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RECENT ADVANCES IN
TUBERCULOSIS PROGRAMME
Presenters: Avantika Gupta
L.Tarakishwor Singh
Moderator: Prof. Romola P
OUTLINE
Burden
Timeline
End TB
strategy
Goals &
Objectives
NSP 2020-2025
Pillars
Conclusion
In 2019, an estimated 10 million people fell ill with
TB worldwide
1.4 million people died from TB
Eight countries account for two thirds of the total,
with India leading the count
TB incidence is falling at about 2% per year
Present rate of ~3% annual
decline needs to be accelerated
to ~11% to achieve 2030 SDG
targets by 2025
OUTLINE
Burden
Timeline
End TB
strategy
Goals &
Objectives
NSP 2020-2025
Pillars
Conclusion
TIMELINE
1962
National TB Control Program started
with the aim to detect cases at earliest
& treat them
1992
WHO and SIDA evaluated the NTCP
1993 • NTP revised to RNTCP
• WHO declared TB as global
emergency
• DOTS strategy adopted
1997 Large scale implementation of
RNTCP began in phased
manner
1998
• Phase I RNTCP (1998-2005)
• Focus: Expansion of quality
DOTS services to the entire
country
• Sep: RNTCP implemented in
Imphal, Manipur
2002
RNTCP covered state of
Manipur
2006
• India achieved country wide
coverage under RNTCP in
March
• Phase II RNTCP (2006-2012)
• DOTS PLUS
2012
• Phase III RNTCP (2012-2017)
• National Strategic Plan (NSP)
2012-2017 was documented with
the goal of ‘universal access to
quality TB diagnosis and
treatment for all TB patients in
the community’
• Mandatory notification of TB
• NIKSHAY
2017
NSP 2017-2025
2018
13th March:
“TB Free India
Campaign”
2018
25th Sep:
“TB Harega, Desh
Jeetega”
2019
11th – 22nd Nov:
WHO-GoI
JMM two week
intensive review
of TB program
in India
2020
• 1st Jan:
RNTCP
renamed
NTEP
• NSP 2020-
2025
CHALLENGES
JOINT MONITORING MISSION, 2019
Only 6%
annually
28% case
notification
from private
sector
Vacancy rate (%) for
state level positions
OUTLINE
Burden
Timeline
End TB
strategy
Goals &
Objectives
NSP 2020-2025
Pillars
Conclusion
Adaptation of the strategy and targets at country level, with global
collaboration
Protecting & promoting human rights, ethics and equity
Building a strong coalition with civil society & communities
Gvt. Stewardship & accountability, with monitoring & evaluation
Integrated,
patient-
centred TB
care and
prevention
Bold policies
& supportive
systems
Intensified
research &
innovation
Pillars
Principles
OUTLINE
Burden
Timeline
End TB
strategy
Goals &
Objectives
NSP 2020-2025
Pillars
Conclusion
• To cure ≥ 85% of all newly detected infectious
cases of pulmonary TB
• To detect ≥ 70% of estimated new smear +ve
pulmonary TB cases
OBJECTIVES
• To reduce mortality and morbidity from TB
• To interrupt chain of transmission until TB
ceases to be a public health problem in India
GOALS
To reduce incidence of TB & mortality due to TB
To prevent emergence of drug resistance & effectively manage drug
resistant TB
To improve outcomes among HIV-infected TB patients
To involve private sector
To decentralize & align RNTCP management units with NHM block
level units within general health system
NEW OBJECTIVES
OUTLINE
Burden
Timeline
End TB
strategy
Goals &
Objectives
NSP 2020-2025
Pillars
Conclusion
GOAL:
To achieve a rapid decline in
burden of TB, morbidity &
mortality to achieve the SDG of
80% ↓ in incidence and 90% ↓ in
deaths by 2025
VISION:
TB-Free India with zero deaths,
disease and poverty due to TB
Impact Indicators:
Outcome Indicators:
44
OBJECTIVES
Build, strengthen and sustain enabling policies,
empowered institutions, multi-sectoral collaborations,
engaged communities, and human resources with
enhanced capacities to create a supportive ecosystem
Prevent the emergence of TB in vulnerable
populations
Initiate & sustain, equitable access to free high quality
TB treatment, care and support services
Early identification of presumptive TB, at the
first point of contact & prompt diagnosis
B-P-D-T
(NSP 2020-2025)
D-T-P-B
(NSP 2017-2025)
OUTLINE
Burden
Timeline
End TB
strategy
Goals &
Objectives
NSP 2020-2025
Pillars
Conclusion
TB FREE INDIA
USD 201 million
(Jan 2018 – March 2021)
USD 280 million
(April 2021 – March 2024)
“RNTCP World Bank IBRD
USD 500 million” project
moving towards elimination of
TB 2018-2025
Update terms of reference (TOR)
Leverage Health System
Training
Human resource recruitment agencies
Health worker surveillance
National fellowship & experiential learning program
National TB Policy & TB bill
• Accelerate efforts
• Contextual strategies
• Generate healthy competition
• Recognition
Sub-national certification of disease
free status
Sub-national certification of disease free status
Award
categories
Criteria: decline
in incidence rate
compared to 2015
Monetary
award for
district (Rs)*
Monetary
award for
state (Rs)*
Non-monetary
award
Bronze 20% 2 lakh 25 lakh Medal &
felicitation at
national level
Silver 40% 3 lakh 50 lakh
Gold 60% 5 lakh 75 lakh
TB Free
State/
District
80% 10 lakh 1 crore
Certification &
felicitation at
national level
*For states/ UTs with population <50 lakh & districts <2 lakhs, award shall be 50% of
the amounts considered
One district (Budgam, J&K) and one UT (Lakshadweep)
were declared TB Free on 24 Mar 2021
National TB Policy & TB bill
Sub-national certification of disease free status
Gazette on TB notification
• Provision of 269 &
270 IPC
• Jail from 6 months
to 2 yrs or a fine or
both
Direct benefit transfer schemes
Nikshay Poshan Yojana
(NPY)
Incentive to Treatment
supporters/ DOTS
providers
Transport incentive to
Tribal TB patients
Notification incentive to
private providers
DBT
Introduced in April 2018
Beneficiary
All notified TB patients for
duration of treatment
Objective
To provide financial incentive
for nutritional support to TB
patients from time of
notification
Benefit
amount
Rs 500/month during course of
treatment
Incentive to Treatment
supporters/ DOTS
providers
Beneficiary
Community Treatment
supporters
Objective To provide honorarium
Benefit
amount
• Rs 1000 on update of
outcome for drug sensitive
TB patients
• Rs 2000 on completion of
IP & Rs 3000 on
completion of CP
Notification incentive to
private providers
Beneficiary
Private providers who notify TB
patients to NTEP
Objective To provide financial incentives
Benefit
amount
• Rs 500 as one- time payment
on notification
• Rs 500 for updating patient’s
treatment outcome
Transport incentive to
Tribal TB patients
Beneficiary
All notified TB patients from
