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A Semantic Web Platform for Improving the Automation and Reproducibility of Finite Element Bio-simulations
1. A Semantic Web Platform for
Automating the Interpretation of
Finite Element Bio-simulations
Dr. Ratnesh Sahay
Semantics in eHealth & Life Sciences (SeLS)
Insight Centre for Data Analytics
NUI Galway, Ireland
10-12-2014
SWAT4LS-2014, Berlin
Germany
2. Background – Hearing Loss
278 Million People
• Outer ear gets excited both by the sound waves propagate through the ear canal and strike the eardrum
• In the middle ear the ear drum vibrates generating pressure waves in the inner ear fluid chambers
• The inner ear turns pressure waves into electrical signals that our brain can understand
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3. Background – Hearing Loss
• The ear drum vibrates generating pressure waves in the inner ear fluid chambers
• The inner ear turns pressure waves into electrical signals that our brain can understand
Infrastructure to integrate clinical knowledge, experimental data and inner ear models
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4. Inner Ear - Bio Simulation Model & System
PAK - FM
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5. SIFEM Project
Electrical Coupling Model
Micromechanics Model
Finite Element Model
Fluid Coupling Model
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6. Goals
Automate the interpretation of finite element (FE)
biosimulations ...
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8. Characteristics of the FE Domain
• Difficult to represent
• Physics, geometrical models, topological relations, algoithmic,
mathematics
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9. Dimensions of a FE Bio-simulation
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14. Lid-driven cavity flow
Physical Model
FEM Model
Solver
If there a vortex close to
the lid?
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15. Lid-driven cavity flow
Physical Model
FEM Model
Solver
definition of a simulation
If there a vortex close to
the lid?
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16. Numerical Data Interpretation
description of the
simulation
Is translated into
Rules using references
to anatomical, physical
and data feature
elements
Multiple simulations
Feature extraction
Interpretation = rules
applied over data at
the symbolic level
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17. Data View
Data Selection
y
0.05
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18. Feature Extraction
maximum
velocity is 0.93
at the lid
fast increase
(avg first derivative > 35)
Minima=(0.055,-0.20)
velocity starts
at 0 at the
bottom
slow decrease
followed by
Based on the TEDDY
ontology
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20. Data Analysis Rules
IF( minima(velocity) is negative AND
decreases very slowly(velocity) AND
increases very fast (velocity) )
VALID VELOCITY BEHAVIOUR
SPARQL Rule
CONSTRUCT
{ :LidSimulation sif: hasInterpretation :ValidVelocityBehaviour }
WHERE {
?dataview rdf:type dao:DataView .
?dataview dao:hasFeature ?x .
...
}
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25. Take-away message
• Contemporary science demands new infrastructures to
scale scientific discovery in a complex knowledge
environment.
• Numerical data is everywhere, not only in FE simulations.
• In this work we started exploring how to represent and
extract numerical data features to a conceptual level.
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26. Future Directions
• Better integration of the proposed representation and data
analysis framework to the (TErminology for the Description of
DYnamics) TEDDY conceptual model [EMBL-EBI].
• Use of the feature set and rules as a heuristic method to
improve the simulation configuration space.
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27. SIFEM TEAM
• Andre Freitas
• Kartik Asooja
• Joao B. Jares
• Stefan Decker
• Ratnesh Sahay
Th a n k Yo u !
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