Open data and open access - A biomedical data- and text-mining perspective

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Lars Juhl Jensen

Open data and open access - A biomedical data- and text-mining perspective

Lars Juhl Jensen
Open data and open access
A biomedical data- and text-mining
perspective

>10 km

too much to read

even more data

unknown what is known

molecular biology

support for open science

public databases

data deposition required

open access publishing

integrative resources

data/text mining

knowledge overview

string-db.org

open licenses

medicine

Jensen et al., Nature Reviews Genetics, 2012

opposition to open science

clinical trial data hidden

“research parasites”

valid privacy concerns

direct benefits for patients

roadmap of diseases

Jensen et al., Nature Communications, 2014

6 million Danish patients

pharmacovigilance

Eriksson et al., Drug Safety, 2014
Drug introduction Drug discontinuation
Adverse eventNegative modifier Indication Pre-existing
condition
Adverse drug reaction Possible
adverse drug reaction
Adverse event
ADR of
additional drug
Identification start

discover new ADRs

only 3,394 patients

magine Europe-wide studie

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Context. WASP-76 b has been a recurrent subject of study since the detection of a signature in high-resolution transit spectroscopy data indicating an asymmetry between the two limbs of the planet. The existence of this asymmetric signature has been confirmed by multiple studies, but its physical origin is still under debate. In addition, it contrasts with the absence of asymmetry reported in the infrared (IR) phase curve. Aims. We provide a more comprehensive dataset of WASP-76 b with the goal of drawing a complete view of the physical processes at work in this atmosphere. In particular, we attempt to reconcile visible high-resolution transit spectroscopy data and IR broadband phase curves. Methods. We gathered 3 phase curves, 20 occultations, and 6 transits for WASP-76 b in the visible with the CHEOPS space telescope. We also report the analysis of three unpublished sectors observed by the TESS space telescope (also in the visible), which represents 34 phase curves. Results. WASP-76 b displays an occultation of 260±11 and 152±10 ppm in TESS and CHEOPS bandpasses respectively. Depending on the composition assumed for the atmosphere and the data reduction used for the IR data, we derived geometric albedo estimates that range from 0.05 ± 0.023 to 0.146 ± 0.013 and from <0.13 to 0.189 ± 0.017 in the CHEOPS and TESS bandpasses, respectively. As expected from the IR phase curves, a low-order model of the phase curves does not yield any detectable asymmetry in the visible either. However, an empirical model allowing for sharper phase curve variations offers a hint of a flux excess before the occultation, with an amplitude of ∼40 ppm, an orbital offset of ∼−30◦ , and a width of ∼20◦ . We also constrained the orbital eccentricity of WASP-76 b to a value lower than 0.0067, with a 99.7% confidence level. This result contradicts earlier proposed scenarios aimed at explaining the asymmetry observed in high-resolution transit spectroscopy. Conclusions. In light of these findings, we hypothesise that WASP-76 b could have night-side clouds that extend predominantly towards its eastern limb. At this limb, the clouds would be associated with spherical droplets or spherically shaped aerosols of an unknown species, which would be responsible for a glory effect in the visible phase curves.

Asymmetry in the atmosphere of the ultra-hot Jupiter WASP-76 b

Asymmetry in the atmosphere of the ultra-hot Jupiter WASP-76 b

Asymmetry in the atmosphere of the ultra-hot Jupiter WASP-76 b

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Zoology 5th semester notes( Sumit_yadav).pdf

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The Mariana Trench remarkable geological features on Earth.pptx

The Mariana Trench remarkable geological features on Earth.pptx

The Mariana Trench remarkable geological features on Earth.pptx

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Atp synthase , Atp synthase complex 1 to 4.

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Open data and open access - A biomedical data- and text-mining perspective

1. Lars Juhl Jensen Open data and open access A biomedical data- and text-mining perspective

3. too much to read

4. even more data

5. unknown what is known

6. molecular biology

7. support for open science

8. public databases

9. data deposition required

10. open access publishing

11. integrative resources

12. data/text mining

13. knowledge overview

14. string-db.org

15. open licenses

17. Jensen et al., Nature Reviews Genetics, 2012

18. opposition to open science

19. clinical trial data hidden

20. “research parasites”

21. valid privacy concerns

22. direct benefits for patients

23. roadmap of diseases

24. Jensen et al., Nature Communications, 2014

25. 6 million Danish patients

26. pharmacovigilance

27. Eriksson et al., Drug Safety, 2014 Drug introduction Drug discontinuation Adverse eventNegative modifier Indication Pre-existing condition Adverse drug reaction Possible adverse drug reaction Adverse event ADR of additional drug Identification start

28. discover new ADRs

29. only 3,394 patients

30. magine Europe-wide studie