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TforG Roadshow London
The Impact of Pressure on
HealthCare Expenditure
2
- Bart Van den Mooter–
CEO TforG Group
London Roadshow
© 2015 TforG | www.tforg.com | +32 3 201 64 00
Who is TforG?
Since 1991, the TforG Group provides strategic & decisive
Business Intelligence and Decision Support to international
business managers.
Its unique focus is the medical devices and medical technology.
The company operates from offices in Antwerp, Shanghai and
Dalian.
3
© 2015 TforG | www.tforg.com | +32 3 201 64 00
Product Portfolio
AD HOC DECISION SUPPORT:
• Create sustainable
differentiators
• Add value
• Justify premium offers
• Shift handling in mature
markets
• Growth management in
emerging markets
• Product Marketing
BI PLATFORMS:
• Up to date & accurate
information
• Customizable
• Single point of access
• World HealthCare Scan
• Country Reports
• Care Tracks
4
© 2015 TforG | www.tforg.com | +32 3 201 64 00
Global Reach
Healthcare business professionals face global challenges and need
global answers. TforG is committed to be on top of trends,
opportunities and challenges in mature markets as well as in high
growth emerging markets.
5
© 2015 TforG | www.tforg.com | +32 3 201 64 00
MedTech markets under pressure
Impact of CRISES:
o Medical Device markets: decline or zero growth
o Capex: replacement rates down & negative growth rates
o Reduced customer loyalty invites new “good enough” suppliers in
Changes in “MODUS OPERANDI”
o Complex reimbursement context, role of payers
o Impact of Registration and HTA, changing Regulatory climate
o Complex purchasing systems
o Products have “Longer time to patient”
o Guidelines, Hospital processes and Hospital budgetting rules
New “CARE MODELS”
o Power play surgeons vs interventional specialists
o Tele health, home care
6
© 2015 TforG | www.tforg.com | +32 3 201 64 00
Creating Value for the hospital
1. Integration of primary – secondary – tertiary Care
2. Multi Disciplinary DMU’s
3. Economic value vs Clinical performance
4. Care Delivery Chain
7
© 2015 TforG | www.tforg.com | +32 3 201 64 00
Creating Value for the hospital
Care Delivery Chain:
The usage of your product is more than a single
moment in the medical treatment.
It’s part of a process.
8
© 2015 TforG | www.tforg.com | +32 3 201 64 00
TforG Care Tracks:
The tool to create value for the hospital.
Position your product in the care delivery chain to understand:
o choices made before and after,
o alternative solutions,
o bottlenecks in the process
Use this information to support the hospital & create Value
o Identify in which part of the chain value can be created
o Shorten the time to diagnosis / treatment.
o Accelerate the access to the patient,
o Create new benefits for the hospitals & staff
o Implement cost effective solutions / care tracks
9
© 2015 TforG | www.tforg.com | +32 3 201 64 00
Programme
10.00 : Bart van den Mooter: CEO TforG Group
 Welcome and introductions.
10.10 : Mario Varela: Managing Director NHS London Procurement Partnership
 Financial challenges for the NHS & strategies to counteract
10.40 : Sebastian Brandner – Professor and Chair of Neuropathology (UCL)
 Turnaround times for molecular pathology tests
11.10: Bart Ongena: VP business development at TforG
 TforG Care Tracks: Benefits & Cases
11.40: Networking lunch
10
11
- Mario Varela –
Managing Director NHS London Procurement Partnership
NHS
London Procurement
Partnership
Mario Varela
BA,MCIPS,MCIPD,MBA
Managing Director
TforG event: 20th May 2015
NHS London Procurement Partnership:
• A collaborative procurement organisation funded and
governed by our NHS members
• Established April 2006: Permanent
organisation since 2011
• Hosted by Guys and St Thomas
• Professional, operational and process efficiencies to
procurement and supply chain services
NHS London Procurement Partnership:
• Focus on NHS expenditure categories:
• Agency and Temporary Staffing
• Estates, Facilities and Professional Services
• Medical, Surgical and Supply Chain
• Medicines Optimisation and Pharmacy Procurement
• Technology
We now have £7-8bn of spend data, and influence £3bn of that
NHS London Procurement Partnership:
• Savings and improvements for the NHS through procurement
collaboration, supporting our members to deliver better
patient care:
£ 110m
£ 755m
2014-15:
Total 2006-15:
Five Year Forward View and efficiency
• NHS’ long run performance on efficiency has been
0.8% annually
• This has risen to 1.5-2% in recent years (largely due
to pay restraints), but the NHS needs to repeatedly
achieve 2% net savings for the rest of the decade,
perhaps rising to 3% by the end of the period if
action is taken on prevention, new care models,
sustained social care services and wider system
improvements.
• This is a daunting task for NHS providers and one that requires
forensic analysis of costs and a coordinated programme of action to
support them
• We know that the English health system represents better value for
taxpayers than any other health system in the world…..
• ……and we are sure we have hospitals that are up with the best in the
world in terms of operational efficiency……
• …..but we suspect our hospitals are not necessarily good at everything,
leading to inconsistency, and the average across the system is lower than it
should be……
• …..in fact we already know there are inexplicable differences in efficiencies
across providers…..
• …..so we need a process for identifying and addressing these performance
differences to help providers deliver the 2-3% required by 5YFV
Proposition
1. We need a set of metrics that allow providers to compare themselves
with their peers, and help them identify opportunities for performance
improvement
2. We need a process that supports providers on this journey, and helps
them deliver and sustain these opportunities
3. We need to develop and deliver support mechanisms, be they local,
regional or national, to help providers improve their performance
4. We need to embed the approach so that providers are able to regularly
monitor their efficiency improvement, month-on-month, year-on-year
How can providers be helped?
