This document provides a review of muscular dystrophy, including its signs and symptoms, classification, epidemiology, diagnosis, treatment approaches, and future research directions. The key points are:
1. Muscular dystrophy refers to a group of inherited muscle-destroying diseases that cause progressive skeletal muscle degeneration.
2. Signs and symptoms vary by type but commonly include progressive muscle wasting, drooping eyelids, difficulty walking, and respiratory problems.
3. There are several types of muscular dystrophy including Duchenne, Becker, Emery-Dreifuss, and limb-girdle. Duchenne muscular dystrophy is the most common type.
4. Muscular
(Rocky) Jaipur Call Girl - 9521753030 Escorts Service 50% Off with Cash ON De...
Muscular dystrophy
1. By:
MR: SHAIKH MOHD ATHAR ABDUL QUDDUS
MAHATMA GANDHI VIDYAMANDIR’S
PHARMACY COLLEGE PANCHAVATI, NASHIK- 422003.
2014-2015
AREVIEW ON MUSCULAR
DYSTROPHY
1
2. CONTENT
1. Introduction
2. Sign And Symptoms
3. Clinical Stages of Muscular Dystrophy
4. Epidemiology
5. Types
6. Etiology
7. Animal Models
8. Diagnosis Of Muscular Dystrophy
9. Pharmaceutical Approach
10.Complication and Their Management
11.Case Study
12.Future Scope
13.Conclusion
14.References
2
3. INTRODUCTION
The term muscular dystrophy refers to a group of
inherited muscle-destroying diseases that cause
progressive degeneration of skeletal muscle. [1]
3
4. SIGN AND SYMPTOMS
Signs and symptoms vary with every type but some common are
progressive muscular wasting,
drooping eyelids, atrophy,
Scoliosis,
Inability to walk, frequent falls,
limited range of movement,
respiratory difficulty, joint contractures,
cardiomyopathy, arrhythmias,
muscle spasms,
gowers' sign. [2]
4
5. CLINICAL STAGES OF
MUSCULAR DYSTROPHY
Stage 1: Early/pre-symptomatic
Stage 2: Early ambulatory (Walking)
Stage 3: Late Ambulatory (going off feet)
Stage 4: Early non-ambulatory
Stage 5: Late non-ambulatory
Stage 6 Palliative Cares / End of Life. [3]
5
7. EPIDEMIOLOGY
Duchenne muscular dystrophy
is the most common form of
MD.
DMD strikes boys almost
exclusively. (World wide about
1 in every 3500 male babies)
Age of onset differs with every
type. [1]
7
8. TYPES
A. Duchenne (most common) and
Becker
B. Emery-Dreifuss
C. Limb-girdle,
D. Facioscapulohumeral,
E. Distal
F. Oculopharyngeal.[4]
8
9. ETIOLOGY
Muscular dystrophies are caused by mutations in genes encoding
proteins that are essential for normal muscle function.
The main gene associated is Dystrophin gene.[2]
9
14. CASE STUDY
Duchenne Muscular Dystrophy
A case of 11 year old male, who complained of gradually
progressive bilateral lower limb weakness since 5 years.
Clinical Improvements seen After Stem Cell Therapy:
Stamina and endurance improved
Psychologically was more confident alert and responsive
He was able to walk independently with KAFO [Knee
Ankle Foot Orthosis].
Following muscles showed improved strength
Hip, knee, ankle, shoulder, abdominals.[3]
14
16. CONCLUSION
Very rare and harmful disease, only caused by genetic
defect
DNA fingerprints of patient muscle
Gene or stem-cell therapy
However, the cure is not present till now, an effective
management and treatment can give some relief to patient
for some time.
16
17. REFRENCES
1) Tortora Gerard J. and Derrickson Bryan, “Principles Of Anatomy And
Physiology”, Twelfth Edition, 2008, John Wiley & Sons Publication, pg. no. 331.
2) wikipedia.org/wiki/Muscular dystrophy
3) Sharma Alok, “Stem Cell Therapy & Other Recent Advances in Muscular
Dystrophy”, 2011, Neurogen Brain and Spine Institute publication, pg. no. 1, 48-
51.
4) Emery E H Alan, “The Muscular Dystrophies”, Seminar, 2002, Volume 359,
Lancet publishing group, pg. no. 687-689.
5) Chambers Leigh “A Home Exercise Book Physiotherapy Management for
Duchenne Muscular Dystrophy”, Muscular Dystrophy Campaign publication,
2009, pg. no 2-6.
6) Hermans A., Pinto Y.M. , Merkies I.S.J., Smulders D., Crijns H.J., Faber C.G.
“Hereditary Muscular Dystrophies And The Heart”, Elsevier, 2010, Elsevier
publication , pg. no. 1-14.
7) Allamand Valérie and Campbell Kevin P., “Animal models for muscular
dystrophy: valuable tools for the development of therapies” Human Molecular
Genetics, 2000, Vol. 9, No. 16, pg. no 1-9.
17