Emily Craven, Manager, Sterilization Science & Engineering, Nordion Bård M. Pedersen, Senior Manager, Technical Marketing, Adesto Technologies

1. Innovative Non-volatile
Memory for Medical Devices
Sterilized using
Gamma Irradiation
Emily Craven, Nordion
Bård M. Pedersen, Adesto Technologies
www.nordion.com

2. Gamma Centre of Excellence
Our Mission: Expand and enhance the use
of gamma through outreach
and education
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3. Partnering with Nordion
Our partner’s success is our success
• Specialized Irradiation Capabilities
• Specialized Modeling Capabilities
• Accredited Dosimetry Laboratory
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4. Collaboration Goals
• Enhance the use of gamma for high value devices
• Expand the use of gamma to new industries
• Research into gamma effects on new and unique materials
• Range of collaboration partners:
– Medical Device manufacturers, Polymer manufacturers,
Universities, Research Institutions, Laboratories
Adesto – a new generation of
medical device capability
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5. Gamma -Tolerant Electronic Data Storage
Solution for Medical Devices
12 February 2014
www.adestotech.com/

6. Convergence of growth in Medical Devices & Sterilization Modalities

Medical Device market valued at $228B by 2017 with a healthy growth rate of 7%

Utilization of embedded electronics for intelligent medical devices forecasted at >$11B
40% of Single-Use
Wider applications growth
7% CAGR
$228B
$11B
$65B

7. Storage of data is the ‘MEMORY’ backbone in intelligent devices
 Primary embedded architecture in Consumer, Industrial and Intelligent Medical
equipment and devices
Stored Data
 Stored Data used as:
• System boot
• Data log
• Reference values for controller operation
• E-Pedigree/product traceability in RFID applications
• User information

8. Conventional Data Storage Architecture- 1 & 0
 MEMORY or data storage semiconductor solutions are based on trapping and
removing electrons from a storage transistor.
Sensing of a charge threshold determines a 1 or a 0 value
If electrons were to escape, the threshold voltage of the cell would change
and therefore the determined value.
Flash memory cell
Floating gate, electrons present
indicating a charged state

9. EEPROM & Flash Susceptible to Sterilization Modalities
 Data integrity of the Memory component is critical to device operation

Standard memory solutions are unable to withstand harsh conditions involving radiation, heat and
pressure.
 EEPROM/Flash technology can not survive ionizing effects at >50 krads.

Typical gamma dose = 100x greater than the survival threshold of EEPROM memory solutions
 Failure Mode- Scramble, Corrupt, Escape

High energy disturbance of the trapped electrons, causing Charge Loss

Stored data is corrupted or no longer present, rendering the system/device inoperable

Internal registers that are critical to the device operation are UNRECOVERABLE

10. As Gamma Adoption Increases, Robust Data Storage is Required
 Standard Flash/EEPROM data storage can not support intelligent medical applications
•
Adverse impact to supply chain and manufacturing logistics.
•
Costly manufacturing steps to program the memory component AFTER the sterilization cycle
•
Longer manufacturing cycle time
•
Limitation of the advanced features that could be offered on medical devices.
A data storage solution is needed that can maintain stored data during
exposure to radiation and pressure based sterilization modalities

11. Gamma Tolerant Data Storage Solution for Intelligent Devices
Adesto Technologies CBRAM- Power Conscious, Fast, and Robust
•
Mass production electronic data storage solution for standalone and embedded
memory applications.
•
Ultra Low Power
• Technology demonstration <1.0 volt for energy harvesting applications
•
Fast Read
• Data Storage needs to be able to respond to controller clock cycles
•
Robust
• Retains data in extreme temperature environments
• Qualified to 500 Mrads

12. CBRAM® Gamma Tolerance Study
CBRAM devices exhibited 0 failures at 1.5 Mrad, 2.5 Mrad & 5.0 Mrad (2X normal dose
used in the Gamma Sterilization process)
n=80
Testing performed by Nordion, the leading provider of isotopes
and irradiation therapy services to the medical and healthcare industry
Standard Flash and CBRAM comparison testing:
Flash vs CBRAM Radiation Effect
Device
Technology
DUT ID Gamma Dose (krad Si)
Std by Current mA
Data Loss
# bit errors)
Result
512kbit CMOS Flash
Floating Gate
1
447
101.6
859
FAIL
512kbit CMOS Flash
Floating Gate
2
447
99.21
6519
FAIL
512kbit CMOS Flash
Floating Gate
3
131
51.56
955
FAIL
512kbit CMOS Flash
Floating Gate
4
131
53.7
4
FAIL
RM24EP128KS
CBRAM
1
447
40
0
PASS
RM24EP128KS
CBRAM
2
447
38.8
0
PASS
RM24EP128KS
CBRAM
3
131
39.4
0
PASS
RM24EP128KS
CBRAM
4
131
39.8
0
PASS
GONZALEZ-VELO et al.: TID RETENTION CAPABILITY OF CBRAM – Submitted to IEEE Electron Device Letters
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13. Data Storage for Medical & Healthcare Applications
 CBRAM ultra-low power, fast performance and Gamma compatibility is ideal for:
•
Battery-operated Wearable
•
Ultra-Low Power Embedded Devices
•
Energy-Harvesting Body Monitors
•
Gas flow sensing
•
Fluid management
•
Orthopaedics
•
Surgical- multi-use sterilization
•
RFID applications
Bio containers
Single use ventilation
Smart Syringe
Dose delivery
Manifolds
Ampules

14. Ultra Low-Power Capability of CBRAM® Memory
Wireless body sensor nodes enable inexpensive
continuous monitoring of patients
Information
An embedded
ultra low-power
CBRAM nonvolatile memory
block can operate
without battery power,
on the energy generated
by body heat alone
(2013 Symposia on VLSI Technology and Circuits , Kyoto, Japan)
Assessment,
Treatment

15. Adesto Overview
Adesto Technologies is a leading developer of a broad portfolio of non-volatile
memory solutions, including DataFlash®, Serial Flash and Conductive Bridge
RAM (CBRAM) memory technology.
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16. Broad Data Storage Portfolio
Differentiated Storage-Centric Solutions
DataFlash
Fusion Family
CBRAM
BIOS Flash
+
Growth Markets
+
Customer Base
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17. Differentiated Solutions To Address The New Requirements
CBRAM
Technology
Platform
BIOS
Flash
Family
Fusion
Family
Adesto
Data
Storage
Solutions
DataFlash
Family
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18. Explore
For more information on CBRAM technology, contact:
Bard Pedersen
Paul Fulhorst
Bard.Pedersen@Adestotech.com
Paul.Fulhorst@Adestotech.com
Case Study: Gamma Radiation Tolerant CBRAM Technology
http://www.adestotech.com/news/white-papers /
Adesto DataFlash and BIOS Memory products:
http://www.adestotech.com/
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19. Thank you for your interest in Adesto Data Storage solutions
Adesto thanks Nordion, the leading provider of isotopes
and irradiation therapy services to the medical and healthcare industry
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