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Layers of the eyeball
• The most pathetic person in the world is
  someone who has sight, but has no vision.
  – Helen Keller
General features
• Image focusing system, composed of
1. Cornea
2. Lens
3. Refractive media
• Internally black- prevents ‘scatter effect’
• In front of iris – anterior chamber
• Behind the iris – posterior chamber
• Refractive media enclosed in 3 coats
1. Fibrous [sclera, cornea]
2. Vascular/uveal coat [choroid, ciliary body, iris]
3. Nervous [retina]
Sclera
• Posterior 5/6ths
• Opaque - composed of dense collagen and
  elastic fibres
• Thinnest at equator
• Pierced by recti muscles
• Thickest at back, except where pierced by fibres
  of CN II [lamina cribrosa]
• ‘cupping’ of optic disc= posterior bulging of disc
  in sustained ↑in intraocular pressure
• Blends with dura mater
• Site of muscle insertion
• Pierced by ciliary nerves and arteries, venae
  vorticosae
• Almost avascular, except ehere connected to
  fascial sheath of eye and bulbar conjunctiva
Cornea
• Forms anterior 1/6th of fibrous coat
• Transparent fibrous tissue laminae
• Avascular [no transplant rejection]
Layers
1. Corneal epithelium
2. Bowman’s membrane /anterior limiting
   membrane; scattered collagen fibrils and
   ground substance
3. Corneal stroma/substantia propria
• 200 collagen fibril lamellae
• Scattered fibroblasts
• Transparency because of lattice arrangement
4. Descemet’s membrane /posterior limiting
  membrane
5. Corneal endothelium
Nerve supply
• Short and long ciliary nerves
• Mainly short ciliary
• Corneal reflex pathway; short ciliary nerves→
  trigeminal ganglion→ main CN V sensory
  nucleus→ reticular formation→ both CN VII
  motor nuclei [both orbicularis oculi muscles act]
• Components  choroid, ciliary body, iris
CHOROID
• Thin, pigmented
• Outer layer separated from sclera by
  suprachoroid lamina [delicate connective tissue]
• Inner layer firmly attached to pigmented layer of
  retina
• Rods and cones nourished by choroidal
  capillaries
• Venae voricosae [4-5] drain choroid- exit
  through sclera
Ciliary body
• Continuous with choroid behind and iris in front
• Like a flat ring applied to inner scleral surface
• Thick in front, thin behind
• Triangular ;2 lond sides in contact with sclera
  and vitroeus
• Attachment of iris halfway along flat anterior
  short base
• Ciliary muscle in scleral surface
• Vitreous surface – bilayered epithelium [outer
  pigmented, inner nonpigmented]
• Layers represent pigment and nervous layers of
  retina
• Scleral surface projected into70-80 ciliary
  processes that lie in reciprocal grooves on
  anterior surface of vitreous body
Iris
• Attached at periphery to anterior surface of
  ciliary body and a narrow rim of sclera to form
  iridocorneal angle of anterior chamber
• Perforated centrally by pupil
• Main bulk- vascular connective tissue connective
  tissue
• Amount of melanin granules increases from
  anterior to posterior
• Amount of pigment increases with age
• Color is variable in different individuals
Sphincter pupillae
• Circular smooth muscle
• Supplied from Edinger – Westphal nucleus of
  CN III
Dilator pupillae
• Radial smooth muscle
• Supplied by cervical sympathetics
• Preganglionic neurons lie in T1 segment of
  spinal cord
Trabecular meshwork and scleral
venous sinus
Lens
• Transparent, biconvex
• More convex posteriorly
• Transparent ,elastic capsule
• Posteriorly rests on vitreous, anteriorly in
  contact with iris
• 10 mm dia., 4 mm thick
• Centrally , single layer of cubical cells
• Peripherally , cells elongate to produce fibres
• Increase in length leads to increase in lens
  substance
Suspensory ligament/zonule
• Series of delicate fibrils attached to ciliary
  processes and through the furrows between
  them, further back on ciliary body
• Most fibres attach themselves to the lens- mostly
  in front and a few behind the circumference
• Holds lens flattened under tension
• Contraction of ciliary muscle→ forward
  displacement of choroid and ciliary body
• This relieves some tension exerted by zonule on
  the lens; makes it more globular→ increased
  refractive power [Accomodation]
•   Delicate
•   Outer surface in contact with choroid
•   Inner surface in contact with vitreous
•   Ora serrata- anterior limit of light ssensitive area
•   Beyond ora serrata- thin light insensitive layer
    continues as epithelial layers of ciliary body and
    iris
Retina - components
1. Retinal pigment epithelium
2. Neural retina
Retinal pigment epithelium

• Outer layer
• Simple cuboidal melanin-containing cells
• Firm attachment to choroid via Bruch’s
  membrane [thin refractile layer –multilaminar]
Neural retina

• Contains light – sensitive receptors [ rods and
  cones] + complex neuronal networks
• Potential space exists between neural retina and
  RPE
• Layers can be separated mechanically
• Eye disease or trauma also leads to separation
  [Retinal detachment]
Components of neural retina
• Nonvisual part; anterior to ora serrata- lines
  inner aspect of ciliary body and posterior surface
  of iris
• Photosensitive /visual part; lines inner
  surface of eye posterior to ora serrata, except
  where it is pierced by CN II
Optic disc
• i.5 mm dia.
