CV-Ingles-2016

CURRICULUM VITAE
PERSONAL
Name : ABRAHAM JAIME VAISBERG WOLACH
Address : Eucaliptos 355. San Isidro. Lima 27, Peru.
Born : August 4, 1946 in Lima, Peru.
DEGREES AND TITLES
- Bs. C. : Universidad Peruana Cayetano Heredia
Lima, Peru. June 1969
- Ph. D. in : Brandeis University
Biology Waltham, Massachusetts 02154, USA.
February 1975.
CURRENT UNIVERSITY APPOINTMENTS
Director. Laboratories for Research and Development. Faculty of Sciences and Philosophy. Universidad
Peruana Cayetano Heredia.
Professor. Department of Cellular and Molecular Sciences. Universidad Peruana Cayetano Heredia. Lima,
Peru.
ACADEMIC AND PROFESSIONAL EXPERIENCIE :
1968 - 1969 Lecturer : Introductory Course in Virology. Department of Microbiology. Universidad
1969 - 1974 Research Assistant. Department of Biology. Brandeis University, U.S.A.
1970 - 1971 Teaching Assistant. Department of Biology. Brandeis University, U.S.A.
1970 Appointed Laboratory Instructor Department of Microbiology. Universidad Peruana
Cayetano Heredia
1972 Attended the Course: Experimental Marine Botany. Woods Hole. Massachusetts. June -
August 1972.
1975 Promoted to Assistant Professor. Department of Microbiology. Universidad Peruana
Cayetano Heredia
1976 Seminar Courses on:
- "Didactics applied to higher Education"
- "Learning by Modules"
At the Nucleo de Tecnologia Educacional para a Saude. Universidade Federal do Rio de
Janeiro / Centro Latino-Americano de Tecnologia Educacional para a Saude. Pan
American Health Organization. May 1976.
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l977 Seminar Course on: The Status of the Biological Sciences in Peru. As a representative of
the National Committee of the Regional Program for Post-Graduate Trainning in the
Biological Sciences UNPD/UNESCO RLA 76/006. November 1977.
1978 Professor in charge of the "Laboratory for Cell Biology and Virology". Since January
1978.
1979 Coordinator of the Post-Graduate Course on "Tissue Culture". Sponsored by the United
Nations Program for Development. February, 1979.
1979 Promoted to Associate Professor. Department of Microbiology. Universidad Peruana
Cayetano Heredia
1980 Member of the Instituto de Medicina Tropical Alexander von Humboldt. Universidad
1982 Invited by the International Foundation for Science and the University of Panama to
participate in the Course on "Pharmacologic Screening of plants and natural products".
November, 1982.
1983 Promoted to Principal Professor. Department of Microbiology. Universidad Peruana
Cayetano Heredia.
1984 Lecturer of the Post-Graduate Course on Advances in Pharmacology. Sponsored by the
Peruvian Society of Pharmacology. November, 1984.
1985 Appointed member of the Advisory Committee in the area of Biochemical Sciences for
the National Council of Sciences and Technology.
1986 Invited to participate in The International Colloquy on "Phytochemical Investigation of
Plants of the Andenean Area". Sponsored by the Convenio Andres Bello, and The
Concejo Nacional de Ciencia y Tecnologia del Ecuador. February 24 - 26, 1986.
Riobamba, Ecuador.
1987-1990 Elected Dean of the Faculty of Sciences and Philosophy. Universidad Peruana Cayetano
Heredia.
1988 Invited to attend the PSTC Conference on Biotechnology for Health and Agriculture.
Sponsored by USAID/PSTC. Washington D.C. June, 1988.
1990-1993 Re-elected Dean of the Faculty of Sciences and Philosophy.
1991 Member of the Instituto de Genetica. Universidad Peruana Cayetano Heredia
1993 Appointed member of the Advisory Committee in the area of Basic Sciences for the
National Council of Sciences and Technology (CONCYTEC).
1993 Member of the committee that organized the "Primera Reunión Nacional de
Investigadores en Productos Naturales de Uso Medicinal". October 18-19, 1993. Lima.
Programa Ibero-Americano de Ciencia y Tecnología para el Desarrollo (CYTED).
1993 Invited to attend the "Primeras Jornadas Franco-Latinoamericanas Sobre la Etica y los
Avances de la Investigación Bio-médica". Organized by the Office of Regional
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Cooperation of the Ministry of Foreign Affairs of France. November 23 - 25, 1993.
Buenos Aires, Argentina.
1994 Appointed member of the National Committee of the Biological Sciences Latinoamerican
Ned.
1994 Lecturer of the National Course on Bioassay Techniques for the Evaluation of
Antiinflamatory activity. Sub-Red de Productos Naturales de Uso Medicinal-CYTED,
Lima, 3-7 October de 1994.
1995-1999 Chairman of the Peruvian Nominating Committee for International Research Fellowships
of the Fogarty International Center.
1996-1999 Elected Chairman of the Department of Microbiology. Universidad Peruana Cayetano
Heredia.
1997 Visiting Professor. Washington University. Saint Louis, Missouri. USA.
1999 Invited to attend the Conference on Achievements in Innovation. Science and Technology
Task Force. Pacific Economic Council. Vancouver, Canada. September 22-25
1999-2005 Dean of the Faculty of Sciences and Philosophy. Universidad Peruana Cayetano Heredia.
1995- Appointed Director of the Laboratories for Research and Development. Faculty of
Sciences and Philosophy. Universidad Peruana Cayetano Heredia.
2000-2001 Appointed member of the Directive Committee of the National Council for Sciences and
Technology (CONCYTEC).
2002-2012 Appointed by the National Council for Sciences and Technology, as Governor to the
International Center for Genetic Engineering and Biotechnology (ICGEB).
2004 Invited to participate in the workshop “Encuentro Hispano-Peruano de las Biociencias y
la Bioindustria”. Bilbao, Spain. March 29-30
2005 Invited by the Internacional Atomic Energy Agency to participate in the workshop “Taller
Regional sobre l Metodología del Marco Lógico para la Preparación de Proyectos de
Cooperación Técnica”. Quito, Ecuador. Noviembre 7-11
2008 Member of the Committee for Research in Natural Products Used for Health. Peruvian
National Institute of Health
2009 Appointed Director of the area of Life Sciences of the Academia Nacional de Ciencias
2012 Elected Vice-President of the National Academy of Sciences, Perú
2014 Elected President of the National Academy of Sciences, Perú
PROFESSIONAL SOCIETIES
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1974-84 American Society of Plant Physiologists.
