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Effects of green tea (camellia sinensis) on serum cholesterol
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Alexander Decker
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This study assessed the effects green leaf tea extract on male reproductive function of male albino wistar rats. Twenty rats weighing between 150 250g, grouped into 4 of 5 rats each, were used for the research that lasted for four weeks. Group I, the control group, received normal rat chow and water ad libitum. The three test groups II IV, received 2.5gm 100ml 0f water, 5gm 100ml of water, 7.5gm 100ml of water of green leaf tea extract given via oral administration with normal rat food and water for four weeks. Blood was collected via ocular puncture and serum was assayed for testosterone levels. Semen was also analyzed for sperm motility and sperm count. The testicular weight was recorded and net body weight gain was also recorded. The study showed significant decrease in net body weight gain and testicular weight. It has been shown that the reduction of body weight after application of green tea extract may be due to inhibition of catechol O methyl transferase transferase COMT enzyme by epigallocatechin gallate EGCG of the green tea. The study also showed significant decrease in sperm motility and sperm count. It also showed a significant decrease in testosterone levels. In conclusion, green leaf tea extract had a negative effect on male reproductive function and its use as a daily tea should be curtailed. Okonkwo, C. O. J | Maduka, S. O | Akude Harrison | Mmaju, C. I | Okwuonu, I. F1; Goji A. D "The Effect of Green Tea Leaf Extract on Reproductive Function of Male Wistar Rats" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-4 , June 2021, URL: https://www.ijtsrd.compapers/ijtsrd42471.pdf Paper URL: https://www.ijtsrd.commedicine/other/42471/the-effect-of-green-tea-leaf-extract-on-reproductive-function-of-male-wistar-rats/okonkwo-c-o-j
The Effect of Green Tea Leaf Extract on Reproductive Function of Male Wistar ...
The Effect of Green Tea Leaf Extract on Reproductive Function of Male Wistar ...
ijtsrd
This study investigated the effect of protein isolate from leaf extract of Vernonia amygdalina in diabetic rats. Thirty (30) adults male Wistar rats were randomly divided into six (6) groups of five (5) each based on their body weight. Diabetes was induced with administration of alloxan, 150 mg/kg body weight (i.p). Group A served as the control and received 1 mL/kg body weight of 5% ethanol being solvent used, Group B received 1 mL alloxan containing 150 mg/kg only. Group C, D, E and F were respectively alloxanized but treated with 1%, 3%, 5% and 7% of protein isolate obtained from V. amygdalina leaves for 14 days. On the 15th day, the animals were humanely sacrificed and their liver homogenates were prepared. Standard biochemical procedures were adopted for determination of catalase (CAT), superoxide dismutase (SOD) activities, Malondialdehyde (MDA) and glucose levels. Data were subjected to one-way Analysis of Variance (ANOVA) with Tukey-Kramer multiple comparison post-hoc test using Graph Pad, version 6 software. Results showed that CAT activity in alloxan-induced untreated rats (1.17 μmole H2O2) was significantly (p < 0.05) lower than observed in control rats (2.10 mole H2O2). Treatment with the respective doses recorded comparable values to those observed in control rats. Similar observation was seen with SOD data. Rats treated with 7% protein isolate recorded the most significant (p < 0.05) decrease in serum glucose level. The study suggests that the protein isolate possesses anti-diabetic and hypoglycaemic effects on alloxan-induced diabetic rats.
Analysis of certain biochemical indices on alloxan induced diabetic rats admi...
Analysis of certain biochemical indices on alloxan induced diabetic rats admi...
African Journal of Biological Sciences
HydrationHydration scientific library volume 2 http://www.europeanhydrationinstitute.org/ scientific library volume 2
Hydration scientific library volume 2
Hydration scientific library volume 2
EHIfoundation
Gongronema latifolium GL has gained research interest in the field of Medicine. The present study investigated the cardioprotective potentials of the ethanolic and ethyl acetate fraction of the leaves extract of G.L. 18 Male Wistar rats were divided equally into three groups. Group 1 was the control group, and was administered 0.9 normal saline. Group 2 was administered 200mg kg ethanolic leaves extract of GL. Group 3 received 200mg kg ethyl acetate fraction of the leaves extract of GL. Administration was via oral gavage and lasted for 14 days. The rats were sacrificed under chloroform anaesthesia. Blood was collected via cardiac puncture, allowed to clot, and later centrifuged to get serum. Laboratory assays were done for serum concentrations of total cholesterol Tc , total triglycerides Tg , high density lipoprotein HDL-c , low density lipoprotein LDL , malondialedyde MDA , total antioxidant capacity TAC , and total plasma peroxide TPP . The heart, aorta, and kidneys were also harvested for organ weight and histological studies. Administration of GL extracts resulted in an increase p 0.001 serum concentrations of HDL-c and TAC, with a consequent reduction in the serum concentrations of Tg, LDL-c, VLDL, MDA, and TPP. There was no significant p 0.01 change in organ weights of the heart, aorta, and kidneys across the groups. Histology of the blood vessels showed intact layers across the groups. There was no derangement of cellular architecture in the heart and kidney. This study therefore concludes that Gongronema latifolium leaves extract is cardioprotective, and thus provides a basis for the use of this plant as an alternative for the prevention, management or control of cardiovascular diseases. Justin Atiang Beshel | Favour Nyoh Beshel | Clement Oshie Nku | Daniel Udofia Owu "Gongronema Latifolium: A Plant with Cardioprotective Potentials" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-2 , February 2019, URL: https://www.ijtsrd.com/papers/ijtsrd21431.pdf Paper URL: https://www.ijtsrd.com/medicine/physiology/21431/gongronema-latifolium-a-plant-with-cardioprotective-potentials/justin-atiang-beshel
