Cervical cancer is a type of cancer that occurs in the cells of the cervix — the lower part of the uterus that connects to the vagina.

1. CERVICAL CANCER
Presented by:
Mr. Abhay Rajpoot

2. INTRODUCTION
• Cervical cancer is a type of cancer that occurs in the cells of the
cervix — the lower part of the uterus that connects to the vagina.
• Various strains of the human papillomavirus (HPV), a sexually
transmitted infection, play a role in causing most cervical cancer.

3. DEFINITION
• Cervical cancer is a type of cancer that occurs in the cells of the
cervix — the lower part of the uterus that connects to the vagina.

4. RISK FACTORS

5. ETIOLOGY
• Cervical cancer begins when healthy
cells in the cervix develop changes
(mutations) in their DNA A cell’s DNA
contains the instructions that tell a
cell what to do
• Various strains of the human
papillomavirus (HPV), a sexually
transmitted infection, play a role in
causing most cervical cancer.

6. TYPES

7. Conti…
• Squamous cell carcinoma. This type of cervical cancer begins in
the thin, flat cells (squamous cells) lining the outer part of the
cervix, which projects into the vagina. Most cervical cancers are
squamous cell carcinomas.
• Adenocarcinoma. This type of cervical cancer begins in the
column-shaped glandular cells that line the cervical canal

8. TNM CLASSIFICATION

9. STAGGING

10. CLINICAL MANIFESTATIONS

11. DIAGNOSIS
• History
• Physical examination
• PAP smear
• Blood test
• DNA test
• Biopsy
• Radiological exam

12. PAP Smear

13. Management
• Chemotherapy
• Radiation therapy
• Surgery
• Targeted therapy
• Immunotherapy

14. Chemotherapy:
Chemotherapy is a widely used treatment for cancer. The term
chemotherapy refers to the drugs that prevent cancer cells from dividing and
growing. It does this by killing the dividing cells.
Ex.
-Vincristine
-Nethotrexate

16. Side effect
• Hair loss
• Nausea
• Vomiting
• Mouth sores
• Loss of appetite
• Tiredness, easy bruising or bleeding, and an increased chance of infection.

17. Targeted therapy
• Targeted therapies are drugs that interfere with one specific property or
function of a cancer cell, rather than acting to kill all rapidly growing cells
indiscriminately.

18. Radiation therapy
• Radiation therapy uses high energy radiation to target cancer cells.
Radiation therapy may be used in the treatment of leukemia that has spread
to the brain, or it may be used to target the spleen or other areas where
leukemia cells have accumulated.

19. SURGICAL MANAGEMENT
• Surgery to cut away the cancer only. For a very small cervical
cancer, it might be possible to remove the cancer entirely with a
cone biopsy. This procedure involves cutting away a cone-shaped
piece of cervical tissue, but leaving the rest of the cervix intact.
This option may make it possible for you to consider becoming
pregnant in the future.
• Surgery to remove the cervix (trachelectomy). Early-stage
cervical cancer might be treated with a radical trachelectomy
procedure, which removes the cervix and some surrounding tissue.
The uterus remains after this procedure, so it may be possible to
become pregnant, if you choose.

20. Surgery to remove the cervix and uterus (hysterectomy). Most
early-stage cervical cancers are treated with a radical hysterectomy
operation, which involves removing the cervix, uterus, part of the
vagina and nearby lymph nodes. A hysterectomy can cure early-
stage cervical cancer and prevent recurrence. But removing the
uterus makes it impossible to become pregnant.

21. PREVENTION