1980- American Society for Microbiologists.
1980- Sociedad Peruana de Biologia Celular.
1983- Sociedad Latinoamericana de Fitoquimica.
2000- The American Society of Pharmacognosy
SCHOLARSHIPS AND FELLOWSHIPS
1) Wien International Scholarships. For graduate studies in the Biology Department. Brandeis
University, U.S.A. September 1969 - August 1972.
2) Brandeis University's Graduate School Fellowship September 1970 - August 1972.
3) Brandeis University's Kessner Predoctoral Fellowship. September 1972 - December 1974.
4) Scholarship from the Ministry of Foreign Affairs of Brasil. To attend the Courses:
- "Didatics applied to higher Education"
- "Learning by Modules"
At the Nucleo de Tecnologia Educacional para a Saude.
Pan American Health Organization. May 1976.
HONORS AND AWARDS
1989 Elected Member of the National Academy of Sciences of Peru.
1998 Awarded the “Carlos Monge Medrano Prize”. Patronato de la Asociación Peruana
Cayetano Heredia.
1999 Member of the Cayetano Heredia Order, Grand Officer Level
2000 Appointed Honorary Member of the Colegio de Biologos del Perú.
2002 Awarded the “ Premio Cobian de Estimulo a las Publicaciones de la Facultad de Ciencias y
Filosofía”. Universidad Peruana Cayetano Heredia.
2004 Appointed Member of the Academia de Ciencias de América Latina.
2010 Eponymous of the Laboratorios de Investigación y Desarrollo de la Facultad de Ciencias y
Filosofía”. Universidad Peruana Cayetano Heredia.
2014 Awarded the “Distinction Santiago Antúnez de Mayolo Gomero for Research in Sciences”.
Consejo Nacional de Ciencia Tecnología e Innovación Tecnológica (CONCYTEC).
PERSONAL BIBLIOGRAPHY
1.- Vaisberg, A. Algunas consideraciones sobre la Inducción y Síntesis del Sistema Interferón. Tesis de
Bachiller en Ciencias. Universidad Peruana Cayetano Heredia. June 1969.
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2.- Vaisberg, Abraham J. The Influence of Inhibitors of Carotenoid and Protein Biosynthesis on
Chloroplast. Development in Euglena gracilis Klebs var. bacillaris Pringsheim. Ph. D. Thesis,
Brandeis University l974. University Microfilms. Ann Arbor, MIchigan, U.S.A.
3.- Vaisberg, Abraham J., Schiff, J.A. Events Surrounding the Early Development of Euglena
Chloroplasts. 7. Inhibition of Carotenoid Biosynthesis by the Herbicide SAN 9789 (4-Chloro-5-
(methylamino)-2-(α, α, α trifluoro-m-tolyl) -3 (2H) Pyridazinone) and its Developmental
Consequences. Plant Physiology 1976; 57: 260-269.
4.- Vaisberg, Abraham J., Schiff J.A., Lynn Li, Zachary Freedman. Events Surrounding the Early
Development of Euglena Chloroplasts. VIII Photocontrol of the Source of Reducing Power for
Chloramphenicol Reduction by the Ferredoxin-NADP Reductase System. Plant Physiology 1976;
57: 594-601.
5.- Johnson, R. T., Hirsch, R.L., Griffin, D.E., Wolinsky, J.S., Roedenbeck, S., Lindo, I, Vaisberg, A.
Clinical and Immunological Studies of Measles Encephalitis (l98l). Transactions of the American
Neurological Association 1981; 106:42-45..
6.- Vaisberg, A., Patrucco, R., Roedenbeck, S., Lindo, I., Torres I., Hirsch, L., Griffin, D., y Johnson,
R. Estudios Inmunológicos en las Complicaciones del Sarampión: Reporte Preliminar. Diagnostico
1982; 10: 61-65.
7.- Johnson, R.T., Griffin, D.E., Hirsh, R., Vaisberg, A.J. Measles Encephalitis. Clinical Experimental
Neurology 1983; 19: 13-16.
8.- Griffin, D.E., Hirsh, R. L., Johnson, R.T., Lindo de Soriano, J., Roedenbeck, S., and Vaisberg, A.J.
Changes in Serum C-Reactive Protein during Complicated and Uncomplicated Measles Virus
Infections. Infection and Immunity 1983; 41(2): 861-864.
9.- Hirsch, R.L., Griffin, D.E., Johnson, R.T., Cobb, S.J., Lindo de Soriano, I., Roedenbeck, S.,
Vaisberg, A.J. Cellular Immune Responses during Complicated and Uncomplicated Measles Virus
Infections of Man. Clinical Immunology and Immunopathology 1984; 31(1): 1-12.
10.- Johnson, R.T., Griffin, D.E., Hirsh, R.L., Wolinsky, J.S., Roedenbeck, S., Lindo de Soriano, I., and
Vaisberg, A.J. Measles Encephalomyelitis-Clinical and Immunologic Studies. The New England
Journal of Medicine 1984; 310(3):137-141.
11.- Graves, M., Griffin, D.E., Johnson, R.T., Hirsch, R.L., Lindo de Soriano, I., Roedenbeck S., and
Vaisberg, A. Development of Antibody to Measles Virus Polypeptides during Complicated and
Uncomplicated Measles Virus Infections. Journal of Virology 1984; 49(2):409-412.
12.- Griffin, D.E., Cooper, S.J., Hirsh, R.L., Johnson, R.T., Lindo de Soriano, I., Roedenbeck, S., and
Vaisberg, A.J. Changes in Plasma IgE Levels during Complicated and Uncomplicated Measles
Virus Infections. The Journal of Allergy and Clinical Immunology. 1985; 76(2 Pt 1):206-213.
13.- Griffin, D.E., Moench, T.R., Johnson, R.T., Lindo de Sorinao, I., and Vaisberg, A.J. Peripheral
Blood Mononuclear Cells During Natural Measles Virus Infection: Cell Surface Phenotypes and
Evidence for Activation. Clinical Immunology and Immunopathology Clin Immunol Immunopathol.
1986; 40(2):305-312.
