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Hvordan bør vi udnytte mulighederne for
analyse af registre og sundhedsdata i
fremtiden?
Lars Juhl Jensen
strukturerede data
Jensen et al., Nature Reviews Genetics, 2012
ustrukturerede data
tekstmining
computer
smart som en hund
ordbog
bivirkninger
lægemidler
Clozapine
clozapi
n
clossapi
n
klozapin
e
chlosapi
n
chlosapi
ne
chlozapi
n
chlozapi
ne
klossapi
n
closapin
e
klozapi
nklosapi
n
kan det gavne patienter?
bivirkningsovervågning
Eriksson et al., Drug Safety, 2014
Drug introduction Drug discontinuationAdverse event
Adverse eventNegative modifier Indication Pre-existing
condition
Adverse drug reaction Possible
adverse drug reaction
ADR of
additional drug
Eriksson et al., Drug Safety, 2014
Drug introduction Drug discontinuationAdverse eventIdentification start
Adverse eventNegative modifier Indication Pre-existing
condition
Adverse drug reaction Possible
adverse drug reaction
ADR of
additional drug
Eriksson et al., Drug Safety, 2014
Drug introduction Drug discontinuation
Adverse eventNegative modifier Indication Pre-existing
condition
Adverse drug reaction Possible
adverse drug reaction
Adverse event
ADR of
additional drug
Identification start
Eriksson et al., Drug Safety, 2014
Drug introduction Drug discontinuation
Adverse eventNegative modifier Indication Pre-existing
condition
Adverse drug reaction Possible
adverse drug reaction
Adverse event
ADR of
additional drug
Identification start
statistik
nye bivirkninger
hyppighed
Eriksson et al., Drug Safety, 2014
heterogen IT infrastruktur
sygdomstrajektorier
Landspatientregistret
Jensen et al., Nature Reviews Genetics, 2012
dslige sygdomskorrelatione
trajektorier
Jensen et al., Nature Communications, 2014
trajektorienetværk
Jensen et al., Nature Communications, 2014
centrale diagnoser
Jensen et al., Nature Communications, 2014
confounding
alder og køn
Jensen et al., Nature Communications, 2014
livsstil
undersøgelsesbias
udfordringer
standardisering af data
løbende data opdatering
integration med hospitaler
Mange tak!
Bivirkninger
Robert Eriksson
Thomas Werge
Søren Brunak
Sygdomstrajektorier
Anders Bøck Jensen
Tudor Oprea
Pope Moseley
Søren Brunak
Tekstmining
Peter Bjødstrup
Jensen
Robert Eriksson
Henriette Schmock
Francisco S. Roque
Anders Juul
Marlene Dalgaard
Massimo Andreatta
Sune Frankild
Eva Roitmann
Thomas Hansen
Karen Søeby
Søren Bredkjær
Thomas Werge
Søren Brunak

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