Development of spinal cord

1. EMBRYOLOGY
By;
RazaRehman, 152
Maria Ilyas, 148
Isfandyar; 156
S p i n a l C o r d

2. Neural Tube
■ Arises from the ectoderm
overlying the notochord
■ Gives rise to the brain and
spinal cord

3. Neural Tube Formation
■ The neural plate folds to
form neural groove with
prominent neural folds
■ The neural folds approach
each other with deepening
of the neural groove

4. Neural Tube Formation
■ The neural folds fuse and a
neural tube is formed
■ The tube, then, separates
from the overlying ectoderm

5. Development of Spinal Cord
Nueroepithilial cells form:
•Ventricular zone
- Ependymal cells
•Intermediate zone
- Form from neuroblasts
•Marginal zone
- Forms white matter

6. Development of the Spinal Cord
■ The cells of the neural tube migrate to form the mantle
layer o f gray matter which differentiates into
Q An alar plate, mostly sensory neurons
Q A basal plate, mostly motor neurons.
Q Separated by sulcuc limitans

7. Development of the Spinal Cord
■ The cells of the mantle layer have axons which
collect in the marginal layer o f white matter

8. Meninges
•Dura mater
-External layer
•Pia arachnoid
- Separated by arachnoid trabeculae
Develop from neural crest cells

9. Neural Crest Cells
■ Originate from cells of
neural folds.
■ Lie between the neural
tube and surface
ectoderm.

10. Neural Crest Cells
■ They, then, migrate to new locations; gives
many derivatives
G A M E S
■ Ganglion cells (DRG, Cranial sensory, Autonomic)
■ Arachnoid and pia maters
■ Melanocytes, Mesenchyme of the pharyngeal arches
■ Enteric ganglia
■ Schwann cells, Suprarenal medulla cells