14.- Griffin, D.E., Johnson, R.T., Tamashiro, V.G., Moench, T.R., Lindo de Soriano I., Vaisberg, A.J.
In Vitro Studies of the Role of Monocytes in the Immunosuppression Associated with Natural Virus
Infections. Clinical Immunology and Immunopathology 1987; 45(3):375-383.
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15.- Johnson, R.T., Griffin, D.E., Arregui A., Mora C., Gibbs J., Cuba J.M., Trelles L., Vaisberg A.
Spastic Paraparesis and Human T-Lymphotropic Virus Type I Infection in Peru. Annals of
Neurology 1988; 23 Suppl:S151-55.
16.- Vaisberg, A., Guillen D., Hernandez H., , Chu P., Suarez de Loayza, V., Colarossi A., Alvarez J.
Evolucion de la Inmunidad Pasiva y Respuesta a la Vacunacion Contra el Sarampion. Diagnostico
1988; 21: 69-76.
17.- Moench, T.R., Griffin, D.E., Obriecht, Ch. R., Vaisberg, A.J., Johnson, R.T. Acute Measles in
Patients with and Without Neurological Involvement: Distribution of Measles Virus Antigen and
RNA. The Journal of Infectious Diseases 1988; 158(2):433-42.
18.- Vaisberg, A.J., Milla M., Planas M., Cordova J.L., Mustiga M., Carlin L., Rosas E., Ferreyra R.,
Hammond G.B. Taspine is the Cicatrizant Principle in Sangre de Grado Extracted from Croton
lechleri. Planta Medica 1989; 55: 140-143.
19.- Griffin, D.E., Ward, B.J.,Jauregui, E., Johnson, R.T., Vaisberg, A. Immune Activation in Measles.
New England Journal of Medicine 1989; 320: 1667-1672.
20.- Kirchhausen T., Nathanson K.L., Matsui W., Vaisberg A., Chow E.P., Burne C., Keen J.H., Davies
A.E. Structural and Functional Division into Two Domains of the Large Chains of the Clathrin
Associated Protein Complex AP-2. Proc. Natl. Acad. Sci. USA. 1989; 86: 2612-2616.
21.- Vaisberg, A., Alvarez J., Hernandez H., Guillen D., Chu P. Colarossi A. Loss of Maternally
Acquired Measles Antibodies in Well Nourished Peruvian Infants and Response to Measles
Vaccination,Peru. American Journal of Public Health 1990; 80:736-738.
22.- Griffin, D.E., Ward, B.J.,Jauregui, E., Johnson, R.T., Vaisberg, A. Immune Activation during
Measles: Interferon-g and Neopterin in Plasma and Cerebrospinal Fluid in Complicated and
Uncomplicated Disease. Journal of Infectious Diseases 1990; 161: 449-453.
23.- Griffin, D.E., Ward, B.J.,Jauregui, E., Johnson, R.T., Vaisberg, A. Natural Killer Cell Activity
during Measles. Clinical Experimental Immunology 1990; 81: 218-224.
24.- Ward, B.J., Johnson, R.T., Vaisberg, A., Jauregui, E., Griffin, D.E. Spontaneous Proliferation of
Peripheral Mononuclear Cells in Natural Measles Virus Infection: Identification of Dividing Cells and
Correlation with Mitogen Responsiveness. Clinical Immunology and Immunopathology 1990; 55:
315-326.
25.- Zavaleta, A.,Perez, E., Lock de Ugaz, O., Moran, M., Vaisberg, A. (1990).Directorio de Tesis
Universitarias Peruanas (1950-1986). Volumen I. Recurso Flora. Megaprint Ediciones S.A.
26.- Greenberg B.L., Sack R.B., Salazar-Lindo E., Budge E., Gutierrez M., Campos M., Vaisberg A.,
Leon-Barua R., Yi A., Maurutia D., Gomez M., Lindo I., Jauregui E. Measles-Associated Diarrhea
in Hospitalized Children in Lima, Peru: Pathogenic agents and impact on growth. Journal of
Infectious Diseases 1991; 163: 495-502.
27.- Ward, B.J., Johnson, R.T., Vaisberg, A., Jauregui, E., Griffin, D.E. Cytokine Production in Vitro
and the Lymphoproliferative defect of Natural Measles Virus Infection. Clinical Immunology and
Immunopathology 1991; 61: 236-248.
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28.- Goñi M., Vaisberg, A., Zavaleta, A. Citotoxicidad Inducida por Venenos de Serpientes Peruanas
sobre Fibroblastos de Raton. Revista de Biologia Tropical 1992; 40:143-145.
29.- Griffin, D.E., Ward, B.J.,Jauregui, E., Johnson, R.T., Vaisberg, A. Immune Activation during
Measles: ß2-Microglobulin in Plasma and Cerebrospinal Fluid in Complicated and Uncomplicated
Disease. Journal of Infectious Diseases. The Journal of Infectious Diseases 1992; 166: 1170-1173.
30.- Leon M.E., Ward, B.J.,Kanashiro R., Hernandez H., Berry S., Vaisberg, A., Escamilla J., Campos
M., Bellomo S., Azabache V., Halsey N. Immunological Alterations Two Years After High Titer
Measles Immunization in Peruvian Children. Journal of Infectious Diseases 168: 1097-1104, 1993
31.- Salas J., Tello V., Zavaleta A., Villegas L., Salas M., Fernandez I., Vaisberg A. Actividad
Cicatrizante del Latex de Jatropha curcas. Revista de Biologia Tropical 42: 323-326, 1994
32.- Esolen L.M., Takahashi K., Johnson, R.T., Vaisberg, A., Moench T.R., Wesselingh S.L., Griffin,
D.E. Brain Endothelial Cell Infection in Children with Acute Fatal Measles. Journal of Clinical
Investigation 1995; 96(5): 2478-2481.
33.- Carlin L., Vaisberg, A.J., Hammond G.B. Isolation of Sinoacutine from the leaves Croton lechleri.
Planta Medica 1996; 62: 90-91.
34.- Villegas L., Fernandez I., Maldonado H., Torres R., Zavaleta A., Vaisberg A.J., Hammond G.
Evaluation of the Wound Healing Activity of Selected Traditional Medicinal Plants from Peru.
Journal of Ethnopharmacology 1997; 55: 193-200.
