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Targeted Medical Pharma, Inc.
Innovators in Pharmaceutical Technology
April 2014
Safe Harbor Statement
This document does not constitute or form part of an invitation or recommendation to subscribe for or purchase any securities of Targeted Medical Pharma, Inc. (“Targeted
Medical Pharma”, “TMP” or “the Company”). This document was prepared exclusively for the benefit and internal use of investors in order to evaluate the feasibility of a
possible transaction or transactions and does not carry any right of publication or disclosure to any other party. This document is incomplete without reference to, and
should be viewed in conjunction with, the oral briefing provided by TMP, the Company’s public filings with the Securities and Exchange Commission (the “SEC”) and press
releases. This presentation may not be used for any other purpose without the prior written consent of Targeted Medical Pharma.
In preparing this document we have relied upon and assumed, without independent verification, the accuracy and completeness of all information available from public
sources or which was provided to us or otherwise reviewed by us. The information contained in this document has been taken from sources deemed to be reliable. We do
not represent that such information is accurate or complete and it should not be relied on as such. Any opinions expressed herein reflect our judgment at this date, all of
which are subject to change. We have based the forward-looking statements on our current expectations and projections about future events. These forward-looking
statements are subject to known and unknown risks, uncertainties and assumptions about us and with respect to specific factors identified in this presentation and in the
Company’s filings with the SEC, specifically the reported risk factors, that may cause our actual results, levels of activity, performance or achievements expressed or implied
by such forward-looking statements. Actual results in each case could differ materially from those currently anticipated in such statements.
Non-GAAP Financial Measures
In this presentation, TMP uses the non-GAAP measures adjusted EBITDA and adjusted earnings per share. TMP believes these non-GAAP financial measures are helpful in
understanding its past financial performance and its potential future results. They are not meant to be considered in isolation or as a substitute for comparable GAAP
measures and should be read in conjunction with the consolidated financial statements prepared in accordance with GAAP. TMP’s management regularly uses these
supplemental non-GAAP financial measures internally to understand, manage and evaluate its business and make operating decisions.
TMP believes that the use of these non-GAAP measures enhances the ability of investors to compare its results from period to period. Investors should note that adjusted
EBIDTA and adjusted earnings per share, as used by TMP, may be calculated differently from, and therefore may not be directly comparable to, similarly titled measures
used by TMP’ competitors and other companies. The non-GAAP historical financial measures may exclude amortization of intangible assets, share-based
compensation, transaction related costs, non-cash interest expense, loss on extinguishment of debt, and the effect of change in the timing of when certain revenue was
recognized. The non-GAAP 2012 financial guidance may excludes amortization of intangible assets, share-based compensation, transaction and integration costs, purchase
accounting inventory step-up adjustments and the tax effect of these adjustments to GAAP net income.
Trademarks
All products named in this presentation are protected under trademark including those not marked “TM”.
Safe Harbor Statement, Non-GAAP Financial Measures and Trademarks
TARGETED MEDICAL PHARMA (OTCQB:TRGM)2
Company Overview
TARGETED MEDICAL PHARMA (OTCQB:TRGM)3
 Biotechnology company that develops prescription medical foods for treatment of
chronic disease
 Including pain syndromes, sleep , cognitive disorders and obesity
 Safe option for treatment without significant side effects
 FDA regulated products on the market generating revenue
 Does not require FDA pre-approval
 Low cost development platform
 Robust pipeline and patent portfolio
 FDA GRAS/GRAE ingredients (Generally Recognized As Safe and Effective)
 Diversified sales/distribution channels
 Diversified sources of reimbursement
Corporate Profile
TARGETED MEDICAL PHARMA (OTCQB:TRGM)4
Targeted Medical Pharma, Inc. OTC QB: TRGM
Corporate Headquarters Los Angeles, CA
Stock Price (3-28-2014), 52-Week Range $0.84; $0.49 - $5.10
Shares Outstanding 26.3 M
Average Daily Volume (13Wks) 12,459
Market Capitalization (3-28-2014) $22.1M
Debt at 12-31-13 $5.5M
Cash at 12-31-13 $492k
Enterprise Value $26.9M
Revenue/EBITDA (Year Ended 12-31-2013) $9.6M / ($2.7M)
Full-time Employees 57
Fiscal Year Ends December 31st
Accounting Firm Marcum, LLP
Key Management
TARGETED MEDICAL PHARMA (OTCQB:TRGM)5
David Silver, M.D.
President and Chief Operating Officer
• University of California Los Angeles - Associate Professor
• Cedars-Sinai Medical Center – Clinical Chief of Rheumatology
and Dir. of Chronic Pain Rehabilitation Program
• Osteoporosis Medical Center - Associate Director
• American College of Rheumatology – Scientific Advisory
Committee Member
• Conducted more then 100 clinical trials
• Nationally-recognized expert on pain, fibromyalgia and PTSD
• Boston University – BA in Medical Sciences with minor in
Economics
• Boston University School of Medicine – M.D.
• Northwestern University – Residency in Internal Medicine
• Cedars Sinai Medical Center – Fellowship in Rheumatology
• Board Certified - Internal Medicine and Rheumatology
William Shell, M.D.
Co-Founder, CEO and Chief Science Officer
• USAF American Soviet Exchange Program – First physician
representative in Moscow
• Keesler Air Force Base –Director of Coronary Case Unit
• Cedars Sinai Medical Center – Dir. of Cardiovascular
Biochemistry Research Laboratories
• Interactive Medical Technologies - Chairman and Chief
Science Officer
• Beverly Glen Medical Systems – Chief Science Officer
• Board Certified - Internal Medicine and Cardiology
• University of California Los Angeles - Associate Professor
• Conducted more than 100 clinical trials
• Dr. Shell’s innovations have led to 16 issues patents and 6 pending
• Published 99 peer-reviewed scientific papers and wrote chapters
in 17 books
• University of Michigan Medical School – M.D.
• National Institutes of Health – Fellow ship under Dr. Eugene
Braunwald and member CK-MB team
William Horne
Chief Financial Officer
• OptimisCorp – Chief Financial Officer
• Patient Safety Technologies (OTCBB:PSTX) – CFO and Interim CEO
• Alaska Wireless Communications - Managing Member and CFO
• Apex Financial Management – CFO and Founding Member
• Phoenix Partners VC – Chief Financial Officer
• Price Waterhouse, LLP – Accountant
• U.S. Marine Corps
• Seattle University – BA Business Administration, Magna Cum
Laude
Board of Directors
TARGETED MEDICAL PHARMA (OTCQB:TRGM)6
INDEPENDENT DIRECTORS
Maurice J. DeWald
Chairman of the Board
KPMG - Regional Managing Partner
Serves on the board of director of several healthcare companies
Arthur R. Nemiroff
Chairman of the Audit Committee
BDO USA LLP - Partner
City of Hope Medical Center - Director and Audit Committee Member
Donald J. Webster
Chairman of the Nominating
and Corporate Governance Committee
Chevron Corporation - General Manager of Procurement
Thomas R. Wenkart, M.B.B.S.
Chairman of the Compensation Committee
Macquarie Health Corporation - Chairman
NON-INDEPENDENT DIRECTORS
William Shell, M.D.
CEO and Chief Science Officer
David Silver, M.D.
