Genetic Linkage

Genetics ~Part II Genetic Recombination & Gene Linkage

Genetic Recombination ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Crossing Over ,[object Object],[object Object],[object Object]

Linkage ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Genetic Markers ,[object Object],[object Object],[object Object],[object Object],[object Object]

Independent Assortment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Analyzing Crosses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

ab aabb  ab ab 25% aB aaBb  ab aB 25% Ab Aabb  ab Ab 25% AB AaBb  ab AB 25% Progeny phenotype Progeny genotype Gamete from aabb parent Gamete from AaBb parent Frequency

Crosses Involving Linked Genes ,[object Object],[object Object]

Case 1 Case 2 A - B - A - b - - B - b - a - a Both are Genotype AaBb

Notation for Linked Genes ,[object Object],[object Object],CASE 1 AB or AB/ab Ab CASE 2 Ab or Ab/aB aB If A & B are wild-type, use (+): ++ or ++/ab ab +b or +b/a+ a+

Parental Types ,[object Object],[object Object]

Recombination ,[object Object],[object Object]

Case 1 Gametes ,[object Object],r/2 recombinant +b r/2 recombinant a+ p/2 parental ++ p/2 parental ab Frequency Type Gamete

Case 2 Gametes ,[object Object],r/2 recombinant ++ r/2 recombinant ab p/2 parental +b p/2 parental a+ Frequency Type Gamete

Parental vs. Recombinant Types ,[object Object],[object Object],[object Object],[object Object]

Test Cross ,[object Object],[object Object]

Sample Test Cross ,[object Object],r/2 recombinant +b +b/ab r/2 recombinant a+ a+/ab p/2 parental ++ ++/ab p/2 parental ab ab/ab Frequency Type Progeny Phenotype Progeny Genotype

Why A Test Cross? ,[object Object],[object Object]

Other Mapping Crosses ,[object Object],[object Object],[object Object],[object Object],[object Object]

Recombination Frequency ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Recombination Frequency & Map Distance ,[object Object],[object Object],[object Object],[object Object]

Understanding Frequency ,[object Object],[object Object],[object Object],[object Object],[object Object]

Genetic Mapping ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Linkage Problems - Example ,[object Object],[object Object],[object Object],[object Object],[object Object]

Linkage Problem (Cont.) ,[object Object],[object Object],[object Object],[object Object]

Strategies ,[object Object],[object Object],[object Object]

The Test Cross ,[object Object],[object Object],[object Object],[object Object],[object Object]

Solving ,[object Object],[object Object],[object Object],[object Object]

Genetic Linkage

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Genetic Linkage