35.- Hammond G.B., Fernandez I., Villegas L., Vaisberg, A.J. A Survey of Traditional Medicinal Plants
from the Callejón de Huaylas, Department of Ancash, Perú. Journal of Ethnopharmacology 1998;
61: 17-30.
36.- Lee K.K., Zhou b., Kingston D.G.I, Vaisberg, A.J., Hammond G.B. Bioactive Indole Alkaloids
from the Bark of Uncaria guianensis. Planta Medica 1999; 65: 759-760.
37.- Lewis W. H., Lamas G., Vaisberg, A., Corley D.G., Sarasara C. Peruvian Medicinal Plant Sources
of New Pharamaceuticals. Pharmaceutical Biology 1999; 37(Supplement): 69-83.
38.- Neto C. C., Vaisberg, A.J., Zhou B.N., Kingstone D.G., Hammond G.B. Citotoxic Triperpine Acid
from the Peruvian Medicinal Plant Polylepis racemosa. Planta Medica: 2000; 66(5): 483-484.
39.- Bautista-Lopez N.L., Vaisberg A., Kanashiro R., Hernandez H., Ward B.J. Inmune Response to
Measles Vaccine in Peruvian Children. WHO Bulletin 2001; 79: 1038-1046
40.- Villegas L., Marcalo A., Fernandez I., Maldonado H., Vaisberg A.J., Hammond G. (+)-Epi-α-
Bisabolol is the Wound Healing Principle in Peperomia galioides. Investigation of the In Vivo
Wound-Healing Activity of Related Terpenols. Journal of Natural Products 2001; 64: 1357-1359.
41.- Lee K., Wood C.A., Vaisberg A.J., Kingston D.G.I., Neto C.C., Hammond G. A Bioactive
Spirolactone Iridoid and Triterpenoids from Himatanthus sucuuba. Chemical & Pharmaceutical Bull.
2001; 49: 1477-1478
42.- Neto C.C.,Owens Ch. C., Langfield R., Comeau A.B., Onge J. St.,Vaisberg, A.J., Hammond G.B.
Antibacterial Activity of Some Peruvian Medicinal Plants from the Callejón de Huaylas. Journal of
Ethnopharmacology 2002; 79(1): 133-138.
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43.- Murphy b.T., MacKinnon S.L., Yan X., ., Hammond G.B., Vaisberg, A.J., Neto C.C. Identification
of Triterpene Hydroxycinnamates with in vitro Antitumor Activity from Whole Cranberry Fruit
(Vaccinium macrocarpon). Journal of Agricultural and Food Chemistry 2003; 51(12): 3541-3545.
44.- Lewis W. H., Vaisberg, A., Lamas G., Sarasara C., and Elvin-Lewis M.. Advantage of
Ethnobotanically-Based Research For Searching New Pharmaceuticals. Ethnobotany 2004; 16: 10-
15.
45.- Heitzman M.E., Neto C.C., Winiarz E., Vaisberg, A.J., Hammond G.B. Ethnobotany,
Phytochemistry and Pharmacology of Uncaria (Rubiaceae). Phytochemistry 2005; 66: 5-29.
46.- Rojas R., Caviedes L., Aponte J.C., Vaisberg A.J., Lewis W.H., Lamas G., Sarasara C., Gilman
R.H., Hammond G.B. Aegicerin, the First Oleanane Triterpene with wide-Ranging Antimycobacterial
Activity, Isolated from Clavija procera (Theophrastaceae). Journal of Natural Products 2006;
69:845-846.
47.-Moura-Letts G., Villegas L.F., Marçalo A., Vaisberg A.J., Hammond G.B. In Vivo wound-healing
Activity of Oleanolic Acid Derived from the Acid Hydrolysis of Anredera diffusa. Journal of Natural
Products 2006; 69:978-979.
48.- Neto C.C.,Krueger C.G.,Lamoureaux T.L., Kondo M., Vaisberg, A.J., Hurta R AR., Curtis S.,
Matchett M.D., Yeoung H., Sweeney M.I., Reed J.D. MALDI-TOF MS Characterization of
Proanthocyanidins from Cramberry Fruit (Vaccinium macrocarpon) that Inhibit Tumor Cell Growth
and Matrix Metalloproteinase Expression in vitro. Journal of the Science of Food and Agriculture
2006; 86(1): 18-25.
49.- Zegarra L., Vaisberg A., Loza C., Aguirre R., Campos M., Fernandez I., Talla O., Villegas L.
Double-Blind Randomized Placebo Controlled Study of Bixa orellana in Patients with Lower
Urinary Tract Symtoms Associated to Benign Prostatic Hyperplasia. International Brazilian Journal
of Urology 2007; 33(4): 493-501
50.- Castillo D., Arevalo J., Herrera F., Ruiz C., Rojas R., Rengifo E., Vaisberg A., Lock O., Lemesre
JL., Gornitzka H., Sauvain M. Spirolactone Iridoids might be Responsible for the AntiLeishmanial
Activity of a Peruvian Traditional Remedy Made wth Himatanthus sucuuba (Apocynaceae). J.
Ethnopharmacol. 2007; 112(2): 410-404.
51.- Aponte J.C., Vaisberg A.J., Rojas R., Caviedes L., Lewis W.H., Lamas G., Sarasara C., Gilman
R.H., Hammond G.B. Isolation of Cytotoxic Metabolites from Targeted Peruvian Amazonian
Medicinal Plants. Journal of Natural Products 2008; 71: 102-105..
52.- Aponte J.C., Estevez Y., Gilman R.H., Lewis W.H., Rojas R., , Sauvain M., Vaisberg A.J.,
Hammond G.B. Antiinfective and cytotoxic Compounds present in Blepharodon nitidum. Planta
Medica 2008; 74: 407-410.
53.- Callacondo D., Quispe-Mauricio A., Lido-Gammara S., Vaisberg A.J. Actividad Citotóxica del
Extracto Etanólico de Gnaphalium Spicatum “Keto Keto” en cultivos de Líneas celulares
Humanas. Revista Peruana de Medicina Experimental y Salud Pública 2008; 25(4): 380-385.
54.- Aponte J.C., Verastegui M., Malaga E., Zimic M., Quiliano M., Vaisberg A.J., Gilman R.H.,
Hammond G.B. Synthesis, cytotoxicity, and anti-Trypanosoma cruzi activity of new chalcones. J.