• Site of entry of CN II
• Overlies lamina cribrosa of sclera
• Deepened to a variable degree to form a
  ‘physiological’ cup
• Insensitive to light – ‘blind spot’
Fundus
• Disc and whole of surrounding area at the back
  of the eye seen with ophthalmoscope
Macula lutea –
• yellowish shallow depression, avascular
• 3mm lateral to optic disc
Fovea centralis
•   Shallow central pit in macula
•   Thinnest area of retina
•   Avascular
•   No rods
•   High concentration of cones=site of most acute
    vision
Arrangement
• Outer layer- pigmented cells attached to choroid
• Not a firm attachment
• In retinal detachment- pigmented cells remain
  in position; rods and cones and other layers
  displaced onwards
Physiological arrangement
• Similar to any sensory pathway
• 1st order neuron – bipolar cell – peripheral
  process connected to rods and cones
• Synapses with 2nd order neurons – ganglion cell
• Passes to thalamus [lateral geniculate body]
  which has 3rd order neurons
• Axons pass through retrolentiform part of
  internal capsule to visual cortex
Eye layers 1

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Eye layers 1

  • 1.
  • 2. Layers of the eyeball
  • 3.
  • 4.
  • 5.
  • 6.
  • 7.
  • 8.
  • 9.
  • 10. • The most pathetic person in the world is someone who has sight, but has no vision. – Helen Keller
  • 11.
  • 12.
  • 13.
  • 14.
  • 15. General features • Image focusing system, composed of 1. Cornea 2. Lens 3. Refractive media • Internally black- prevents ‘scatter effect’ • In front of iris – anterior chamber • Behind the iris – posterior chamber
  • 16. • Refractive media enclosed in 3 coats 1. Fibrous [sclera, cornea] 2. Vascular/uveal coat [choroid, ciliary body, iris] 3. Nervous [retina]
  • 17.
  • 18.
  • 19.
  • 20.
  • 21.
  • 22. Sclera • Posterior 5/6ths • Opaque - composed of dense collagen and elastic fibres • Thinnest at equator • Pierced by recti muscles
  • 23. • Thickest at back, except where pierced by fibres of CN II [lamina cribrosa] • ‘cupping’ of optic disc= posterior bulging of disc in sustained ↑in intraocular pressure • Blends with dura mater • Site of muscle insertion
  • 24. • Pierced by ciliary nerves and arteries, venae vorticosae • Almost avascular, except ehere connected to fascial sheath of eye and bulbar conjunctiva
  • 25. Cornea • Forms anterior 1/6th of fibrous coat • Transparent fibrous tissue laminae • Avascular [no transplant rejection]
  • 26. Layers 1. Corneal epithelium 2. Bowman’s membrane /anterior limiting membrane; scattered collagen fibrils and ground substance 3. Corneal stroma/substantia propria • 200 collagen fibril lamellae • Scattered fibroblasts • Transparency because of lattice arrangement
  • 27.
  • 28. 4. Descemet’s membrane /posterior limiting membrane 5. Corneal endothelium
  • 29. Nerve supply • Short and long ciliary nerves • Mainly short ciliary • Corneal reflex pathway; short ciliary nerves→ trigeminal ganglion→ main CN V sensory nucleus→ reticular formation→ both CN VII motor nuclei [both orbicularis oculi muscles act]
  • 30.
  • 31.
  • 32.
  • 33. • Components choroid, ciliary body, iris CHOROID • Thin, pigmented • Outer layer separated from sclera by suprachoroid lamina [delicate connective tissue] • Inner layer firmly attached to pigmented layer of retina
  • 34.
