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Identical features
SPECIE

MOLD FORM

YEAST FORM

Sporothrix schenckii

Rosette shape @ Gram stain;
septate hyphae w/ conidia in
daisy wheel patter

Cigar shape

Cryptococcus neoformans

-

No pseudohyphae; encapsulated

Candida albicans

-

Blastoconidia, chlamydoconidia,
pseudohyphae + germ tube

Aspergillus

Uniseriate/biseriate

-

Histoplasma capsulatum

Tuberculate macroconidia

Small intracellular yeast

Blastomyces dermititidis

Lollipop forms

Large yeast cells w/ broad based
buds; double contoured wall

Coccidiodes immitis

Thick walled; arthroconidia

Round walled spherules; Barrel
shape

Paracoccidiodes
brasiliensis

Similar to lollipop forms

Mariner’s wheel-multiple
blastoconidia budding from sides of
large blastospore
Micky mouse cap

OPPORTUNISTIC

SYSTEMIC (Dimorphic)
SPECIE
Sporothrix schenckii

NAMES OF DISEASES

EPIDEMIOLOGY

Gardener’s Dse, Farmer’s Dse, Rose
handler’s Dse, Lymphocutaneous
sporotrichosis

Mexico, Brazil, Uruguay
and South Africa

Cryptococcus neoformans

Meningitis, pulmonary dse, septicemia
and major cause of AIDS

Worldwide

Candida albicans

Thrush

Worldwide

Aspergillus

Invasive and Allergic aspergillosis

worldwide

Histoplasma capsulatum

Caver’s Dse, Darling’s Dse, Spelunker’s
Dse, Pulmunary Dses, RE cytomycosis

Ohio, Missouri &
Mississippi River Valleys

Blastomyces dermititidis

North America Blastomycosis, Gilchrist
Dse, Chicago Dse

North America, Africa,
Mississippi, Ohio River
valleys, St. Lawrence
River Basin

Coccidiodes immitis

Valley Fever, Desert rheumatism

San Joaquin valley
California, Arizona

Paracoccidiodes brasiliensis

South America Blastomycosis , LutzSplendore-Almeids Dse, Brazilian
blastomycosis, paracoccidiodal
granuloma

Central and South
America

OPPORTUNISTIC

SYSTEMIC (Dimorphic)
SPECIE
Sporothrix schenckii

MOT

SPECIMEN

NOTED TESTS

Traumatic skin
inoculation

OPPORTUNISTIC
Cryptococcus
neoformans

Inhalation from
pigeons and bird
droppings

Spinal fluid

India ink (+), Niger seed agar,
brown on Bird seed agar

Candida albicans

Alteration of host
condition as it is NF

Germ tube w/ capsule,
Chlamydoconidia on CMA

Aspergillus

Airborne/ foodborne

Fungus balls @ X-ray, Biopsy,
Serological testing

SYSTEMIC
(Dimorphic)
Histoplasma
capsulatum

Inhalation through
bird (avian) and bat
droppings

Blastomyces
dermititidis

Inhalation of conidia
from dog or horses

Coccidiodes immitis

Inhalation

Paracoccidiodes
brasiliensis

Inhalation of spores

Bone marrow

Can be confused w/ Sepedonium

Can be confused w/
Scedosporium apiospermum;
Calcuflour white
Sputum

Spheruled yeast
10-20%KOH

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Opportunistic & systemic mycoses tabulated summary

  • 1.
  • 2. Identical features SPECIE MOLD FORM YEAST FORM Sporothrix schenckii Rosette shape @ Gram stain; septate hyphae w/ conidia in daisy wheel patter Cigar shape Cryptococcus neoformans - No pseudohyphae; encapsulated Candida albicans - Blastoconidia, chlamydoconidia, pseudohyphae + germ tube Aspergillus Uniseriate/biseriate - Histoplasma capsulatum Tuberculate macroconidia Small intracellular yeast Blastomyces dermititidis Lollipop forms Large yeast cells w/ broad based buds; double contoured wall Coccidiodes immitis Thick walled; arthroconidia Round walled spherules; Barrel shape Paracoccidiodes brasiliensis Similar to lollipop forms Mariner’s wheel-multiple blastoconidia budding from sides of large blastospore Micky mouse cap OPPORTUNISTIC SYSTEMIC (Dimorphic)
  • 3. SPECIE Sporothrix schenckii NAMES OF DISEASES EPIDEMIOLOGY Gardener’s Dse, Farmer’s Dse, Rose handler’s Dse, Lymphocutaneous sporotrichosis Mexico, Brazil, Uruguay and South Africa Cryptococcus neoformans Meningitis, pulmonary dse, septicemia and major cause of AIDS Worldwide Candida albicans Thrush Worldwide Aspergillus Invasive and Allergic aspergillosis worldwide Histoplasma capsulatum Caver’s Dse, Darling’s Dse, Spelunker’s Dse, Pulmunary Dses, RE cytomycosis Ohio, Missouri & Mississippi River Valleys Blastomyces dermititidis North America Blastomycosis, Gilchrist Dse, Chicago Dse North America, Africa, Mississippi, Ohio River valleys, St. Lawrence River Basin Coccidiodes immitis Valley Fever, Desert rheumatism San Joaquin valley California, Arizona Paracoccidiodes brasiliensis South America Blastomycosis , LutzSplendore-Almeids Dse, Brazilian blastomycosis, paracoccidiodal granuloma Central and South America OPPORTUNISTIC SYSTEMIC (Dimorphic)
  • 4. SPECIE Sporothrix schenckii MOT SPECIMEN NOTED TESTS Traumatic skin inoculation OPPORTUNISTIC Cryptococcus neoformans Inhalation from pigeons and bird droppings Spinal fluid India ink (+), Niger seed agar, brown on Bird seed agar Candida albicans Alteration of host condition as it is NF Germ tube w/ capsule, Chlamydoconidia on CMA Aspergillus Airborne/ foodborne Fungus balls @ X-ray, Biopsy, Serological testing SYSTEMIC (Dimorphic) Histoplasma capsulatum Inhalation through bird (avian) and bat droppings Blastomyces dermititidis Inhalation of conidia from dog or horses Coccidiodes immitis Inhalation Paracoccidiodes brasiliensis Inhalation of spores Bone marrow Can be confused w/ Sepedonium Can be confused w/ Scedosporium apiospermum; Calcuflour white Sputum Spheruled yeast 10-20%KOH