Medicinal Chemistry 2008; 51: 6230-6234
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55.- Hernández W., Paz J., Vaisberg A., Spodine E., Richter R. and Beyer L. Synthesis,
Characterization, and In Vitro Cytotoxic Activities of Benzaldehyde Thiosemicarbazone
Derivatives and Their Palladium(II) and Platinum(II) Complexes against Various Human Tumor
Cell Lines. Bioinorganic Chemistry and Applications Volume 2008. Article ID 690952
56.- Aponte J.C., Vaisberg A. J., Rojas R., Sauvain M., Lewis W.H.L., Lams G., Sarasara C., Gilman
R.H., Hammond GB. A Multipronged Approach to the Study of Peruvian Ethnomedicinal Plants. A
Legacy of the ICBG-Peru Project.. Journal of Natural Products 2009; 72: 524-526.
57.- Quispe-Mauricio A, Callacondo D, Rojas J, Zavala D, Posso M, Vaisberg A.J. Actividad
Citotóxica de Physalis peruviana en cultivos celulares de Adenocarcinoma Colorectal, Prostata y
Leucemia Mieloide Crónica. Revista Gastroenterológica. Perú. 2009; 29(3): 239-246.
58.- Quispe-Mauricio A, Callacondo D, Rojas J, Zavala D, Posso M. C., Vaisberg A.J. Efecto
Citotóxico de las Semillas de Annona cherimola en cultivos celulares de Cáncer de Cérvix, Mama
y Leucemia Mieloide Crónica. Acta Médica Peruana. 2009; 26(3): 156-161.
59.- José C. Aponte, Abraham J. Vaisberg, Denis Castillo, German Gonzalez, Yannick Estevez, Jorge
Arevalo, Miguel Quiliano, Mirko Zimic, Manuela Verástegui, Edith Málaga, Robert H. Gilman,
Juan M. Bustamante, Rick L. Tarleton, Yuehong Wang, Scott G. Franzblau, Guido F. Pauli, Michel
Sauvaini, Gerald B. Hammond. Trypanoside, anti-tuberculosis, leishmanicidal, and cytotoxic
Activities of tetrahydrobenzothienopyrimidines. Bioorganic and Medicinal Chemistry 2010; 18:
2880-2886.
60.- Patricia Rijo, M. Fátima Simoes, A. Paula Francisco, Rosario Rojas, Robert H. Gilman, Abraham J.
Vaisberg, Benjamin Rodriguez, Cristina Moiteiro. Antimycobacterial Metabolites from
Plectranthus: Royleanone Derivatives agaisnt Mycobacterium tuberculosis Strains. Chemistry and
Biodiversity 2010; 7: 922-932.
61.- José C. Aponte, Han Yang, Abraham J. Vaisberg, Denis Castillo, Edith Malaga, Manuela
Verástegui, Lavona K. Casson, Nicole Strivers , Paula J. Bates, Rosario Rojas, Irma Fernandez,
Walter H. Lewis, Michel Sauvain, Robert H. Gilman, Gerald B. Hammond. Cytotoxic and Anti-
ifective Sesquiterpenes Present in Plagiochila Disticha (Plagiochilsceae) and Ambrosia peruviana
(Asteraceae). Planta Medica 2010; 76: 705-707.
62.- Wilfredo Hernández, Juan Paz, Fernando Carrasco, Abraham Vaisberg, Jorge Manzur, Evgenia
Spodine, Lothar. Hennig, Joachim Sieler, and Lothar Beyer . Synthesis and Characterization of
New Palladium(II) Complexes with Ligands Derived from Furan-2-carbaldehyde and Benzaldehyde
Thiosemicarbazone and their in vitro Cytotoxic Activities against Various Human Tumor Cell
Lines. Zeitschrift fur Natursforschung 2010; 65B: 1271-1278.
63.- Mendoza A., Pérez-Silanes S., Quiliano M., Pabón A., Galiano S., González G., Garavito G., Zimic
M., Vaisberg A., Aldana I., Monge A., Deharo E. Aryl Piperazine and Pyrrolidine as Antimalarial
Agents. Synthesis and Investigation of Structure-Activity Relationships. Experimantal Parasitology
2011; 128: 97-103.
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64.- Aponte JC, Jin Z, Vaisberg AJ, Castillo D, Málaga E, Lewis WH, Sauvain M, Gilman RH,
Hammond GB. Cytotoxic and anti-infective phenolic compounds isolated from Mikania decora and
Cremastosperma microcarpum. Planta Medica 2011; 77(14):1597-1599
65.- Camacho J, Barazarte A, Gamboa N, Rodrigues J, Rojas R, Vaisberg A, Gilman R, Charris J.
Synthesis and biological evaluation of benzimidazole-5-carbohydrazide derivatives as antimalarial,
cytotoxic and antitubercular agents. Bioorg. Med. Chem. 2011; 19(6):2023-2029
66.- Z. Jin, M. Mashuta, N. Stolowich, W. J. Lewis, A. J. Vaisberg, N. S. Stivers, P. J. Bates, G. B.
Hammond Physangulidines A, B and C: Three New Antiproliferative Withanolides from Physalis
angulata L. Org. Lett 2012; 14: 1230-1233.
67.- Doroteo V.H., Terry C., Díaz C., Vaisberg A., Rojas R.Compuestos Fenólicos y Actividades
Antioxidante, Antielastasa, Anticolagenasa y Fotoprotectora in Vitro de Myrciaria dubia (camu
camu) y Caesalpinia spinosa (tara). Revista de la Sociedad Química del Perú 2012; 78(4): 254-263
68.- Mohamed Haddad, Anne-Cécile Lelamer, Laetitia Moreno Y Banuls, Maelle Carraz , Abraham
Vaisberg, Denis Castillo, Michel Sauvain, Rosario Rojas, Robert Kiss. In Vitro Growth Inhibitory
Effects of 13, 28-epoxyoleanane Triterpene Saponins in Cancer Cells. Phytochemistry Letters 2013;
6: 128-134.
69.- Reyes-Reyes E.M., Jin Z., Vaisberg A.J., Hammond G.B., and Bates P.J. Physangulidine A, a
Withanolide from Physalis angulata, Perturbs the Cell Cycle and Induces Cell Death by Apoptosis
in Prostate Cancer Cells. Journal of Natural Products 2013; 76: 2-7.