President and Chief Operating Officer
Kim Giffoni
Co-founder and Executive Vice President
NutraCorp Scientific – President
Giffoni Development Company - CEO
Medical foods are FDA-regulated medications intended for the dietary management of a
disease that has distinctive nutritional needs that cannot be met by normal diet alone as
defined in the Food and Drug Administration's 1988 Orphan Drug Act Amendments.
Physician Supervised Medical Foods
TARGETED MEDICAL PHARMA (OTCQB:TRGM)7
 Must make a disease claim
 Require ongoing physician supervision
 Do not require FDA pre-approval
 Enteral administration
 FDA GRAS/GRAE ingredients (Generally Recognized As Safe and Effective)
 Address specific nutritional deficiencies
Five-component System for Efficient Uptake and Utilization of Amino Acids
Targeted Cellular Technology®
TARGETED MEDICAL PHARMA (OTCQB:TRGM)8
Reduced
Attenuation
Improved
Efficacy
Milligram
Quantities
Amino Acids Are the
Precursors to Neurotransmitters >>
5 HTP
Choline
Arginine
Tyrosine
GABA
Histidine
Serotonin
Acetylcholine
Nitric Oxide
Catecholamine
GABA
Histamine
The Five Components of TCT:
1. Neurotransmitter precursor
2. Uptake Stimulator
3. Neuron activator
4. Adenosine brake inhibitor
5. Attenuation inhibitor
neurotransmittersneurotransmitters
heldinstorage
synapse
release
binding
changein
potential
Receptorsite
Therapeutic Area Product Product Class
% of
Monthly
Doses**
Pain and inflammation Theramine Medical Food 42%
Sleep Disorders Sentra PM / GABAdone Medical Food 24%
Osteoarthritis Trepadone Medical Food 12%
Cognitive Disorders, Fatigue, Vision Sentra AM Medical Food 11%
Metabolic Disorders / Obesity AppTrim and AppTrim-D Medical Food 8%
Hypertension Hypertensa Medical Food 2%
Viral Infection / Impaired Immunity ListerV Medical Food 1%
Neuropathy Percura* Medical Food 1%
Nasal Congestion ClearWayz Oral†
Dietary Supplement < 1%
* First Known Oral Stimulation of Stem Cells
** Cumulative for 2010 to 2012, and including convenience kits
† Direct-to-Consumer
Current Products
TARGETED MEDICAL PHARMA (OTCQB:TRGM)9
Product Indication Platform Global
Market
Value*
Expected
Commercialization
ASD-AA Autism Quick Release Wafer $26B+ Q3'2014
AP-113†(New oral deliverysystem) Appetite Suppression Quick Release Wafer $390B+ Q4'2014
ESS-1818*††
ChronicAnemia Capsule $10B+ Q1'2015
PulmonaNew Asthma Capsule $12B+ Q2'2015
Oral IGF1††
Diabetes Capsule $15B+ Q3'2015
Tablet
PARK -AA Parkinson's Disease Capsule $3M+ Q4'2015
ALZ- AA Alzheimer's Disease Capsule $10B+ Q4'2015
† † Enteral alternative to injection therapies
* Estimated global market value
Pipeline Products
TARGETED MEDICAL PHARMA (OTCQB:TRGM)10
Often embedded in large pharmaceutical
companies
Mead Johnson--17 billion market
Abbot laboratories-- Abbott Nutrition $6 billion
annual sale
Targeted medical Pharma41% per year revenue
growth rate
Nestlé has entered the medical food space
12
Medical Foods - A large poorly recognized marketplace
TARGETED MEDICAL PHARMA (OTCQB:TRGM)12
Purchased Pam labs - Vitamin B12 for pregnancy - $350 million
purchase
Purchased Acerra-- Alzheimer's Disease - $250 million
purchase
Damone Medical Nutrition - offer of $4 Billion
CM&D Pharma: Acquired in 2011, specializes in the
development of products for patients with chronic kidney and
gastrointestinal disease
13
Nestlé Medical Food Entry
TARGETED MEDICAL PHARMA (OTCQB:TRGM)13
Low-Cost, Shorter Time to Market
TARGETED MEDICAL PHARMA (OTCQB:TRGM)14
Medical Foods Have a Shorter Time to Market due
to GRAS/GRAE status
Development
and Testing
(1 to 2 yrs)
Database
Registration
(3 to 6 mos)
Revenue and
Post-Marketing
MedWatch
(Milestone)
IND
Submission
(Milestone)
Database
Registration
(3 to 6 mos)
Revenue and
Post-Marketing
MedWatch
(Milestone)
Phase 1 to 3 Trials
(6 to 7 yrs)
Development
and Testing
(1 to 2 yrs)
FDA Review
(1 to 2 yrs)
Medical
Food
1 to 2.5 yrs
Drug
8 to 12 yrs
Intellectual Property Highlights
TARGETED MEDICAL PHARMA (OTCQB:TRGM)
1 Targeted Cellular Technology® is a five-component system the stimulates the uptake and
utilization of amino acids. It enables efficacy from microgram quantities of amino acids.
*First Known Oral Stimulation
of Stem Cells
16
Seven Patents Issued Three Patents Pending
 4 USPTO neurotransmitter-specific patents covering
Targeted Cellular Technology® (TCT)
 1 Japanese patent covering TMP’s Targeted Cellular Technology®
 1 USPTO patent covering the convenience pack presentation
 1 USPTO Billing methodology for physician dispensing of medication
TAT-related patents:
 Stimulation of RBC production*
 Oral Insulin / Insulin Resistance*
 Neuropathy treatment
Reimbursement Channels
TARGETED MEDICAL PHARMA (OTCQB:TRGM)17
 Medicare Advantage / Secondary
 DOD / VA
 Medicaid
 Tricare
 Cigna
 BlueCross/Blue Shield
 United Healthcare
 Aetna
 Health Net
 Rx Solutions
 Medco
 Caremark
 Catamaran (Walgreens)
 MedImpact
 Express Scripts
 Workers’ Compensation
 Private Insurance
 Medicare Secondary Insurance Plans
Top PBMs
Top Medical Plans
Channel Types
Government
Reimbursement
Blue = Current payers 
Black = In process
Balance Sheet
TARGETED MEDICAL PHARMA (OTCQB:TRGM)19
Balance Sheet as of 9/30/13
ASSETS LIABILITIES
Cash And Equivalents 0.168 Accounts Payable 2.237
Short Term Investments - Accrued Exp. 3.195
Total Cash & ST Investments 0.168 Short-term Borrowings 3.997
Accounts Receivable 0.397 Curr. Income Taxes Payable -
Notes Receivable - Def. Tax Liability, Curr. -
Total Receivables 0.397 Other Current Liabilities 4.593
Inventory 0.604 Total Current Liabilities 14.022
Prepaid Exp. - Long-Term Debt -
Deferred Tax Assets, Curr. - Def. Tax Liability, Non-Curr. -
Other Current Assets 1.276 Other Non-Current Liabilities -
Total Current Assets 2.445 Total Liabilities 14.022
Gross Property, Plant & Equipment - Common Stock 0.024
Accumulated Depreciation - Additional Paid In Capital 14.405
Net Property, Plant & Equipment 0.26 Retained Earnings (23.52)
Treasury Stock -
Other Intangibles 2.226 Comprehensive Inc. and Other -
Accounts Receivable Long-Term - Total Common Equity (9.091)
Deferred Tax Assets, LT - Total Equity (9.091)
Other Long-Term Assets -
Total Assets 4.931 Total Liabilities And Equity 4.931
Income Statement
TARGETED MEDICAL PHARMA (OTCQB:TRGM)20
Income Statement
For the Fiscal Period Ending
Restated
3 months
Q4
Dec-31-2011
3 months
Q1
Mar-31-2012