Notified Tribal areas
Objective
To provide financial support for
transportation
Benefit
amount
Rs 750 as one-time payment at
time of notification
Fast tracking DBT under NTEP:
• CTD introduced Digital Signature Certificate
(DSC) in year 2019, to ensure that DBT
beneficiaries get their due benefits much quicker
• 82% districts have implemented DSC
National TB Policy & TB bill
Sub-national certification of disease free status
Gazette on TB notification
Expedite setting up of governance & management structures to
State & district level
Direct benefit transfer schemes
MoHFW
Central TB Division
State TB Cell
District TB Centre (DTC)
TB Unit (TU)
TB Diagnostic Centres
(TDCs)
TB treatment centres (DOT)
ORGANOGRAM
National level
State level
District level
Sub-district level
PHC/BPHC
HWCs
National TB
Elimination
Board
State TB
Elimination
Board
District TB
Elimination
Board
Block TB
Elimination
Board
“MISSION MODE”
25th Sep, 2020:
M/o Labour & Employment
8th Oct, 2020:
M/ o Department of North Eastern
region
Two latest MoUs signed
Incentives through DBT
Joint Effort for Elimination of TB (JEET)
15th May, 2018 (Delhi launch)
OBJECTIVE:
To set up effective and sustainable structures to
strengthen existing systems and seamlessly extend
quality TB care to patients in the private sector
JEET efforts during COVID-19:
• Advocacy & facilitation of case finding strategies
 Bidirectional screening
 Outreach
 Establishing linkages
• Treatment services
• Patient support services
• Direct Benefit Transfer (DBT)
Incentives
Joint Effort for Elimination of TB (JEET)
15th May, 2018 (Delhi launch)
Corporate TB Pledge (CTP) initiative (April, 2019)
Silver
Commitment
Gold
Commitment
Awareness
Platinum
Commitment
Awareness
Investment
Diamond
Commitment
Awareness
Investment
Champion
Offers a tiered approach for
corporates to use their
resources (human and
financial), to combat TB, raise
awareness & ultimately
improve TB health outcomes
Apollo Tyres Foundation organized
“TB free transhipment locations”
campaign for reaching out to trucking &
migrant communities of India
• 2 week campaign at 31 different
locations in 19 states
• Of 1310 TB facilitated during
campaign, 52 TB patients were
identified and put on treatment
Institutional mechanism of
community led response
•These forums have
representation of
people affected by
TB, elected
representatives,
policy makers,
CSO/ NGOs &
program managers
By end of 2019, TB forums constituted in >700 (99%)
districts across country
TB
treatment
literacy Advocacy
Counselling
&
mentoring
Health
financing
Programme
planning
Implementation
Monitoring
& review
TB champions
TB survivors
Engaging
existing
community
groups
Tb survivor led
networks in 6
states & national
level
In partnership with NTEP,
working towards integrating TB
services at AB-HWCs
Operational guidelines
launched on 28th Dec, 2020
Collaborative framework for
management of TB in
pregnancy (to be launched in
2021)
Learning resource package
for training of CHOs
(to be rolled out in 2021)
Vulnerability score cards for
differential TB care
Rebranding RNTCP
Red colour:
beginning,
emotions &
energy
yellow colour:
protection
Objectivity
Swirl of flag:
Pride of all
Focus of the
programme
Human figure:
celebration,
positivity &
success
Signifies bigger
picture
Rebranding RNTCP
National photo exhibition “Courage & Resilience”
Media engagement-National media sensitization workshop
Television
New India
Sankalp-2 on TB
(12th Feb,2020)
MTV NISHEDH
“Alone Together”
27th Nov, 2020
Radio: Popularizing Free diagnosis, drugs & NPY
Advocacy for industry
17th Aug, 2020
Nikshay Patrika Newsletter
Nikshay Patrika Newsletter:
A significant
communication tool to
build, motivate, raise
awareness, learnings &
achievements
Pledge for TB Free India
CTD collaborated with MyGov
platform for all citizens to
pledge to make every village,
district, state and country TB
free under initiative “TB
Harega, Desh Jeetega”
Online review of program performance to
overcome impact of COVID-19
National TB prevalence survey: 25th Sep, 2019
• Buses will serve as fully-
equipped mobile clinics,
with trained staff , backed
by a chain of reference
laboratories
State TB Index: A composite measure of the program’s performance
has been developed
• CTD assesses the states/UTs achievements & performances
using 9 key indicators
• Maximum total score of 100
1. Studies on strengthening surveillance & TB notifications
2. Studies for improvement of TB disease burden estimation; improved TB
diagnostics including childhood TB and EPTB
3. Studies on TB transmission and its interruption
4. Related to systematic screening of high-risk groups and intensified case findings
5. DR-TB management
6. Cascade of care in public & private sector
7. Preventive therapy
8. Socio-economic impact & poverty alleviation
9. Strengthening NTEP management
10. TB therapeutics (recurrent re-infection TB)
11. Co-morbidity studies
12. Lab, supply chain, sample transportation
13. ACSM
14. Collaborative studies with other ministries
RESEARCH PRIORITIES 2020
(MoHFW)
CTD
ICMR
NIRT
Non-
NTEP
ITRC
BRICS
66 proposals were received
by 20th Noc,2020
a. DST on newer drugs
b. NTBP Survey
c. Accuracy of 99 DOTS
d. Phase III RCT to evaluate
efficacy & safety of two
vaccines
 VPM1002
 Immuvac (Mw)
e. Airborne Infection Control
(AIC) practices in health
facilities
a. TB STAMP (TB Screen,
Track & Map Project)
b. Value TB project
c. RATIONS (Reducing
Activation of TB by
Improvement Of
Nutritional Status)
4 thematic areas:
1. Therapeutics
2. Diagnostics
3. Vaccines
4. Implementation Research
BRICS Countries (Brazil, India, China,
Russia & South Africa) established
collaborative TB research network
Nikshay Aushadhi
Launched on 24th
March, 2018:
Electronic drug
distribution
management system
To enable real time
visibility into stock
status at all levels and
enable forecasting,
quantification &
further distribution of
TB drugs and
diagnostics
Procurement &
supply chain
managemnet Quantification
and Forecasting
Monitoring and
Distribution
Recording and
Reporting
Data
Management
and Analysis
Training and
Capacity
Building
3PL system (Third party logistic system)
NSP 2020-2025 will aggressively pursue the
expansion of the digital information
ecosystem over the next five years
Vision: To create a digital information ecosystem where information is
captured in real time, processed and visualized, enabling efficient service