Gongronema Latifolium A Plant with Cardioprotective Potentials
Gongronema Latifolium A Plant with Cardioprotective Potentials
ijtsrd
This study was carried out to evaluate the effect of ethanolic leaf extract of Sida acuta on the micro-anatomy of the liver and some biochemical parameters in adult Wistar rats. Thirty rats weighing between 140-180g were assigned to three groups (A, B and C) with ten animals each. Group A served as the control while groups B and C served as the experimental groups and received 100mg/kgbw and 200mg/kgbw of the extract respectively for fourteen days. All the animals were sacrificed after fourteen days. Blood was collected by cardiac puncture for biochemical analysis of serum liver enzymes s The liver was removed, preserved and processed for paraffin sections and hematoxylin and eosin (H&E) staining. The animals in the control group showed normal histological and biochemical parameters. Conversely, animals that received 100mg/kgbw of the extract showed slight difference in their hepatic cyto-architecture while animals that were administered with 200mg/kgbw of the extract revealed distorted morphological feature showing shrunken sinusoid and dilation of the central vein suggesting that the extract has adverse effect on the morphology of the liver. Results of the serum liver enzymes of animals treated with 100mg/kgbw and 200mg/kg revealed significantly decreased values of AST, ALP and ALT (P <0.05) relative to the control. From the result of this experiment, it is concluded that administration of ethanolic extract of Sida acuta leaves may be toxic to Wistar rats at the doses administered.
The evaluation of the effect of Sida acuta leaf extract on the microanatomy a...
The evaluation of the effect of Sida acuta leaf extract on the microanatomy a...
IOSR Journals
Introduction Sida acuta is shrub indigenous to pantropical areas, widely distributed in regions and found in pastures, waste lands, cultivated lands, roadsides, lawns and planted forests. Sida acuta is ethanomedically used as treatment of diuretic, asthma, fever, headache, cough, cold, ulcer, anthelmintic, snake bite, urinary disease, female disorders, sedative, eczema, kidney stone, elephantiasis, testicular swelling, poultice for dandruff, rheumatic affections, facial paralysis, pulmonary tuberculosis and gonorrheae. Methods Preparation of hydroalcoholic extract of Sida acuta and Hydro-alcoholic extract of Sida acuta was evaluated for its antidiabetic studies by alpha amylase method. Results The inhibitory concentration (IC50) of Hydro-alcoholic extract of Sida acuta against alpha amylase inhibitory effect was found to be 17.10µg/ml in comparison with acarbose 9.27µg/ml. Hydro-alcoholic extract of Sida acuta showed significant alpha amylase inhibitory effect when compared with acarbose. Hence preparation may be formulated with hydro-alcohol and aqueous extract. Conclusion The present research draws the conclusion that Sida acuta plant showed mild antidiabetic effect, which may be due to the phytoconstituents.
Invitro alpha amylase effect of Sida acuta Burm
Invitro alpha amylase effect of Sida acuta Burm
SriramNagarajan16
Food and Chemical Toxicology 48 (2010) 1178–1184
Cranberry (Vaccinium macrocarpon) protects against doxorubicin-induced cardio...
Cranberry (Vaccinium macrocarpon) protects against doxorubicin-induced cardio...
Ahmed Elberry
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Yagyapathy: A Holistic Approach for Treatment of Severe Disease by Indian Sys...
Yagyapathy: A Holistic Approach for Treatment of Severe Disease by Indian Sys...
iosrjce
Empfohlen
This study assessed the effects green leaf tea extract on male reproductive function of male albino wistar rats. Twenty rats weighing between 150 250g, grouped into 4 of 5 rats each, were used for the research that lasted for four weeks. Group I, the control group, received normal rat chow and water ad libitum. The three test groups II IV, received 2.5gm 100ml 0f water, 5gm 100ml of water, 7.5gm 100ml of water of green leaf tea extract given via oral administration with normal rat food and water for four weeks. Blood was collected via ocular puncture and serum was assayed for testosterone levels. Semen was also analyzed for sperm motility and sperm count. The testicular weight was recorded and net body weight gain was also recorded. The study showed significant decrease in net body weight gain and testicular weight. It has been shown that the reduction of body weight after application of green tea extract may be due to inhibition of catechol O methyl transferase transferase COMT enzyme by epigallocatechin gallate EGCG of the green tea. The study also showed significant decrease in sperm motility and sperm count. It also showed a significant decrease in testosterone levels. In conclusion, green leaf tea extract had a negative effect on male reproductive function and its use as a daily tea should be curtailed. Okonkwo, C. O. J | Maduka, S. O | Akude Harrison | Mmaju, C. I | Okwuonu, I. F1; Goji A. D "The Effect of Green Tea Leaf Extract on Reproductive Function of Male Wistar Rats" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-4 , June 2021, URL: https://www.ijtsrd.compapers/ijtsrd42471.pdf Paper URL: https://www.ijtsrd.commedicine/other/42471/the-effect-of-green-tea-leaf-extract-on-reproductive-function-of-male-wistar-rats/okonkwo-c-o-j
The Effect of Green Tea Leaf Extract on Reproductive Function of Male Wistar ...