3 months
Q2
Jun-30-2012
3 months
Q3
Sep-30-2012
3 months
Q4
Dec-31-2012
3 months
Q1
Mar-31-2013
3 months
Q2
Jun-30-2013
3 months
Q3
Sep-30-2013
Revenue 1.94 1.375 1.448 2.077 2.396 2.811 1.917 2.194
Other Revenue - - - - - - - -
Total Revenue 1.94 1.375 1.448 2.077 2.396 2.811 1.917 2.194
Cost Of Goods Sold 0.791 0.635 0.621 1.116 0.829 0.899 0.735 0.633
Gross Profit 1.149 0.74 0.827 0.96 1.567 1.912 1.182 1.561
Selling General & Admin Exp. 3.44 2.284 2.494 2.431 2.892 2.389 2.966 2.862
R & D Exp. 0.043 0.027 0.03 0.037 0.04 0.032 0.034 0.104
Depreciation & Amort. - - - - - - - -
Other Operating Expense/(Income) - - - - - - - -
Other Operating Exp., Total 3.484 2.312 2.524 2.468 2.931 2.421 3.0 2.966
Operating Income (2.335) (1.571) (1.697) (1.508) (1.364) (0.508) (1.818) (1.405)
Interest Expense (0.292) (0.076) (1.867) (0.327) - (0.09) (0.152) (0.239)
Interest and Invest. Income 0.0 - - - 0.07 - - -
Net Interest Exp. (0.292) (0.076) (1.867) (0.327) 0.07 (0.09) (0.152) (0.239)
Other Non-Operating Inc. (Exp.) - - - - - - 0.033 -
EBT Excl. Unusual Items (2.627) (1.647) (3.564) (1.834) (1.294) (0.598) (1.937) (1.644)
Merger & Related Restruct. Charges (0.23) - - - - - - -
Impairment of Goodwill - - - - - - - -
Other Unusual Items 0.675 - - 0.011 (4.444) 0.088 - (0.078)
EBT Incl. Unusual Items (2.182) (1.647) (3.564) (1.823) (5.738) (0.51) (1.937) (1.721)
Income Tax Expense (0.811) (0.671) (0.739) (0.582) (1.194) (0.24) 5.905 0.001
Earnings from Cont. Ops. (1.371) (0.976) (2.825) (1.241) (4.544) (0.27) (7.842) (1.723)
Earnings of Discontinued Ops. - - - - - - - -
Extraord. Item & Account. Change - - - - - - - -
Net Income to Company (1.371) (0.976) (2.825) (1.241) (4.544) (0.27) (7.842) (1.723)
Minority Int. in Earnings - - - - - - - -
Net Income (1.371) (0.976) (2.825) (1.241) (4.544) (0.27) (7.842) (1.723)
Shipments:
Contract
Receivables
Collections:
Recognized
Revenue
Contract Receivables are amounts due
but not yet recognized as revenue
Monthly collections are approximately
1.5% to 2.0%
Collected amounts impact bottom-line
operating revenue almost directly
Contract receivables are constantly
rejuvenated by additional shipments
$14.8 million as of September 30, 2013
Supported by existing claims.
Off-Balance Sheet Asset: Contract Receivables
TARGETED MEDICAL PHARMA (OTCQB:TRGM)21
Near-Term Goals
TARGETED MEDICAL PHARMA (OTCQB:TRGM)23
Grow sales to physicians with well-insured (PPO) patients
• A National Sales Manager was hired in March
• A contract was signed to accelerate cash collections
• We are contemplating the acquisition of a distributor network
Begin sales of a dietary supplement product in Q4’2013
Begin sales of first stem-cell product in Q2’2014
• Stimulation of red blood cell production
Grow national sales force
• HI and WA are performing, next are NV and AZ
Bring doctors current on amounts payable to them
• Improving practice management and profitability
Targets and Milestones
TARGETED MEDICAL PHARMA (OTCQB:TRGM)24
 Revenues - Maintain 40% per year growth rate
 Margins
 Gross Margin - Continue to grow gross profit by more than 40% per year
 EBITDA - Maintain positive EBITDA and net profit growth
 Reimbursement - Expand the channels for reimbursement including both private
insurance direct payments for cash and direct to consumer market
 Sales Channels - Expand sales channels to include Workers Comp, PPO insurance,
HMO insurance, direct to federal agencies including military, direct to consumer and
direct sales to pharmacies
Investment Considerations
PRODUCTS HAVE LOW SIDE-EFFECT PROFILE TARGETED MEDICAL PHARMA (OTCQB:TRGM)25
HIGH DEMAND PRODUCTS ADDRESSING LARGE MARKETS
DIVERSIFIED, GROWING SALES
GROWING ADOPTION OF MEDICAL FOODS
BROAD-REACHING PATENTS AND ROBUST PIPELINE
PROVEN SAFETY AND EFFICACY THROUGH CLINICAL TRIALS
LOW-COST, HIGH-SPEED PRODUCT DEVELOPMENT PLATFORM
TRACK RECORD OF EXCELLENT COST CONTROLS
DIVERSIFIED REIMBURSEMENT SOURCES
SPECIALTY REIMBURSEMENT OPERATIONS
Revenue Growth
Revenue Security
Profitability
Robust Patent Portfolio and Pipeline
“Better health through medical foods”
Appendix
TARGETED MEDICAL PHARMA (OTCQB:TRGM)26
 Business Team
 Key Links
 Clearwayz™
 Clinical Trial: Sentra PM® and Trazodone (Trazamine®)
 Clinical Trial: Theramine® with Ibuprofen (Theraprofen®)
 Pain Reduction with Theramine®
 Inflammation Reduction with Theramine®
 Clinical Trial: Theramine® with Ibuprofen (Theraprofen®)
 Disability Reduction with Theramine® and Naproxen (Theraproxen®)
 Pharmacoeconomic Analysis of Theramine
 Clinical Trial: Sentra PM® and Trazodone (Trazamine®)
 Pipeline: Initial Data Indicating ESS-1818 Increases Red Blood Cell Production
 Autism Product
 Autism Spectral Disorder – Pilot
 Appetite Suppression Product
Business Team
TARGETED MEDICAL PHARMA (OTCQB:TRGM)27
Legal Counsel Accounting
Investor Relations and Public Relations
FDA
HEALTHCARE
HEALTHCARE
SECURITIES
AUDITORS
INVESTOR
RELATIONS
Key Links
TARGETED MEDICAL PHARMA (OTCQB:TRGM)28
 Company website: http://www.targetedmedicalpharma.com/
 FDA definition of medical food:
http://www.fda.gov/Food/GuidanceRegulation/GuidanceDocumentsRegulatoryInformation
/MedicalFoods/
 Public filings: http://www.sec.gov/cgi-bin/browse-
edgar?action=getcompany&CIK=0001420030&owner=exclude&count=40&hidefilings=0
Clearwayz™
TARGETED MEDICAL PHARMA (OTCQB:TRGM)29
Direct to Consumer Market
Rapid inhibition of nasal congestion
with food based pharmaceuticals
Clinical Trial: Sentra PM® and Trazodone (Trazamine®)
TARGETED MEDICAL PHARMA (OTCQB:TRGM)30
Source: Shell, et al., “Sentra PM and Trazodone for the management of Sleep Disorders”
Journal of Central Nervous System Disease; 2012:4
2.8
18.9**
-19.3**
-28.4**
-40
-30
-20
-10
0
10
20
30
Time(min)
Less Morning Grogginess
pla/pla pla/tra Sentra PM/pla Sentra PM/tra
**p<0.01
n=111
Change in Visual Analog Scale (VAS) Negative change indicates reduced grogginess
Clinical Trial: Theramine® with Ibuprofen (Theraprofen®)
TARGETED MEDICAL PHARMA (OTCQB:TRGM)31
0.09
-6.15
-9.08
-10
-8
-6
-4
-2
0
2
Ibuprofen Theramine Combination
ChangeinVASfrom
Day1today28
Roland Morris Score After 28 Days
n=122
p<(0.01)
-6.2
-9.1
0.1
Source: Shell, et al., “A Double-Blind Controlled Trial of a Single Dose Ibuprofen and an Amino Acid
Medical Food Theramine for the Treatment of Low Back Pain; Publication pending, 2010.