delivery and responsive program management, driving TB Elimination in
India and all over the world
NIKSHAY SAMPARK
• National TB Call Centre for TB helpline
managed by CTD (May 2018)
• Operating from two sites
 Noida
 Mumbai
• 7 days/ week (7am to 11pm)
Services provided:
Resolving queries related to TB
Reporting & management of TB services related grievances
Resolving queries related to Hepatitis under NVHCP
Tele-counselling
Feedback on NTEP services
COVID-19 (Toll Free 1075 since 16th March, 2020)
Sep 2018, CTD launched enhanced vision of Nikshay
Establish the National
Knowledge Cell under
Central TB Division
Strengthening TSN & make TA responsive
to emerging TB landscape in India
Extend TA to other ministries
Expedite establishment of planned TSUs
Create a platform to enlist & provide information on available TA
experts
All partner organizations (health economics, digital health etc) under
one umbrella of WHO-TSN consultants network
• To aim for equitable, rights-based TB services for women, men and
transgender persons by adopting a gender-specific programmatic approach at
all levels
• To mobilise, empower and engage women, men and transgender persons in
the TB response at the health system and community levels
Framework for addressing stigma
Data from Nikshay TB
notification system for
April to Aug 2020, in
comparison to similar
data for 2019
Number of patients with
TB registered on DOTS
and completed
treatment, in India’s
NHM-HMIS for the Jan
to June 2020 period, in
comparison to similar
data for 2019
Modelling analysis project:
Additional 6.3 mil cases of TB
& 1.4 mil TB deaths
attributable to COVID-19
between 2020 & 2025
Manipur
Total notification Jan-Feb 2020 (A) 430
Total notification Mar-April 2020 (B) 207
Total notification May-Dec 2020 (C) 926
% decrease between B & A 52%
% increase between C & B 11%
Diagnostic
algorithm
Case
finding-
public &
private
sector
Sample
collection &
transportation
services
Treatment
services
Patient
support
services
Provider
support
services
DBT
services
Demand
generation
activities
Rationale
use of
PPE
Monitoring,
surveillance
& evaluation
Program
management,
administrative
support
TB FREE INDIA
TB Preventive Treatment (TPT) &
Programmatic Management of TPT
(PMTPT)
Airborne Infection Control (AIC)
TB Preventive Treatment (TPT) & Programmatic Management of TPT
(PMTPT)
In September 2018, countries committed to
provide TPT to at least 30 million individuals
by 2022, including 24 mil household contacts
of TB patients and 6 mil PLHIV
TB Preventive Treatment (TPT) & Programmatic Management of TPT
(PMTPT)
In 2020, NTEP plans saturation of TPT & monitoring in:
• PLHIV
• Paediatric contact of active TB patients
• Additional inclusion of
 Asymptomatic contact of all ages
 Patient with silicosis
 Immunosuppressive therapy
 Anti-TNF treatment
 Dialysis
 Transplantation
Fast track approvals & phase wise capacity augmentation for
detection of LTBI:
• TST
• 4th generation IGRA
Rapidly adopt & scale-up use of shorter rifamycin based TPT
regimen:
• 3HP (3 months of Isoniazid + Rifapentine)
• 1HP ( 1 month of Isoniazid + Rifapentine)
• 3HR (3 months of Isoniazid + Rifampicin)
• 4R (4 months of Rifampicin)
• Rapid scale up to reach 5 mil/yr
• Establish TB prevention cell at national & state level
• Integrate TB preventive services in all ACF efforts
• Financial incentives for complete coverage
• Strengthening monitoring & evaluation by ensuring capture of
data for TPT in:
 Nikshay platform
 Scaling of digital tools: LTBI mobile app
Airborne Infection Control (AIC)
Revise AIC
guidelines
in line with
NTEP
AIC as
necessary
clause in
NABH
accreditation in
private sector
Leverage
ongoing
initiatives
(HWCs,
Kayakalp)
AIC
helpdesk
Sustained
national
campaign in
education
institutions
Provide
AIC kits
to all TB
patients
TB FREE INDIA
Evolution of strategies for improving case finding
TB Co morbidities
Launch by MoHFW and MoTA with technical
assistance by USAID
In the tribal districts of the states under fifth
schedule and tribal districts of NE states under
sixth schedule
TB vulnerability mapping and periodic TB-
Active case finding drives of all individuals in
all tribal districts
Provision of Isoniazid preventive
therapy(IPT)
Improving the operational efficiency of
Village Health Sanitation
Nutrition days
Jan Arogya Samiti plateform
Jan Andolan initiative
Engaging TB champions
Training of faith healers
Linking of Swasthya with Nikshay
Notified TB patient get Rs.750 at the time of notification
Join TB-Diabetes collaboration
• Collaboration with NTEP and NPCDCS
• Bidirectional screening of TB and Diabetes Mellitus
• TB patient linked to anti diabetic treatment
Join TB-HIV collaboration
• Collaboration with NTEP and NACO
• In 2019, TB-HIV collaboration committee was restructured by MoHFW to
form a TB Co-morbidity collaborative committee at National, State and
District level
• Bidirectional screening of TB and HIV
• During the routine outreach services of HIV, team member screen HRG and
bridge populations for TB symptoms and refer to the nearest TB center for
diagnosis and treatment
• “Single window” services for TB and HIV
• Gazette notification by GoI dated 28th October 2020 about the
mandatory requirement of ART centers and Drug resistant TB services
in all Medical colleges
TB-Tobacco
• Collaboration between NTEP and NTCP
• Tobacco used status were identified among TB patient and linked to
tobacco cessation services
Childhood TB
• NTEP collaboration with Child Health Programme in the country (RBSK and
RKSK)
• Screening of children in the age group(0-18 years) will be done through
Mobile health teams of RBSK and Adolescent Friendly Resource centres of
RKSK
NTEP-COVID-19
TB FREE INDIA
Classification of TB diagnosis
1. Drug sensitive TB
2. H mono/ poly DR-TB
3. MDR/RR TB
4. XDR TB
National strategic plan(2020-2025)
Diagnosis
• Rapid transition of TB diagnosis from smear microscopy to molecular testing
using NAAT right up to the Block level
• Introduction of Point of care (POC) sequencing platform
• Roll out the use of novel skin test like C-Tb to support the diagnosis of
pediatric TB( replacement for PPD based TST)
• Introduction of next generation whole genome sequencing
Treatment
Pan country roll out of injectible free regimen for DS-TB
Post treatment follow up till 2 years after completion of the anti-TB
treatment
