The presentations explain the role of bioinformatics in cancer Research

1. Role of Bioinformatics
in Cancer Research
Presented By : Akash Arora
(1410105001))
Department of Biotechnology
Faculty of Engineering & Technology

2.  What Is Cancer ?
An abnormal growth of cells which tend to proliferate in an uncontrolled way
mainly due to :
Chromosomal RearrangementsMutations Errors in Molecular machinery

3.  What Is Cancer ?
An abnormal growth of cells which tend to proliferate in an uncontrolled way
mainly due to :
Chromosomal RearrangementsMutations Errors in Molecular machinery
[ Image : http://byjus.com/biology/mutation-genetic-change/ ]

4.  What Is Cancer ?
An abnormal growth of cells which tend to proliferate in an uncontrolled way
mainly due to :
Chromosomal RearrangementsMutations Errors in Molecular machinery
[ URL : https://ghr.nlm.nih.gov/primer/mutationsanddisorders/structuralchanges ]

5.  What Is Cancer ?
An abnormal growth of cells which tend to proliferate in an uncontrolled way
mainly due to :
Chromosomal RearrangementsMutations Errors in Molecular machinery
[ Image : http://www.radiolab.org/story/223276-double-blasted/ ]

6.  Why is cancer research important to us ?
[Image : https://www.cancer.gov/about-cancer/understanding/statistics ]

7.  Why is cancer research important to us ?
Image :http://health.economictimes.indiatimes.com/news/industry/cancer-what-it-costs-to-india/46588327

8. The science of collecting and analyzing complex biological data such as genetic
codes which mainly uses tools for : (Cancer research perspective)
 What is Bioinformatics ?
[ Image : https://www.researchgate.net/publication/2599872IM71 ]

11.  From where can we get the data ?

12.  What does the Databases offer ?
https://dcc.icgc.org/projects
[ URL : https://dcc.icgc.org/projects ]

15. [ URL : https://portal.gdc.cancer.gov/ ]

18. [ URL : https://portal.gdc.cancer.gov/repository ]

21. What can be
done with
this data ?

22. Incite of cancer progression
Bio-simulations
Identification of drug able targets
 Early detection of cancer via identification of
biomarkers
 Risk analysis
Personalized medicine

23. How it can
be done ?
?

24. Tools for data analysis [ URL : https://dcc.icgc.org/analysis ]

27. [ URL : https://dcc.icgc.org/analysis ]

31. [ URL : https://dcc.icgc.org/analysis ]

35. [ URL : https://dcc.icgc.org/analysis ]

38. Software
Packages for
Data Analysis

39. The GBG's mission is to :
 Manage and assess molecular interaction data obtained through
multiple platforms
 Increase the understanding of the effect of those interactions on the
chemo sensitivity of cancer.
 Create tools that will facilitate that process.
 Translation of that information will be directed towards the
recognition of diagnostic and therapeutic cancer biomarkers, and
directed cancer therapy.
[URL : https://discover.nci.nih.gov/index.jsp ]

40.  Match Miner
 Ab Miner
 CIMminer clustered image
 Go Miner tree display Go Miner
 High-Throughput Go Miner
 Cell Miner
 Splice Center Array-Check tool Splice
Center
 Splice Miner

41. [ URL : http://genetics.bwh.harvard.edu/pph2/ ]

42.  R-Project : The Project for Statistical Computing
R provides a wide variety of statistical (linear and nonlinear
modelling, classical statistical tests, time-series analysis,
classification, clustering and graphical techniques, and is
highly extensible.
[ URL: https://www.r-project.org/ ]

43.  References
• https://icgc.org/
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675499/
• https://cancergenome.nih.gov/
• http://health.economictimes.indiatimes.com/news/industry/cancer-what-it-
costs-to-india/46588327
• https://www.cancer.gov/about-cancer/understanding/statistics
• https://discover.nci.nih.gov/