10. Abstract Hyponatremia with hyperkalemia in infancy is an uncommon but life-threatening occurrence. In the first weeks of life, this scenario is often associated with aldosterone deficiency due to salt-wasting congenital adrenal hyperplasia . However, alternative diagnoses involving inadequate mineralocorticoid secretion or action must be considered, particularly for infants one month of age or older. We report four infants who presented with profound hyponatremia accompanied by urinary tract infection , ultimately leading to the diagnosis of transient pseudohypoaldosteronism. Our cases provide support for the idea that the renal tubular resistance to aldosterone is due to urinary tract infection itself rather than to underlying urinary tract anomalies typically found in these infants. Awareness of this condition is important so that serum aldosterone, urine sodium, and urine cultures may be obtained immediately in any infant presenting with hyponatremia and hyperkalemia in whom a diagnosis of congenital adrenal hyperplasia was not found. Adequate replacement with intravenous saline and antibiotic therapy is sufficient to correct sodium levels over 24–48 hours.
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15. International Journal of Pediatric Endocrinology Volume 2009 (2009), Article ID 132041, 8 pages doi:10.1155/2009/132041 Commentary Propylthiouracil (PTU) Hepatoxicity in Children and Recommendations for Discontinuation of Use Scott A. Rivkees 1 and Donald R. Mattison 2 1 Yale Pediatric Thyroid Center, Yale University School of Medicine, New Haven, CT 06520, USA 2 Obstetric and Pediatric Pharmacology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA Received 5 April 2009; Accepted 7 April 2009 Izveštaj workshop -a koji je održan pod pokroviteljstvom Best Pharmaceuticals for Children Act, oktobra 2008 da bi se procenila bezbednost primene PTU kod dece
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