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Investor Presentation
        January 2012
SAFE HARBOR


  Certain statements in this release concerning our future growth prospects are forward-
  looking statements, which are subject to a number of risks, uncertainties and
  assumptions that could cause actual results to differ materially from those contemplated
  in such forward-looking statements. Important factors that could cause actual results to
  differ materially from our expectations include, amongst others general economic and
  business conditions in India, our ability to successfully implement our strategy, our
  research and development efforts, our growth and expansion plans and technological
  changes, changes in the value of the Rupee and other currency changes, changes in the
  Indian and international interest rates, change in laws and regulations that apply to the
  Indian and global biotechnology and pharmaceuticals industries, increasing competition
  in and the conditions of the Indian biotechnology and pharmaceuticals industries,
  changes in political conditions in India and changes in the foreign exchange control
  regulations in India. Neither our company, nor our directors, nor any of their respective
  affiliates have any obligation to update or otherwise revise any statements reflecting
  circumstances arising after this date or to reflect the occurrence of underlying events,
  even if the underlying assumptions do not come to fruition.




                                                                                              2
AGENDA



     BIOCON SNAPSHOT


     BRANDED FORMULATIONS


     STRATEGIC ALLIANCES


     RESEARCH & DEVELOPMENT


     FINANCIAL HIGHLIGHTS



                              3
BIOCON SNAPSHOT
INTRODUCTION


       Biocon is an emerging, global Bio-pharmaceutical enterprise,
    focused on innovation to develop affordable products and services
      for patients, partners and healthcare systems across the world.


 Biocon is committed towards:

         Reducing therapy costs of chronic diseases. (diabetes, cancer & auto-immune diseases)



                   Strategic Research and marketing partnerships that provide global access



         Leveraging the India advantage to deliver high value, licensable R&D assets




                                                                                                 5
BUSINESS STRUCTURE & HOLDINGS




                                            Biocon Research , India | 100%
                                            R&D- Novel Molecules

                                            Biocon Biopharmaceuticals | 100%
                                            Mabs and Biosimilars
  ~61%    | Promoters
                                            Biocon Sdn. Bhd, Malaysia | 100%        PRODUCTS
  ~ 7 % | Employees & ESOP trust   Biocon   Overseas subsidiary

  ~32 % | Public                            Biocon SA, Switzerland | 100%
                                            Overseas subsidiary

                                            NeoBiocon, UAE | 50%
                                            Overseas subsidiary




                                            Syngene International, India | 100%
                                            Custom research, drug discovery         RESEARCH
                                            Clinigene International, India | 100%   SERVICES
                                            Clinical development




                                                                                         6
A PORTFOLIO BASED APPROACH




                      Insulins &
                                           Other                Branded               Research              Novel
   Statins             Immuno
                                         Biopharma            Formulations            Services             Molecules
                     Suppressants




 Portfolio                Constituents

 Statins                  Simvastatin, Atorvastatin, Lovastatin, Rosuvastatin, Fluvastatin & Pravastatin

 Insulins &               Insulin, Glargine & 2 Analogs (under development)
 Immuno suppressants      Tacrolimus, MMF & MPA
 Other Biopharma           Orlistat, Fidaxomicin, 50+ other molecules

 Branded Formulations     Diabetology, Cardiology, Nephrology, Oncology, Immunotherapy, Comprehensive Care

 Research Services        Syngene (Custom Research)
                          Clinigene (Clinical research)
 Novel Molecules          IN-105, Itolizumab and others                                                                7
A RISK BALANCED GROWTH STRATEGY




                                   Small
                                  Molecules




               Research                               Biosimilars
               Services                              (Biologics &
                                  Growth               Insulins)
                                  Verticals




                      Novel                     Branded
                     Molecules                Formulations



                          EMERGING MARKETS FOCUS
                            EMERGING MARKETS FOCUS                  8
RESEARCH SERVICES




                    9
BRANDED FORMULATIONS
BRANDED FORMULATIONS : THERAPEUTICS SEGMENTS




                                               11
BRANDED FORMULATIONS : PRODUCTS & MARKETS

                                        INDIA PRODUCT RANKINGS*
                                        Cardiology
                                                        Myokinase           2