Digital adherence technologies to inform and enable more
differentiated patient care
Recommended daily dose regimen for drug sensitive TB
Adult
Intensive phase
4 FDC (2 months)
Isoniazide(H)
Rifampicin(R)
Pyrazinamide(Z)
Ethambutol(E)
 Continuation phase
3 FDC (6 months)
HRZ
Children
Intensive phase
3 FDC (2 months)
 HRZ
Continuation phase
2 FDC (6 months)
 HR
Shorter oral bedaquiline-containing MDR/RR-TB regimen
Inclusion criteria
1.DST based inclusion criteria
Rifampicin resistance detected/inferred
MDR/RR-TB with H resistance detected/ inferred based on InhA mutation
only or based on KatG mutation only (not both)
MDR/RR-TB with FQ resistance not detected
2.Other inclusion criteria
 Children, aged 5 years to less than 18 years of age and weighing at least
15 kg, given their special needs, in consultation with the pediatrician
 No history of exposure to previous treatment with second-line medicines
in the regimen(Bdq, Lfx, Eto or Cfz) for > 1 month
 No extensive TB disease
 No severe extra-pulmonary TB
 Women who are not pregnant or lactating
Exclusion criteria
1. DST based exclusion criteria
 MDR/RR-TB patients with H resistance detected with both KatG and
InhA mutation; and
 MDR/RR-TB patients with FQ resistance detected
Exclusion criteria
2.Other exclusion criteria
If result for FL-LPA, SL-LPA and DST to Z,BDQ & Cfz is not available
after pre-treatment evaluation is completed and it is a time to initiate the
first dose of the regimen, then, excluded those with history of exposure
for>1 month to Bdq, Lfx, Eto or Cfz
Intolerence to any drug or risk of toxicity from a drug in shorter oral
Bedaquiline containing MDR/RR-TB regimen
 Extensive TB disease found in presence of bilateral cavitary disease or
extensive parenchymal damage on chest radiography
 In children aged under 15 yrs, presence of cavities or bilateral disease on
chest radiography
 Severe EP-TB disease where there is a presence of military TB or TB
meningitis or CNS TB. In children aged under 15 yrs, extrapulmonary
forms of ds other than lymphadenopathy
 Pregnant and lactating women
 Children below 5 years
Shorter oral bedaquiline-containing MDR/RR-TB regimen
• From start to end of 4 months-Bdq, Lfx, Cfz, Z, E, Hh ,Eto
• From start of 5 months to end of 6 months-(If IP not extended)
-Bdq, Lfx, Cfz, Z, E
• From start of 6 months to end of 9 months-Lfx, Cfz, Z, E
• If the IP is extended upto 6 months then all 3 drugs Bdq, Hh and Eto are
stopped together
(4-6) Bdq(6 m), Lfx, Cfz, Z, E, Hh, Eto (5)Lfx, Cfz, Z, E
Grouping of anti-TB drugs & steps for designing long MDR-TB regimen
Groups & Steps Medicine Abbreviation
Group A Levofloxacin or Lfx
Include all three medicines Moxifloxacin Mfx
Bedaquiline Bdq
Linezolid Lzd
Group B Clofazimine Cfz
Add one or both medicines Cycloserine or Cs
Terizidone Tr
Grouping of anti-TB drugs & steps for designing long MDR-TB regimen
Groups & Steps Medicine Abbreviation
Group C Ethambutol E
Add to complete the
regimen and when
medicines from group A &
B cannot be used
Delamanid Dlm
Pyrazinamide Z
Imipenem-cilastatin or Ipm-Cln
Meropenem Mpm
Amikacin Am
(or Streptomycin) S
Ethionamide or Eto
Prothionamide Pto
p-aminosalicylic acid PAS
Longer oral M/XDR-TB regimen
• It is of 18 -20 months with no separate IP or CP
• Dose of Lzd will be tapered to 300 mg after the initial 6-8 months of treatment
• Bdq will be given for 6 months and extended beyond 6 months as an exception
• Pyridoxine to be given to all DR-TB patients as per weight band
• For XDR-TB patients the duration of longer oral XDR-TB regimen would be for
20 months
(18-20) Lfx, Bdq(6 month or longer), Lzd, Cfz, Cs
Management of MDR-TB patients during pregnancy
Bedaquiline,Pretomanid,Linezolid (BPaL) regimen
• Bpal regimen for MDR-TB with additional fluoroquinolones resistance
• Duration: 6-9 months
• Used under operational research conditions to TB patient who have either no
previous exposure to bedaquiline and linezolid or have been exposed for no
more than 2 weeks
Bedaquiline,Pretomanid,Linezolid (BPaL) regimen
Dosage
• Pretomanid - 200 mg once daily for 26 weeks
• Bedaquiline - 400 mg once daily for the first 2 weeks and then 200 mg three
times/ week for 24 weeks
• Linezolid – 1200 mg once daily for 24 weeks
OUTLINE
Burden
Timeline
End TB
strategy
Goals &
Objectives
NSP 2020-2025
Pillars
Conclusion
170
148
120
199
44
0
50
100
150
200
250
2019 2020 2021 2022 2023 2024 2025
Inciddence
rate
(cases
per
100,000
population)
Scenario I Scenario II Scenario III Scenario SDG
NTEP impact modelling
Scenario 1: Sustained service delivery at the current trends with available tools
Scenario 2: Scale-up of existing strategies and introduction of newer tools
Scenario 3: Accelerated expansion of existing and newer tools
Scenario SDG: Newer vaccine, drugs, diagnostics, and non-pharmaceutical interventions
- Highest level of political &
administrative commitment
- State strategic plans based on NSP
- Much greater financial resources
- Availability of new drugs, regimens,
diagnostics, approaches
- Insufficient human resources
- Low coverage of basic program services
for those accessing care in private sector
- Addressing social determinants of TB
- COVID-19 pandemic response focus
attention on Respiratory Diseases
- Integration with other ministries
- Enforcement of mandatory notification
- Expansion of AB-PMJAY to cover TB
- Innovative solutions
• - Insufficient budgetary outlay for
health in national budgets
• - COVID-19 derailing efforts of TB
programs
• - Economic slowdown owing to
lockdown
SWOT
1. MoHFW. National multisectoral action framework for TB- free India. New Delhi:MoHFW;2020 [cited
2021 May 15]. Available from: https://tbcindia.gov.in/showfile.php?lid=3525
2. MoHFW. Guidelines on Airborne Infection Control in Healthcare and Other Settings. New
Delhi:MoHFW;2010 [cited 2021 May 14]. Available from:
https://tbcindia.gov.in/index1.php?lang=1&level=1&sublinkid=4519&lid=3015
3. Ministry of tribal affairs government of India. Improving the cascade of TB care and support services
among Tribal Populations in India. New Delhi:MoHFW;2020.[cited 2021 May 16]. Available from:
https://tbcindia.gov.in/WriteReadData/l892s/5883826004Tribal%20TB%20Initiative.pdf
4. MoHFW. Guidelines for programmatic management of drug resistant tuberculosis in India. New
Delhi:MoHFW;2021. [cited 2021 May 16]. Available from:
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6. Shrinivasan R, Rane S, Pai M. India’s syndemic of tuberculosis and COVID-19. BMJ Global
Health. 2020;5:e003979. Available from: doi:10.1136/bmjgh-2020-003979
7. 7. MoHFW. National strategic plan for tuberculosis: 2017-25 elimination by 2025. New
Delhi:MoHFW; 2017. [cited 2021 May 16]. Available
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8. 8. Sharma DC. India launches tuberculosis prevalence survey. Lancet Respir Med. 2019;S2213-
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Recent updates in TB programme

  • 1. RECENT ADVANCES IN TUBERCULOSIS PROGRAMME Presenters: Avantika Gupta L.Tarakishwor Singh Moderator: Prof. Romola P
  • 3. In 2019, an estimated 10 million people fell ill with TB worldwide 1.4 million people died from TB Eight countries account for two thirds of the total, with India leading the count TB incidence is falling at about 2% per year Present rate of ~3% annual decline needs to be accelerated to ~11% to achieve 2030 SDG targets by 2025
  • 5. TIMELINE 1962 National TB Control Program started with the aim to detect cases at earliest & treat them 1992 WHO and SIDA evaluated the NTCP 1993 • NTP revised to RNTCP • WHO declared TB as global emergency • DOTS strategy adopted 1997 Large scale implementation of RNTCP began in phased manner 1998 • Phase I RNTCP (1998-2005) • Focus: Expansion of quality DOTS services to the entire country • Sep: RNTCP implemented in Imphal, Manipur 2002 RNTCP covered state of Manipur 2006 • India achieved country wide coverage under RNTCP in March • Phase II RNTCP (2006-2012) • DOTS PLUS 2012 • Phase III RNTCP (2012-2017) • National Strategic Plan (NSP) 2012-2017 was documented with the goal of ‘universal access to quality TB diagnosis and treatment for all TB patients in the community’ • Mandatory notification of TB • NIKSHAY 2017 NSP 2017-2025 2018 13th March: “TB Free India Campaign” 2018 25th Sep: “TB Harega, Desh Jeetega” 2019 11th – 22nd Nov: WHO-GoI JMM two week intensive review of TB program in India 2020 • 1st Jan: RNTCP renamed NTEP • NSP 2020- 2025
  • 6. CHALLENGES JOINT MONITORING MISSION, 2019 Only 6% annually 28% case notification from private sector Vacancy rate (%) for state level positions
  • 8.
  • 9. Adaptation of the strategy and targets at country level, with global collaboration Protecting & promoting human rights, ethics and equity Building a strong coalition with civil society & communities Gvt. Stewardship & accountability, with monitoring & evaluation Integrated, patient- centred TB care and prevention Bold policies & supportive systems Intensified research & innovation Pillars Principles
  • 11. • To cure ≥ 85% of all newly detected infectious cases of pulmonary TB • To detect ≥ 70% of estimated new smear +ve pulmonary TB cases OBJECTIVES • To reduce mortality and morbidity from TB • To interrupt chain of transmission until TB ceases to be a public health problem in India GOALS
  • 12. To reduce incidence of TB & mortality due to TB To prevent emergence of drug resistance & effectively manage drug resistant TB To improve outcomes among HIV-infected TB patients To involve private sector To decentralize & align RNTCP management units with NHM block level units within general health system NEW OBJECTIVES
  • 14. GOAL: To achieve a rapid decline in burden of TB, morbidity & mortality to achieve the SDG of 80% ↓ in incidence and 90% ↓ in deaths by 2025 VISION: TB-Free India with zero deaths, disease and poverty due to TB
  • 16. OBJECTIVES Build, strengthen and sustain enabling policies, empowered institutions, multi-sectoral collaborations, engaged communities, and human resources with enhanced capacities to create a supportive ecosystem Prevent the emergence of TB in vulnerable populations Initiate & sustain, equitable access to free high quality TB treatment, care and support services Early identification of presumptive TB, at the first point of contact & prompt diagnosis B-P-D-T (NSP 2020-2025) D-T-P-B (NSP 2017-2025)
  • 19. USD 201 million (Jan 2018 – March 2021) USD 280 million (April 2021 – March 2024) “RNTCP World Bank IBRD USD 500 million” project moving towards elimination of TB 2018-2025
  • 20. Update terms of reference (TOR) Leverage Health System Training Human resource recruitment agencies Health worker surveillance National fellowship & experiential learning program
  • 21. National TB Policy & TB bill • Accelerate efforts • Contextual strategies • Generate healthy competition • Recognition Sub-national certification of disease free status
  • 22. Sub-national certification of disease free status Award categories Criteria: decline in incidence rate compared to 2015 Monetary award for district (Rs)* Monetary award for state (Rs)* Non-monetary award Bronze 20% 2 lakh 25 lakh Medal & felicitation at national level Silver 40% 3 lakh 50 lakh Gold 60% 5 lakh 75 lakh TB Free State/ District 80% 10 lakh 1 crore Certification & felicitation at national level *For states/ UTs with population <50 lakh & districts <2 lakhs, award shall be 50% of the amounts considered One district (Budgam, J&K) and one UT (Lakshadweep) were declared TB Free on 24 Mar 2021
  • 23. National TB Policy & TB bill Sub-national certification of disease free status Gazette on TB notification • Provision of 269 & 270 IPC • Jail from 6 months to 2 yrs or a fine or both Direct benefit transfer schemes
  • 24. Nikshay Poshan Yojana (NPY) Incentive to Treatment supporters/ DOTS providers Transport incentive to Tribal TB patients Notification incentive to private providers DBT Introduced in April 2018 Beneficiary All notified TB patients for duration of treatment Objective To provide financial incentive for nutritional support to TB patients from time of notification Benefit amount Rs 500/month during course of treatment Incentive to Treatment supporters/ DOTS providers Beneficiary Community Treatment supporters Objective To provide honorarium Benefit amount • Rs 1000 on update of outcome for drug sensitive TB patients • Rs 2000 on completion of IP & Rs 3000 on completion of CP Notification incentive to private providers Beneficiary Private providers who notify TB patients to NTEP Objective To provide financial incentives Benefit amount • Rs 500 as one- time payment on notification • Rs 500 for updating patient’s treatment outcome Transport incentive to Tribal TB patients Beneficiary All notified TB patients from Notified Tribal areas Objective To provide financial support for transportation Benefit amount Rs 750 as one-time payment at time of notification Fast tracking DBT under NTEP: • CTD introduced Digital Signature Certificate (DSC) in year 2019, to ensure that DBT beneficiaries get their due benefits much quicker • 82% districts have implemented DSC