70.- Wilfredo Hernández, Juan Paz, Fernando Carrasco, Abraham Vaisberg, Evgenia Spodine, Jorge
Manzur, Lothar Hennig, Joachim Sieler, Steffen Blaurock and Lothar Beyer. Synthesis,
Characterization and In Vitro Cytotoxic Activity of New Complexes of Palladium(II) with
Thiosemicarbazones against Various Human Tumor Cell Lines. Bioinorganic Chemistry and
Applications 2013, Article ID 524701, 12 pages http://dx.doi.org/10.1155/2013/524701
71.- Synthesis, antileishmanial activity and cytotoxicity of 2,3-diaryl- and 2,3,8-trisubstituted
imidazo[1,2-a]pyrazines. Pascal Marchand, Marc-Antoine Bazin, Fabrice Pagniez , Guillaume
Rivière, Lizeth Bodero, Sophie Marhadour , Marie-Renée Nourrisson, Carine Picot , Sandrine
Ruchaud, Stéphane Bach, Michel Sauvain , Abraham J. Vaisberg, Patrice Le Pape. European
Journal of Medicinal Chemistry 2015; 103:381-395
72.- A new 5-Alkylresorcinol glucoside derivative from Cybianthus magnus. B. Cabanillas, P. Vasquez-
Ocmín, I. Zebiri, E. Rengifo, M. Sauvain, H.L. Le, A. Vaisberg, L Voutquenne-Nazabadioko and
M. Haddad. Natural Product Research, 2016; 30: 293-298.
http://dx.doi.org/10.1080/14786419.2015.1056188
73.- In VitroCytotoxicity Evaluation of Three Root-End Filling Materials in Human Periodontal
Ligament Fibroblasts. Hernán Coaguila-Llerena, Abraham Vaisberg, Zulema Velásquez-Huamán.
Brazilian Dental Journal 2016; 27(2): 187-191.
74.- Discovery of novel (imidazo[1,2-a]pyrazin-6-yl)ureas as antiproliferative agents targeting p53 in
non-small cell lung cancer cell lines. Marc-Antoine Bazin, Bénédicte Rousseau, Sophie Marhadour,
Christophe Tomasoni, Pierre Evenou, Sylvie Piessard, Abraham J. Vaisberg, Sandrine Ruchaud,
10

Stéphane Bach, Christos Roussakis and Pascal Marchand. Anticancer Research 2016; 36: 1621-
1630.
75.- Elucidation of cladofulvin biosynthesis reveals a cytochrome P450 monooxygenase required for
anthraquinone dimerization. Scott Griffiths, Carl H. Mesarich, Benedetta Saccomanno, Abraham
Vaisberg, Pierre J. G. M. De Wit, Russell Cox, and Jérôme Collemare. Proc. Natl. Acad. Sci. 2016;
113 (25) 6851-6856.
PATENTS
1. “Synthesis of stable organogold compounds and methods of use thereof” PCT/US2009/065488.
Filing date: November 23, 2009. Inventors: G. B. Hammond, P. J. Bates, A. J. Vaisberg, L. Liu, B.
Xu.
2. “Compund, Compositions, Pharmaceutical Compositions, and Methods of Use”.
PCT/WO2013/074905. Filing date: May 23, 2013. Inventors: G. B. Hammond, J. Zhuang, P. J.
Bates, E.M. Reyes-Reyes, A. J. Vaisberg.
ABSTRACTS
l.- Vaisberg, A.J., Lynn, Li, Jerome A. Schiff. Detoxification of Chloramphenicol in Euglena gracilis
var. bacillaris. Plant Physiology 53s: 5, l974.
2.- Vaisberg, A.J., Jerome A. Schiff. Inhibition of Carotenoid Synthesis in Euglena gracilis var.
bacillaris by SAN 9789 (4-chloro-5-(methylamino)-2- (α, α,α trifluoro -m- tolyl -3- (2H)
pyridazinone). Journal of Protozoology 2l: 447, l974.
3.- Vaisberg, Abraham J., Jerome A. Schiff. Detoxificacion de Cloranfenicol en Euglena gracilis var.
bacillaris. II Jornada Peruana de Microbiologia y Parasitologia Trujillo, Peru. October, l975.
4.- Vaisberg, A.J., Jerome A. Schiff. Sintesis de Pigmentos y Ensamblaje de Membranas en Euglena
gracilis. I Jornada Cientifica del XV Aniversario de la Universidad Peruana Cayetano Heredia.
January, l977.
5.- Vaisberg, A. Estudio del Efecto Cicatrizante de la Sangre de Grado en Cultivo de Tejidos. II
Jornada Cientifica de la Universidad Peruana Cayetano Heredia. December l979.
6.- Johnson, R. T., Hirsch, R.L., Griffin, D.E., Wolinsky, J.S., Roedenbeck, S., Lindo, I, Vaisberg, A.
Clinical and Immunological Studies of Measles Encephalitis. Abstract presented at the Annual
Meeting of the American Neurological Association (l98l).Transactions of the American Neurological
Association 106:42-45,1981
7.- Johnson, R.T., Griffin, D.E., Hirsch, R., Vaisberg, A. Measles Encephalitis. Clinical and
Experimental Neurology. Proceedings of the Australian Association of Neurologists. 19: 13-16,
1982.
11

8.- Cordova Rojas, J., Rosas de Agusti E., Vaisberg, A. Estudio de la Posible Actividad Mutagenica,
Carcinogenica, y/o Promotora de Cancer de la Sangre de Grado y su Principio Activo la Taspina. IV
Jornada Cientifica de la Universidad Peruana Cayetano Heredia. Setiembre de 1986.
9.- Regalado Saldana C., Vaisberg, A., Inmunidad Humoral Contra el Sarampion en Ninos Despues de
la Vacunacion y Despues de la Enfermedad: Estudio Preliminar. IV Jornada Cientifica de la
Universidad Peruana Cayetano Heredia. Setiembre de 1986.
10.- Vaisberg, A.J., Milla M., Planas M., Cordova J.L., Mustiga M., Carlin L., Goni M., Hammond G.B.