                                        Oncotherapeutics
                                                     BioMAb EGFR            2
                                                           Abraxane         3


                                        Immunotherapy
                                                                Tbis        2
                                                               Picon        2
                                                           * November MAT 2011




                                                                             12
BIOCON’S INSULIN BUSINESS (INDIA)


                                            MAT November 2011 YoY
     Biocon’s ranking                                                                         Biocon’s market share by
                                            growth for value sales of 40
                                                                                              volume:
                                            IU insulin:


     #4 in overall insulin                   Market:   18%                                  40 IU Insulin:   11%
     #3 in the 40 IU Insulin market                    36%
                                             Biocon:
                                                                                            Glargine vials:   68%
     #1 in the Glargine vial market          Novo Nordisk:   18%
  Source: IMS Health – MAT, November 2011
                                                                                                     10 players in
                                                                          Biocon has                 the insulin
                                                                          both OADs                  space
                                                                          and insulins



                                                              60 of these are in the oral
                                                              anti-diabetics space

                                                   63 players operate in the
                                                   anti-diabetics market
                                                                                                                         13
BRANDED FORMULATIONS : INSUPenÂź ease LAUNCH


          Designed for accuracy, efficiency, safety & economy.

                                             ‱ Launched in October, 2011

                                             ‱ Based on proprietary German
                                               technology

                                             ‱ Reusable delivery device capable
                                               of delivering both InsugenTM &
                                               BasalogTM

                                             ‱ “One Call Does All” Support
                                               helpline

     Expected to add further impetus to branded formulations’ sales in H2FY12
                                                                                  14
STRATEGIC ALLIANCES
STRATEGIC PARTNERSHIPS




                         16
BIOSIMILARS COMMERCIALIZATION PARTNERSHIP: PFIZER

 Insulin and Insulin analogs
                           Combines Biocon's research and manufacturing
                           capabilities with Pfizer's global marketing prowess

                    Global agreement for commercialization of Biocon's biosimilar versions of
                      Insulin & Insulin Analogs: rh- Insulin, Glargine, Aspart, and Lispro.

                    Pfizer will have exclusive rights (with some exceptions) to commercialize
                                             these products globally.


                   Biocon will be responsible for clinical development, manufacture, supply, &
                                              regulatory approvals.

        Upfront from Pfizer                                             100 USD mn
    +   New manufacturing facility setup milestone payments             100 USD mn (in escrow a/c)
    +   Development, regulatory & launch milestone payments             150 USD mn
    +   Payments linked to supplies and sales.
                                                                                                 17
Diabetes Prevalence (% of population)




Diabetics (absolute nos. )




Source: International Diabetes Atlas 2011
                                            18
BIOSIMILARS: GLOBAL OPPORTUNITY



 Total 2010 Insulin Market USD ~15 Bn                             Total 2010 Biologics Market* USD ~138 Bn

                           rh insulin                                                              Biocon’ s
                              21%                                                                   Target
                                                                                                  Opportunity
                                            Lispro
                                             14%
        Glargine
          32%                               detemir
                                              8%


                               Aspart                 glulisine
                                                         2%
                                23%

     Expected to be USD ~20 Bn in 2020                                 Expected to be USD ~200 Bn in 2015


* Biologics Includes MAbs, Vaccines, Growth Factors
 Source: Industry reports, IMS data                                                                         19
BIOSIMILARS COMMERCIALIZATION PARTNERSHIP: MYLAN

Monoclonal Antibodies (MAbs)
                            Combines Biocon's R&D and manufacturing prowess of
                            novel biologics/ bio-generics with Mylan’s regulatory &
                             commercialization capabilities in the US and Europe

                Market size for product portfolio in 2010 : USD ~30 bn
                    Exclusive collaboration for development and commercialization of
                                                    .
                                  complex biogenerics and biosimilars.

           A basket of products with patents expiring between 2014-18. MAbs in particular.

