A brief college level seminar for Herbals in pharma industry... Short n Sweet... Regards...Swapnil M. Sanghavi

1. HERBALS In Pharmaceutical industry 1/26

3. Why we should include herbs in pharmaceuticals? 3

4. 1. HERBS ARE IMPORTANT SOURCE OF LEAD GENERATION:- 4 DRUG DRUG OF CHOICE IN ORIGINAL SOURCE DIGOXIN CCF FLOXGLOVE COLCHICINE GOUT COLCHICUM SEEDS QUININE MALARIA CINCHONA CROMOGLYCATE SODIUM ASTHMA IN CHILDREN AMI MAJUS.

6. Plant name/family Drugs Treatment Cathranthus rosesus L. (Apocynaceae) Vinblastine and vincristine Hodgkins, Lymphosarcomas and children leukemia. Podophyllum emodi Wall. (Beriberidaceae) Podophyllotaxin, Testicular cancer, small cell lung cancer and lymphomas. Taxus brevifolius (Taxaceae) Paciltaxel, taxotere Ovarian cancer, lung cancer and malignant melanoma. Mappia foetida Miers. Comptothecin, lrenoteccan and topotecan Lung, ovarian and cervical cancer. Comptotheca acuminata Quinoline and comptothecin alkaloids used in Japan for the treatment of cervical cancer Juniperus communis L. (Cupressaceae) Teniposide and etoposie Lung cancer

7. 3 rd reason:- Market potential of phytomedicine 7 Country Years Drugs sales in US $ (billion) 1 Europe Germany France Italy Others 2006 6 3.0 1.6 0.6 0.8 2 Europe 2006 10.0 3 USA 2006 4.0 4 India 2006 1.0 5 Other countries 2006 5.0 6 All countries 2006 30.0 - 60.0

18. CDB example: CNPD- China Natural Products Database 18

20. HDC patented its ‘Herbal Laxative’ preparation for treatment of constipation in February 2001 in the US . HDC’s 5 products have been endorsed by more than 250,000 doctors worldwide, and the company exports its products to more than 60 countries . Today, HDC is the only phytopharmaceutical company whose ayurvedic products are registered as a ‘pharmaceutical specialty’ in Switzerland. Dabur, which owns 29 patents in the US, is amongst the leaders in healthcare. It became one of the only two companies in the world to introduce an anti-cancer drug, Intaxel (Paclitaxel). 20

25. THANKS [email_address]