• Health systems all over the world, be they ‘for profit’ or ‘not for profit’, have
adopted a common set of metrics to monitor and improve the performance of
their individual hospitals
• Hospitals in the US have been operating such metrics (Adjusted Admissions) for
nearly 50 years
• There is clear evidence that by adopting such an approach hospital efficiency
improves significantly – but we don’t have such a metric in the NHS
• By examining methodologies around the world, we have now developed a metric
for NHS providers, and with the enthusiastic support of 22 diverse providers, we
are confident this metric can support our vision to make NHS providers the most
efficient in the world by 2020
Metrics and vision
Identifying the opportunity – 6 areas of spend
NHS Providers
Prescribing costs
Pharmaceuticals services
DH & ALBs
Commissioning non-NHS
bodies
GPs
Training (doctors)
Dental
£72bn
£3bn
£5bn
£8bn
£2bn
£9bn
£13bn
£8bn
DH overall budget £120bn
Source NHS Accounts 2013-14
£45.35bn
£3.80bn
£0.65bn
£5.08bn
£0.99bn
£4.79bn
£3.69bn
£7.22bn
NHS Providers £72bn
Staff Costs
Clinical goods & services
Purchase of Healthcare from
non NHS bodies
Financing Costs
Clinical Negligence Costs
Common goods & services
Property
Inventories Consumed
£45bn Pay
£22bn Non-pay
£5bn Financing costs
Unless we address workforce and
pharmacy costs, all other savings
pale in to insignificance
All doctors
Qualified nursing, midwifery &
health visitors
Qualified scientific, therapeutic &
technical
Qualified ambulance staff
Support to Clinical staff
NHS infrastructure (central
functions / management)
£9.9bn
£13.1bn
£6.9bn
£7.4bn
£0.8bn
£6n
Pay £45bn
Influenceable Non-Pay £18bn
And we need more granular
data to forensically examine
cost differences
Pharmacy
Everyday
consumables
Medical
technologies
Common Goods &
Services
Estates
£6bn
£2bn
£3bn
£4bn
£3bn
Split between pharma, everyday
consumables and medtech is best
guess as £7.2bn is accounted for
by ‘inventories consumed’
2
1
3
4
5
6
6
• Developing and applying the Adjusted Admission metric to accounts data allows us
to see variation between trusts
• But we then need to forensically examine of every area of operating expenditure, so
we need granular detail
• To demonstrate how this can be done we have assembled a team of subject matter
experts and are working with a cohort of 22 trusts to better understand variances
and opportunities in 5 areas:
• Workforce
• Pharmacy
• Procurement (everyday consumables, medtech, and common
goods/services)
• Estates
• Pathology and Radiology
• We will have gathered and analysed detailed data by the end of March 2015
Process
Process continued
Feb 15 Mar 15 Apr 15 May 15 Jun 15 Jul 15 Aug 15 Sep 15 Oct 15 Nov 15 Dec 15 Jan 16 Feb 16 Mar 16 Apr 16
Develop and
validate a set
of efficiency
metrics for
NHS
Providers
Develop and
issue a
‘template’ for
selected
providers to
complete to
show how
each provider
has budgeted
for 15-16
(32 providers)
Roll out metrics and new ‘efficiency
performance support system’ for all NHS
Phase 1 Phase 2 Phase 3
Gather level 4
and 5 data from
22 cohort for:
• Workforce
• Pharma
• Estates
• Procurement
• Clinical
SR settlement
Learning
workshops with
32 providers to
help them
revisit their
plans
Gather level 4
and 5 data
from 10
further trusts
32 trusts to share
revised budget
plans with
programme
Establish size
of opportunity
Analysis to
inform
2016-17
tariff Agree individual
trust efficiency
plans for all
providers
Compile an
assessment of
where each
provider can
make savings
and issue to
32 trusts
• 3 stage process
• Phase 1 is to develop and apply the metrics to 32 trusts
• Phase 2 is to forensically examine costs in the 22 and help them with their
budget planning for 2015-16. This will also help us understand the ‘size of the
prize’ for all NHS efficiency
• Phase 3 is to both roll out the approach to all NHS trusts and deliver support
solutions at local, regional and national level to help trusts improve their
efficiency performance
Gathering line level
detail…….
Workforce
Pharmacy
Medtech/Clinical
Everyday supplies
Common Goods/Services
Estates
Procurement:DatadrawnfromAP/POsystemsforperiod??
• Data drawn from trust systems for every ward for Feb 2015
• Looking at doctors and other areas such as pathology
• Led by Lyn McIntyre
• Data drawn from pharmacy systems
• Focusing on pharmacy optimisation, usage and
procurement
• Led by Ann Jacklin and Keith Ridge
• Global best practice
• Development of ‘core list’
• NHS Supply Chain (procurement & logistics)
• Compliance processes and systems
• Led by Andy Jones and FOM team
• Looking at clinical practice and supporting supply chains
• Building on ‘Getting it right first time’
• Looking at 10 clinical specialties
• Engaging clinicians in the management of device costs
• Changing the relationship with the medtech industry
• Led by Prof Tim Briggs, Rob Hurd and Andy Brown
• Global best practice
• Solving the ‘non-stock’ conundrum in trusts
• CCS
• Led by Anthony Doyle
13,9
7,8
7,8
8,9
15,2
13,7
Investment Capacity
Space Productivity
Resource Productivity
-Estates & Facilities
Running Costs Efficiency
Environmental
Performance
!Estates Compliance,
Safety & Risk
• Data drawn from ERIC
• Led by David Harrison
Pathology/Radiology services
• Led by Phil Hudson
Core List
Understanding the LPP collaborative /1:
• LPP represents, and is governed by, its NHS
members:
• Steering Board
• Executive Management
Board
• Category Boards
• Acute and Mental Health
stakeholder meetings
Workplanning and relevant priorities are agreed in
consultation with members at every stage
Understanding the LPP collaborative /2:
• A collaborative member-led approach to work
planning, with decisions made according to
members needs
• LPP is funded by its NHS members,
and must demonstrate savings
and added value for each member’s
investment in the service we
provide
Understanding the LPP collaborative /3:
For 2013-16, this translates into:
• Targeting £3bn of London’s £6bn influenceable
spend through a core set of category priorities
• Achieving a minimum saving of £300m/5 per
cent
• Providing transparent, trackable and easily
identifiable savings
Understanding the LPP collaborative /4:
For 2013-16, this translates into:
• Providing professional procurement expertise
and added value services such as benchmarking
and analytics, and e-sourcing tools
• Working more closely than ever
with other NHS procurement hubs
Collaborating across the NHS: the NHS Collaborative
Procurement Partnership
• NHS London Procurement Partnership
• North of England Commercial Procurement Collaborative
• East of England Commercial Procurement Hub
• NHS Commercial Solutions
• Opening up frameworks
• Reducing duplication
• Creating new national opportunities:
• National Collaborative Framework for the
supply of Nursing and Nursing related staff
• Total Orthopaedic Solutions
• Total Cardiology Solutions
Thank You
Any questions?
Mario Varela
Managing Director, NHS London Procurement Partnership
mario.varela@lpp.nhs.uk
36
- Sebastian Brandner –
Professor and Chair of Neuropathology UCL
UCL DEPARTMENT OF GEOGRAPHYUCL INSTITUTE OF NEUROLOGY
Using digital pathology to improve
workflow and cut turnaround times:
A feasibility study
Sebastian Brandner, UCL Institute of Neurology,
and The National Hospital for Neurology and
Neurosurgery
Queen Square, London
UCL INSTITUTE OF NEUROLOGY
Integration of molecular diagnostic into the
histopathology workflow using digital
pathology
• Molecular diagnostics in the context of the cancer
pathway.
• Diagnostic Neuropathology: From morphological to
integrated molecular diagnostics.
• Apply lean principles to molecular diagnostic workflow.
• Establishing a rapid throughput image analysis pathway
for tissue-based molecular diagnostics.
