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[object Object],[object Object],[object Object],[object Object]
Intracellular Acuumulations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Most accumulations are attributable to three types of abnormalities   ,[object Object],[object Object],[object Object]
LIPIDS ,[object Object],[object Object],[object Object],[object Object]
Fatty Change,Liver
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cholesterolosis,gall bladder
PROTEINS ,[object Object],[object Object],[object Object]
Other Accumulations ,[object Object],[object Object],[object Object],[object Object],[object Object]
Lipofuscin
Hemosiderin
Melanin
Hemosiderosis
Billirubin Liver
Carbon,Lungs
Pathologic Calcification ,[object Object],[object Object]
DYSTROPHIC CALCIFICATION ,[object Object],[object Object],[object Object],[object Object]
METASTATIC CALCIFICATION ,[object Object],[object Object],[object Object]
Continued… ,[object Object],[object Object],[object Object]
Dystrophic Calcification
Metastatic Calcification
Cellular adaptations
Objectives: ,[object Object],[object Object],[object Object]
 
Non-Neoplastic Proliferation: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Neoplastic Proliferation:Tumors ,[object Object],[object Object],[object Object],[object Object],[object Object]
Metaplasia ,[object Object],[object Object]
Examples ,[object Object],[object Object],[object Object],[object Object]
Mechanisms of metaplasia ,[object Object],[object Object]
Influences that predispose to metaplasia ,if persistent,may induce malignant transformation in metaplastic epithelium
 
 
 
Atrophy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Atrophy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
Hyperplasia ,[object Object],[object Object],[object Object],[object Object],[object Object]
Pathologic hyperplasia constitutes a fertile soil in which cancerous proliferation may eventually arise
 
 
Goitre – Iodine Deficiency
Hypertrophy ,[object Object],[object Object],[object Object],[object Object],[object Object]
LVH in Chronic Hypertension: Left Ventricular Hypertrophy
Dysplasia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
Pathogenesis – Smoke - Lung Dis.
Normal  Adaptation  Benign    Malignant   Polyclonal   Monoclonal Mechanism of Growth Disorders
Take home messages ,[object Object],[object Object],[object Object]
Watch your thoughts; they become words. Watch your words; they become actions. Watch your actions; they become habits. Watch your habits; they become character. Watch your character; it becomes your destiny
Thank you

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