The Effect of Green Tea Leaf Extract on Reproductive Function of Male Wistar ...
ijtsrd
This study investigated the effect of protein isolate from leaf extract of Vernonia amygdalina in diabetic rats. Thirty (30) adults male Wistar rats were randomly divided into six (6) groups of five (5) each based on their body weight. Diabetes was induced with administration of alloxan, 150 mg/kg body weight (i.p). Group A served as the control and received 1 mL/kg body weight of 5% ethanol being solvent used, Group B received 1 mL alloxan containing 150 mg/kg only. Group C, D, E and F were respectively alloxanized but treated with 1%, 3%, 5% and 7% of protein isolate obtained from V. amygdalina leaves for 14 days. On the 15th day, the animals were humanely sacrificed and their liver homogenates were prepared. Standard biochemical procedures were adopted for determination of catalase (CAT), superoxide dismutase (SOD) activities, Malondialdehyde (MDA) and glucose levels. Data were subjected to one-way Analysis of Variance (ANOVA) with Tukey-Kramer multiple comparison post-hoc test using Graph Pad, version 6 software. Results showed that CAT activity in alloxan-induced untreated rats (1.17 μmole H2O2) was significantly (p < 0.05) lower than observed in control rats (2.10 mole H2O2). Treatment with the respective doses recorded comparable values to those observed in control rats. Similar observation was seen with SOD data. Rats treated with 7% protein isolate recorded the most significant (p < 0.05) decrease in serum glucose level. The study suggests that the protein isolate possesses anti-diabetic and hypoglycaemic effects on alloxan-induced diabetic rats.
Analysis of certain biochemical indices on alloxan induced diabetic rats admi...
Analysis of certain biochemical indices on alloxan induced diabetic rats admi...
African Journal of Biological Sciences
HydrationHydration scientific library volume 2 http://www.europeanhydrationinstitute.org/ scientific library volume 2
Hydration scientific library volume 2
Hydration scientific library volume 2
EHIfoundation
Gongronema latifolium GL has gained research interest in the field of Medicine. The present study investigated the cardioprotective potentials of the ethanolic and ethyl acetate fraction of the leaves extract of G.L. 18 Male Wistar rats were divided equally into three groups. Group 1 was the control group, and was administered 0.9 normal saline. Group 2 was administered 200mg kg ethanolic leaves extract of GL. Group 3 received 200mg kg ethyl acetate fraction of the leaves extract of GL. Administration was via oral gavage and lasted for 14 days. The rats were sacrificed under chloroform anaesthesia. Blood was collected via cardiac puncture, allowed to clot, and later centrifuged to get serum. Laboratory assays were done for serum concentrations of total cholesterol Tc , total triglycerides Tg , high density lipoprotein HDL-c , low density lipoprotein LDL , malondialedyde MDA , total antioxidant capacity TAC , and total plasma peroxide TPP . The heart, aorta, and kidneys were also harvested for organ weight and histological studies. Administration of GL extracts resulted in an increase p 0.001 serum concentrations of HDL-c and TAC, with a consequent reduction in the serum concentrations of Tg, LDL-c, VLDL, MDA, and TPP. There was no significant p 0.01 change in organ weights of the heart, aorta, and kidneys across the groups. Histology of the blood vessels showed intact layers across the groups. There was no derangement of cellular architecture in the heart and kidney. This study therefore concludes that Gongronema latifolium leaves extract is cardioprotective, and thus provides a basis for the use of this plant as an alternative for the prevention, management or control of cardiovascular diseases. Justin Atiang Beshel | Favour Nyoh Beshel | Clement Oshie Nku | Daniel Udofia Owu "Gongronema Latifolium: A Plant with Cardioprotective Potentials" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-2 , February 2019, URL: https://www.ijtsrd.com/papers/ijtsrd21431.pdf Paper URL: https://www.ijtsrd.com/medicine/physiology/21431/gongronema-latifolium-a-plant-with-cardioprotective-potentials/justin-atiang-beshel
Gongronema Latifolium A Plant with Cardioprotective Potentials
Gongronema Latifolium A Plant with Cardioprotective Potentials
ijtsrd
This study was carried out to evaluate the effect of ethanolic leaf extract of Sida acuta on the micro-anatomy of the liver and some biochemical parameters in adult Wistar rats. Thirty rats weighing between 140-180g were assigned to three groups (A, B and C) with ten animals each. Group A served as the control while groups B and C served as the experimental groups and received 100mg/kgbw and 200mg/kgbw of the extract respectively for fourteen days. All the animals were sacrificed after fourteen days. Blood was collected by cardiac puncture for biochemical analysis of serum liver enzymes s The liver was removed, preserved and processed for paraffin sections and hematoxylin and eosin (H&E) staining. The animals in the control group showed normal histological and biochemical parameters. Conversely, animals that received 100mg/kgbw of the extract showed slight difference in their hepatic cyto-architecture while animals that were administered with 200mg/kgbw of the extract revealed distorted morphological feature showing shrunken sinusoid and dilation of the central vein suggesting that the extract has adverse effect on the morphology of the liver. Results of the serum liver enzymes of animals treated with 100mg/kgbw and 200mg/kg revealed significantly decreased values of AST, ALP and ALT (P <0.05) relative to the control. From the result of this experiment, it is concluded that administration of ethanolic extract of Sida acuta leaves may be toxic to Wistar rats at the doses administered.