UCL INSTITUTE OF NEUROLOGY
A&E
Tertiary
2WW
A&E
Royal London
Newham
Whipps Cross
Homerton
NHNN
Referral
(with CT and MRI)
SMDT to
discuss
treatment
options
Local clinic
to discuss
treatment
options
Diagnosis
giving
Surgical
Treatment Recurrence
UCLH
Mount
Vernon
BH
Tertiary / GP
RL
Southend
Basildon
Harlow
Chelmsford
Newham
Whipps Cross
Homerton
Moorfields
BH*
NHNN NHNN
Ward
attended
NHNN
Inpatient
at
NHNN
Clinic
appt at
BH
Clinic at
NHNN
(low
grade)
Surgical
follow
NHNN
BH*
Oncology
0-14
Max 28 days
Pathology
The NE London Cancer Pathway for
malignant brain tumours
1-3d
8-15 d
Histology
Mol Path
-124ATGbalancedbalancedhet-delhet-delpositiveMutOligodendrogliomaOligodendroglioma
-124ATGbalancedbalancedhet-delhet-delpositiveMutOligodendrogliomaOligodendroglioma
-146ATGbalancedbalancedhet-delhet-delpositiveMutOligodendrogliomaOligoastrocytoma
-124ATGbalancedgainhet-delhet-delpositiveMutOligodendrogliomaOligodendroglioma
-124ATGbalancedbalancedhet-delhet-delpositiveMutOligodendrogliomaOligoastrocytoma
-124ATGbalancedbalancedhet-delhet-delpositiveMutOligodendrogliomaOligodendroglioma
-124ATGbalancedbalancedhet-delhet-delpositiveMutOligodendrogliomaOligodendroglioma
-124ATGbalancedbalancedhet-delhet-delpositiveMutOligodendrogliomaOligodendroglioma
-146ATGbalancedbalancedhet-delhet-delpositiveMutOligodendrogliomaOligodendroglioma
-146ATGbalancedbalancedhet-delhet-delpositiveMutOligodendrogliomaOligodendroglioma
-124ATGbalancedbalancedhet-delhet-delpositiveMutOligodendrogliomaOligoastrocytoma
-124ATGbalancedbalancedhet-delhet-delpositiveMutOligodendrogliomaOligodendroglioma
-146ATGbalancedbalancedhet-delhet-delpositiveMutOligodendrogliomaDiffuseastrocytoma
ex3wt-146ATGbalancedbalancedhet-delhet-delpositiveMutOligodendrogliomaOligodendroglioma
-146ATGbalancedbalancedhet-delhet-delpositiveMutOligodendrogliomaOligodendroglioma
-146ATGhet-delsegmentalbalancedhet-delhet-delpositiveMutOligodendrogliomaOligodendroglioma
inUTRNDbalancedbalancedhet-delhet-delpositiveMutOligodendrogliomaOligodendroglioma
balancedbalancedhet-delhet-delpositiveMutOligodendrogliomaOligoastrocytoma
balancedbalancedhet-delhet-delpositiveMutOligodendrogliomaOligodendroglioma
inUTRwtbalancedbalancedhet-delhet-delpositiveMutOligodendrogliomaDiffuseastrocytoma
inUTRNDbalancedbalancedhet-delhet-delpositiveMutOligodendrogliomaOligodendroglioma
balancedbalancedhet-delhet-delpositiveMutOligodendrogliomaOligodendroglioma
balancedbalancedhet-delhet-delpositiveMutOligodendrogliomaDiffuseastrocytoma
inUTRwtbalancedbalancedhet-delhet-delpositiveMutOligodendrogliomaOligodendroglioma
balancedbalancedhet-delhet-delpositiveMutOligodendrogliomaDiffuseastrocytoma
balancedbalancedhet-delhet-delpositiveMutOligodendrogliomaOligodendroglioma
balancedbalancedhet-delhet-delpositiveMutOligodendrogliomaOligodendroglioma
balancedbalancedhet-delhet-delpositiveMutOligodendrogliomaAnaplastic
-124ATGhet-delbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-146ATGhet-delgainhet-delhet-delpositiveMutAnaplasticGlioblastomawith
-146ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticGlioblastoma
-124ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-124ATGbalancedgainhet-delhet-delpositiveMutAnaplasticAnaplastic
-124ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-124ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticGlioblastomawith
-124ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-124ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-124ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-124ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-146ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticGlioblastoma
-146ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-146ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-124ATGhet-delsegmentalbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-124ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
ex3wt-124ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-124ATGbalancedhet-delsegmentalhet-delhet-delpositiveMutAnaplasticAnaplastic
-146ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-124ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-146ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-146ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticOligodendroglioma
-146ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-124ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-124ATGbalancedgainhet-delhet-delpositiveMutAnaplasticAnaplastic
-124ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-146ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-124ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-146ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-124ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-124ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-124ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-124ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-146ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-124ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-124ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-124ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-124ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-124ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-124ATGbalancedgainhet-delhet-delpositiveMutAnaplasticAnaplastic
-124ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-146ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-124ATGbalancedgainhet-delhet-delpositiveMutAnaplasticAnaplastic
-124ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-146ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-124ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-124ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-146ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-124ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-124ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
-124ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
ex3wt-124ATGbalancedbalancedhet-delhet-delpositiveMutAnaplasticGlioblastomawith
inUTRwtbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
inUTRNDbalancedbalancedhet-delhet-delpositiveMutAnaplasticOligodendroglioma
inUTRwtbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
balancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
inUTRwtbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
inUTRwtbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
inUTRwtbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
balancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
inUTRwtbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
inUTRwtbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
NDbalancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
balancedbalancedhet-delhet-delpositiveMutAnaplasticOligodendroglioma
balancedbalancedhet-delhet-delpositiveMutAnaplasticGlioblastomawith
balancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
balancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
balancedbalancedhet-delhet-delpositiveMutAnaplasticGlioblastoma
balancedbalancedhet-delhet-delpositiveMutAnaplasticGlioblastoma(WHO
balancedbalancedhet-delhet-delpositiveMutAnaplasticAnaplastic
inUTRwtbalancedbalancedhet-delhet-dellossMutAnaplasticAnaplastic
inUTRwthet-delsegmentalbalancedhet-delhet-dellossMutAnaplasticAnaplastic
inUTRNDbalancedbalancedhet-delbalancedlossMutDiffuseastrocytomaDiffuseastrocytoma
inUTRwtbalancedbalancedhet-delbalancedlossMutDiffuseastrocytomaDiffuseastrocytoma
inUTRwtbalancedbalancedhet-delbalancedlossMutDiffuseastrocytomaDiffuseastrocytoma
inUTRwtbalancedbalancedhet-delbalancedlossMutDiffuseastrocytomaDiffuseastrocytoma
balancedbalancedhet-delbalancedlossMutDiffuseastrocytomaOligoastrocytoma
balancedbalancedbalancedbalancedpositiveMutDiffuseastrocytomaDiffuseastrocytoma
inUTRwtbalancedbalancedbalancedbalancedlossMutDiffuseastrocytomaDiffuseastrocytoma
inUTRwtbalancedgainhet-delsegmentalbalancedlossMutDiffuseastrocytomaDiffuseastrocytoma
inUTRwtbalancedbalancedbalancedbalancedlossMutDiffuseastrocytomaDiffuseastrocytoma
inUTRwtbalancedbalancedbalancedbalancedlossMutDiffuseastrocytomaDiffuseastrocytoma
inUTRwtbalancedbalancedbalancedbalancedlossMutDiffuseastrocytomaDiffuseastrocytoma
inUTRwtbalancedbalancedbalancedbalancedlossMutDiffuseastrocytomaDiffuseastrocytoma
inUTRNDbalancedbalancedbalancedbalancedlossMutDiffuseastrocytomaDiffuseastrocytoma
inUTRwtbalancedbalancedbalancedbalancedlossMutDiffuseastrocytomaDiffuseastrocytoma
inUTRwtbalancedbalancedbalancedbalancedlossMutDiffuseastrocytomaDiffuseastrocytoma
inUTRwtbalancedbalancedhet-delsegmentalbalancedlossMutDiffuseastrocytomaDiffuseastrocytoma
inUTRwthet-delsegmentalbalancedhet-delsegmentalbalancedlossMutDiffuseastrocytomaDiffuseastrocytoma
inUTRNDbalancedgainbalancedbalancedlossMutDiffuseastrocytomaDiffuseastrocytoma
balancedbalancedhet-delsegmentalbalancedlossMutDiffuseastrocytomaDiffuseastrocytoma
inUTRwtgainsegmentalgainbalancedbalancedlossMutDiffuseastrocytomaDiffuseastrocytoma
inUTRwtbalancedbalancedbalancedbalancedlossMutDiffuseastrocytomaOligodendroglioma
inUTRwtbalancedbalancedbalancedbalancedlossMutDiffuseastrocytomaDiffuseastrocytoma
balancedbalancedbalancedbalancedlossMutDiffuseastrocytomaOligoastrocytoma
inUTRwtbalancedgainsegmentalbalancedbalancedlossMutDiffuseastrocytomaOligodendroglioma
inUTRwtbalancedbalancedbalancedbalancedlossMutDiffuseastrocytomaDiffuseastrocytoma
inUTRNDbalancedbalancedbalancedbalancedlossMutDiffuseastrocytomaDiffuseastrocytoma
NDhet-delsegmentalbalancedbalancedbalancedlossMutDiffuseastrocytomaDiffuseastrocytoma
balancedbalancedbalancedbalancedlossMutDiffuseastrocytomaDiffuseastrocytoma
inUTRwtbalancedbalancedbalancedbalancedlossMutDiffuseastrocytomaDiffuseastrocytoma
inUTRwtbalancedbalancedbalancedbalancedlossMutDiffuseastrocytomaDiffuseastrocytoma
NDhet-delsegmentalgainbalancedbalancedlossMutDiffuseastrocytomaDiffuseastrocytoma
balancedbalancedbalancedbalancedlossMutDiffuseastrocytomaOligoastrocytoma
balancedbalancedbalancedbalancedlossMutDiffuseastrocytomaDiffuseastrocytoma
balancedbalancedhet-delsegmentalbalancedlossMutDiffuseastrocytomaDiffuseastrocytoma
balancedbalancedbalancedbalancedlossMutDiffuseastrocytomaDiffuseastrocytoma
het-delsegmentalbalancedbalancedbalancedlossMutDiffuseastrocytomaDiffuseastrocytoma
balancedgainbalancedbalancedlossMutDiffuseastrocytomaDiffuseastrocytoma
balancedbalancedhet-delbalancedloss0DiffuseastrocytomaDiffuseastrocytoma
-124ATGhet-delgainbalancedbalancedpositive0DiffuseastrocytomaDiffuseastrocytoma
balancedbalancedbalancedbalancedpositive0DiffuseastrocytomaDiffuseastrocytoma
inUTRNDbalancedbalancedbalancedbalancedpositive0DiffuseastrocytomaDiffuseastrocytoma
balancedbalancedbalancedbalancedloss0DiffuseastrocytomaDiffuseastrocytoma
inUTRwtcomplexgainhet-delhet-delsegmentalpositiveMutAnaplasticAnaplastic
inUTRwthet-delsegmentalbalancedhet-delbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedhet-delsegmentalhet-delbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedhet-delbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedgainhet-delbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedhet-delbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedhet-delbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedhet-delbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedhet-delhet-delsegmentallossMutAnaplasticAnaplastic
inUTRwthet-delsegmentalbalancedhet-delhet-delsegmentallossMutAnaplasticAnaplastic
balancedbalancedhet-delbalancedlossMutAnaplasticAnaplastic
inUTRwthet-delbalancedbalancedbalancedpositiveMutAnaplasticAnaplastic
NDbalancedgainbalancedbalancedpositiveMutAnaplasticDiffuseastrocytoma
inUTRwtbalancedbalancedbalancedbalancedpositiveMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedpositiveMutAnaplasticAnaplastic
inUTRwtbalancedgainbalancedbalancedpositiveMutAnaplasticAnaplastic
ex3wtinUTRwthet-delbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwthet-delbalancedbalancedbalancedlossMutAnaplasticAnaplastic
ex3wtinUTRwthet-delbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwthet-delbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwthet-delbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwthet-delbalancedbalancedbalancedlossMutAnaplasticAnaplastic
-146ATGbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossmutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedhet-delsegmentalbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedgainhet-delsegmentalbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedgainbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedgainhet-delsegmentalbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedgainbalancedbalancedlossMutAnaplasticAnaplastic
ex3wtinUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwthet-delsegmentalbalancedhet-delsegmentalbalancedlossMutAnaplasticAnaplastic
inUTRwthet-delsegmentalbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRNDbalancedbalancedbalancedbalancedlossMutAnaplasticOligoastrocytoma
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
ex3wtinUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
balancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
