activities

1. Thyme and Ivy Syrup for of Acute Productive Cough Treatment
Reham Mostafa, Mahmoud Adel, Hossam Mostafa, Mariam Hossam, Dina Ramadan, Mohamed Youssef, Esraa Ramadan,
Mohsen Mohamed, Tarek Kamel, Nada Gamal, Yasmin Mukhtar, Yasmin Thabet,
Prof Dr/ Abdelsalam Ibrahem - Dr/ Ahmed Ismail Sabry
Ass. Lecturer/ Shimaa M. Abdelgawad
Under Supervision of 1. The Book Of Pharmacognosy I, Pharmacognosy Department Fuculty of Pharmacy Fayoum University
2. Fundamentals of pharmacognosy and phytotherapy book
3. MONOGRAPH FROM NATURAL STANDARD by Catherine Ulbricht, PharmD, Column Editor
4. Phytotherapy: a textbook for pharmacy students by Dr. Dezső Csupor, University of Szeged
5. Review on Thymus vulgaris Traditional Uses and Pharmacological Properties by Prasanth Reddy, Ravi Vital Kandisa, Varsha and Satyam.
6. Lutsenko, Yulia & Bylka, Wiesława & Matławska, Irena & Darmohray, Roman. (2010). Hedera helix as a medicinal plant. Herba Pol. 56.
7. https://www.herbalgram.org/resources/herbalgram/issues/80/table-of-contents/article3352/
8. https://www.slideshare.net/MarwaFayed1/herb-2-88178339
9. https://www.medicalnewstoday.com/articles/266016#benefits
10. https://pfaf.org/user/Plant.aspx?LatinName=Hedera+helix
11. https://www.rxlist.com/thyme/supplements.htm
References
Name and Origin Active constituents of plant Indication of the product
Dose of the product
Procedure of Preparation
Plant photos
Content of the product
Side effects of the products
Precaution & Contraindications of the product
Fayoum university
Faculty of Pharmacy
Pharmacognosy department
- Cultivated in most of the European countries, France,
Spain and Italy.
Hedera helix L.
Family: Araliaceae
English Name: English Ivy, common Ivy, European
Ivy
Thymus vulgaris L.
Family: Lamiaceae (Labiatae).
English Name: English Thyme, Garden Thyme.
- English ivy is native to Europe, Western Asia and Africa.
Uses of plant
• Eliminate Respiratory congestion
• Expectorant that dislodges mucus in bronchi due to
saponins and sapogenins.
• Volatile oils: Thymol, carvacrol,,
thymol methyl ether.
• Flavonoids: apigenin, thymonin
• Polyphenolic acids: rosmarinic and
caffeic acids
Thyme
Ivy
• Cough associated with cold.
• Symptoms of bronchitis, whooping cough
• Indigestion, flatulence and colic (carminative).
• Expectorant in reproductive cough.
• Anti-spasmodic, Anti-inflammatory
• Disinfecting minor burns as an antibacterial.
Adult Dosing adolescents over 12 years of age:
5 ml of the syrup three times a day (corresponding to 201 mg of
dry ivy/thyme extract daily).
Children from 6 to 11 years of age: 5 ml of syrup twice a day
(corresponding to 134 mg of dry ivy/thyme extract daily).
Pulmonary/Respiratory: Occupational asthma provoked by thyme
Gastrointestinal: Oral thyme and thyme oil may elicit heartburn,
nausea, vomiting, diarrhea, and gastrointestinal irritation.
• Avoid if known allergy/hypersensitivity to members of the
Lamiaceae (mint) family or to any component of thyme or Ivy.
• Use cautiously in patients with gastrointestinal irritation or
peptic ulcer disease due to gastrointestinal irritation.
• It's unsafe to use ivy if you are pregnant as it could cause
miscarriage.
• Ivy contain irritant chemical to kidney, so not used if you have
kidney problems.
For Thyme
For Ivy
The most common side effect is contact dermatitis, a type of
allergic reaction by skin contact with ivy leaves and is caused by
a compound called falcarinol.
Figure 1: Thymol and
carvacol structures
Figure 2: hederacoside C
Thyme/Ivy cough syrup
(Hedera helix leaves 50% + Thymus vulgaris leaves 50%)
120 ml solution contains
- 2 g of powder mixture in 80 ml Ivy/thyme Extract
- 40 ml Glucose honey
*Indicated as Expectorant specially
for bronchitis and catarrh.
Figure 5: Infusion of Thyme/Ivy
Thyme
Stem: quadrangular; greenish-brown
Leaves: Small, opposite decussate
Flowers: bilabiate, pinkish purple in
color.
1) Ivy and thyme leaves
were freshly collected,
dried, milled into a
powder, and then mixed.
4) Infusion was filtered
to obtain the extract of
the active constituents.
5) Syrup was prepared
as Extract to glucose
honey (2:1 ratio)
6) 80 ml of extract was
mixed with 40 ml
honey homogenously to
get 120 ml syrup.
Therapeutic effect is related to the agonistic
effect of the beta 2 adrenoreceptors,
bronchodilator, mucolytic and expectorant
Photo of prepared Product
Traditional Use: in heartburn, asthma and bronchitis
- To stimulate menustrual flow
- Aid in resolving childhood diarrhea and bedwetting.
Traditional Use: in the treatment of rheumatism,
swollen tissue, painful joints, burns and cuts
• Triterpenoid saponins:
hederasaponin C (=hederacoside C),
B and D and α-hederin.
• Flavonoids: Quercetin, kaempferol
• Polyacetylenes: falcarinol
Macroscopical and microscopical features
2) 4 gm of mixed
powder was used. 3) Infusion was prepared
by adding 200ml boiling
water to 4 gm powder
and left for 1 hr.
Figure 6: Final Prepared product
Figure 7:
Thyme/Ivy cough syrup
Figure 3: Thyme plant Figure 4: Ivy plant
Stomata of Hedera helix
• Thymol (main constituent): Antiseptic, Antimicrobial
• Improve liver function
• Appetite stimulant
• As Gargle with chlorhexidine
• For sciatica, dermatitis
• Relieves Neuralgia and rheumatic pain.
Ivy
Leaves: Pattern, opposite shape
Fruit: blue-black drupe
Flowers: bisexual, regular
greenish white
Non-glandular hairs of thyme
Uniseriate multicellular.
Labiaceous hairs: unicellular
stalk and a glandular head of
radiating cells. Under L.M