Tom Krohn, Business Lead for the Lilly Clinical Open Innovation Team, gave this presentation at the Patients at the Center of Clinical Research Workshop on Nov. 14, 2013. In it, he discusses ways in which patients can become collaborators in drug development

1. Patient-at-the-Center
of Clinical Trials Workshop
Lilly’s Patient Centric Engagement Overview
14 November 2013
Tom Krohn
Company Confidential
Copyright © 2013 Eli Lilly and Company

2. What if patients…
• were viewed as collaborators in drug development, not
sources of data?
• considered of clinical studies as part of their healthcare
treatment options?
• could bring their own data and in real-time determine if
they were a match for study eligibility?
• could explore what it was like to be in a study, BEFORE
they visited the site?
• received study information in a form that was easy to
understand – in THEIR context?
• were viewed as the real heroes of clinical research?

3. Today’s environment
Patients
• Have choice
• Are becoming empowered
• Are knowledgeable about their disease
• Have unmet needs
• Often view clinical trials as last resort
• Are willing to engage in research, but often do know how
Sponsors (Lilly)
• Is committed to innovation
• Is targeting unmet needs and therapeutic areas with innovation
• Thinks, processes and communicates through a scientific perspective
• Primarily reaches patients through investigator sites

4. Lilly’s Patient-Centric Engagement Strategy
•
•
•
•
•
•
Voice of patient in development
Patient-centric communication
Enabling marketplace for trial matching
Targeted/Tailored Therapeutics
Patient simulation of study for deep understanding
Patient Experience – before, during and after study

5. Patient-Centric Communication & Design Input
1
Study Representation
PatientCentric
Design
Ct.Gov
Informed Consent
Document
Open
Study Design
2
Patients
Patient
Voice
Platform

6. Finding a trial for me
OPEN
API

7. Enabling marketplace for trial matching
Study Sponsors
Patient &
Communities
Patient Study
“Target Profiles”
Open
Open
Web
REST
API
Daily
Updates
Patients
Platform
Match
Process
Consent
to
Match
Personal Electronic
Medical Records
api.lillycoi.com
April 2014 POC

8. Targeted/Tailored Therapeutics
phenotype
biomarkers
Personalized
genome
Medicine
quantified self

9. Lilly’s Patient-Centric Engagement Strategy
•
•
•
•
•
•
Voice of patient in development
Patient-centric communication
Enabling marketplace for trial matching
Targeted/Tailored Therapeutics
Patient simulation of study for deep understanding
Patient Experience – before, during and after study

10. Patient Experience
Informed Consent
Streamlined visits
Study mobile app
Continuity of care

11. Lilly’s Patient-Centric Engagement Strategy
•
•
•
•
•
•
Voice of patient in development
Patient-centric communication
Enabling marketplace for trial matching
Targeted/Tailored Therapeutics
Patient simulation of study for deep understanding
Patient Experience – before, during and after study

12. Breakout Group Themes
•
•
•
•
Understanding clinical trials (pre-trial)
Joining a clinical trial (consent)
Support while in a CT
CT Integration into patient lifestyle
• Other?