The evaluation of the effect of Sida acuta leaf extract on the microanatomy a...
The evaluation of the effect of Sida acuta leaf extract on the microanatomy a...
IOSR Journals
Introduction Sida acuta is shrub indigenous to pantropical areas, widely distributed in regions and found in pastures, waste lands, cultivated lands, roadsides, lawns and planted forests. Sida acuta is ethanomedically used as treatment of diuretic, asthma, fever, headache, cough, cold, ulcer, anthelmintic, snake bite, urinary disease, female disorders, sedative, eczema, kidney stone, elephantiasis, testicular swelling, poultice for dandruff, rheumatic affections, facial paralysis, pulmonary tuberculosis and gonorrheae. Methods Preparation of hydroalcoholic extract of Sida acuta and Hydro-alcoholic extract of Sida acuta was evaluated for its antidiabetic studies by alpha amylase method. Results The inhibitory concentration (IC50) of Hydro-alcoholic extract of Sida acuta against alpha amylase inhibitory effect was found to be 17.10µg/ml in comparison with acarbose 9.27µg/ml. Hydro-alcoholic extract of Sida acuta showed significant alpha amylase inhibitory effect when compared with acarbose. Hence preparation may be formulated with hydro-alcohol and aqueous extract. Conclusion The present research draws the conclusion that Sida acuta plant showed mild antidiabetic effect, which may be due to the phytoconstituents.
Invitro alpha amylase effect of Sida acuta Burm
Invitro alpha amylase effect of Sida acuta Burm
SriramNagarajan16
Food and Chemical Toxicology 48 (2010) 1178–1184
Cranberry (Vaccinium macrocarpon) protects against doxorubicin-induced cardio...
Cranberry (Vaccinium macrocarpon) protects against doxorubicin-induced cardio...
Ahmed Elberry
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Yagyapathy: A Holistic Approach for Treatment of Severe Disease by Indian Sys...
Yagyapathy: A Holistic Approach for Treatment of Severe Disease by Indian Sys...
iosrjce
MEDC-533 Group 2 Green Tea Final
MEDC-533 Group 2 Green Tea Final
William Wolanski
Awodele toxicidad moringa
Awodele toxicidad moringa
Fausto Dutan
EXTRAPOLATION OF IN VITRO DATA TO PRECLINICAL TO HUMANS
EXTRAPOLATION OF IN VITRO DATA TO PRECLINICAL TO HUMANS
EXTRAPOLATION OF IN VITRO DATA TO PRECLINICAL TO HUMANS
KARNATAKA COLLEGE OF PHARMACY
In recent years as a result of the observation that the toxic effects of boron and its products have increased intensive studies have been initiated in our country and in the world regarding its effects, especially in the central nervous system, digestive system and reproductive system. The aim was to determine the histopathological changes caused by boric acid in rat testis, liver, kidney and brain tissues by light microscopy after oral administration of toxic dose of acute boric acid.
33133 article text-60219-2-10-20211104
33133 article text-60219-2-10-20211104
nalayranc
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
Effects of Acalypha torta (Muell) Leaf Extract on Histological Indices of the...
Effects of Acalypha torta (Muell) Leaf Extract on Histological Indices of the...
iosrphr_editor
Objective:Many of the available therapies for diabetes have a number of serious adverse effects; therefore the search for more effective and safer hypoglycaemic agents becomes a paramount. This research was set to investigate the antidiabetic potential and cytoprotective effect of ethanolic root extract of Salacianitida on alloxan induced hyperglyceamic rats. Method:Acute toxicity and phytochemical constituents were evaluated using standardized methods. The study lasted for a period of thirty days comprising of two phases: induction phase and treatment phase. Thirty animals were grouped into five groups of six rats each. Group 1 and 2 serve as normal and toxic control respectively while groups 3, 4, and 5 were treated with 750, 1500mg of S.nitidaand 5mg glibenclamide respectively. The BGL, food and fluid intake was monitored daily while the body weight was measured on weekly. The last day of the study after an overnight fast, the animals were loaded with glucose and the OGTT measured prior to and at 30minutes interval for two hours after which the animals were sacrificed under ether anaesthesia and the organs isolated for histological examination. Results/Conclusion:The results of the present study indicate that S.nitida possessantidiabetic potentials and cytoprotective effect noted in its significant percentage reduction in the glucose level, slight increase in body weight and restoration of the toxic organs to normal.