balancedbalancedbalancedbalancedlossMutAnaplasticGlioblastoma(WHO
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
ex3wtinUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
balancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRNDbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
intUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwthet-delsegmentalbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwthet-delsegmentalbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedgaingainsegmentallossMutAnaplasticAnaplastic
inUTRwtbalancedgainbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
NDhet-delsegmentalbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedhet-delsegmentalbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedhet-delsegmentalbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedhet-delbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRNDbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedgainbalancedbalancedlossMutAnaplasticDiffuseastrocytoma
balancedbalancedbalancedbalancedlossMutAnaplasticGlioblastoma(WHO
balancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
het-delsegmentalbalancedbalancedbalancedlossMutAnaplasticAnaplastic
balancedbalancedhet-delsegmentalbalancedlossMutAnaplasticAnaplastic
het-delsegmentalbalancedbalancedbalancedlossMutAnaplasticAnaplastic
balancedbalancedbalancedbalancedlossMutAnaplasticOligoastrocytoma
balancedbalancedbalancedbalancedlossMutAnaplasticOligodendroglioma
balancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
balancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
balancedbalancedhet-delsegmentalhet-delsegmentallossMutAnaplasticAnaplastic
balancedbalancedbalancedgainsegmentallossMutAnaplasticAnaplastic
balancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
balancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
balancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
balancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
het-delsegmentalbalancedcomplexgainlossMutAnaplasticAnaplastic
balancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
balancedbalancedbalancedbalancedlossMutAnaplasticAnaplastic
balancedgainbalancedgainsegmentallossMutAnaplasticAnaplastic
ex3wtinUTRwtbalancedbalancedhet-delbalancedpositive0AnaplasticAnaplastic
inUTRwthet-delbalancedbalancedbalancedpositive0AnaplasticAnaplastic
-124ATGbalancedbalancedbalancedbalancedpositive0AnaplasticAnaplastic
K27MinUTRwtbalancedgainsegmentalbalancedbalancedpositive0AnaplasticAnaplastic
ex3wtinUTRwtbalancedbalancedbalancedbalancedpositive0AnaplasticAnaplastic
inUTRwtbalancedgainbalancedbalancedpositive0AnaplasticAnaplastic
K27MinUTRwthet-delbalancedbalancedhet-delsegmentalloss0AnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedloss0AnaplasticAnaplastic
ex3wtinUTRwtbalancedgainbalancedbalancedloss0AnaplasticAnaplastic
inUTRwtbalancedbalancedbalancedbalancedloss0AnaplasticAnaplastic
inUTRwthet-delbalancedhet-delbalancedlossMutGlioblastoma(WHOGlioblastoma(WHO
ex3wtinUTRwtbalancedbalancedhet-delhet-delsegmentallossMutGlioblastoma(WHOGlioblastoma
-124ATGhet-delbalancedbalancedbalancedpositiveMutGlioblastoma(WHOGlioblastoma(WHO
inUTRwthet-delbalancedgainbalancedlossMutGlioblastoma(WHOGlioblastomawith
inUTRNDhet-delbalancedbalancedbalancedlossMutGlioblastoma(WHOGlioblastoma(WHO
inUTRwthet-delbalancedbalancedbalancedlossMutGlioblastoma(WHOGlioblastoma
inUTRwthet-delbalancedbalancedbalancedlossMutGlioblastoma(WHOGlioblastoma(WHO
het-delbalancedhet-delsegmentalbalancedlossMutGlioblastoma(WHOGlioblastoma(WHO
het-delbalancedhet-delsegmentalbalancedlossMutGlioblastoma(WHOGlioblastoma(WHO
inUTRwtbalancedbalancedbalancedbalancedlossMutGlioblastoma(WHOGlioblastoma(WHO
inUTRwtbalancedbalancedbalancedbalancedlossMutGlioblastoma(WHOGlioblastoma(WHO
inUTRwtbalancedbalancedbalancedbalancedlossMutGlioblastoma(WHOGlioblastoma
het-delsegmentalgainbalancedbalancedlossMutGlioblastoma(WHOGlioblastoma(WHO
balancedcomplexhet-delsegmentalbalancedlossMutGlioblastoma(WHOGlioblastoma
ex3wtinUTRwtbalancedbalancedhet-delsegmentalhet-delpositive0Glioblastoma(WHOGlioblastoma(WHO
-124ATGamphet-delgainhet-delbalancedpositive0Glioblastoma(WHOAnaplastic
-146ATGhet-delgainhet-delbalancedpositive0Gliosarcoma(WHOGliosarcoma(WHO
-124ATGhet-delgainhet-delbalancedpositive0GiantcellGiantcell
ex3wt-146ATGhet-delgainhet-delgainpositive0Glioblastoma(WHOGlioblastoma(WHO
-146ATGhet-delgainhet-delhet-delsegmentalpositive0Glioblastoma(WHOAnaplastic
inUTRwthet-delbalancedhet-delbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
balancedgainhet-delbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
K27Mbalancedbalancedhet-delbalancedloss0Glioblastoma(WHOGlioblastoma(WHO
-124ATGamphet-delgainbalancedbalancedpositive0Glioblastoma(WHOAnaplastic
-124ATGamphet-delgainhet-delsegmentalhet-delsegmentalpositive0Glioblastoma(WHOAnaplastic
-124ATGamphet-delgainbalancedbalancedpositive0Glioblastoma(WHOAnaplastic
-124ATGamphet-delgaingainbalancedpositive0Glioblastoma(WHOAnaplastic
-124ATGamphet-delgainbalancedhet-delsegmentalpositive0Glioblastoma(WHOAnaplastic
-146ATGamphet-delgainbalancedbalancedpositive0Gliosarcoma(WHOGliosarcoma(WHO
-124ATGamphet-delgainbalancedbalancedpositive0Glioblastoma(WHOAnaplastic
-124ATGamphet-delgaingainbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
-124ATGamphet-delgaingainbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
-124ATGamphet-delgaingainbalancedpositive0Glioblastoma(WHOAnaplastic
-124ATGamphet-delgaingainbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
-124ATGamphet-delgainbalancedbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
-146ATGamphet-delgainbalancedbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
ex3wt-124ATGamphet-delgainbalancedbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
-124ATGamphet-delgaingainbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
ex3wt-124ATGamphet-delgainbalancedhet-delsegmentalpositive0Glioblastoma(WHOGlioblastoma(WHO
-124ATGamphet-delgainbalancedbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
-124ATGamphet-delbalancedbalancedbalancedpositive0Glioblastoma(WHOAnaplastic
-146ATGamphet-delgainbalancedbalancedpositive0Glioblastoma(WHOAnaplastic
-124ATGamphet-delgainbalancedbalancedpositive0Glioblastoma(WHOAnaplastic
ex3wtinUTRwtamphet-delgaingainbalancedpositive0Glioblastoma(WHOGlioblastomawith
ex3wtinUTRwtamphet-delgaingainamppositive0Glioblastoma(WHOGlioblastomawith
inUTRNDamphet-delbalancedbalancedbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
