Figure 1: 2 hour pain relief & pain free rates in patients treated with LEVADEX (MAP0004) compared to placebo (1st
pivotal trial)
47
Figure 2: Improvement at two hours in people who took LEVADEX compared to Placebo (2nd pivotal trial) 47
Figure 3: Global Drug X-1 Market Size, By Value, Forecast, 2019-2022 (USD Billion) 48
Figure 4: Percentage of patients achieving primary end point 59
Figure 5: Percentage of patients achieving secondary endpoint 59
Figure 6: Global Drug X-2 Market Size, By Value, Forecast, 2019-2022 (USD Million) 60
Figure 7: Efficacy in 2 hour pain freedom 74
Figure 8: Global Drug X-3 Market Size, By Value, Forecast, 2019-2022 (USD Billion) 75
Figure 9: Reduction in Monthly migraine days – weeks 1 through 12 87
Figure 10: Percentage of patients with ≥75% reduction in number of migraine days – weeks 1 through 24 88
Figure 11: Percentage of patients with 100% response rate (no migraine in any given month) – months 1 through 6 89
Figure 12: Global Drug X-4 Market Size, By Value, Forecast, 2019-2022 (USD Million) 90
Figure 13: Global Drug X-5 Market Size, By Value, Forecast, 2019-2022 (USD Million) 103
Figure 14: Global Drug X-6 Market Size, By Value, Forecast, 2019-2022 (USD Million) 115
Figure 15: Monthly migraine days reduction vs placebo in previous prophylactic drugs failure group 125
Figure 16: Reduction in days using acute pain medications in recent drug overuse group 125
Figure 17: Global Drug X-7 Market Size, By Value, Forecast, 2019-2022 (USD Million) 127
Figure 18: Global Migraine Drugs Market Size, By value, 2012-2016 (USD Billion) 131
Figure 19: Global Migraine Drugs Market Size, By Value, Forecast, 2017-2022 (USD Billion) 132
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13. (c) AZOTH Analytics
List of Figures
Figure No. Figure Title Page No.
Figure 20: Global consumption of chocolate confectionary, By volume (in 1000 metric tones) 134
Figure 21: Global Migraine Drugs Market Share, By Type, 2016 (%) 136
Figure 22: Global Migraine Drugs Market Share, By Type, 2022 (%) 137
Figure 23: Global Migraine Drugs Market, By Acute, By Value, 2012-2016 (USD Million) 139
Figure 24: Global Migraine Drugs Market, By Acute, By Value, 2017-2022 (USD Million) 139
Figure 25: Global Migraine Drugs Market, By Prophylaxis, By Value, 2012-2016 (USD Million) 140
Figure 26: Global Migraine Drugs Market, By Prophylaxis, By Value, 2017-2022 (USD Million) 140
Figure 27: U.S. Migraine Drugs Market, By Value, 2012-2016 (USD Billion) 142
Figure 28: U.S. Migraine Drugs Market, By Value, 2017-2022 (USD Billion) 142
Figure 29: U.S Adult Migraine Patients, In Percentage 143
Figure 30: U.S Migraine Patients, By gender, In Percentage 143
Figure 31: U.K Migraine Drugs Market, By Value, 2012-2016 (USD Billion) 144
Figure 32: U.K. Migraine Drugs Market, By Value, 2017-2022 (USD Billion) 144
Figure 33: U.K. Migraine Patient, In Percentage 145
Figure 34: NHS Budget for mental illness, In Billion 145
Figure 35: Japan Migraine Drugs Market, By Value, 2012-2016 (USD Billion) 146
Figure 36: Japan Migraine Drugs Market, By Value, 2017-2022 (USD Billion) 146
Figure 37: Japan Migraine Patient out of total population, In Percentages 147
Figure 38: France Migraine Drugs Market, By Value, 2012-2016 (USD Billion) 148
Figure 39: France Migraine Drugs Market, By Value, 2017-2022 (USD Billion) 148
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14. (c) AZOTH Analytics
List of Figures
Figure No. Figure Title Page No.