Antidiabetic and Cytoprotective Effect of Ethanolic Extract of SalaciaNitida ...
Antidiabetic and Cytoprotective Effect of Ethanolic Extract of SalaciaNitida ...
IOSRJPBS
Objective: To investigate the effects of Aquilaria subintegra leaf aqueous extracts on the aphrodisiac properties including sexual behaviour, testosterone level, percentage of pregnancy, number of offspring and male to female ratio of offspring in ICR mice. Methods: In this experiment, each male cohabitated with one female in a polysulfone cage. 30 ICR male mice were divided into 6 groups that received normal saline (the control group), 50 mg/kg, 100 mg/kg, 200 mg/kg, 500 mg/kg, and 1 000 mg/kg body weight of Aquilaria subintegra leaf aqueous extracts orally for 21 days consecutively. Sexual behavior, percentage of pregnancy, number of offspring and male to female ratio of offspring in ICR mice were measured according to the established methods. Testosterone level was measured by using enzyme-linked immunosorbent assay. Results: Mice that received Aquilaria subintegra leaf aqueous extracts at 50 mg/kg body weight (day 0) had significantly higher mount frequency as compared to the control group; groups treated with 100, 500, 1 000 mg/kg body weight extracts produced a greater number of offsprings when compared to the control group. All aphrodisiac parameters were similar between the treatment groups and the control group, indicating that Aquilaria subintegra leaf aqueous extract did not significantly alter the aphrodisiac parameters. Conclusions: Aquilaria subintegra leaf aqueous extracts have no effect on the aphrodisiac properties, but could increase the breeding rate in mice.
Effect of lyophilized aqueous leaf extract of Aquilaria subintegra on aphrodi...
Effect of lyophilized aqueous leaf extract of Aquilaria subintegra on aphrodi...
Mohammed Muayad TA
International journals call for papers, http://www.iiste.org/
Comparative evaluation of the effects of artemisinin based combination therap...
Comparative evaluation of the effects of artemisinin based combination therap...
Alexander Decker
Antioxidant Status and Lipid Peroxidation in Diabetic Rats under Hyperbaric Oxygen Exposure
Matsunami et al., 2010 2nd
Matsunami et al., 2010 2nd
松波動物病院メディカルセンター
Published by Pratik Umesh Parikh Master of Pharmacy (Pharmaceutical Biotechnology)
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Experiment modelling of Auto-immune diseases
Pratik Parikh
Enhancement of glucose toxicity by hyperbaric oxygen exposure in diabetic rats
Matsunami et al., 2008 1st
Matsunami et al., 2008 1st
松波動物病院メディカルセンター
Andrographolide, a bicyclic diterphenoid lactose, extracted from a plant, Andrographis paniculata, is known for its multiple clinical applications in traditional Siddha and Ayurvedic systems in India. Its therapeutic value is perhaps by virtue of its mechanism of action through enzyme induction. The present study is aimed to determine the effects of andrographolide on succinate dehydrogenase (SDH) activity, in vitro, using mitochondrial fractions isolated from different organs of BALB/c mice. Administration of andrographolide into mitochondrial fraction of liver, lung and kidney resulted in the induction of SDH. Mitochondrial fraction of lung tissues indicated the maximum SDH acceleratory activity (68.19%), in vitro, against 50 μg/ml concentration of andrographolide.
Andrographolide Induced Succinate Dehydrogenase Activity in Isolated Mitochon...
Andrographolide Induced Succinate Dehydrogenase Activity in Isolated Mitochon...
IOSR Journals
International peer-reviewed academic journals call for papers, http://www.iiste.org/Journals
In vivo comparative evaluation of effects of
In vivo comparative evaluation of effects of
Alexander Decker
Assignment on Limitation of animal experimentation
Assignment on Limitation of animal experimentation
Assignment on Limitation of animal experimentation
Deepak Kumar
Kindly find this paper useful in all fields, you can as well share the resource with friends in all learning institutions. This is entirely the my original work. The paper will also be useful in fields like medicine, law and social science.
Green tea revised4
Green tea revised4
musyokasaff
Justifications for invasive experiments on animals rely on claims that such research is essential for the advancement of biomedical knowledge, for the development of cures to human diseases, or for the evaluation of the toxicity of compounds to which humans are exposed. Until recently, critical evaluations of the accuracy of such claims have been rare. However, a growing body of large-scale systematic reviews have now been published in scientific and medical journals. The outcomes have been consistent: animal experiments have contributed far less than advocates would have us believe. This presentation summarises these recent results, and comprehensively reviews the alternatives to invasive animal use with biomedical research, toxicity testing, and education. Published studies are available at www.AnimalExperiments.info.