inUTRwtamphet-delgainbalancedbalancedpositive0Glioblastoma(WHOAnaplastic
inUTRwtamphet-delgainbalancedbalancedpositive0Glioblastoma(WHOAnaplastic
inUTRwtamphet-delgainbalancedbalancedpositive0Glioblastoma(WHOAnaplastic
intUTRwtamphet-delbalancedbalancedhet-delsegmentalpositive0Glioblastoma(WHOAnaplastic
amphet-delbalancedgainbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
amphet-delgainbalancedhet-delsegmentalpositive0Glioblastoma(WHOGlioblastoma(WHO
amphet-delbalancedgainbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
amphet-delgainbalancedbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
amphet-delgaingainbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
amphet-delgainsegmentalcomplexbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
amphet-delgainbalancedbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
amphet-delgaingainhet-delsegmentalpositive0Glioblastoma(WHOGlioblastoma(WHO
-124ATGampbalancedgainbalancedbalancedpositive0Glioblastoma(WHOAnaplastic
-124ATGampbalancedgainbalancedbalancedpositive0Glioblastoma(WHOAnaplastic
-124ATGhet-delgainbalancedbalancedpositive0Gliosarcoma(WHOGliosarcoma(WHO
-124ATGhet-delgaingainbalancedpositive0Glioblastoma(WHOGlioblastomawith
-124ATGhet-delgainbalancedbalancedpositive0Glioblastoma(WHODiffuseastrocytoma
-124ATGhet-delgainbalancedbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
-146ATGhet-delgainbalancedbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
-124ATGhet-delgaingainbalancedpositive0Gliosarcoma(WHOGliosarcoma(WHO
ex3wt-146ATGhet-delgainhet-delsegmentalbalancedpositive0Glioblastoma(WHOGlioblastomawith
-124ATGhet-delgainbalancedhet-delsegmentalpositive0Glioblastoma(WHOAnaplastic
-124ATGhet-delgainbalancedbalancedpositive0Gliosarcoma(WHOGliosarcoma(WHO
-146ATGhet-delgainbalancedbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
-146ATGhet-delgainbalancedbalancedpositive0GiantcellGiantcell
-124ATGhet-delgainbalancedbalancedpositive0Gliosarcoma(WHOGliosarcoma(WHO
ex3wt-124ATGhet-delgainbalancedbalancedpositive0Gliosarcoma(WHOGliosarcoma(WHO
-124ATGhet-delgainbalancedbalancedpositive0Gliosarcoma(WHOGliosarcoma(WHO
-124ATGhet-delgainbalancedhet-delsegmentalpositive0Gliosarcoma(WHOGliosarcoma(WHO
-124ATGhet-delgainbalancedbalancedpositive0Gliosarcoma(WHOGliosarcoma(WHO
ex3wt-124ATGhet-delgaingainbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
-146ATGhet-delbalancedbalancedbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
ex3wt-124ATGhet-delgainbalancedbalancedpositive0Gliosarcoma(WHOGliosarcoma(WHO
-124C228Thet-delgainbalancedhet-delsegmentalpositive0Glioblastoma(WHOGlioblastoma(WHO
-124ATGhet-delgainbalancedbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
-124ATGhet-delgainbalancedbalancedpositive0Glioblastoma(WHOAnaplastic
-124ATGhet-delgaingainbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
-124ATGhet-delgaingainbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
-124ATGhet-delgaingainbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
-124ATGhet-delgainbalancedbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
-146ATGhet-delbalancedbalancedbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
-124ATGhet-delgaingainbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
ex3wt-124ATGhet-delgainbalancedgainpositive0Glioblastoma(WHOGlioblastoma(WHO
-124ATGhet-delgaingainsegmentalbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
-124ATGhet-delgainbalancedbalancedpositive0Glioblastoma(WHOAnaplastic
-124ATGhet-delgainbalancedbalancedpositive0Glioblastoma(WHOAnaplastic
-124ATGhet-delgainbalancedbalancedpositive0Glioblastoma(WHOAnaplastic
-124ATGhet-delbalancedbalancedhet-delsegmentalpositive0Glioblastoma(WHOGlioblastoma(WHO
-124ATGhet-delgainbalancedbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
-146ATGhet-delgainbalancedbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
ex3wt-124ATGhet-delbalancedbalancedbalancedpositive0Glioblastoma(WHOGlioblastomawith
inUTRwthet-delgainbalancedhet-delsegmentalpositive0Glioblastoma(WHOGlioblastomawith
inUTRwthet-delgainbalancedbalancedpositive0Glioblastoma(WHOAnaplastic
inUTRwthet-delgainbalancedbalancedpositive0Gliosarcoma(WHOGliosarcoma(WHO
het-delgainbalancedbalancedpositive0Glioblastoma(WHODiffuseastrocytoma
inUTRNDhet-delgainbalancedbalancedpositive0Glioblastoma(WHODiffuseastrocytoma
inUTRNDhet-delgainbalancedbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
het-delgaingainhet-delsegmentalpositive0Glioblastoma(WHOAnaplastic
inUTRwthet-delgaingainbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
inUTRNDhet-delgaingainbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
inUTRwthet-delgainbalancedbalancedpositive0Glioblastoma(WHOAnaplastic
inUTRwthet-delbalancedbalancedbalancedpositive0Glioblastoma(WHOAnaplastic
het-delgainbalancedhet-delsegmentalpositive0Glioblastoma(WHOGlioblastoma(WHO
het-delgaingainbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
het-delgainbalancedbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
het-delgainbalancedbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
het-delgainbalancedbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
het-delgainbalancedbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
het-delbalancedbalancedbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
het-delgainhet-delsegmentalbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
het-delgaingainbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
het-delgainbalancedbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
het-delgainbalancedbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
het-delgainbalancedbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
het-delgaingainhet-delsegmentalpositive0Glioblastoma(WHOGlioblastoma(WHO
het-delgaingainbalancedpositive0Glioblastoma(WHODiffuseastrocytoma
het-delgainbalancedbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
inUTRNDhet-delgainbalancedbalancedpositive0GiantcellGiantcell
-146ATGbalancedbalancedbalancedgainpositive0Gliosarcoma(WHOGliosarcoma(WHO
-124ATGbalancedgaingainbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
ex3wt-124ATGbalancedbalancedbalancedbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
ex3wt-146ATGbalancedgaingainbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
-124ATGbalancedgaingainbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
-124ATGhet-delsegmentalgainbalancedbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
-124ATGbalancedbalancedbalancedhet-delsegmentalpositive0Glioblastoma(WHOGlioblastoma(WHO
-124ATGhet-delsegmentalgaingainbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