Pain Reduction with Theramine®
TARGETED MEDICAL PHARMA (OTCQB:TRGM)32
Source: Shell, et al.,“A Double-Blind Controlled Trial of a Single Dose Naproxen and an Amino Acid Medical
Food Theramine for the Treatment of Low Back Pain”; American Journal of Therapeutics; 2012 108-114
2.95
-44
-65-70
-60
-50
-40
-30
-20
-10
0
10
Percent(%)
Percent Reduction of Roland-Morris Pain Index
Naproxen Theramine Both
* p<0.05
n=126
Inflammation Reduction with Theramine®
TARGETED MEDICAL PHARMA (OTCQB:TRGM)33
184.5
-16.7
-78.6-100
-50
0
50
100
150
200
Percent(%)
Change in hsCRP from Baseline at 28 Days
Naproxen Theramine Both
p<0.01
n=126
Source: Shell, et al.,“A Double-Blind Controlled Trial of a Single Dose Naproxen and an Amino Acid Medical
Food Theramine for the Treatment of Low Back Pain”; American Journal of Therapeutics; 2012 108-114
Clinical Trial: Theramine® with Ibuprofen (Theraprofen®)
TARGETED MEDICAL PHARMA (OTCQB:TRGM)34
Source: Shell, et al., “A Double-Blind Controlled Trial of a Single Dose Ibuprofen and an Amino Acid
Medical Food Theramine for the Treatment of Low Back Pain; Publication pending, 2010.
Disability Reduction with Theramine® and Naproxen (Theraproxen®)
TARGETED MEDICAL PHARMA (OTCQB:TRGM)35
Source: Shell, et al.,“A Double-Blind Controlled Trial of a Single Dose Naproxen and an Amino Acid Medical
Food Theramine for the Treatment of Low Back Pain”; American Journal of Therapeutics; 2012 108-114
-3.4
-32.9
-60.5
-70
-60
-50
-40
-30
-20
-10
0
Percent(%)
Change in Oswestry Disability Index Score at 28 Days
Naproxen Theramine Both
p<0.05
n=126
Pharmacoeconomic Analysis of Theramine
TARGETED MEDICAL PHARMA (OTCQB:TRGM)
Theramine NSAID
Product 633,600,000$ 36,000,000$
GI Bleed Treatment - 225,000,000
Protective Medications - 432,000,000
Laboratory Testing 1,000,000 75,000,000
Negative GI Workup - 144,000,000
Total 634,600,000$ 912,000,000$
Estimated Comparative Annual Treatment Cost
Over 45,000,000 capsules administered with no
reported G.I. bleeds or deaths.
Use of Theramine Potentially Reduces the Cost of Care by >30%
36
Sources: Silver DS, et al. Theramine (A Medical Food) Versus Non-Steroidal Anti Inflammatory Agents in Elderly Patients: A Pharmacoeconomic Analysis/
Journal of Pharmacy Research 2012,5(5),2806-2809; and Gaskin DJ, Richardy P. The Economic Costs of Pain in the United States/ The Journal of
Pain, Vol 13, No 8 (August), 2012: pp 715-724
Clinical Trial: Sentra PM® and Trazodone (Trazamine®)
TARGETED MEDICAL PHARMA (OTCQB:TRGM)37
1Pittsburgh Sleep Quality Index
Source: Shell, et al., “Sentra PM and Trazodone for the management of Sleep Disorders”
Journal of Central Nervous System Disease; 2012:4
1.0
2.0
3.9**
6.5**
0
1
2
3
4
5
6
7
10-PointScale
Sleep Quality (PSQI1)
Change from Baseline at Day 14
Placebo Trazodone Sentra PM Both
**p<0.01
n=111
1 Effect on one patient in pre-clinical trials. Pre-clinical trials resulted in an 80% response rate.
Pipeline: Initial Data Indicating ESS-1818 Increases Red Blood Cell Production
TARGETED MEDICAL PHARMA (OTCQB:TRGM)38
Source: Initial data from an open label study of an oral amino acid-based erythrocyte
stimulating system (ESS) for the treatment of chronic anemia; 2013.
