OncologyPipeline is an online, easy to use tool that allows its users to track the entire Oncology pipeline and all relevant clinical trials, results and timelines of the pharmaceutical and biotech industry worldwide

1. www.oncologypipeline.com

2. Oncology Pipeline Tool
• Oncology launches are increasing at an almost exponential rate: from
10 launches in Europe in 2010 to 60+ launches in 2018
• The Oncology Pipeline Tool is an online, easy to use tool that analyzes
the entire Oncology pipeline of the pharmaceutical and biotech
industry worldwide (emphasis on EU and US)
• The database contains over 1.600 drugs in development from more
than 600 companies
• User friendliness: search engine combined with filters allow to analyze
data by year of launch, tumor, line of treatment, company, budget
impact etc. (one filter or all of the above combined)
• The database is updated on a daily basis and data from
clincialtrials.gov is fully integrated and updated automatically

3. • New trials: we review every day all new clinical trials that are published on
Clinicaltrials.gov and include them in our database. We monitor changes in
recruitment status and data readout timelines. Our database is fully integrated
with Clinicaltrials.gov and changes in recruitment status, sample size are
updated automatically. Other changes such as study readout timelines are
revised manually
• Scientific conferences and journals: we monitor all key congresses and
journals in Oncology and update our database accordingly. All relevant data are
summarized and we provide a link to the original data source (abstract,
publication etc).
• Individual companies: every day we review hundreds of press releases.
Relevant news items are included in the database with a link to the original
data source
• Investor conferences: we participate in investor conferences and quarterly
webcasts. Study timelines are updated based on company information and
comments from management. That’s why our data readout estimates are as
accurate as possible and in many cases far more accurate than the
information provided by the companies on Clinicaltrials.gov
Oncology Pipeline - methodology

4. Oncology launches in Europe
Source: OncologyPipeline.com
Launches for 2017 / 2018 are risk-adjusted for historical phase III success rates: 189 projects x 65% chance of success

5. Oncology Pipeline: search engine and filters

6. Database: 40+ variables, 8.000+ trials
• Generic name, brand name, mode of action, company
• Country
• Immuno-Oncology (Yes/No), Biosimilar (Yes/No), Key trial (Yes/No)
• Budget impact (+5 bn WW, 2.5-5.0 bn WW, 1.0-2.5 bn WW etc.)
• Oncology or Hematology, Development stage (approved, phase III etc.)
• Tumor, Indication, Line of treatment
• Trial name, control arm, primary endpoint
• Key results (if available): PFS months, PFS delta, PFS HR (hazard ratio), OS
months, OS delta, OS HR, ORR (%), ORR delta etc.
• Data readout date, Filing date (EU), approval date (EU), Months needed
to obtain approval
• Data from ClinicalTrials.gov: NCT Number, Title, Recruitment, Study
Results, Sponsor & Collaborators, Enrollment, First Received, Start Date,
Completion Date, Last Update, Acronym, Primary Completion Date

7. Example: NSCLC, IO Yes, 1st line

8. Phase III trials CDK4/6 inhibitors
Green = positive results
communicated
Expected data readout
(left column) and expected
launch date (right column)

9. Search tool for all combination trials

10. Project summary
Summary provided by
experienced medical writers
based on congress presentations,
journal articles, company
releases, investor events etc.

11. Project summary – external references

12. Launch timelines are updated
constantly based on information
in clinicaltrials.gov and / or
company disclosures
Clinicaltrials.gov is fully
integrated and updated
automatically
Project summary - ClinicalTrials.gov

13. Congresses & journals

14. Press releases

15. Clinical results by tumor, line of treatment etc.

16. Clinical results by tumor, line of treatment etc.

17. www.oncologypipeline.com