ex3wt-124ATGbalancedbalancedbalancedbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
ex3wtinUTRNDbalancedhet-delbalancedbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
balancedgainbalancedbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
balancedgaingainbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
ex3wtbalancedbalancedbalancedbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
balancedgaingainbalancedpositive0Glioblastoma(WHOGlioblastoma(WHO
ex3wtamphet-delgaingainbalancedloss0Glioblastoma(WHOGlioblastoma(WHO
ex3wt-124ATGhet-delgainbalancedbalancedloss0Gliosarcoma(WHOGliosarcoma(WHO
G34RinUTRwthet-delbalancedbalancedbalancedloss0Glioblastoma(WHOGlioblastoma(WHO
G34RinUTRwthet-delbalancedbalancedbalancedloss0Glioblastoma(WHOGlioblastoma(WHO
K27MinUTRwthet-delbalancedbalancedbalancedloss0Glioblastoma(WHOGlioblastoma(WHO
G34Rhet-delbalancedbalancedbalancedloss0Glioblastoma(WHOGlioblastoma(WHO
G34Rhet-delgainsegmentalbalancedbalancedloss0Glioblastoma(WHOGlioblastoma(WHO
K27MinUTRwthet-delsegmentalbalancedbalancedbalancedloss0Glioblastoma(WHOGlioblastoma(WHO
K27MinUTRwthet-delsegmentalbalancedbalancedbalancedloss0Glioblastoma(WHOGlioblastomawith
ex3wtinUTRwtbalancedbalancedbalancedbalancedloss0Glioblastoma(WHOGlioblastoma(WHO
ex3wtinUTRwthet-delsegmentalgainbalancedbalancedloss0Glioblastoma(WHOGlioblastoma(WHO
ex3wtbalancedgaingainbalancedloss0Glioblastoma(WHOGlioblastoma(WHO
O II O III OA II A IIOA III A III GBM GBM-O
WHO 2007
Integrated
Oligodendroglioma
Grade II
GBM
IDH
Glioblastoma
Age 42 48 38 39 44 59
IDH
ATRX
1p
19q
7p
10q
EGFR
TERT
H3
Chr lossChr gain
IDH mut ATRX loss
Amp
TERT mut
Age 20 30 40
50 60 70 80
Chr loss
segmental
H3 mut
Grade III
Astrocytoma
Grade II Grade III
IHC; sequencing
IHC
qPCR
qPCR
qPCR
qPCR
UCL INSTITUTE OF NEUROLOGY
Neuropathology turnaround times at NHNN
0
0,1
0,2
0,3
0,4
0,5
0,6
0,7
0,8
0,9
1
1 2 3 4 5 6 7 8 9 10 15 20 30 60 90
Cumulativefraction
TAT (Days)
Mol Path 2014 (675) Mol Path 2015 (208)
GBM Histology (108) All Surgical Pathology (751)
UCL INSTITUTE OF NEUROLOGY
Turnaround time and clinical oncology
information
• Histological diagnosis of common brain tumours:
90% in 3 days
– Patients can be referred back to local hospital
– Treatment plan can be devised in most cases
• Complete molecular integrated diagnosis:
90% in 15 days
– Delay in allocation to clinical trials possible
– Delay in final decision making re treatment plan
UCL INSTITUTE OF NEUROLOGY
Workflow difference between DNA based and
tissue based assays
• Specimen frequency 1-3/day
– Nucleic acid based: 4-8 per week, batch of tests
– Tissue based: daily test, along with IHC, on machine
Mon Tue Wed Thu Fri Sat Sun Mon
AM PM AM PM AM PM AM PM AM PM AM PM
DNA based: batching Sample Test Sample
TAT 1-5 days +WE Sample Test
Sample Test
Sample Test
Sample Test
Sample Test
Sample Test
Reports
Tissue based: queue Sample Test Sample Test Sample Test Sample Test Sample
TAT 1 day + WE Sample Test Sample Test
Sample Test Test
Reports Reports Reports Reports Reports
UCL INSTITUTE OF NEUROLOGY
Process A Process B Process C
Batch and queue processing
10 min 10 min 10 min
30 minutes total order
21 minutes first product
Continuous flow processing
Process A Process B Process C
12 minutes total order
3 minutes first product
UCL INSTITUTE OF NEUROLOGY
Detection and quantification of chromosomal
losses in SISH slides
• Aim: to develop a fast-track image analysis to
detect SISH signals on FFPE tissue
• Procedure:
– Use established (HER2) control slides from ROCHE
– Setting up image analysis algorithm in Definiens Tissue
Studio and Developer
– Validating image analysis algorithm
UCL INSTITUTE OF NEUROLOGY
Specimen preparation and staining
Preparation of
histological
slides
Diagnostic
decision
making
Choice of test QC: Visual inspection of slide
12-24 h
Surgical removal of
tissue
4 h
Automated
IHC, CISH or
SISH
8h 10 min
Tissue processing
in PathLab
Experimental
tissues
UCL INSTITUTE OF NEUROLOGY
Digitising and automated image analysis
Slide scanning
File archiving
Web based slide
management
Submission for
image analysisSlides
Image analysis
Data output to user
1h 20min 1h
UCL INSTITUTE OF NEUROLOGY
Definiens Developer and Tissue Studio
Identification of region of interest
(Ventana control slide; HER2)
Regions of interest in detail
UCL INSTITUTE OF NEUROLOGY
High magnification of signal within ROI
UCL INSTITUTE OF NEUROLOGY
Definiens Developer and Tissue Studio
First nuclear identification
UCL INSTITUTE OF NEUROLOGY
Nuclear segmentation
UCL INSTITUTE OF NEUROLOGY
• Result: all nuclei are
identified and
segmented within the
ROI
UCL INSTITUTE OF NEUROLOGY
Spot identification (ISH signal)
Red= red signal, blue= silver signal
UCL INSTITUTE OF NEUROLOGY
Representation of ISH signal on sectioned
nuclei
Section 2.5-4μm
Nucleus
~10μm
UCL INSTITUTE OF NEUROLOGY
Validation step: identification and
visualisation of red and silver spots
code Red Silver
2 0
2 1
1 0
0 2
1 1
0 1
2 2
1 1
0 0
UCL INSTITUTE OF NEUROLOGY
Result: Segmentation and spot quantification
UCL INSTITUTE OF NEUROLOGY
Data output: counts of red and silver spots in
test slide
Feature Value Red Silver
No Spots 3270 0 0
Red 1 Silver 1 504 504 504
Red 1 Silver 2 237 237 474
Red 2 Silver 1 213 426 213
Red 2 Silver 2 126 252 252
1419 1443
Red spots (total) 4713
Silver spots (total) 5667
UCL INSTITUTE OF NEUROLOGY
Conclusion: image analysis of ISH signal
• Accurate determination of ISH spot count in tissue
sections
• 1000’s of nuclei counted in minutes (5000 in our ROI)
• Superior to manual counting of FISH nuclei (usually 100)
UCL INSTITUTE OF NEUROLOGY
Conclusions
• Proof of principle to use tissue based molecular
diagnostics can be used
• Further evaluation includes
– Cost effectiveness (probes)
– Accuracy on routine diagnostic material
– User interface to select region of interest
– Actual turnaround
UCL INSTITUTE OF NEUROLOGY
0,00
0,10
0,20
0,30
0,40
0,50
0,60
0,70
0,80
0,90
1,00
1 2 3 4 5 6 7 8 9 10 15 20 30 60 90
Turnaround Histology and Molecular Pathology with
Future Aims
GBM Histology (108) All Surgical Pathology (751) Mol Path 2014 (675) MolPAth 2015 (208) Digital Pathology: aim
UCL INSTITUTE OF NEUROLOGY
What would be the impact on patient care and
patient pathway:
• Oncologists know the result when discharging
patient (4-8 d)
• No additional visit to specialist hospital needed to
discuss diagnoses
• Treatment plan can be devised during hospital
stay and is ready when patient discharged for
adjuvant therapy at local hospital
UCL INSTITUTE OF NEUROLOGY
Thanks to….
