19. Approach to normocytic anemia (Pure red cell aplasia check reticulocyte count normocytic anemia increased Is there evidence of hemolysis? hemolytic anemia yes Is there evidence of: - renal failure anemia of renal failure - endocrine failure anemia of endocrine failure - chronic inflammation anemia of chronic disease normal or decreased recent bleed no If not, then consider a primary marrow problem (MDS, MM, infiltration…) bone marrow investigation