                      Mylan and Biocon to share development and capital costs.


             Mylan will have exclusive commercialization rights in the regulated markets;
                                         profits to be shared

             Biocon and Mylan to have co-exclusive commercialization rights in other markets.

                                                                                                20
Research & Development
RESEARCH PARTNERSHIPS : HIGH POTENTIAL PRODUCT PIPELINE




      US IND filed by partner (Amylin) for AC165198

      Several Bi-specific fusion proteins under development with IATRICa
   * Including molecules from collaborative programs                        22
ANTI-CD6 MAb: Itolizumab

Drug Highlights
   Targets CD6
  CD6 is a type 1 cell membrane glycoprotein belonging to the scavenger receptor cysteine-rich
  (SRCR) super family group B.
  CD6 is predominantly expressed by T cells & a B cell subset.
  CD6 binds ALCAM (activated leukocyte cell adhesion molecule)
    which is expressed on:
       Activated T, cells, B cells & monocytes.
        Skin fibroblasts, keratinocytes, rheumatoid arthritis synovium.


Drug Development :
 Database lock for Phase II(b) clinical trial in Psoriasis done. Data Analysis ongoing

 TREAT-PLAQ Study in Psoriasis

                               Total Patient Enrollment                     223
                                      Trial Duration                      52 Weeks
                                Interim Data Presented                    28 Weeks

                                                                                                 23
TREAT PLAQ STUDY: SUMMARY OF RESULTS#


  PRIMARY ENDPOINT                                                             Result*
  Statistically significant patient cohort with ≄ PASI 75 at 12 Weeks             

  SECONDARY ENDPOINTS
  Significant Proportion of subjects achieving PASI 50 and PASI 90                
  Safety & Tolerability                                                           
  Improvement in PGA scores                                                       
  Considerable Proportion of subjects with PGA score of “clear” or “minimal”      

 PASI: Psoriasis Area Severity Index   PGA: Physicians Global Assessment   *p <0.05
 Results of Interim 28 Week data                                                      24
TREAT PLAQ STUDY : EFFICACY RESULTS
 Representative patient samples from each arm.
            Week        Baseline                 12 Weeks   28 Weeks

     Trial Arm


    Induction
    Dose Arm




   Fixed Dose
          Arm




  Placebo Arm



                                                                       25
TREAT PLAQ STUDY: OVERALL CONCLUSIONS


     First in class therapy, with a novel MOA, novel target and an
      excellent safety profile

     Successfully achieved primary endpoint of PASI-75 at 12 weeks
      with continued improvement in efficacy over time

     Very low infection rates observed compared to reported rates
      from other approved therapies (~10% compared to ~30%)

     Promising preclinical and clinical efficacy data in other auto-
      immune indications (RA, MS)


      Planned       Initiation of Phase 2 double blind trial in RA


                                                                        26
ORAL INSULIN IN-105

 Drug Highlights

    Conjugated peptide
    Lower immunogenicity and mitogenicity.
    Comparable safety and good clearance profile.
    Metabolically equivalent.

    Monotherapy.
    Combination therapy with metformin,
    sulfonylurea, PPAR agonists, DPP4i.
    Pre-meal insulin in combination with
    basal insulins.

    Proof of Concept : Stable tablet formulation.

    Established oral delivery




                                                    27
IN-105 INDIA PHASE III RESULT SUMMARY




         SECONDARY END POINTS
     Efficacy – Secondary Endpoints
           Statistically significant reduction in PPG during STM          
          Significant reduction in SMBG post prandial glucose excursion   
     Safety – Secondary Endpoints
          No clinically significant hypoglycemia                          
          Very low immunogenicity                                         
          No neutralizing antibodies detected                             
          No effect on liver enzymes                                      
          No effect on lipid profiles                                     
          No effect on renal function                                     
      Efficacy – Primary Endpoint
          Change in Hb1Ac for IN-105 not statistically significant        X
                  due to higher than anticipated placebo effect               28
FINANCIAL HIGHLIGHTS
TOP LINE# & BOTTOM LINE#
                                                                                                                             INR crore / USD mn