-
20,000
40,000
60,000
80,000
100,000
120,000
1 2 5 7 17
Increased Reticulocyte Count in Healthy Volunteers1
Treatment
Initiated
Treatment
Discontinued
Primitive
Reticulocytes
(illustration)
Autism Product
TARGETED MEDICAL PHARMA (OTCQB:TRGM)39
0
1
2
3
4
5
1 2 3 4 5 6 7 8
Day
Initiation of
Treatment
Number of Events Involving
Anger, Frustration, and Self-Directed Aggressive Behavior
Nutritional Deficiency
Initial Data
Development Status
Distribution Channels
Autism Spectral Disorder - Pilot
TARGETED MEDICAL PHARMA (OTCQB:TRGM)40
 34 patients aged 7- 21
 ASD symptoms including mood disorders, explosive behavior and
social isolation
 33 experienced a significant reduction of symptoms
 Compared to baseline the average improvement was 83%
 The range was 50 to 100 %
Investigator Initiated Observations:
Appetite Suppression Product
TARGETED MEDICAL PHARMA (OTCQB:TRGM)41
Nutritional Deficiency
Initial Data
Development Status
Distribution Channels
Anticipated Launch Date
Appetite Suppression
Early Satiety
Carbohydrate Craving
Increase in Fat Metabolism
152
154
156
158
160
162
164
166
168
170
8/8/2013
8/9/2013
8/10/2013
8/11/2013
8/12/2013
8/13/2013
8/14/2013
8/15/2013
8/16/2013
8/17/2013
8/18/2013
8/19/2013
8/20/2013
8/21/2013
8/22/2013
8/23/2013
8/24/2013
8/25/2013
8/26/2013
8/27/2013
Weight(Pounds)
Date
Appetite Suppression Effect
Contact
2980 Beverly Glen Circle, Suite 301
Los Angeles, CA 90077
Telephone: 310-474-9809
Fax: 310-474-3869
investors@tmedpharma.com
Brand site: www.ptlcentral.com
Company site: www.tmedpharma.com

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Targeted Medical Pharma Innovating Healthcare for Better Patient Health IP 2014

  • 1. Targeted Medical Pharma, Inc. Innovators in Pharmaceutical Technology April 2014
  • 2. Safe Harbor Statement This document does not constitute or form part of an invitation or recommendation to subscribe for or purchase any securities of Targeted Medical Pharma, Inc. (“Targeted Medical Pharma”, “TMP” or “the Company”). This document was prepared exclusively for the benefit and internal use of investors in order to evaluate the feasibility of a possible transaction or transactions and does not carry any right of publication or disclosure to any other party. This document is incomplete without reference to, and should be viewed in conjunction with, the oral briefing provided by TMP, the Company’s public filings with the Securities and Exchange Commission (the “SEC”) and press releases. This presentation may not be used for any other purpose without the prior written consent of Targeted Medical Pharma. In preparing this document we have relied upon and assumed, without independent verification, the accuracy and completeness of all information available from public sources or which was provided to us or otherwise reviewed by us. The information contained in this document has been taken from sources deemed to be reliable. We do not represent that such information is accurate or complete and it should not be relied on as such. Any opinions expressed herein reflect our judgment at this date, all of which are subject to change. We have based the forward-looking statements on our current expectations and projections about future events. These forward-looking statements are subject to known and unknown risks, uncertainties and assumptions about us and with respect to specific factors identified in this presentation and in the Company’s filings with the SEC, specifically the reported risk factors, that may cause our actual results, levels of activity, performance or achievements expressed or implied by such forward-looking statements. Actual results in each case could differ materially from those currently anticipated in such statements. Non-GAAP Financial Measures In this presentation, TMP uses the non-GAAP measures adjusted EBITDA and adjusted earnings per share. TMP believes these non-GAAP financial measures are helpful in understanding its past financial performance and its potential future results. They are not meant to be considered in isolation or as a substitute for comparable GAAP measures and should be read in conjunction with the consolidated financial statements prepared in accordance with GAAP. TMP’s management regularly uses these supplemental non-GAAP financial measures internally to understand, manage and evaluate its business and make operating decisions. TMP believes that the use of these non-GAAP measures enhances the ability of investors to compare its results from period to period. Investors should note that adjusted EBIDTA and adjusted earnings per share, as used by TMP, may be calculated differently from, and therefore may not be directly comparable to, similarly titled measures used by TMP’ competitors and other companies. The non-GAAP historical financial measures may exclude amortization of intangible assets, share-based compensation, transaction related costs, non-cash interest expense, loss on extinguishment of debt, and the effect of change in the timing of when certain revenue was recognized. The non-GAAP 2012 financial guidance may excludes amortization of intangible assets, share-based compensation, transaction and integration costs, purchase accounting inventory step-up adjustments and the tax effect of these adjustments to GAAP net income. Trademarks All products named in this presentation are protected under trademark including those not marked “TM”. Safe Harbor Statement, Non-GAAP Financial Measures and Trademarks TARGETED MEDICAL PHARMA (OTCQB:TRGM)2
  • 3. Company Overview TARGETED MEDICAL PHARMA (OTCQB:TRGM)3  Biotechnology company that develops prescription medical foods for treatment of chronic disease  Including pain syndromes, sleep , cognitive disorders and obesity  Safe option for treatment without significant side effects  FDA regulated products on the market generating revenue  Does not require FDA pre-approval  Low cost development platform  Robust pipeline and patent portfolio  FDA GRAS/GRAE ingredients (Generally Recognized As Safe and Effective)  Diversified sales/distribution channels  Diversified sources of reimbursement
  • 4. Corporate Profile TARGETED MEDICAL PHARMA (OTCQB:TRGM)4 Targeted Medical Pharma, Inc. OTC QB: TRGM Corporate Headquarters Los Angeles, CA Stock Price (3-28-2014), 52-Week Range $0.84; $0.49 - $5.10 Shares Outstanding 26.3 M Average Daily Volume (13Wks) 12,459 Market Capitalization (3-28-2014) $22.1M Debt at 12-31-13 $5.5M Cash at 12-31-13 $492k Enterprise Value $26.9M Revenue/EBITDA (Year Ended 12-31-2013) $9.6M / ($2.7M) Full-time Employees 57 Fiscal Year Ends December 31st Accounting Firm Marcum, LLP