Caracterizacion, Mecanismo de Accion, y Posible Actividad Mutagenica del Principio Cicatrizante de
la Sangre de Grado: Taspina. Abstract presented at the 1er. Congreso Latinoamericano de
Fitoquimica. Montevideo, Uruguay. Noviembre de 1987.
11.- Vaisberg, A., Alvarez J., Guillen D., Chu P., Colarossi A., Hernandez H. Rate of Loss of Maternally
Acquired Measles Antibodies From Birth to 9 Months and Response to Measles Vaccination.
Presented at the International Congress of Infectious Diseases. Rio de Janeiro Abril de 1988.
12.- Planas, M., Milla, M., Mustiga, M., Carlin, L., Hammond G.B., Vaisberg, A.J. Caracterización y
Mecanismo de Acción del Principio Cicatrizante de la Sangre de Grado: Taspina. Abstract
presented at the V Jornada Científica de la Universidad Peruana Cayetano Heredia. September,
1988.
13.- Goñi, M., Zavaleta, A., Vaisberg, A. Citotoxicidad Inducida por Veneno de Serpiente. Abstract
1988.
14.- Guillen, D., Chu, P., Colarossi, A., Suarez de Loayza, V., Hernandez H., Alvarez J., Vaisberg, A.
Evolución de la Inmunidad Pasiva y Respuesta a la Vacunación Contra el Sarampión. Abstract
1988.
15.- Vaisberg, A.J., Hammond, G.B. Investigation of the Wound Healing Properties of Some Peruvian
Plants and Their Possible Utilization as therapeutic agents. Abstract presented at the 102nd Session
of the Iowa Academy of Sciences. pp. A-19, April 1990.
16.- Maldonado H., Castagnetto J., Zavaleta A., Fernandez I., Vaisberg A. Estudio Fitoquímico de
Plantas Cicatrizantes Peruanas. Abstract presented at the VI Jornada Científica de la Universidad
Peruana Cayetano Heredia. September, 1990.
17.- Tello V., Salas J., Villegas L., Fernandez I., Vaisberg A., Zavaleta A. Estudio Farmacológico de
Jatropha curcas (Piñón). Abstract presented at the VI Jornada Científica de la Universidad Peruana
Cayetano Heredia. September, 1990.
18.- Villegas L., Bushby J., Salas M., , Fernandez I., Maldonado H., Zavaleta A., Vaisberg A. Estudio
Farmacológico de Jatropha curcas (Piñón). Abstract presented at the VI Jornada Científica de la
Universidad Peruana Cayetano Heredia. September, 1990.
19.- Torres-Vadillo R., Vaisberg A. Caracterización de la Actividad Mutagénica del Latex de Sangre de
Grado y del Alcaloide Taspina. Abstract presented at the VII Jornada Científica de la Universidad
Peruana Cayetano Heredia. Rev. Med. Herediana 3: 80S, 1992.
20.- León M.E., Ward B., Kanashiro R., Hernandez H., Berry S., Vaisberg A., Escamilla J., Campos M.,
Bellomo S., Halsey N. Alteraciones Inmunológicas Persistentes 2 Años Despues de Inmunización
12

para Sarampión con Títulos altos. Abstract presented at the VII Jornada Científica de la Universidad
21.- Muñoz S., Zavalaga C., Landers M., Fajardo A., Rivera M., Millas S., Fontanot M., Fajardo D.,
Beltrán R., Valdés A., Fernandez I., Maldonado H., Vaisberg A., Planas-Silva M. Caracterización
de la Actividad Antitumoral de Plantas Medicinales Peruanas. Abstract presented at the VII Jornada
Científica de la Universidad Peruana Cayetano Heredia. Rev. Med. Herediana 3: 62S, 1992.
22.- Villegas L., Fernandez I., Maldonado H., Salas M., Zavaleta A., Vaisberg A. Evaluación
Farmacológica de 12 Plantas Medicinales Peruanas Conocidas Como Cicatrizantes. Abstract
presented at the VII Jornada Científica de la Universidad Peruana Cayetano Heredia. Rev. Med.
Herediana 3: 84S, 1992.
23.- Moscoso Y., Villegas L., Salas M., Maldonado H., Fernandez I., Zavaleta A., Vaisberg A. Estudio
Fitoquímico y Farmacológico de la Anredera diffusa. Abstract presented at the VII Jornada
24.- Torres-Vadillo R., Vaisberg A. Caracterización de la Actividad Mutagénica del Latex de Sangre de
Grado y del Alcaloide Taspina. Abstracto presentado en la VII Jornada Científica de la Universidad
25.- Torres-Vadillo R., Vaisberg A. Evaluación de la Actividad Mutagénica de Productos Naturales
Peruanos con Propiedade Cicatrizantes. Abstracto presentado en el XI Congreso Nacional de
Biología. Tacna, Perú. Setiembre 1994.
26.- Ochoa T., Salas M., Villegas L., Zavaleta A., Fernandez I., Maldonado H., Vaisberg A. Evaluación
de Taspina en la Prevención de Lesiones Gástricas en Ratas. Abstract presented at the VIII Jornada
27.- Lewis W. H., Lamas G., Vaisberg A., & Nación Aguaruna. Targeting Plant Ethnomedicines as
Potential Pharmaceuticals among the Aguarunas of Amazonian Perú. Abstract presented at the XVI
International Botanical Congress. St. Louis, USA. August 1999.
28.- Villegas L., Marcalo A., Fernandez I., Maldonado H., Vaisberg A.J., Hammond G. (+)-Epi-α-
Bisabolol es el Principio Cicatrizante en Peperomia galioides. Investigación de la Actividad
Cicatrizante de Terpenoles Relacionados. Abstract presented at the XIII Jornada Científica de la
Universidad Peruana Cayetano Heredia. Rev. Med. Herediana 12: 43S, 2001.
29.- Talla O., Palacios D., Villegas L., Fernandez I., Vaisberg A.J. Estudio Comparativo de la
Actividad Antisecretoria en Células Ováricas de Hamster Chino (CHO-k1) der dos especies de
Uncaria (U. Tomentosa y U. Guianensis). Abstract presented at the XIII Jornada Científica de la
Universidad Peruana Cayetano Heredia. Rev. Med. Herediana 12: 65S, 2001.
