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C:\documents and settings\administrator\桌面\20100607 nephrotic syndrome
1.
Department of pediatrics
The first affiliated hospital Sun Yat Sen University Sun Liangzhong ( 孙良忠 ) [email_address] Nephrotic Syndrome
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a Basement membrane
b Epithelial cell c Endothelial cell d Mesangial cell Glomerular filtration barrier
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Glomerular filtration
barrier a Basement membrane b Epithelial cell c Endothelial cell d Mesangial cell
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aperture barrier Endothelium
slit diaphragm
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Charge-selective barrier Endothelium
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Nonselective proteinuria
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Mild Moderate Mesangial
proliferative glomerulonephritis
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Focal segmental glomerulosclerosis
(FSGS)
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membranous nephrosis (MN)
21.
Membranoprliferative glomerulonephritis
22.
Pathological patterns of
INS in children and adults
23.
Pathophysiology Pathogenetic factor
glomerular permeability↑ massive proteinuria Hypoproteinemia lipoproteins synthesis ↑ hyperlipidemia Plasma oncotic pressure↓ Intravascular volume ↓ RAA(aldosterone)↑ ADH↑ Water sodium retention Edema Fluid Interstitial space Lipoprotein lipase ↓
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Thank You
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