  • 5. Key Management TARGETED MEDICAL PHARMA (OTCQB:TRGM)5 David Silver, M.D. President and Chief Operating Officer • University of California Los Angeles - Associate Professor • Cedars-Sinai Medical Center – Clinical Chief of Rheumatology and Dir. of Chronic Pain Rehabilitation Program • Osteoporosis Medical Center - Associate Director • American College of Rheumatology – Scientific Advisory Committee Member • Conducted more then 100 clinical trials • Nationally-recognized expert on pain, fibromyalgia and PTSD • Boston University – BA in Medical Sciences with minor in Economics • Boston University School of Medicine – M.D. • Northwestern University – Residency in Internal Medicine • Cedars Sinai Medical Center – Fellowship in Rheumatology • Board Certified - Internal Medicine and Rheumatology William Shell, M.D. Co-Founder, CEO and Chief Science Officer • USAF American Soviet Exchange Program – First physician representative in Moscow • Keesler Air Force Base –Director of Coronary Case Unit • Cedars Sinai Medical Center – Dir. of Cardiovascular Biochemistry Research Laboratories • Interactive Medical Technologies - Chairman and Chief Science Officer • Beverly Glen Medical Systems – Chief Science Officer • Board Certified - Internal Medicine and Cardiology • University of California Los Angeles - Associate Professor • Conducted more than 100 clinical trials • Dr. Shell’s innovations have led to 16 issues patents and 6 pending • Published 99 peer-reviewed scientific papers and wrote chapters in 17 books • University of Michigan Medical School – M.D. • National Institutes of Health – Fellow ship under Dr. Eugene Braunwald and member CK-MB team William Horne Chief Financial Officer • OptimisCorp – Chief Financial Officer • Patient Safety Technologies (OTCBB:PSTX) – CFO and Interim CEO • Alaska Wireless Communications - Managing Member and CFO • Apex Financial Management – CFO and Founding Member • Phoenix Partners VC – Chief Financial Officer • Price Waterhouse, LLP – Accountant • U.S. Marine Corps • Seattle University – BA Business Administration, Magna Cum Laude
  • 6. Board of Directors TARGETED MEDICAL PHARMA (OTCQB:TRGM)6 INDEPENDENT DIRECTORS Maurice J. DeWald Chairman of the Board KPMG - Regional Managing Partner Serves on the board of director of several healthcare companies Arthur R. Nemiroff Chairman of the Audit Committee BDO USA LLP - Partner City of Hope Medical Center - Director and Audit Committee Member Donald J. Webster Chairman of the Nominating and Corporate Governance Committee Chevron Corporation - General Manager of Procurement Thomas R. Wenkart, M.B.B.S. Chairman of the Compensation Committee Macquarie Health Corporation - Chairman NON-INDEPENDENT DIRECTORS William Shell, M.D. CEO and Chief Science Officer David Silver, M.D. President and Chief Operating Officer Kim Giffoni Co-founder and Executive Vice President NutraCorp Scientific – President Giffoni Development Company - CEO
  • 7. Medical foods are FDA-regulated medications intended for the dietary management of a disease that has distinctive nutritional needs that cannot be met by normal diet alone as defined in the Food and Drug Administration's 1988 Orphan Drug Act Amendments. Physician Supervised Medical Foods TARGETED MEDICAL PHARMA (OTCQB:TRGM)7  Must make a disease claim  Require ongoing physician supervision  Do not require FDA pre-approval  Enteral administration  FDA GRAS/GRAE ingredients (Generally Recognized As Safe and Effective)  Address specific nutritional deficiencies
  • 8. Five-component System for Efficient Uptake and Utilization of Amino Acids Targeted Cellular Technology® TARGETED MEDICAL PHARMA (OTCQB:TRGM)8 Reduced Attenuation Improved Efficacy Milligram Quantities Amino Acids Are the Precursors to Neurotransmitters >> 5 HTP Choline Arginine Tyrosine GABA Histidine Serotonin Acetylcholine Nitric Oxide Catecholamine GABA Histamine The Five Components of TCT: 1. Neurotransmitter precursor 2. Uptake Stimulator 3. Neuron activator 4. Adenosine brake inhibitor 5. Attenuation inhibitor neurotransmittersneurotransmitters heldinstorage synapse release binding changein potential Receptorsite
  • 9. Therapeutic Area Product Product Class % of Monthly Doses** Pain and inflammation Theramine Medical Food 42% Sleep Disorders Sentra PM / GABAdone Medical Food 24% Osteoarthritis Trepadone Medical Food 12% Cognitive Disorders, Fatigue, Vision Sentra AM Medical Food 11% Metabolic Disorders / Obesity AppTrim and AppTrim-D Medical Food 8% Hypertension Hypertensa Medical Food 2% Viral Infection / Impaired Immunity ListerV Medical Food 1% Neuropathy Percura* Medical Food 1% Nasal Congestion ClearWayz Oral† Dietary Supplement < 1% * First Known Oral Stimulation of Stem Cells ** Cumulative for 2010 to 2012, and including convenience kits † Direct-to-Consumer Current Products TARGETED MEDICAL PHARMA (OTCQB:TRGM)9
  • 10. Product Indication Platform Global Market Value* Expected Commercialization ASD-AA Autism Quick Release Wafer $26B+ Q3'2014 AP-113†(New oral deliverysystem) Appetite Suppression Quick Release Wafer $390B+ Q4'2014 ESS-1818*†† ChronicAnemia Capsule $10B+ Q1'2015 PulmonaNew Asthma Capsule $12B+ Q2'2015 Oral IGF1†† Diabetes Capsule $15B+ Q3'2015 Tablet PARK -AA Parkinson's Disease Capsule $3M+ Q4'2015 ALZ- AA Alzheimer's Disease Capsule $10B+ Q4'2015 † † Enteral alternative to injection therapies * Estimated global market value Pipeline Products TARGETED MEDICAL PHARMA (OTCQB:TRGM)10
  • 11. Often embedded in large pharmaceutical companies Mead Johnson--17 billion market Abbot laboratories-- Abbott Nutrition $6 billion annual sale Targeted medical Pharma41% per year revenue growth rate Nestlé has entered the medical food space 12 Medical Foods - A large poorly recognized marketplace TARGETED MEDICAL PHARMA (OTCQB:TRGM)12
  • 12. Purchased Pam labs - Vitamin B12 for pregnancy - $350 million purchase Purchased Acerra-- Alzheimer's Disease - $250 million purchase Damone Medical Nutrition - offer of $4 Billion CM&D Pharma: Acquired in 2011, specializes in the development of products for patients with chronic kidney and gastrointestinal disease 13 Nestlé Medical Food Entry TARGETED MEDICAL PHARMA (OTCQB:TRGM)13
  • 13. Low-Cost, Shorter Time to Market TARGETED MEDICAL PHARMA (OTCQB:TRGM)14 Medical Foods Have a Shorter Time to Market due to GRAS/GRAE status Development and Testing (1 to 2 yrs) Database Registration (3 to 6 mos) Revenue and Post-Marketing MedWatch (Milestone) IND Submission (Milestone) Database Registration (3 to 6 mos) Revenue and Post-Marketing MedWatch (Milestone) Phase 1 to 3 Trials (6 to 7 yrs) Development and Testing (1 to 2 yrs) FDA Review (1 to 2 yrs) Medical Food 1 to 2.5 yrs Drug 8 to 12 yrs
  • 14. Intellectual Property Highlights TARGETED MEDICAL PHARMA (OTCQB:TRGM) 1 Targeted Cellular Technology® is a five-component system the stimulates the uptake and utilization of amino acids. It enables efficacy from microgram quantities of amino acids. *First Known Oral Stimulation of Stem Cells 16 Seven Patents Issued Three Patents Pending  4 USPTO neurotransmitter-specific patents covering Targeted Cellular Technology® (TCT)  1 Japanese patent covering TMP’s Targeted Cellular Technology®  1 USPTO patent covering the convenience pack presentation  1 USPTO Billing methodology for physician dispensing of medication TAT-related patents:  Stimulation of RBC production*  Oral Insulin / Insulin Resistance*  Neuropathy treatment
  • 15. Reimbursement Channels TARGETED MEDICAL PHARMA (OTCQB:TRGM)17  Medicare Advantage / Secondary  DOD / VA  Medicaid  Tricare  Cigna  BlueCross/Blue Shield  United Healthcare  Aetna  Health Net  Rx Solutions  Medco  Caremark  Catamaran (Walgreens)  MedImpact  Express Scripts  Workers’ Compensation  Private Insurance  Medicare Secondary Insurance Plans Top PBMs Top Medical Plans Channel Types Government Reimbursement Blue = Current payers  Black = In process