Division of Neuropathology UCL-IoN
Matthew Ellis: Implementation of all tissue analysis algorithms and implementation
of digital imaging workflow. Complete analysis of muscle, nerve and tumours
UCL IQPath team
Angela Richard Loendt (lead) with Tamsin Wilkins, Francesca Launchbury and
Jessica Broni
Preparation of histological slides, slides scanning and data management
Definiens, Munich
Tamara Haeberlin; Bjorn Reiss, Jan Schoblocher
Roche diagnostics (HER slides)
Alex McDonald
63
- Bart Ongena –
VP Business Development TforG
TforG CareTracks
© 2015 TforG | www.tforg.com | +32 3 201 64 00
TforG Care Tracks
1. Introduction
2. Applications & Cases:
o Facilitate Fast Tracking
o Solutions to improve Patient Throughput
o Optimize Potential for new Products/Technologies
o Anticipate impact of Competition & new technologies
3. The TforG Care Tracks
64
© 2015 TforG | www.tforg.com | +32 3 201 64 00
Creating Value for the hospital
Care Delivery Chain:
The usage of your product is more than a single
moment in the medical treatment.
It’s part of a process.
65
© 2015 TforG | www.tforg.com | +32 3 201 64 00
TforG Care Tracks:
The tool to create value for the hospital.
Position your product in the care delivery chain to understand:
o choices made before and after,
o alternative solutions,
o bottlenecks in the process
Use this information to support the hospital & create Value
o Identify in which part of the chain value can be created
o Shorten the time to diagnosis / treatment.
o Accelerate the access to the patient,
o Create new benefits for the hospitals & staff
o Implement cost effective solutions / care tracks
66
© 2015 TforG | www.tforg.com | +32 3 201 64 00
Demo
67
© 2015 TforG | www.tforg.com | +32 3 201 64 00
Applications:
Facilitate Fast Tracking
Support the hospital to
reduce the ‘Time-to-Diagnose’ or ‘Time-to-Therapy’
Diagnosis & Referral Support
o Re-engineer the pre-hospital diagnosis.
o Obtain faster detections and more accurate referrals
o Reduce hospital workload & resources.
© 2015 TforG | www.tforg.com | +32 3 201 64 00
Applications:
Facilitate Fast Tracking
CASE: Time to Therapy
Supplier: Pump therapy for severe spasticity
Objective:
o Support hospitals in reduction of ‘Time to Pump Therapy’
o Through better understanding of:
• Care Track of spasticity patients
• Eligible patients
• how to increase ‘Time to baclofen pump Therapy’
© 2015 TforG | www.tforg.com | +32 3 201 64 00
Support the hospital identify
• Bottlenecks in the patient flow
• Optimal / most cost effective patient flow
Trends:
o Open vs. Minimal invasive treatment
o In-patient vs. Out-patient treatment
o Increasing impact of external influences:
• DRG based finance systems
• Clinical guidelines
Applications:
Solutions to improve Patient Throughput
© 2015 TforG | www.tforg.com | +32 3 201 64 00
Applications:
Solutions to improve Patient Throughput
CASE: DRG impact on strategy
Supplier:
innovative, minimally invasive treatment
for lumbar spinal stenosis
EU market
Objective:
o Acquire acceptance of an alternative intervention within hospital
o Identify a more cost effective patient flow
© 2015 TforG | www.tforg.com | +32 3 201 64 00
Care Track Analysis:
identified most favorable patient flow
Overnight stay  more favorable DRG
vs.
Outpatient solution  apply for new reimbursement
Outcomes:
Introduction of alternative interventions:
o Require in-depth knowledge of DRG effects & strategy
o Need to overcome ‘resistance’ from medical professionals
o Requires shift to other medical professional (e.g. from spinal surgeon to
interventional radiologist)
Applications:
Solutions to improve Patient Throughput
© 2015 TforG | www.tforg.com | +32 3 201 64 00
Applications:
Optimize potential for new technologies
Reduce the number of patients leaving the track early
Through identification of:
o Best partners for your activities
o Impact of Evidence Based Medicine:
- NICE (UK): Dominant influence on application / introduction
of new therapies, treatments & technologies.
- EU: similar institutes, increasing influence by HTA-agencies
73
© 2015 TforG | www.tforg.com | +32 3 201 64 00
CASE: Channel selection
Supplier:
Interventional Pain Management: new DNS technology
Objective:
o Identify best Channel / Partners:
Compatible companies active in Pain Management
o Identify relevant target group
Methodology:
- Care Track Analysis
- Interviews with the target group (interventional pain managers, anesthesiologists,
orthopaedic and neurosurgeons, physical therapy physicians)
Applications:
Optimize potential for new technologies
© 2015 TforG | www.tforg.com | +32 3 201 64 00
Applications:
Anticipate the impact of competition & new
technologies
Increase your Market Share potential
Determine go-to-market strategy
by
Supporting hospitals to:
• Identify most cost effective patient flow
• Understand impact of innovative solutions & new technologies
• Implement Change management
• Become reference centers
• Attract more patients
75
© 2015 TforG | www.tforg.com | +32 3 201 64 00
Applications:
Anticipate the impact of competition & new
technologies
CASE: Optimize data-exchange in Digital Pathology
Objective:
o Introduce of this new technology
o Understanding the current workflow
o Identify budget & benefit owners
o Understand how to convince hospitals with a cost-benefit
analysis
© 2015 TforG | www.tforg.com | +32 3 201 64 00
Follow patients with a specific disease,
on their path through the Health Care system.
– Layer 1: Care track & statistics
• From symptom to follow-up
• Description of each treatment and diagnosis step
• Incidence & prevalence
• Population
– Layer 2: Locator
• Department
• Care provider
• Equipment/devices
– Layer 3: Decision points
• Drivers
• Decision Making Unit
• Consequences & outcomes
TforG Care Tracks
The tool to create value for the hospital
© 2015 TforG | www.tforg.com | +32 3 201 64 00
TforG Care Tracks
The tool to create value for the hospital
DIFFERENTIATING VIEW ON THE CARE DELIVERY PROCESS
o Customized to your Product / Technology
in any specific country
o provide (visual) overview of the patient flow
o identify strategic elements (drivers & decision making units)
o And give you the necessary tools to create value for the
hospital & support
TforG
Tel: +32 3 201 64 00
Address: Ankerrui 8-10, 2000 Antwerp
Website: www.tforg.com
CEO: Bart Van den Mooter
Tel: +32 3 201 64 01
Email: b.vandenmooter@tforg.com
VP Business Development: Bart Ongena
Tel: +32 3 201 64 02
Email: b.ongena@tforg.com

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Does TforG offer MedTech companies a workable solution for the European markets under pressure?