  • 25. National TB Policy & TB bill Sub-national certification of disease free status Gazette on TB notification Expedite setting up of governance & management structures to State & district level Direct benefit transfer schemes
  • 26. MoHFW Central TB Division State TB Cell District TB Centre (DTC) TB Unit (TU) TB Diagnostic Centres (TDCs) TB treatment centres (DOT) ORGANOGRAM National level State level District level Sub-district level PHC/BPHC HWCs National TB Elimination Board State TB Elimination Board District TB Elimination Board Block TB Elimination Board
  • 27. “MISSION MODE” 25th Sep, 2020: M/o Labour & Employment 8th Oct, 2020: M/ o Department of North Eastern region Two latest MoUs signed
  • 28. Incentives through DBT Joint Effort for Elimination of TB (JEET) 15th May, 2018 (Delhi launch) OBJECTIVE: To set up effective and sustainable structures to strengthen existing systems and seamlessly extend quality TB care to patients in the private sector JEET efforts during COVID-19: • Advocacy & facilitation of case finding strategies  Bidirectional screening  Outreach  Establishing linkages • Treatment services • Patient support services • Direct Benefit Transfer (DBT)
  • 29. Incentives Joint Effort for Elimination of TB (JEET) 15th May, 2018 (Delhi launch) Corporate TB Pledge (CTP) initiative (April, 2019) Silver Commitment Gold Commitment Awareness Platinum Commitment Awareness Investment Diamond Commitment Awareness Investment Champion Offers a tiered approach for corporates to use their resources (human and financial), to combat TB, raise awareness & ultimately improve TB health outcomes
  • 30. Apollo Tyres Foundation organized “TB free transhipment locations” campaign for reaching out to trucking & migrant communities of India • 2 week campaign at 31 different locations in 19 states • Of 1310 TB facilitated during campaign, 52 TB patients were identified and put on treatment
  • 31. Institutional mechanism of community led response •These forums have representation of people affected by TB, elected representatives, policy makers, CSO/ NGOs & program managers By end of 2019, TB forums constituted in >700 (99%) districts across country TB treatment literacy Advocacy Counselling & mentoring Health financing Programme planning Implementation Monitoring & review TB champions TB survivors Engaging existing community groups
  • 32. Tb survivor led networks in 6 states & national level
  • 33. In partnership with NTEP, working towards integrating TB services at AB-HWCs Operational guidelines launched on 28th Dec, 2020 Collaborative framework for management of TB in pregnancy (to be launched in 2021) Learning resource package for training of CHOs (to be rolled out in 2021) Vulnerability score cards for differential TB care
  • 34. Rebranding RNTCP Red colour: beginning, emotions & energy yellow colour: protection Objectivity Swirl of flag: Pride of all Focus of the programme Human figure: celebration, positivity & success Signifies bigger picture
  • 35. Rebranding RNTCP National photo exhibition “Courage & Resilience” Media engagement-National media sensitization workshop Television New India Sankalp-2 on TB (12th Feb,2020) MTV NISHEDH “Alone Together” 27th Nov, 2020 Radio: Popularizing Free diagnosis, drugs & NPY Advocacy for industry 17th Aug, 2020 Nikshay Patrika Newsletter Nikshay Patrika Newsletter: A significant communication tool to build, motivate, raise awareness, learnings & achievements Pledge for TB Free India CTD collaborated with MyGov platform for all citizens to pledge to make every village, district, state and country TB free under initiative “TB Harega, Desh Jeetega”
  • 36. Online review of program performance to overcome impact of COVID-19 National TB prevalence survey: 25th Sep, 2019 • Buses will serve as fully- equipped mobile clinics, with trained staff , backed by a chain of reference laboratories State TB Index: A composite measure of the program’s performance has been developed • CTD assesses the states/UTs achievements & performances using 9 key indicators • Maximum total score of 100
  • 37. 1. Studies on strengthening surveillance & TB notifications 2. Studies for improvement of TB disease burden estimation; improved TB diagnostics including childhood TB and EPTB 3. Studies on TB transmission and its interruption 4. Related to systematic screening of high-risk groups and intensified case findings 5. DR-TB management 6. Cascade of care in public & private sector 7. Preventive therapy 8. Socio-economic impact & poverty alleviation 9. Strengthening NTEP management 10. TB therapeutics (recurrent re-infection TB) 11. Co-morbidity studies 12. Lab, supply chain, sample transportation 13. ACSM 14. Collaborative studies with other ministries RESEARCH PRIORITIES 2020 (MoHFW) CTD ICMR NIRT Non- NTEP ITRC BRICS 66 proposals were received by 20th Noc,2020 a. DST on newer drugs b. NTBP Survey c. Accuracy of 99 DOTS d. Phase III RCT to evaluate efficacy & safety of two vaccines  VPM1002  Immuvac (Mw) e. Airborne Infection Control (AIC) practices in health facilities a. TB STAMP (TB Screen, Track & Map Project) b. Value TB project c. RATIONS (Reducing Activation of TB by Improvement Of Nutritional Status) 4 thematic areas: 1. Therapeutics 2. Diagnostics 3. Vaccines 4. Implementation Research BRICS Countries (Brazil, India, China, Russia & South Africa) established collaborative TB research network
  • 38. Nikshay Aushadhi Launched on 24th March, 2018: Electronic drug distribution management system To enable real time visibility into stock status at all levels and enable forecasting, quantification & further distribution of TB drugs and diagnostics Procurement & supply chain managemnet Quantification and Forecasting Monitoring and Distribution Recording and Reporting Data Management and Analysis Training and Capacity Building 3PL system (Third party logistic system)