                                                       FY08                   FY09               FY10                 FY11
    Revenue                                    1090 273               1194 260                1493        318        1834 402
    EBITDA                                      335  83                372 81                  455         97          574 126
    Net profit                                  225  56                238 52                  273         58          340 74


                                                          9M FY12                    9M FY11
                                  Revenue               1511 | 319                 1355 | 297
                                  EBIDTA                  425 | 90                   426 | 93
                                                                       28%                       31%
                                  PAT                     241 | 51                   246 | 54
                                                                       16%                       18%
                                  EPS                          12                        13.6

    FY08-11: Avg.exch.rate in that fiscal ; 9M FY12: USD 1 = INR 47.3; 9M FY11: USD 1= INR 45.67

    # 78% stake acquired in Axicorp GmBH in April ‘08.; fully divested as of March’11 . Hence all figures are ex-Axicorp

    * Net profit is pre-exceptional in table 1.No exceptional items in FY10 and FY11..                                                      30
Thank You

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Biocon Investor Presentation_Q3_FY12

  • 1. Investor Presentation January 2012
  • 2. SAFE HARBOR Certain statements in this release concerning our future growth prospects are forward- looking statements, which are subject to a number of risks, uncertainties and assumptions that could cause actual results to differ materially from those contemplated in such forward-looking statements. Important factors that could cause actual results to differ materially from our expectations include, amongst others general economic and business conditions in India, our ability to successfully implement our strategy, our research and development efforts, our growth and expansion plans and technological changes, changes in the value of the Rupee and other currency changes, changes in the Indian and international interest rates, change in laws and regulations that apply to the Indian and global biotechnology and pharmaceuticals industries, increasing competition in and the conditions of the Indian biotechnology and pharmaceuticals industries, changes in political conditions in India and changes in the foreign exchange control regulations in India. Neither our company, nor our directors, nor any of their respective affiliates have any obligation to update or otherwise revise any statements reflecting circumstances arising after this date or to reflect the occurrence of underlying events, even if the underlying assumptions do not come to fruition. 2
  • 3. AGENDA BIOCON SNAPSHOT BRANDED FORMULATIONS STRATEGIC ALLIANCES RESEARCH & DEVELOPMENT FINANCIAL HIGHLIGHTS 3
  • 5. INTRODUCTION Biocon is an emerging, global Bio-pharmaceutical enterprise, focused on innovation to develop affordable products and services for patients, partners and healthcare systems across the world. Biocon is committed towards: Reducing therapy costs of chronic diseases. (diabetes, cancer & auto-immune diseases) Strategic Research and marketing partnerships that provide global access Leveraging the India advantage to deliver high value, licensable R&D assets 5
  • 6. BUSINESS STRUCTURE & HOLDINGS Biocon Research , India | 100% R&D- Novel Molecules Biocon Biopharmaceuticals | 100% Mabs and Biosimilars ~61% | Promoters Biocon Sdn. Bhd, Malaysia | 100% PRODUCTS ~ 7 % | Employees & ESOP trust Biocon Overseas subsidiary ~32 % | Public Biocon SA, Switzerland | 100% Overseas subsidiary NeoBiocon, UAE | 50% Overseas subsidiary Syngene International, India | 100% Custom research, drug discovery RESEARCH Clinigene International, India | 100% SERVICES Clinical development 6
