Presentation by Prof Deniz Kirik, MD, PhD at the Parkinson's UK Research Conference, November 2010 in York.
With introduction by Dr Oliver Bandmann.
Part 2: http://www.slideshare.net/ParkinsonsResearchUK/cell-and-gene-therapy-for-parkinsons-disease-part-2.
Part 3: http://www.slideshare.net/ParkinsonsResearchUK/cell-and-gene-therapy-for-parkinsons-disease-part-3
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Cell and gene therapy for Parkinson’s disease - part 1
1. Cell and gene therapy for Parkinson’s disease
Deniz Kirik, MD, PhD
Professor of Neuroscience
Brain Repair And Imaging in Neural Systems (BRAINS) Unit
Department of Experimental Medical Science
Lund University, Sweden
2. Major symptoms of Parkinson’s disease
• Difficulty to initiate movement
• Slowness of movement
• Stiffness
• Shaking at rest
• Postural imbalance
3. Parkinson’s disease is characterized by degeneration of
dopamine producing cells located in the substantia nigra
4. Parkinson’s disease is characterized by degeneration of
dopamine producing cells located in the substantia nigra
13. Grafts of fetal dopamine neurons survive and improve motor
function in Parkinson's disease
Lindvall et al., Science 1990
14. History of Cell Transplantation in Parkinson's Disease
1979: First reports of functional restoration in
rodent models of PD
1990: First report of therapeutic effects in PD patients
in open-label trials
2001: Reports of the first placebo-controlled
double-blind studies