  • 35. • Rods and cones nourished by choroidal capillaries • Venae voricosae [4-5] drain choroid- exit through sclera
  • 36. Ciliary body • Continuous with choroid behind and iris in front • Like a flat ring applied to inner scleral surface • Thick in front, thin behind • Triangular ;2 lond sides in contact with sclera and vitroeus • Attachment of iris halfway along flat anterior short base
  • 37.
  • 38. • Ciliary muscle in scleral surface • Vitreous surface – bilayered epithelium [outer pigmented, inner nonpigmented] • Layers represent pigment and nervous layers of retina
  • 39. • Scleral surface projected into70-80 ciliary processes that lie in reciprocal grooves on anterior surface of vitreous body
  • 40. Iris • Attached at periphery to anterior surface of ciliary body and a narrow rim of sclera to form iridocorneal angle of anterior chamber • Perforated centrally by pupil • Main bulk- vascular connective tissue connective tissue • Amount of melanin granules increases from anterior to posterior
  • 41. • Amount of pigment increases with age • Color is variable in different individuals
  • 42. Sphincter pupillae • Circular smooth muscle • Supplied from Edinger – Westphal nucleus of CN III
  • 43. Dilator pupillae • Radial smooth muscle • Supplied by cervical sympathetics • Preganglionic neurons lie in T1 segment of spinal cord
  • 44.
  • 45.
  • 46.
  • 47. Trabecular meshwork and scleral venous sinus
  • 48. Lens • Transparent, biconvex • More convex posteriorly • Transparent ,elastic capsule • Posteriorly rests on vitreous, anteriorly in contact with iris • 10 mm dia., 4 mm thick
  • 49. • Centrally , single layer of cubical cells • Peripherally , cells elongate to produce fibres • Increase in length leads to increase in lens substance
  • 50. Suspensory ligament/zonule • Series of delicate fibrils attached to ciliary processes and through the furrows between them, further back on ciliary body • Most fibres attach themselves to the lens- mostly in front and a few behind the circumference
  • 51.
  • 52.
  • 53.
  • 54. • Holds lens flattened under tension • Contraction of ciliary muscle→ forward displacement of choroid and ciliary body • This relieves some tension exerted by zonule on the lens; makes it more globular→ increased refractive power [Accomodation]
  • 55.
  • 56. Delicate • Outer surface in contact with choroid • Inner surface in contact with vitreous • Ora serrata- anterior limit of light ssensitive area • Beyond ora serrata- thin light insensitive layer continues as epithelial layers of ciliary body and iris
  • 57.
  • 58. Retina - components 1. Retinal pigment epithelium 2. Neural retina
  • 59. Retinal pigment epithelium • Outer layer • Simple cuboidal melanin-containing cells • Firm attachment to choroid via Bruch’s membrane [thin refractile layer –multilaminar]
  • 60. Neural retina • Contains light – sensitive receptors [ rods and cones] + complex neuronal networks • Potential space exists between neural retina and RPE • Layers can be separated mechanically • Eye disease or trauma also leads to separation [Retinal detachment]
  • 61. Components of neural retina • Nonvisual part; anterior to ora serrata- lines inner aspect of ciliary body and posterior surface of iris • Photosensitive /visual part; lines inner surface of eye posterior to ora serrata, except where it is pierced by CN II
  • 62.
  • 63. Optic disc • i.5 mm dia. • Site of entry of CN II • Overlies lamina cribrosa of sclera • Deepened to a variable degree to form a ‘physiological’ cup • Insensitive to light – ‘blind spot’
  • 64. Fundus • Disc and whole of surrounding area at the back of the eye seen with ophthalmoscope Macula lutea – • yellowish shallow depression, avascular • 3mm lateral to optic disc
  • 65.
  • 66. Fovea centralis • Shallow central pit in macula • Thinnest area of retina • Avascular • No rods • High concentration of cones=site of most acute vision
  • 67.
  • 68. Arrangement • Outer layer- pigmented cells attached to choroid • Not a firm attachment • In retinal detachment- pigmented cells remain in position; rods and cones and other layers displaced onwards
  • 69. Physiological arrangement • Similar to any sensory pathway • 1st order neuron – bipolar cell – peripheral process connected to rods and cones • Synapses with 2nd order neurons – ganglion cell • Passes to thalamus [lateral geniculate body] which has 3rd order neurons • Axons pass through retrolentiform part of internal capsule to visual cortex