Figure 40: France Migraine Patient, In Percentage 149
Figure 41: Unemployment rate in France in percentage 149
Figure 42: Italy Migraine Drugs Market, By Value, 2012-2016 (USD Billion) 150
Figure 43: Italy Migraine Drugs Market, By Value, 2017-2022 (USD Billion) 150
Figure 44:
Italy Migraine Patient out of total population, In Percentages
151
Figure 45: Italy Unemployment rate, In Percentages 151
Figure 46: Germany Migraine Drugs Market, By Value, 2012-2016 (USD Billion) 152
Figure 47: Germany Migraine Drugs Market, By Value, 2017-2022 (USD Billion) 152
Figure 48: Germany Migraine Patient out of total population, In Percentages 153
Figure 49: First Time asylum application, In Number 153
Figure 50: ROW Migraine Drugs Market, By Value, 2012-2016 (USD Billion) 154
Figure 51: ROW Migraine Drugs Market, By Value, 2017-2022 (USD Billion) 154
Figure 52: ROW Migraine Drugs Market, By Value, 2017-2022 (USD Billion) 165
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15. (c) AZOTH Analytics
Research Methodology
For our study of Migraine Drugs Market, we have conducted comprehensive secondary research
followed by an extensive primary research. In the process of secondary research, we have scrutinized
industry documents, accessed from open sources, premium paid databases (Bloomberg, Thomson
Reuters, Factiva) and our internal knowledge base. In the process of primary research, we have
interviewed various industry experts across the value chain of the Migraine Drug industry.
For evaluating the market size of pipeline drugs, both primary and secondary research has been
conducted to validate the launch date, anticipated price and growth in the number of patients.
Market size of the actual period (2012-2016) has been evaluated on the basis of growth trends of
the industry in the last five years, and confirming the findings through primary research. Annual
reports of the companies are scanned to further validate the market size and to estimate the size of
migraine drugs. All the relevant data points/ statistics in the forecast period are validated through
relevant and reliable primary sources.
Report Focus: Global Migraine Drugs Market
- Migraine Pipeline Drugs (Drug X-1, X-2, X-3, X-4, X-5, X-6, X-7)
- By Type (Acute and Prophylaxis)
- By Country (U.S., U.K, Japan, France, Italy, Germany)
- Company Coverage (Amgen, Allergan, Eli Lilly, Alder Pharmaceuticals, Teva Pharmaceutical, Vernalis,
Pfizer, Impax Laboratories, Glaxo Smithkline)
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16. (c) AZOTH Analytics
2019 2020 2021 2022
Source: Azoth Analytics Estimates
CAGR 2019-2022
X%
Figure 14: Global Drug X-1 Market Size, By Value, Forecast, 2019-2022 (USD Million)
Global Fremanezumab Market
115
Xx
Xx
Xx
Xx
Xx
Xx
Xx
Xx
18. (c) AZOTH Analytics
Global Migraine Drugs Market: Sizing and Growth (2012-2016)
Source: Azoth Analytics Estimates
Xx
Xx
Xx
Xx
Xx
Xx
Xx
Xx
Increase in Global Stress levels coupled with growing awareness regarding migraine and availability of its
drugs propelled growth in migraine drugs market.
2012 2013 2014 2015 2016
Figure 18: Global Migraine Drugs Market Size, By value, 2012-2016 (USD Billion)
CAGR 2012-2016
X%
131
19. (c) AZOTH Analytics
Global Heart Valve Replacement Devices Market, By Value
Figure 27: U.S. Migraine Drugs Market, By Value,
2012-2016 (USD Billion)
Source: Azoth Analytics Estimates
CAGR 2012-2016
X%
CAGR 2017-2022
X%
Figure 28: U.S. Migraine Drugs Market, By Value,
2017-2022 (USD Billion)
U.S. Migraine Drugs Market
2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022
142
Xx
Xx
Xx
Xx
Xx
Xx
Xx
Xx
20. (c) AZOTH Analytics
About Azoth Analytics Pvt Ltd.
Azoth Analytics is a business research and analytics firm that creates in-depth research reports and provides customized research solutions and consultancy
Application. Verticals in which Azoth Analytics specializes include healthcare and pharmaceutical, oil and gas, retail, chemicals, automotive, FMCG, food &
beverages and technology. Azoth creates comprehensive and in-depth research reports by recording, interpreting and analyzing information. Strategic
market sizing and data dredging techniques include secondary research, and primary research (interviews with management personnel and industry experts).
Disclaimer: Azoth Analytics report information is based mainly on interviews and therefore, is subject to fluctuation. Azoth Analytics therefore, takes no responsibility for
any incorrect information supplied to us by industry experts, manufacturers or users. Azoth does not warranty the completeness of the information and data. Also, analysis
provided in the report are meant for customers’ internal use only and not for general publication or disclosure to third parties.
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