  • 7. A PORTFOLIO BASED APPROACH Insulins & Other Branded Research Novel Statins Immuno Biopharma Formulations Services Molecules Suppressants Portfolio Constituents Statins Simvastatin, Atorvastatin, Lovastatin, Rosuvastatin, Fluvastatin & Pravastatin Insulins & Insulin, Glargine & 2 Analogs (under development) Immuno suppressants Tacrolimus, MMF & MPA Other Biopharma Orlistat, Fidaxomicin, 50+ other molecules Branded Formulations Diabetology, Cardiology, Nephrology, Oncology, Immunotherapy, Comprehensive Care Research Services Syngene (Custom Research) Clinigene (Clinical research) Novel Molecules IN-105, Itolizumab and others 7
  • 8. A RISK BALANCED GROWTH STRATEGY Small Molecules Research Biosimilars Services (Biologics & Growth Insulins) Verticals Novel Branded Molecules Formulations EMERGING MARKETS FOCUS EMERGING MARKETS FOCUS 8
  • 11. BRANDED FORMULATIONS : THERAPEUTICS SEGMENTS 11
  • 12. BRANDED FORMULATIONS : PRODUCTS & MARKETS INDIA PRODUCT RANKINGS* Cardiology Myokinase 2 Oncotherapeutics BioMAb EGFR 2 Abraxane 3 Immunotherapy Tbis 2 Picon 2 * November MAT 2011 12
  • 13. BIOCON’S INSULIN BUSINESS (INDIA) MAT November 2011 YoY Biocon’s ranking Biocon’s market share by growth for value sales of 40 volume: IU insulin: #4 in overall insulin Market: 18% 40 IU Insulin: 11% #3 in the 40 IU Insulin market 36% Biocon: Glargine vials: 68% #1 in the Glargine vial market Novo Nordisk: 18% Source: IMS Health – MAT, November 2011 10 players in Biocon has the insulin both OADs space and insulins 60 of these are in the oral anti-diabetics space 63 players operate in the anti-diabetics market 13
  • 14. BRANDED FORMULATIONS : INSUPenÂź ease LAUNCH Designed for accuracy, efficiency, safety & economy. ‱ Launched in October, 2011 ‱ Based on proprietary German technology ‱ Reusable delivery device capable of delivering both InsugenTM & BasalogTM ‱ “One Call Does All” Support helpline Expected to add further impetus to branded formulations’ sales in H2FY12 14
  • 17. BIOSIMILARS COMMERCIALIZATION PARTNERSHIP: PFIZER Insulin and Insulin analogs Combines Biocon's research and manufacturing capabilities with Pfizer's global marketing prowess Global agreement for commercialization of Biocon's biosimilar versions of Insulin & Insulin Analogs: rh- Insulin, Glargine, Aspart, and Lispro. Pfizer will have exclusive rights (with some exceptions) to commercialize these products globally. Biocon will be responsible for clinical development, manufacture, supply, & regulatory approvals. Upfront from Pfizer 100 USD mn + New manufacturing facility setup milestone payments 100 USD mn (in escrow a/c) + Development, regulatory & launch milestone payments 150 USD mn + Payments linked to supplies and sales. 17
  • 18. Diabetes Prevalence (% of population) Diabetics (absolute nos. ) Source: International Diabetes Atlas 2011 18
  • 19. BIOSIMILARS: GLOBAL OPPORTUNITY Total 2010 Insulin Market USD ~15 Bn Total 2010 Biologics Market* USD ~138 Bn rh insulin Biocon’ s 21% Target Opportunity Lispro 14% Glargine 32% detemir 8% Aspart glulisine 2% 23% Expected to be USD ~20 Bn in 2020 Expected to be USD ~200 Bn in 2015 * Biologics Includes MAbs, Vaccines, Growth Factors Source: Industry reports, IMS data 19
  • 20. BIOSIMILARS COMMERCIALIZATION PARTNERSHIP: MYLAN Monoclonal Antibodies (MAbs) Combines Biocon's R&D and manufacturing prowess of novel biologics/ bio-generics with Mylan’s regulatory & commercialization capabilities in the US and Europe Market size for product portfolio in 2010 : USD ~30 bn Exclusive collaboration for development and commercialization of . complex biogenerics and biosimilars. A basket of products with patents expiring between 2014-18. MAbs in particular. Mylan and Biocon to share development and capital costs. Mylan will have exclusive commercialization rights in the regulated markets; profits to be shared Biocon and Mylan to have co-exclusive commercialization rights in other markets. 20