Animal Experiments and Alternatives
Animal Experiments and Alternatives
Andrew Knight
Introduction Commelina benghalensis L. commonly known as Benghal dayflower, belongs to the family Commelinaceae. It is widely used for the treatment of wounds and skin diseases. Aim The current study focuses on the evaluation of in vitro anti-inflammatory and antiarthritic property of the leaf extracts ofCommelina benghalensis L. Methods The hydroalcoholic extract (70%) of Commelina benghalensis L. (Leaf) was subjected to anti-inflammatory and anti arthritic activity by membrane stabilisation and inhibition of protein denaturation method were determined. Results The inhibitory concentration (IC50) of HAECB in HRBC membrane stabilization study was found to be 69µg/ml in comparison with diclofenac sodium 57µg/ml. It showed moderate anti-inflammatory activity. The inhibitory concentration (IC50) of HAECB in protein denaturation was found to be 17µg/ml in comparison with diclofenac sodium 14µg/ml. It showed moderate anti-arthritic activity. Conclusion HAECB showed moderate anti-inflammatory activity which may be due to the strong occurrence of polyphenolic compounds such as flavonoids, tannins and phenols. HAECB has shown moderate anti-arthritic activity which may be due to the phenolic constituent.
In Vitro Anti Inflammatory and Anti Arthritic Activity of Commelina benghalen...
In Vitro Anti Inflammatory and Anti Arthritic Activity of Commelina benghalen...
SriramNagarajan16
Summary Vitamin C for preventing and treating the common cold
trabajo practico
trabajo practico
giovannig
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omar 1st
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Effect of the dry aqueous leaf extract of cnidoscolus aconitifolius on blood ...
Effect of the dry aqueous leaf extract of cnidoscolus aconitifolius on blood ...
Alexander Decker
Compilation of research i found on tea :)
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CiaranMcSponge
COMPARATIVE STUDY ON CONSUMPTION OF GREEN & BLACK TEA EXTRACT TO PROMOTE HEA...
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MEDC-533 Group 2 Green Tea Final
MEDC-533 Group 2 Green Tea Final
William Wolanski
Awodele toxicidad moringa
Awodele toxicidad moringa
Fausto Dutan
EXTRAPOLATION OF IN VITRO DATA TO PRECLINICAL TO HUMANS
EXTRAPOLATION OF IN VITRO DATA TO PRECLINICAL TO HUMANS
EXTRAPOLATION OF IN VITRO DATA TO PRECLINICAL TO HUMANS
KARNATAKA COLLEGE OF PHARMACY
In recent years as a result of the observation that the toxic effects of boron and its products have increased intensive studies have been initiated in our country and in the world regarding its effects, especially in the central nervous system, digestive system and reproductive system. The aim was to determine the histopathological changes caused by boric acid in rat testis, liver, kidney and brain tissues by light microscopy after oral administration of toxic dose of acute boric acid.
33133 article text-60219-2-10-20211104
33133 article text-60219-2-10-20211104
nalayranc
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
Effects of Acalypha torta (Muell) Leaf Extract on Histological Indices of the...
Effects of Acalypha torta (Muell) Leaf Extract on Histological Indices of the...
iosrphr_editor
Objective:Many of the available therapies for diabetes have a number of serious adverse effects; therefore the search for more effective and safer hypoglycaemic agents becomes a paramount. This research was set to investigate the antidiabetic potential and cytoprotective effect of ethanolic root extract of Salacianitida on alloxan induced hyperglyceamic rats. Method:Acute toxicity and phytochemical constituents were evaluated using standardized methods. The study lasted for a period of thirty days comprising of two phases: induction phase and treatment phase. Thirty animals were grouped into five groups of six rats each. Group 1 and 2 serve as normal and toxic control respectively while groups 3, 4, and 5 were treated with 750, 1500mg of S.nitidaand 5mg glibenclamide respectively. The BGL, food and fluid intake was monitored daily while the body weight was measured on weekly. The last day of the study after an overnight fast, the animals were loaded with glucose and the OGTT measured prior to and at 30minutes interval for two hours after which the animals were sacrificed under ether anaesthesia and the organs isolated for histological examination. Results/Conclusion:The results of the present study indicate that S.nitida possessantidiabetic potentials and cytoprotective effect noted in its significant percentage reduction in the glucose level, slight increase in body weight and restoration of the toxic organs to normal.
Antidiabetic and Cytoprotective Effect of Ethanolic Extract of SalaciaNitida ...
Antidiabetic and Cytoprotective Effect of Ethanolic Extract of SalaciaNitida ...
