just for some help

1. Bioadhesive ophthalmic drug insert

2. What are the conventional
ophthalmic preparation ?
Drops
(suspensions
,solutions)
ointments

3. What are the non conventional
types(alternative approaches)?
Ocular
iontophoresisDrug-
presoaked
hydrogel
type
contact
Lens.
Artificial
tear
inserts.
Collagen
shields
or
corneal
shields.
Ocular
inserts.
Phase transition systems.
Microspheres and nanoparticles

4. Q/ what are the problem with the
conventional ophthalmic dosage
form? That lead to the
innovation of ocular inserts

5. Problems:
1. rapid precorneal drug loss due to nasolacrimal
drainage
2. tear turnover and drug dilution resulting in
poor bioavailability
3. binding of the lacrimal proteins
4. limited corneal area and poor corneal
permeability
5. nonproductive absorption /adsorption
6. Pulsed dosing of drug.

6. Way this problem is a lot in this
type of dosage forms?
• The anatomy, physiology and biochemistry of
the eye render this organ exquisitely
impervious to foreign substances.SO The
introduction of ophthalmic insert solves many
problems present with conventional ocular
dosage forms

8. So we should concentrate on two things:
1) To prolong the contact time
2) To enhance corneal permeability
either by mild or transient structural alteration
of corneal epithelium or by modification of
chemical structure of the drug molecules.

9. Define “Bioadhesive” and by which
intervention we can obtain
Bioadhesive properties?
• Bioadhesive can be defined as a state in which
two components, of which one is of biological
origin, are held together for extended periods by
the help of interfacial forces. In case of
bioadhesive drug delivery, the term bioadhesion
is used to describe the adhesion between
polymers, either synthetic or natural and soft
tissues.
• So by the use of certain polymer matrix we can
get bioadhesion
Bioadhesive

10. what are the Bioadhesive ophthalmic
drug inserts(BODI) ?
BODIs are soluble type of “ocular insert” .
Ocular inserts: are
-sterile,
-thin, mono or multilayered,
-drug-impregnated or not,
-solid or semisolid devices placed into the cul-de-sac
or conjuctival sac, whose size and shape are
especially designed for ophthalmic application.
“They are composed of a polymeric support that
may or may not contain a drug.”

11. Bioadhesive
ophthalmic
drug inserts
Soluble
adhesive
rods ocular
insert

13. What are the advantage of BODI over the
other types of conventional ocular insert?
• overcome the main problems with
conventional ophthalmic inserts, which
include their site of application and the risk of
expulsion from the site.
• BODI are totally eliminated
• do not need to be removed,
• thus limiting manipulations to insertion only.

14. what are the Criteria for Successful
Ocular Inserts?
• Comfort and noninterference with vision
• Biocompatibility and stability
• Reproducibility of release kinetics
• Applicability to a variety of drugs
• Ease of sterility and nontoxicity
• Ease of handling ( insertion and removal)
• Ease of manufacture and low cost.

15. What are the advantage of ocular
insert ?
• Increased contact time
• prolonged drug release
• Reduction in dosage frequency
• an accurate dose
• Reduction of systemic side effect .
• Reproducibility of release kinetics.
• Sterility.
• Increased shelf life with comparison to
aqueous solutions due to absence of water.

16. So what are the disadvantages?
• Perceived by the patient as a foreign body.
• Movement around the eye.( not the case with
BODI)
• Occasionally lose during sleep or while
rubbing eyes
• Interference with vision
• Difficulty in placement and removal ( BODI
need no removal )

17. what are the considerations of
manufacturing?
• 1. Thickness of Insert
• 2. Surface pH determination
• 3. Mechanical strength
• 4. Bioadhesive strength
• 5. Sterility
• 6. Pattern and rate of the release of drug and
accuracy of the dose
• 7. Dissolution rate
• 8. Type of the polymer used and its swelling
factor

18. What are the Components Of
Soluble Inserts?
Drug polymer Additives

19. Soluble
synthetic
polymers
Cellulose derivatives –
Hydroxypropyl cellulose
methylcellulose, hydroxyethyl cellulose
and hydroxypropyl cellulose.
Divers – Polyvinyl alcohol,
ethylene vinyl acetate copolymer.
Additives Plastisizer – Polyethylene glycol, glycerin,
propylene glycol
Enteric coated polymer –
Cellulose acetate phthalate, hydroxypropyl
methylcellulose phthalate.
Complexing agent – Polyvinyl pyrrolidone.
Bioadhesives – Polyacrylic acids

20. By which methods preparation is
happen?
Various methods used in preparation.
Examples:
1. Solvent casting method
2. Glass substrate technique
3. Melt extrusion technique

21. Solvent casting method
Polymer D.W
Dissolved
polymer plastici
zer
DRUG
Poured in glass petridishEvaporation
dried films thus
obtained

22. Solvent casting method
• using different ratios of drug and polymer
• The polymer is dissolved in distilled water.
• A plasticizer is added under stirring conditions.
• The weighed amount of drug was added
• the casting solution was poured in clean glass
petridish and covered with an inverted funnel to
allow slow and uniform evaporation at room
temperature for 48 h.
• The dried films thus obtained
• The ocular inserts were then stored in an airtight
container (desiccator) under ambient condition

23. examples of drugs that can be
incorporated in the BODI ?
acyclovir
chitosan
gatifloxacin
levofloxacin
natamycin
ofloxacin
phenylephrine
diclofenac sodium
idoxuridine
norfloxacin
pefloxacin
timolol maleate
brimodine and
pilocarpine

24. CONCLUSION
• BODI are sterile polymeric drug
• Soluble type of ocular insert
• Have many advantage the most important is
increase contact time and controlled release
• prepared by polymerization technique
• Applicable with many drugs