61. Drug Development Process
Early Clinical
Discovery Development
Dev.
TI HI LO ECD PoC DfL Reg LCM
Preclinical studies Clinical studies
• Target Identification • Proof of Concept
• Hit Identification • Development for Launch
• Lead Optimisation • Registration and Launch
• Life Cycle Management
The way to semantic Service
Oriented Architecture
62.
63. $1,000 genome;
$100,000 analysis?
50 million sequences
obtained by 2015
The pharma industry loses
$4.2 billion per year due to
drug trial delays
82. what is a “data market place" ?
Service that make it easy to find data from a
range of secondary data sources, then consume
the data in a usable and unified format. Several
of these services are trying to create
marketplaces for data, envisioning that data
providers can offer their data sets for sale to
data seekers
83. what is a "platform" ?
a place where we
encourage...
support...
enable...
our communities
84. You own the data
You control access
You can pull it/change it
You can delete it
You can decide what is best
85.
86. Translational Medicine Platform for Alzheimer´s Disease
Data Integration Platform for Patients, Physicians and Researchers
Use Tabs for play each role.
http://85.48.202.13:8080/AD/index.html
87. Being a Patient
Monitor your progress
Know Side Effects of Drugs you are taking
Mappings to Generic Ontologies
ICD9 Coded
88. Being a Physician
Monitor your patients
Retrieve info from PubMed
Answer complex queries
Are there active clinical trials that my patients may participate with different MOA
because of side effects?
89. Being a Researcher
Retrieve information from distributed sources
Get the latest relevant scientific articles
Answer complex queries
What Biomarkers are associated with or implicated in Alzheimer´s Disease?
90. Breast Cancer Decision Support System
http://85.48.202.13:8080/BreastCancer/BC.html
Deployed at Cruces Hospital – Bilbao
Use of Description Logic and Inference Rules to deduce the Diagnosis and Treatment
Customized Breast Cancer ontology
91. Information Retrieval from Distributed Sources for Breast Cancer
Matchmaking process between Patient´s PHR and Distributed Sources
Retrieves Information such as Clinical Trials, PubMed articles, Adjuvant Treatments, genes,…
92. Information Retrieval from Distributed Sources for Breast Cancer
Matchmaking process between Patient´s PHR and Distributed Sources
Retrieves Information such as Clinical Trials, PubMed articles, Adjuvant Treatments, genes,…
93. OmicsHub
http://85.48.202.13:8080/SWDemo/index.jsp
The inputs for the prototype will be a list of genes and a list of proteins which have
been acquired from different time points of the lifecycle of a cell.
Integrate Both Datasets
Find Relevant Pubmed Articles
Organize into clusters
Known Protein Interactions
103. Mendeley Snags $2 Million In Early-Stage
Funding For Research Paper Management Tool
"Data marketplace" Infochimps raises
$1.2M to build out its data offerings
Factual, a startup that claims to host hundreds
of thousands of data sets, has raised $25
million in its first round of institutional funding.
Sermo Closes 26.7 Million in Funding to
Evolve Online Community for Physicians
PatientsLikeMe take in $8M funding