IOSRJPBS
Objective: To investigate the effects of Aquilaria subintegra leaf aqueous extracts on the aphrodisiac properties including sexual behaviour, testosterone level, percentage of pregnancy, number of offspring and male to female ratio of offspring in ICR mice. Methods: In this experiment, each male cohabitated with one female in a polysulfone cage. 30 ICR male mice were divided into 6 groups that received normal saline (the control group), 50 mg/kg, 100 mg/kg, 200 mg/kg, 500 mg/kg, and 1 000 mg/kg body weight of Aquilaria subintegra leaf aqueous extracts orally for 21 days consecutively. Sexual behavior, percentage of pregnancy, number of offspring and male to female ratio of offspring in ICR mice were measured according to the established methods. Testosterone level was measured by using enzyme-linked immunosorbent assay. Results: Mice that received Aquilaria subintegra leaf aqueous extracts at 50 mg/kg body weight (day 0) had significantly higher mount frequency as compared to the control group; groups treated with 100, 500, 1 000 mg/kg body weight extracts produced a greater number of offsprings when compared to the control group. All aphrodisiac parameters were similar between the treatment groups and the control group, indicating that Aquilaria subintegra leaf aqueous extract did not significantly alter the aphrodisiac parameters. Conclusions: Aquilaria subintegra leaf aqueous extracts have no effect on the aphrodisiac properties, but could increase the breeding rate in mice.
Effect of lyophilized aqueous leaf extract of Aquilaria subintegra on aphrodi...
Effect of lyophilized aqueous leaf extract of Aquilaria subintegra on aphrodi...
Mohammed Muayad TA
International journals call for papers, http://www.iiste.org/
Comparative evaluation of the effects of artemisinin based combination therap...
Comparative evaluation of the effects of artemisinin based combination therap...
Alexander Decker
Antioxidant Status and Lipid Peroxidation in Diabetic Rats under Hyperbaric Oxygen Exposure
Matsunami et al., 2010 2nd
Matsunami et al., 2010 2nd
松波動物病院メディカルセンター
Published by Pratik Umesh Parikh Master of Pharmacy (Pharmaceutical Biotechnology)
Experiment modelling of Auto-immune diseases
Experiment modelling of Auto-immune diseases
Pratik Parikh
Enhancement of glucose toxicity by hyperbaric oxygen exposure in diabetic rats
Matsunami et al., 2008 1st
Matsunami et al., 2008 1st
松波動物病院メディカルセンター
Andrographolide, a bicyclic diterphenoid lactose, extracted from a plant, Andrographis paniculata, is known for its multiple clinical applications in traditional Siddha and Ayurvedic systems in India. Its therapeutic value is perhaps by virtue of its mechanism of action through enzyme induction. The present study is aimed to determine the effects of andrographolide on succinate dehydrogenase (SDH) activity, in vitro, using mitochondrial fractions isolated from different organs of BALB/c mice. Administration of andrographolide into mitochondrial fraction of liver, lung and kidney resulted in the induction of SDH. Mitochondrial fraction of lung tissues indicated the maximum SDH acceleratory activity (68.19%), in vitro, against 50 μg/ml concentration of andrographolide.
Andrographolide Induced Succinate Dehydrogenase Activity in Isolated Mitochon...
Andrographolide Induced Succinate Dehydrogenase Activity in Isolated Mitochon...
IOSR Journals
International peer-reviewed academic journals call for papers, http://www.iiste.org/Journals
In vivo comparative evaluation of effects of
In vivo comparative evaluation of effects of
Alexander Decker
Assignment on Limitation of animal experimentation
Assignment on Limitation of animal experimentation
Assignment on Limitation of animal experimentation
Deepak Kumar
Kindly find this paper useful in all fields, you can as well share the resource with friends in all learning institutions. This is entirely the my original work. The paper will also be useful in fields like medicine, law and social science.
Green tea revised4
Green tea revised4
musyokasaff
Justifications for invasive experiments on animals rely on claims that such research is essential for the advancement of biomedical knowledge, for the development of cures to human diseases, or for the evaluation of the toxicity of compounds to which humans are exposed. Until recently, critical evaluations of the accuracy of such claims have been rare. However, a growing body of large-scale systematic reviews have now been published in scientific and medical journals. The outcomes have been consistent: animal experiments have contributed far less than advocates would have us believe. This presentation summarises these recent results, and comprehensively reviews the alternatives to invasive animal use with biomedical research, toxicity testing, and education. Published studies are available at www.AnimalExperiments.info.
Animal Experiments and Alternatives
Animal Experiments and Alternatives
Andrew Knight
Introduction Commelina benghalensis L. commonly known as Benghal dayflower, belongs to the family Commelinaceae. It is widely used for the treatment of wounds and skin diseases. Aim The current study focuses on the evaluation of in vitro anti-inflammatory and antiarthritic property of the leaf extracts ofCommelina benghalensis L. Methods The hydroalcoholic extract (70%) of Commelina benghalensis L. (Leaf) was subjected to anti-inflammatory and anti arthritic activity by membrane stabilisation and inhibition of protein denaturation method were determined. Results The inhibitory concentration (IC50) of HAECB in HRBC membrane stabilization study was found to be 69µg/ml in comparison with diclofenac sodium 57µg/ml. It showed moderate anti-inflammatory activity. The inhibitory concentration (IC50) of HAECB in protein denaturation was found to be 17µg/ml in comparison with diclofenac sodium 14µg/ml. It showed moderate anti-arthritic activity. Conclusion HAECB showed moderate anti-inflammatory activity which may be due to the strong occurrence of polyphenolic compounds such as flavonoids, tannins and phenols. HAECB has shown moderate anti-arthritic activity which may be due to the phenolic constituent.