  • 16. Balance Sheet TARGETED MEDICAL PHARMA (OTCQB:TRGM)19 Balance Sheet as of 9/30/13 ASSETS LIABILITIES Cash And Equivalents 0.168 Accounts Payable 2.237 Short Term Investments - Accrued Exp. 3.195 Total Cash & ST Investments 0.168 Short-term Borrowings 3.997 Accounts Receivable 0.397 Curr. Income Taxes Payable - Notes Receivable - Def. Tax Liability, Curr. - Total Receivables 0.397 Other Current Liabilities 4.593 Inventory 0.604 Total Current Liabilities 14.022 Prepaid Exp. - Long-Term Debt - Deferred Tax Assets, Curr. - Def. Tax Liability, Non-Curr. - Other Current Assets 1.276 Other Non-Current Liabilities - Total Current Assets 2.445 Total Liabilities 14.022 Gross Property, Plant & Equipment - Common Stock 0.024 Accumulated Depreciation - Additional Paid In Capital 14.405 Net Property, Plant & Equipment 0.26 Retained Earnings (23.52) Treasury Stock - Other Intangibles 2.226 Comprehensive Inc. and Other - Accounts Receivable Long-Term - Total Common Equity (9.091) Deferred Tax Assets, LT - Total Equity (9.091) Other Long-Term Assets - Total Assets 4.931 Total Liabilities And Equity 4.931
  • 17. Income Statement TARGETED MEDICAL PHARMA (OTCQB:TRGM)20 Income Statement For the Fiscal Period Ending Restated 3 months Q4 Dec-31-2011 3 months Q1 Mar-31-2012 3 months Q2 Jun-30-2012 3 months Q3 Sep-30-2012 3 months Q4 Dec-31-2012 3 months Q1 Mar-31-2013 3 months Q2 Jun-30-2013 3 months Q3 Sep-30-2013 Revenue 1.94 1.375 1.448 2.077 2.396 2.811 1.917 2.194 Other Revenue - - - - - - - - Total Revenue 1.94 1.375 1.448 2.077 2.396 2.811 1.917 2.194 Cost Of Goods Sold 0.791 0.635 0.621 1.116 0.829 0.899 0.735 0.633 Gross Profit 1.149 0.74 0.827 0.96 1.567 1.912 1.182 1.561 Selling General & Admin Exp. 3.44 2.284 2.494 2.431 2.892 2.389 2.966 2.862 R & D Exp. 0.043 0.027 0.03 0.037 0.04 0.032 0.034 0.104 Depreciation & Amort. - - - - - - - - Other Operating Expense/(Income) - - - - - - - - Other Operating Exp., Total 3.484 2.312 2.524 2.468 2.931 2.421 3.0 2.966 Operating Income (2.335) (1.571) (1.697) (1.508) (1.364) (0.508) (1.818) (1.405) Interest Expense (0.292) (0.076) (1.867) (0.327) - (0.09) (0.152) (0.239) Interest and Invest. Income 0.0 - - - 0.07 - - - Net Interest Exp. (0.292) (0.076) (1.867) (0.327) 0.07 (0.09) (0.152) (0.239) Other Non-Operating Inc. (Exp.) - - - - - - 0.033 - EBT Excl. Unusual Items (2.627) (1.647) (3.564) (1.834) (1.294) (0.598) (1.937) (1.644) Merger & Related Restruct. Charges (0.23) - - - - - - - Impairment of Goodwill - - - - - - - - Other Unusual Items 0.675 - - 0.011 (4.444) 0.088 - (0.078) EBT Incl. Unusual Items (2.182) (1.647) (3.564) (1.823) (5.738) (0.51) (1.937) (1.721) Income Tax Expense (0.811) (0.671) (0.739) (0.582) (1.194) (0.24) 5.905 0.001 Earnings from Cont. Ops. (1.371) (0.976) (2.825) (1.241) (4.544) (0.27) (7.842) (1.723) Earnings of Discontinued Ops. - - - - - - - - Extraord. Item & Account. Change - - - - - - - - Net Income to Company (1.371) (0.976) (2.825) (1.241) (4.544) (0.27) (7.842) (1.723) Minority Int. in Earnings - - - - - - - - Net Income (1.371) (0.976) (2.825) (1.241) (4.544) (0.27) (7.842) (1.723)
  • 18. Shipments: Contract Receivables Collections: Recognized Revenue Contract Receivables are amounts due but not yet recognized as revenue Monthly collections are approximately 1.5% to 2.0% Collected amounts impact bottom-line operating revenue almost directly Contract receivables are constantly rejuvenated by additional shipments $14.8 million as of September 30, 2013 Supported by existing claims. Off-Balance Sheet Asset: Contract Receivables TARGETED MEDICAL PHARMA (OTCQB:TRGM)21
  • 19. Near-Term Goals TARGETED MEDICAL PHARMA (OTCQB:TRGM)23 Grow sales to physicians with well-insured (PPO) patients • A National Sales Manager was hired in March • A contract was signed to accelerate cash collections • We are contemplating the acquisition of a distributor network Begin sales of a dietary supplement product in Q4’2013 Begin sales of first stem-cell product in Q2’2014 • Stimulation of red blood cell production Grow national sales force • HI and WA are performing, next are NV and AZ Bring doctors current on amounts payable to them • Improving practice management and profitability
  • 20. Targets and Milestones TARGETED MEDICAL PHARMA (OTCQB:TRGM)24  Revenues - Maintain 40% per year growth rate  Margins  Gross Margin - Continue to grow gross profit by more than 40% per year  EBITDA - Maintain positive EBITDA and net profit growth  Reimbursement - Expand the channels for reimbursement including both private insurance direct payments for cash and direct to consumer market  Sales Channels - Expand sales channels to include Workers Comp, PPO insurance, HMO insurance, direct to federal agencies including military, direct to consumer and direct sales to pharmacies
  • 21. Investment Considerations PRODUCTS HAVE LOW SIDE-EFFECT PROFILE TARGETED MEDICAL PHARMA (OTCQB:TRGM)25 HIGH DEMAND PRODUCTS ADDRESSING LARGE MARKETS DIVERSIFIED, GROWING SALES GROWING ADOPTION OF MEDICAL FOODS BROAD-REACHING PATENTS AND ROBUST PIPELINE PROVEN SAFETY AND EFFICACY THROUGH CLINICAL TRIALS LOW-COST, HIGH-SPEED PRODUCT DEVELOPMENT PLATFORM TRACK RECORD OF EXCELLENT COST CONTROLS DIVERSIFIED REIMBURSEMENT SOURCES SPECIALTY REIMBURSEMENT OPERATIONS Revenue Growth Revenue Security Profitability Robust Patent Portfolio and Pipeline “Better health through medical foods”
  • 22. Appendix TARGETED MEDICAL PHARMA (OTCQB:TRGM)26  Business Team  Key Links  Clearwayz™  Clinical Trial: Sentra PM® and Trazodone (Trazamine®)  Clinical Trial: Theramine® with Ibuprofen (Theraprofen®)  Pain Reduction with Theramine®  Inflammation Reduction with Theramine®  Clinical Trial: Theramine® with Ibuprofen (Theraprofen®)  Disability Reduction with Theramine® and Naproxen (Theraproxen®)  Pharmacoeconomic Analysis of Theramine  Clinical Trial: Sentra PM® and Trazodone (Trazamine®)  Pipeline: Initial Data Indicating ESS-1818 Increases Red Blood Cell Production  Autism Product  Autism Spectral Disorder – Pilot  Appetite Suppression Product
  • 23. Business Team TARGETED MEDICAL PHARMA (OTCQB:TRGM)27 Legal Counsel Accounting Investor Relations and Public Relations FDA HEALTHCARE HEALTHCARE SECURITIES AUDITORS INVESTOR RELATIONS
  • 24. Key Links TARGETED MEDICAL PHARMA (OTCQB:TRGM)28  Company website: http://www.targetedmedicalpharma.com/  FDA definition of medical food: http://www.fda.gov/Food/GuidanceRegulation/GuidanceDocumentsRegulatoryInformation /MedicalFoods/  Public filings: http://www.sec.gov/cgi-bin/browse- edgar?action=getcompany&CIK=0001420030&owner=exclude&count=40&hidefilings=0
  • 25. Clearwayz™ TARGETED MEDICAL PHARMA (OTCQB:TRGM)29 Direct to Consumer Market Rapid inhibition of nasal congestion with food based pharmaceuticals
  • 26. Clinical Trial: Sentra PM® and Trazodone (Trazamine®) TARGETED MEDICAL PHARMA (OTCQB:TRGM)30 Source: Shell, et al., “Sentra PM and Trazodone for the management of Sleep Disorders” Journal of Central Nervous System Disease; 2012:4 2.8 18.9** -19.3** -28.4** -40 -30 -20 -10 0 10 20 30 Time(min) Less Morning Grogginess pla/pla pla/tra Sentra PM/pla Sentra PM/tra **p<0.01 n=111 Change in Visual Analog Scale (VAS) Negative change indicates reduced grogginess
  • 27. Clinical Trial: Theramine® with Ibuprofen (Theraprofen®) TARGETED MEDICAL PHARMA (OTCQB:TRGM)31 0.09 -6.15 -9.08 -10 -8 -6 -4 -2 0 2 Ibuprofen Theramine Combination ChangeinVASfrom Day1today28 Roland Morris Score After 28 Days n=122 p<(0.01) -6.2 -9.1 0.1 Source: Shell, et al., “A Double-Blind Controlled Trial of a Single Dose Ibuprofen and an Amino Acid Medical Food Theramine for the Treatment of Low Back Pain; Publication pending, 2010.