  • 22. RESEARCH PARTNERSHIPS : HIGH POTENTIAL PRODUCT PIPELINE  US IND filed by partner (Amylin) for AC165198  Several Bi-specific fusion proteins under development with IATRICa * Including molecules from collaborative programs 22
  • 23. ANTI-CD6 MAb: Itolizumab Drug Highlights Targets CD6 CD6 is a type 1 cell membrane glycoprotein belonging to the scavenger receptor cysteine-rich (SRCR) super family group B. CD6 is predominantly expressed by T cells & a B cell subset. CD6 binds ALCAM (activated leukocyte cell adhesion molecule) which is expressed on: Activated T, cells, B cells & monocytes. Skin fibroblasts, keratinocytes, rheumatoid arthritis synovium. Drug Development : Database lock for Phase II(b) clinical trial in Psoriasis done. Data Analysis ongoing TREAT-PLAQ Study in Psoriasis Total Patient Enrollment 223 Trial Duration 52 Weeks Interim Data Presented 28 Weeks 23
  • 24. TREAT PLAQ STUDY: SUMMARY OF RESULTS# PRIMARY ENDPOINT Result* Statistically significant patient cohort with ≄ PASI 75 at 12 Weeks  SECONDARY ENDPOINTS Significant Proportion of subjects achieving PASI 50 and PASI 90  Safety & Tolerability  Improvement in PGA scores  Considerable Proportion of subjects with PGA score of “clear” or “minimal”  PASI: Psoriasis Area Severity Index PGA: Physicians Global Assessment *p <0.05 Results of Interim 28 Week data 24
  • 25. TREAT PLAQ STUDY : EFFICACY RESULTS Representative patient samples from each arm. Week Baseline 12 Weeks 28 Weeks Trial Arm Induction Dose Arm Fixed Dose Arm Placebo Arm 25
  • 26. TREAT PLAQ STUDY: OVERALL CONCLUSIONS  First in class therapy, with a novel MOA, novel target and an excellent safety profile  Successfully achieved primary endpoint of PASI-75 at 12 weeks with continued improvement in efficacy over time  Very low infection rates observed compared to reported rates from other approved therapies (~10% compared to ~30%)  Promising preclinical and clinical efficacy data in other auto- immune indications (RA, MS) Planned Initiation of Phase 2 double blind trial in RA 26
  • 27. ORAL INSULIN IN-105 Drug Highlights Conjugated peptide Lower immunogenicity and mitogenicity. Comparable safety and good clearance profile. Metabolically equivalent. Monotherapy. Combination therapy with metformin, sulfonylurea, PPAR agonists, DPP4i. Pre-meal insulin in combination with basal insulins. Proof of Concept : Stable tablet formulation. Established oral delivery 27
  • 28. IN-105 INDIA PHASE III RESULT SUMMARY SECONDARY END POINTS Efficacy – Secondary Endpoints Statistically significant reduction in PPG during STM  Significant reduction in SMBG post prandial glucose excursion  Safety – Secondary Endpoints No clinically significant hypoglycemia  Very low immunogenicity  No neutralizing antibodies detected  No effect on liver enzymes  No effect on lipid profiles  No effect on renal function  Efficacy – Primary Endpoint Change in Hb1Ac for IN-105 not statistically significant X due to higher than anticipated placebo effect 28
  • 30. TOP LINE# & BOTTOM LINE# INR crore / USD mn FY08 FY09 FY10 FY11 Revenue 1090 273 1194 260 1493 318 1834 402 EBITDA 335 83 372 81 455 97 574 126 Net profit 225 56 238 52 273 58 340 74 9M FY12 9M FY11 Revenue 1511 | 319 1355 | 297 EBIDTA 425 | 90 426 | 93 28% 31% PAT 241 | 51 246 | 54 16% 18% EPS 12 13.6 FY08-11: Avg.exch.rate in that fiscal ; 9M FY12: USD 1 = INR 47.3; 9M FY11: USD 1= INR 45.67 # 78% stake acquired in Axicorp GmBH in April ‘08.; fully divested as of March’11 . Hence all figures are ex-Axicorp * Net profit is pre-exceptional in table 1.No exceptional items in FY10 and FY11.. 30