  • 39. NSP 2020-2025 will aggressively pursue the expansion of the digital information ecosystem over the next five years Vision: To create a digital information ecosystem where information is captured in real time, processed and visualized, enabling efficient service delivery and responsive program management, driving TB Elimination in India and all over the world NIKSHAY SAMPARK • National TB Call Centre for TB helpline managed by CTD (May 2018) • Operating from two sites  Noida  Mumbai • 7 days/ week (7am to 11pm) Services provided: Resolving queries related to TB Reporting & management of TB services related grievances Resolving queries related to Hepatitis under NVHCP Tele-counselling Feedback on NTEP services COVID-19 (Toll Free 1075 since 16th March, 2020)
  • 40. Sep 2018, CTD launched enhanced vision of Nikshay Establish the National Knowledge Cell under Central TB Division
  • 41. Strengthening TSN & make TA responsive to emerging TB landscape in India Extend TA to other ministries Expedite establishment of planned TSUs Create a platform to enlist & provide information on available TA experts All partner organizations (health economics, digital health etc) under one umbrella of WHO-TSN consultants network
  • 42. • To aim for equitable, rights-based TB services for women, men and transgender persons by adopting a gender-specific programmatic approach at all levels • To mobilise, empower and engage women, men and transgender persons in the TB response at the health system and community levels Framework for addressing stigma
  • 43. Data from Nikshay TB notification system for April to Aug 2020, in comparison to similar data for 2019 Number of patients with TB registered on DOTS and completed treatment, in India’s NHM-HMIS for the Jan to June 2020 period, in comparison to similar data for 2019 Modelling analysis project: Additional 6.3 mil cases of TB & 1.4 mil TB deaths attributable to COVID-19 between 2020 & 2025 Manipur Total notification Jan-Feb 2020 (A) 430 Total notification Mar-April 2020 (B) 207 Total notification May-Dec 2020 (C) 926 % decrease between B & A 52% % increase between C & B 11%
  • 45. TB FREE INDIA TB Preventive Treatment (TPT) & Programmatic Management of TPT (PMTPT) Airborne Infection Control (AIC)
  • 46. TB Preventive Treatment (TPT) & Programmatic Management of TPT (PMTPT) In September 2018, countries committed to provide TPT to at least 30 million individuals by 2022, including 24 mil household contacts of TB patients and 6 mil PLHIV
  • 47. TB Preventive Treatment (TPT) & Programmatic Management of TPT (PMTPT) In 2020, NTEP plans saturation of TPT & monitoring in: • PLHIV • Paediatric contact of active TB patients • Additional inclusion of  Asymptomatic contact of all ages  Patient with silicosis  Immunosuppressive therapy  Anti-TNF treatment  Dialysis  Transplantation Fast track approvals & phase wise capacity augmentation for detection of LTBI: • TST • 4th generation IGRA Rapidly adopt & scale-up use of shorter rifamycin based TPT regimen: • 3HP (3 months of Isoniazid + Rifapentine) • 1HP ( 1 month of Isoniazid + Rifapentine) • 3HR (3 months of Isoniazid + Rifampicin) • 4R (4 months of Rifampicin) • Rapid scale up to reach 5 mil/yr • Establish TB prevention cell at national & state level • Integrate TB preventive services in all ACF efforts • Financial incentives for complete coverage • Strengthening monitoring & evaluation by ensuring capture of data for TPT in:  Nikshay platform  Scaling of digital tools: LTBI mobile app
  • 48. Airborne Infection Control (AIC) Revise AIC guidelines in line with NTEP AIC as necessary clause in NABH accreditation in private sector Leverage ongoing initiatives (HWCs, Kayakalp) AIC helpdesk Sustained national campaign in education institutions Provide AIC kits to all TB patients
  • 50. Evolution of strategies for improving case finding
  • 51. TB Co morbidities Launch by MoHFW and MoTA with technical assistance by USAID In the tribal districts of the states under fifth schedule and tribal districts of NE states under sixth schedule TB vulnerability mapping and periodic TB- Active case finding drives of all individuals in all tribal districts
  • 52. Provision of Isoniazid preventive therapy(IPT) Improving the operational efficiency of Village Health Sanitation Nutrition days Jan Arogya Samiti plateform Jan Andolan initiative Engaging TB champions Training of faith healers
  • 53. Linking of Swasthya with Nikshay Notified TB patient get Rs.750 at the time of notification
  • 54. Join TB-Diabetes collaboration • Collaboration with NTEP and NPCDCS • Bidirectional screening of TB and Diabetes Mellitus • TB patient linked to anti diabetic treatment
  • 55. Join TB-HIV collaboration • Collaboration with NTEP and NACO • In 2019, TB-HIV collaboration committee was restructured by MoHFW to form a TB Co-morbidity collaborative committee at National, State and District level • Bidirectional screening of TB and HIV • During the routine outreach services of HIV, team member screen HRG and bridge populations for TB symptoms and refer to the nearest TB center for diagnosis and treatment
  • 56. • “Single window” services for TB and HIV • Gazette notification by GoI dated 28th October 2020 about the mandatory requirement of ART centers and Drug resistant TB services in all Medical colleges TB-Tobacco • Collaboration between NTEP and NTCP • Tobacco used status were identified among TB patient and linked to tobacco cessation services
  • 57. Childhood TB • NTEP collaboration with Child Health Programme in the country (RBSK and RKSK) • Screening of children in the age group(0-18 years) will be done through Mobile health teams of RBSK and Adolescent Friendly Resource centres of RKSK
  • 60. Classification of TB diagnosis 1. Drug sensitive TB 2. H mono/ poly DR-TB 3. MDR/RR TB 4. XDR TB
  • 61. National strategic plan(2020-2025) Diagnosis • Rapid transition of TB diagnosis from smear microscopy to molecular testing using NAAT right up to the Block level • Introduction of Point of care (POC) sequencing platform • Roll out the use of novel skin test like C-Tb to support the diagnosis of pediatric TB( replacement for PPD based TST) • Introduction of next generation whole genome sequencing
  • 62. Treatment Pan country roll out of injectible free regimen for DS-TB Post treatment follow up till 2 years after completion of the anti-TB treatment Digital adherence technologies to inform and enable more differentiated patient care
  • 63.
  • 64.
  • 65.
  • 66.
  • 67.
  • 68.