30.- Villegas L., Talla O., Palacios D., Chang C., Fernandez I., Vaisberg A.J. Evaluación Biológica del
Extracto Acuoso Liofilizado de Peperomia galioides H.B.K. “Congona”. Abstract presented at the
XIII Jornada Científica de la Universidad Peruana Cayetano Heredia. Rev. Med. Herediana 12: 65S,
2001.
RESEARCH PROJECTS
1.- Investigation of the Cicatrizant Properties of the Plant Extract Sangre de Grado and its possible
utilization as a therapeutic agent. Supported by the International Foundation for Science, Sweden.
Approved in August 1977. Renewed in june 1979, june 1982 and june 1986.
13

2.- Estudio del Desarrollo de la Biología Molecular y Celular en el Perú: Estado actual y Proyecciones
hacia el Perfeccionamiento de Post-Grado. In collaboration with Drs. José Alvarez y Ernesto
Bustamante from the Department of Physiological Sciences of the Universidad Peruana Cayetano
Heredia. Supported by the Ford Foundation. Approved in July 1979 (for 18 months).
3.- A study of the Pathogenesis of Measles Virus Infections in Peru. In collaboration with Drs. Richard
T. Johnson, Diane E. Griffin, Robert L. Hirsch and Jerry Wolinsky from the Departments of
Microbiology, Medicine and Neurology of Johns Hopkins University and Dr. Raúl Patrucco from
the Department of Medicine of the Universidad Peruana Cayetano Heredia. Supported by
Rockefeller Foundation. Approved in August, 1979 (for one year).
4.- Pathogenesis of Measles Virus Encephalitis. In collaboration with Drs. Richard T. Johnson, Diane E.
Griffin, Robert L. Hirsch and Jerry Wolinsky from the Departments of Microbiology, Medicine and
Neurology of Johns Hopkins University. Supported by Kroc Foundation. Approved in August,
1980 (for two years)
5.- Investigation of the Cicatrizant properties of the plant extract Sangre de Grado and its possible
utilization as a therapeutic agent. Supported by the Agency for International Development, USA.
PSTC Program. Approved August, 1983 (for three years).
6.- Characterization of the Active Principles, Mechanism of Action and Possible Mutagenic Activity of
Wound Healing Plants. In collaboration with Professors Alfonso Zavaleta, Holger Maldonado, Irma
Fernandez from the Universidad Peruana Cayetano Heredia (UPCH) and Gerald B. Hammond from
the Department of Chemistry of South Eastern Massachusetts University, USA. Supported by the
Agency for International Development, USA.PSTC Program. Approved May 1989 (for three years).
7.- Role of Nutritional Status in the Early Loss of Passive Immunity and Response to Measles
Vaccination. Study in collaboration with Dr. Herminio Hernadez from the Department of Pediatrics
of UPCH and Dr. José Alvares from the Department of International Health of the University of
Alabama, Birmingham, USA. Supported by the Agency for International Development, USA. PSTC
Program. Approved September, 1989 (for three years).
8.- Detailed comparison of humoral and cellular immune responses to natural measles virus infection and
primary measles vaccination. Study in collaboration with Dr. Herminio Hernadez from UPCH and
Dr. Brian Ward from the University of McGill, Canada. Supported by the World Health
Organization. Approved in September 1993 (US $ 61,450.00)
9.- Measles and Measles Vaccines: Mechanisms of Immune Injury. Study in collaboration with Dr.
Herminio Hernadez from UPCH and Dr. Brian Ward from the University of McGill, Canada.
Supported by NIH. Approved in September 1993 (for two years).
10.- Isolation of Bioactive compounds from Peruvian Plants. Study in collaboration with Dr. Alfonso
Zavaleta, Irma Fernandez and Holger Maldonado from UPCH and Dr. Gerald B. Hammond from the
University of Massachusetts, Darmouth, USA. Supported by NIH. Approved in August 1993 (for
three years).
11.- Natural Products from Peruvian Wound Healing Plants. Study in collaboration with Dr. Alfonso
Zavaleta, Irma Fernandez and Holger Maldonado from UPCH and Dr. Gerald B. Hammond from the
University of Massachusetts, Darmouth, USA. Supported by NSF. Approved in August 1993 (for
two years).
12.- Peruvian Medicinal Plant Sources of New Pharmaceuticals. The participants of this study are:
14

1) Washington University in St. Louis, Central Operations Office with Dr. Walter Lewis as Group
Leader.
2) Washington University in St. Louis, Program 1: Ethnomedicinal Plants, with Dr. Walter Lewis as
Associate Program Leader.
3) Museo de Historia Natural, UNMSM in Lima, Program 2: Biotic Inventories and Conservation,
with Dr. Gerardo Lamas as Associate Program Leader.
4) Universidad Peruana Cayetano Heredia in Lima, Program 3: Medically Significant Plants in the
Tropics, with Dr. Abraham Vaisberg as Associate Program Leader.
5) Monsanto Company in St. Louis, Program 4: Phytochemistry, with Dr. David G. Corley as
Associate Program Leader.
This project was supported by a consortium formed by NIH, NIMH, NSF and AID.
Approved in March 1994 (for five years)
13.- Sponsored Research Agreement on the Characterization of the Active Principles and Mechanism of
Action of Peruvian Medicinal Plants. Supported by Galenica Pharmaceutical Inc. Approved on
January 1998 (for 4 years)
14.- Clinical and Pharmacological Study of the Effect of Bixa orellana on Benign Prostatic Hyperplasia.
Supported by Galenica Pharmaceutical, Inc. Approved June 2000 for 18 months.
15.- Novel Therapeutics for Mental Disorders from Ethnobotanical Sources. Supported by The Stanley
Medical Research Institute. Approved January 2004 for two years.
16.- International Collaborative Research on Plant Diversity Resources of Korea and Peru. Supported by
The Korean Research Institute of Bioscience and Biotechnology. Approved August 2005 for 3 years.
17.- Novel Therapeutics for Mental Disorders from Ethnobotanical Sources:Preclinical Studies.
Investigador Principal: Dr. Abraham Vaisberg. Financiado por The Stanley Medical Research
Institute. Aproved May 2006 for 2 years.
18.- Drug Discovery for Mental Disorders: Preclinical Studies of Peruvian Botanicals. Supported by the
National Institute of Mental Health. Grant No. 5R21MH095644-02. Aproved May 2013- April 2017
for two years.
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