In Vitro Anti Inflammatory and Anti Arthritic Activity of Commelina benghalen...
In Vitro Anti Inflammatory and Anti Arthritic Activity of Commelina benghalen...
SriramNagarajan16
Summary Vitamin C for preventing and treating the common cold
trabajo practico
trabajo practico
giovannig
omar 1st
omar 1st
Omar farid
Effect of the dry aqueous leaf extract of cnidoscolus aconitifolius on blood ...
Effect of the dry aqueous leaf extract of cnidoscolus aconitifolius on blood ...
Alexander Decker
Was ist angesagt?
(20)
MEDC-533 Group 2 Green Tea Final
MEDC-533 Group 2 Green Tea Final
Awodele toxicidad moringa
Awodele toxicidad moringa
EXTRAPOLATION OF IN VITRO DATA TO PRECLINICAL TO HUMANS
EXTRAPOLATION OF IN VITRO DATA TO PRECLINICAL TO HUMANS
33133 article text-60219-2-10-20211104
33133 article text-60219-2-10-20211104
Effects of Acalypha torta (Muell) Leaf Extract on Histological Indices of the...
Effects of Acalypha torta (Muell) Leaf Extract on Histological Indices of the...
Antidiabetic and Cytoprotective Effect of Ethanolic Extract of SalaciaNitida ...
Antidiabetic and Cytoprotective Effect of Ethanolic Extract of SalaciaNitida ...
Effect of lyophilized aqueous leaf extract of Aquilaria subintegra on aphrodi...
Effect of lyophilized aqueous leaf extract of Aquilaria subintegra on aphrodi...
Comparative evaluation of the effects of artemisinin based combination therap...
Comparative evaluation of the effects of artemisinin based combination therap...
Matsunami et al., 2010 2nd
Matsunami et al., 2010 2nd
Experiment modelling of Auto-immune diseases
Experiment modelling of Auto-immune diseases
Matsunami et al., 2008 1st
Matsunami et al., 2008 1st
Andrographolide Induced Succinate Dehydrogenase Activity in Isolated Mitochon...
Andrographolide Induced Succinate Dehydrogenase Activity in Isolated Mitochon...
In vivo comparative evaluation of effects of
In vivo comparative evaluation of effects of
Assignment on Limitation of animal experimentation
Assignment on Limitation of animal experimentation
Green tea revised4
Green tea revised4
Animal Experiments and Alternatives
Animal Experiments and Alternatives
In Vitro Anti Inflammatory and Anti Arthritic Activity of Commelina benghalen...
In Vitro Anti Inflammatory and Anti Arthritic Activity of Commelina benghalen...
trabajo practico
trabajo practico
omar 1st
omar 1st
Effect of the dry aqueous leaf extract of cnidoscolus aconitifolius on blood ...
Effect of the dry aqueous leaf extract of cnidoscolus aconitifolius on blood ...
Andere mochten auch
Compilation of research i found on tea :)
Tea Research
Tea Research
CiaranMcSponge
COMPARATIVE STUDY ON CONSUMPTION OF GREEN & BLACK TEA EXTRACT TO PROMOTE HEA...
COMPARATIVE STUDY ON CONSUMPTION OF GREEN & BLACK TEA EXTRACT TO PROMOTE HEA...
nutritionistrepublic
PROJECT ON UMIYA TEA AND FOOD FOR MBA SIP
UMIYA TEA AND FOOD
UMIYA TEA AND FOOD
jitharadharmesh
This was a presentation for the employees at Legoland in Carlsbad, CA about the difference between conventional and organically grown produce.
Organic vs. Conventional - what's the difference anyway?
Organic vs. Conventional - what's the difference anyway?
Janis Garcia
Greenlife is a cooperative of organoic farmers, organic suppliers and organic consumers,started in the year of 2003,with an aspiration to bridge the gap between the farmers and consumers and also with environment nd society focused values to cherish and sustain the natural cycle of crop growth and food consumtion in the possible cost effective ways. With 8 years of experience research activities , Greenlife has assimilated a thorough knowledge of about the organic farming techniques , organic production, processing and packging . With these core competencies , Greenlife is geared up with its unique concept and now ready to supply the pure , fresh and natural organic products.
Greenlife Organic
Greenlife Organic
NetraBhat
Green tea and longevity: health benefits
Green tea and longevity: health benefits
Dr. Latika Yadav
What is Organic Farming - The Basics !
What is Organic Farming - The Basics !
Satyajit Chemicals Pvt Ltd
valu of frozen and fresh vegetables is comparable differnet practically proved by vijay pachlasiya under the co guidence of asif kanth
comparative study of nutritional value of frozen &fresh fruits & vegetables