1. I N N O V A T I O N H U B F O R C E N T R A L & E A S T E R N E U R O P E
StartVenture@Poland I seed
capital fund
Admir Berbiu
Investment Analyst
Startup Hub Poland Foundation
Tel. +48 786 138 536
e-mail: admir.berbiu@startuphub.pl

2. BIO-TECH
BIO-TECH
CLEAN-TECH
ENERGY EFFICIENCY
FOOD PROCESSING
TECH
AGRO-TECH1. HIPROMINE
2. HOLO SURGICAL
3. CAVINNOVA
4. VIRTUAL POWER PLANT
5. NANOTHEA
6. VORTEX OIL ENGINEERING
7. NANOSANGUIS
MEDICAL DEVICES
2015 Track record - Overview

3. HVAC control &
optimization
via secure overlay
or IP / VPN
1
 First advanced Energy demand management company in CEE (demand side
response).
 Well-targeted customers base and growing sales’ pipeline.
 Energy efficiency - consumption reduced by 25%
 The company's goal is to offer customers a fully fledged DSR (Demand Side
response) IT tool, which allows to shift electricity consumption off the daily peaks in
energy demand. VPPlant’s solution is a natural extension to its energy efficiency
management systems designed for large civil and utility buildings (based on
controlling the HVAC systems and self-learning algorithms).
www.vpplant.pl
based on the load
weather forecast &
energy market
forecast
optimization based on
signals
from energy market
online monitoring
Compensation
from DSR
25% reduction
of energy usage
Adjustment to the usage
of facility (i.e.occupancy)
ENERGY
EFFICIENCY

4. 2
 Life-saving technology solving problem of a growing blood demand for use in
clinical surgeries and/or in blood loss incidents
 In vivo testing phase of an innovative approach of oxygen transportation in living
organisms.
 NanoSanguis develops a sustainable substitute of red blood cells. The final
product will have the form of a slime in perfluorocarbon shell with a diameter less
than 6 microns and can be used in a number of blood-loss related situations
(hospital surgeries, pre-transfusion situations, organs transportation), as well as in
human organ transportation.
www. nanosanguis.com
Ability to reload with
oxygen in lungs
Goal: circulation time in
blood stream 20 days

5. 3
www. nanosanguis.com
 Evaluation of the stability under physiologic conditions,
oxygen capaxity and quality control method
 Lack of cytotoxicity proofed (ISO 10993-5 norm)
 Optimization of the product composition and production
method.
 Experiments ex vivo on animal organs, preparations for
experiments on mice.
Development Plan:
R&D
PRECLINICAL
CLINICAL
R&D
ORGAN FARM
BLOOD SUBSTITUTE
PRECLINICAL
RPO grant
(PLN 2.8 M)
CLINICAL
20172016 20192018
Fast Track grant
(PLN 7.2 M)
?
Stage of Development: product development

6. Tumor injected subcutaneously. Biodistribution in tumor
(L1 sarcoma) bearing mice after 24 h
4
 Promising early phase outcomes in new approach to oncological diagnostics with
use of nanoparticles.
 Creation of new tool in fight against cancer.
 NanoThea develops an oncology diagnostics technology with the idea of
encapsulating radioactive isotopes in dextran-based nanoparticles. Thanks to this
technology, the phenomenon of half-time decay of isotopes creates an effective
radiopharmaceutical which will detect any scattered cancer cells in a human body
undergoing the PET scanning procedure.
www.nanothea.com
i.v. injection of Isotope
carrying nanoparticles
Nanoparticles accumulate
in cancer cells
Isotope decays and emits
radiation detected by PET

7. 5
 Synthesis of the NP.’s – DOTA particle.
 In-vivo studies on mice in POLATOM Institute - comfirmed
the lack of toxicity and radio stability of nanoparticles
carrying a radioisotop in animals.
 Works on optimisation of nanoparticles in direction of
better targeting toward tumor
www.nanothea.com
Stage of Development: product development & pre-clinical
studies on animals
2015 2016 2017 2018-19 2020-22 2023 2024-
PRECLINICAL
STUDIES
GLP
CLINICAL TRIALS FDA / EMA
APPROVAL
DISCOVERY
MARKET
Safe nanocarrier
Fluorescent labelling
Radiolabelling
In vivo first exp.
$13M$1.5M $2M$0.5M
Phase I,II Phase III
$13M
Costs
Development Plan:

8. L O C A L P R E S E N C E W I T H G L O B A L F O O T P R I N T
 HiProMine turns waste into life-giving proteins, oils and nutraceuticals, thus
fighting the global problems of waste management and insufficient supply of
proteins for animal feed.
 The company has developed a technology of scale breeding of insect as source of
high-quality protein.
 Technology involves very low usage of water compared to other breeding
technologies and has very low CO2 emissions.
 The winner of Uber Pitch Contest. One of four projects from Europe invested by Uber
www.hipromine.com
6
PRE –
SEED

9. 7
 World-class healthcare solution developed in Poland and the US.
 Polish-American team focused on the promising augmented reality applications in
healthcare (computer-aided surgery procedures).
 Technology developed with targeted multi-use in selected surgical treatment areas.
 Holo Surgical develops software for 3D navigation in spine surgery applications.
The software processes in real-time images obtained with standard medical
devices (CT, X-Ray, MRI, etc.) into a 3D model of the patient's anatomy allowing
mutual positioning of the patient and medical instruments in the operating field.
The 3D model is displayed on the screen placed over the patient's body, and
ultimately on the glasses for augmented reality.
 CURENT STAGE:
 Prototype ready
 Aplication for a NCBiR grant „Fast Track” sent
MEDICAL
DEVICESwww.holosurgical.com

10.  State-of-the-art device for reduction of water use in oil extraction (eco-friendly
solution).
 With the global daily oil consumption equaling approx 95m bbl, oil companies are
facing both the relative scarcity of water resources and wastewater utilization
costs, as it takes twice as much water to produce the required oil daily amount.
 Vortex Oil Engineering develops devices for the treatment of water used in
extraction of oil in oil deposits with water-flooding technology. The water used to
pump the deposit can be reused after cleaning and restoration of its physic-
chemical features. Due to the mechanical method of operation, cleaning is carried
out in a cheaper and more ecological way.
www.vortex-oil.com CLEAN-TECH
8

11.  2 months into the field test
 6 injection wells fitted
www.vortex-oil.com CLEAN-TECH
9
 Injection rate change after Vortex system implementation – from 20t to 80t daily.
Technology Readines Level (TRL): 8
 1st Gen Vortex devices –
tested
 2nd Gen Vortex devices -
manufactured, implemented in
the field, data being gathered.
Metrics from field tests:
 20% oil recovery increase already registered
 Injection rate changes registered
100% Eco-friendliness
the method allows for more efficient and longer usage of water during the Water Floading procedure — no chemicals are involved.
No power supply needed – compatible with other methods

12.  Created an unique technology for elimination of pathogens in soft drinks with
minimal change of vitamins and microelements by using process of cavitation.
 Huge and growing target market in food and beverage industrial equipment.
 Cavitation proces is a phenomenon which occurs in a flowing liquid as a result of a
decrease and subsequent increase in local pressure - bubbe implosion.
 Cavinnova innovative technology allows for:
 deactivating microbes in different kinds of liquids and aquatic environment
 preserving vitamins and taste of liquids
 providing both pasteurization and homogenization of liquids
 lowering costs, since non -thermal pasteurization economizes the energy
consumption
www.cavinnova.com
10
FOOD PROCESSING
TECH
Cavitation damage to a pump impeller