  • 69. Recommended daily dose regimen for drug sensitive TB Adult Intensive phase 4 FDC (2 months) Isoniazide(H) Rifampicin(R) Pyrazinamide(Z) Ethambutol(E)  Continuation phase 3 FDC (6 months) HRZ Children Intensive phase 3 FDC (2 months)  HRZ Continuation phase 2 FDC (6 months)  HR
  • 70. Shorter oral bedaquiline-containing MDR/RR-TB regimen Inclusion criteria 1.DST based inclusion criteria Rifampicin resistance detected/inferred MDR/RR-TB with H resistance detected/ inferred based on InhA mutation only or based on KatG mutation only (not both) MDR/RR-TB with FQ resistance not detected
  • 71. 2.Other inclusion criteria  Children, aged 5 years to less than 18 years of age and weighing at least 15 kg, given their special needs, in consultation with the pediatrician  No history of exposure to previous treatment with second-line medicines in the regimen(Bdq, Lfx, Eto or Cfz) for > 1 month  No extensive TB disease  No severe extra-pulmonary TB  Women who are not pregnant or lactating
  • 72. Exclusion criteria 1. DST based exclusion criteria  MDR/RR-TB patients with H resistance detected with both KatG and InhA mutation; and  MDR/RR-TB patients with FQ resistance detected
  • 73. Exclusion criteria 2.Other exclusion criteria If result for FL-LPA, SL-LPA and DST to Z,BDQ & Cfz is not available after pre-treatment evaluation is completed and it is a time to initiate the first dose of the regimen, then, excluded those with history of exposure for>1 month to Bdq, Lfx, Eto or Cfz Intolerence to any drug or risk of toxicity from a drug in shorter oral Bedaquiline containing MDR/RR-TB regimen
  • 74.  Extensive TB disease found in presence of bilateral cavitary disease or extensive parenchymal damage on chest radiography  In children aged under 15 yrs, presence of cavities or bilateral disease on chest radiography  Severe EP-TB disease where there is a presence of military TB or TB meningitis or CNS TB. In children aged under 15 yrs, extrapulmonary forms of ds other than lymphadenopathy  Pregnant and lactating women  Children below 5 years
  • 75. Shorter oral bedaquiline-containing MDR/RR-TB regimen • From start to end of 4 months-Bdq, Lfx, Cfz, Z, E, Hh ,Eto • From start of 5 months to end of 6 months-(If IP not extended) -Bdq, Lfx, Cfz, Z, E • From start of 6 months to end of 9 months-Lfx, Cfz, Z, E • If the IP is extended upto 6 months then all 3 drugs Bdq, Hh and Eto are stopped together (4-6) Bdq(6 m), Lfx, Cfz, Z, E, Hh, Eto (5)Lfx, Cfz, Z, E
  • 76. Grouping of anti-TB drugs & steps for designing long MDR-TB regimen Groups & Steps Medicine Abbreviation Group A Levofloxacin or Lfx Include all three medicines Moxifloxacin Mfx Bedaquiline Bdq Linezolid Lzd Group B Clofazimine Cfz Add one or both medicines Cycloserine or Cs Terizidone Tr
  • 77. Grouping of anti-TB drugs & steps for designing long MDR-TB regimen Groups & Steps Medicine Abbreviation Group C Ethambutol E Add to complete the regimen and when medicines from group A & B cannot be used Delamanid Dlm Pyrazinamide Z Imipenem-cilastatin or Ipm-Cln Meropenem Mpm Amikacin Am (or Streptomycin) S Ethionamide or Eto Prothionamide Pto p-aminosalicylic acid PAS
  • 78. Longer oral M/XDR-TB regimen • It is of 18 -20 months with no separate IP or CP • Dose of Lzd will be tapered to 300 mg after the initial 6-8 months of treatment • Bdq will be given for 6 months and extended beyond 6 months as an exception • Pyridoxine to be given to all DR-TB patients as per weight band • For XDR-TB patients the duration of longer oral XDR-TB regimen would be for 20 months (18-20) Lfx, Bdq(6 month or longer), Lzd, Cfz, Cs
  • 79. Management of MDR-TB patients during pregnancy
  • 80. Bedaquiline,Pretomanid,Linezolid (BPaL) regimen • Bpal regimen for MDR-TB with additional fluoroquinolones resistance • Duration: 6-9 months • Used under operational research conditions to TB patient who have either no previous exposure to bedaquiline and linezolid or have been exposed for no more than 2 weeks
  • 81. Bedaquiline,Pretomanid,Linezolid (BPaL) regimen Dosage • Pretomanid - 200 mg once daily for 26 weeks • Bedaquiline - 400 mg once daily for the first 2 weeks and then 200 mg three times/ week for 24 weeks • Linezolid – 1200 mg once daily for 24 weeks
  • 83. 170 148 120 199 44 0 50 100 150 200 250 2019 2020 2021 2022 2023 2024 2025 Inciddence rate (cases per 100,000 population) Scenario I Scenario II Scenario III Scenario SDG NTEP impact modelling Scenario 1: Sustained service delivery at the current trends with available tools Scenario 2: Scale-up of existing strategies and introduction of newer tools Scenario 3: Accelerated expansion of existing and newer tools Scenario SDG: Newer vaccine, drugs, diagnostics, and non-pharmaceutical interventions
  • 84. - Highest level of political & administrative commitment - State strategic plans based on NSP - Much greater financial resources - Availability of new drugs, regimens, diagnostics, approaches - Insufficient human resources - Low coverage of basic program services for those accessing care in private sector - Addressing social determinants of TB - COVID-19 pandemic response focus attention on Respiratory Diseases - Integration with other ministries - Enforcement of mandatory notification - Expansion of AB-PMJAY to cover TB - Innovative solutions • - Insufficient budgetary outlay for health in national budgets • - COVID-19 derailing efforts of TB programs • - Economic slowdown owing to lockdown SWOT
  • 85. 1. MoHFW. National multisectoral action framework for TB- free India. New Delhi:MoHFW;2020 [cited 2021 May 15]. Available from: https://tbcindia.gov.in/showfile.php?lid=3525 2. MoHFW. Guidelines on Airborne Infection Control in Healthcare and Other Settings. New Delhi:MoHFW;2010 [cited 2021 May 14]. Available from: https://tbcindia.gov.in/index1.php?lang=1&level=1&sublinkid=4519&lid=3015 3. Ministry of tribal affairs government of India. Improving the cascade of TB care and support services among Tribal Populations in India. New Delhi:MoHFW;2020.[cited 2021 May 16]. Available from: https://tbcindia.gov.in/WriteReadData/l892s/5883826004Tribal%20TB%20Initiative.pdf 4. MoHFW. Guidelines for programmatic management of drug resistant tuberculosis in India. New Delhi:MoHFW;2021. [cited 2021 May 16]. Available from: https://tbcindia.gov.in/showfile.php?lid=3590 REFERENCES
  • 86. 5. Sachdeva KS. Nikshay patrika. New Delhi:MoHFW. 2020 December;4(3):1-20. Available from: https://tbcindia.gov.in/showfile.php?lid=3576 6. Shrinivasan R, Rane S, Pai M. India’s syndemic of tuberculosis and COVID-19. BMJ Global Health. 2020;5:e003979. Available from: doi:10.1136/bmjgh-2020-003979 7. 7. MoHFW. National strategic plan for tuberculosis: 2017-25 elimination by 2025. New Delhi:MoHFW; 2017. [cited 2021 May 16]. Available from:https://tbcindia.gov.in/WriteReadData/NSP%20Draft%2020.02.2017%201.pdf 8. 8. Sharma DC. India launches tuberculosis prevalence survey. Lancet Respir Med. 2019;S2213- 2600(19)30377-7. Available from: https://www.thelancet.com/pdfs/journals/lanres/PIIS2213- 2600(19)30377-7.pdf 9. Kuldeep Singh Sachdeva (2020): TB free India by 2025: hype or hope. Expert Review of Respiratory Medicine. 2020 July; 10.1080/17476348.2021.1826317. Available from: https://www.tandfonline.com/doi/full/10.1080/17476348.2021.1826317

Hinweis der Redaktion

  1. WHO
  2. Nsp 2020-2025 map
  3. WHO s post 2015 end TB strategy, adopted by WHA in 2014, aims to end global TB epidemic as part of SDG. The NSP adapts this END TB strategy framework for designing its national strategic framework.
  4. multi-pronged approach to engaging with the private sector, as part of the NSP mantra of “go where the patients go”.
  5. 25 VANS Best performing states: himachal Pradesh, Gujarat, Tripura, Sikkim, puducherry, daman and diu
  6. India: 514,370 cases & 151,120 deaths will be added in India btw 2020-2025 owing to 2 month lock down & 2 month restoration periods.
  7. as alternatives to six months of isoniazid.