  • 28. Pain Reduction with Theramine® TARGETED MEDICAL PHARMA (OTCQB:TRGM)32 Source: Shell, et al.,“A Double-Blind Controlled Trial of a Single Dose Naproxen and an Amino Acid Medical Food Theramine for the Treatment of Low Back Pain”; American Journal of Therapeutics; 2012 108-114 2.95 -44 -65-70 -60 -50 -40 -30 -20 -10 0 10 Percent(%) Percent Reduction of Roland-Morris Pain Index Naproxen Theramine Both * p<0.05 n=126
  • 29. Inflammation Reduction with Theramine® TARGETED MEDICAL PHARMA (OTCQB:TRGM)33 184.5 -16.7 -78.6-100 -50 0 50 100 150 200 Percent(%) Change in hsCRP from Baseline at 28 Days Naproxen Theramine Both p<0.01 n=126 Source: Shell, et al.,“A Double-Blind Controlled Trial of a Single Dose Naproxen and an Amino Acid Medical Food Theramine for the Treatment of Low Back Pain”; American Journal of Therapeutics; 2012 108-114
  • 30. Clinical Trial: Theramine® with Ibuprofen (Theraprofen®) TARGETED MEDICAL PHARMA (OTCQB:TRGM)34 Source: Shell, et al., “A Double-Blind Controlled Trial of a Single Dose Ibuprofen and an Amino Acid Medical Food Theramine for the Treatment of Low Back Pain; Publication pending, 2010.
  • 31. Disability Reduction with Theramine® and Naproxen (Theraproxen®) TARGETED MEDICAL PHARMA (OTCQB:TRGM)35 Source: Shell, et al.,“A Double-Blind Controlled Trial of a Single Dose Naproxen and an Amino Acid Medical Food Theramine for the Treatment of Low Back Pain”; American Journal of Therapeutics; 2012 108-114 -3.4 -32.9 -60.5 -70 -60 -50 -40 -30 -20 -10 0 Percent(%) Change in Oswestry Disability Index Score at 28 Days Naproxen Theramine Both p<0.05 n=126
  • 32. Pharmacoeconomic Analysis of Theramine TARGETED MEDICAL PHARMA (OTCQB:TRGM) Theramine NSAID Product 633,600,000$ 36,000,000$ GI Bleed Treatment - 225,000,000 Protective Medications - 432,000,000 Laboratory Testing 1,000,000 75,000,000 Negative GI Workup - 144,000,000 Total 634,600,000$ 912,000,000$ Estimated Comparative Annual Treatment Cost Over 45,000,000 capsules administered with no reported G.I. bleeds or deaths. Use of Theramine Potentially Reduces the Cost of Care by >30% 36 Sources: Silver DS, et al. Theramine (A Medical Food) Versus Non-Steroidal Anti Inflammatory Agents in Elderly Patients: A Pharmacoeconomic Analysis/ Journal of Pharmacy Research 2012,5(5),2806-2809; and Gaskin DJ, Richardy P. The Economic Costs of Pain in the United States/ The Journal of Pain, Vol 13, No 8 (August), 2012: pp 715-724
  • 33. Clinical Trial: Sentra PM® and Trazodone (Trazamine®) TARGETED MEDICAL PHARMA (OTCQB:TRGM)37 1Pittsburgh Sleep Quality Index Source: Shell, et al., “Sentra PM and Trazodone for the management of Sleep Disorders” Journal of Central Nervous System Disease; 2012:4 1.0 2.0 3.9** 6.5** 0 1 2 3 4 5 6 7 10-PointScale Sleep Quality (PSQI1) Change from Baseline at Day 14 Placebo Trazodone Sentra PM Both **p<0.01 n=111
  • 34. 1 Effect on one patient in pre-clinical trials. Pre-clinical trials resulted in an 80% response rate. Pipeline: Initial Data Indicating ESS-1818 Increases Red Blood Cell Production TARGETED MEDICAL PHARMA (OTCQB:TRGM)38 Source: Initial data from an open label study of an oral amino acid-based erythrocyte stimulating system (ESS) for the treatment of chronic anemia; 2013. - 20,000 40,000 60,000 80,000 100,000 120,000 1 2 5 7 17 Increased Reticulocyte Count in Healthy Volunteers1 Treatment Initiated Treatment Discontinued Primitive Reticulocytes (illustration)
  • 35. Autism Product TARGETED MEDICAL PHARMA (OTCQB:TRGM)39 0 1 2 3 4 5 1 2 3 4 5 6 7 8 Day Initiation of Treatment Number of Events Involving Anger, Frustration, and Self-Directed Aggressive Behavior Nutritional Deficiency Initial Data Development Status Distribution Channels
  • 36. Autism Spectral Disorder - Pilot TARGETED MEDICAL PHARMA (OTCQB:TRGM)40  34 patients aged 7- 21  ASD symptoms including mood disorders, explosive behavior and social isolation  33 experienced a significant reduction of symptoms  Compared to baseline the average improvement was 83%  The range was 50 to 100 % Investigator Initiated Observations:
  • 37. Appetite Suppression Product TARGETED MEDICAL PHARMA (OTCQB:TRGM)41 Nutritional Deficiency Initial Data Development Status Distribution Channels Anticipated Launch Date Appetite Suppression Early Satiety Carbohydrate Craving Increase in Fat Metabolism 152 154 156 158 160 162 164 166 168 170 8/8/2013 8/9/2013 8/10/2013 8/11/2013 8/12/2013 8/13/2013 8/14/2013 8/15/2013 8/16/2013 8/17/2013 8/18/2013 8/19/2013 8/20/2013 8/21/2013 8/22/2013 8/23/2013 8/24/2013 8/25/2013 8/26/2013 8/27/2013 Weight(Pounds) Date Appetite Suppression Effect
  • 38. Contact 2980 Beverly Glen Circle, Suite 301 Los Angeles, CA 90077 Telephone: 310-474-9809 Fax: 310-474-3869 investors@tmedpharma.com Brand site: www.ptlcentral.com Company site: www.tmedpharma.com