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Ready, Set, Rectal Microbicides –
A Multinational Update on
Rectal Microbicide Research and Advocacy



Around the World with IRMA
Global Rectal Microbicide
Advocacy Priorities,
Opportunities, and Challenges


         Jim Pickett, IRMA chair
         Sydney, Australia – 16.4.12
Today

• Who is IRMA and what does she do?
• Advocacy
  –Priorities, Opportunities, Challenges
  –Activities
• Be a Rectal Rock Star
Who is IRMA?




               3
IRMA, b.2005




4 people, 4 agencies, 2 countries

                                    4
1100+
   Mission: support
advocates, scientists,
    development of
funders, policymaker
safe, effective, accepta
s from 6 continents –
  ble, and accessible
   S. America/Latin
  rectal microbicides
 America and Nigeria
for all chapters them
        that need




                           5
Balls (and rectums) are fragile…




                   -Betty White, American television star
This is what a complete prevention toolkit looks like

   Prior to exposure      Point of transmission            Treatment
 •Rights-focused          •Male and female        • Improved, expanded ARV
 behaviour change         condoms and lube          therapy
 •Voluntary counselling   •ARV treatment to       • Treatment for
 and testing              prevent vertical          opportunistic infections
 •STI screening and       transmission (PMTCT)    • Basic care/nutrition
 treatment                •Clean injecting
 •Male medical            equipment               • Prevention for positives
 circumcision             •Post-exposure          • Education & rights-focused
 •Preventive Vaccines     prophylaxis (PEP)         behaviour change
 •Pre-exposure            •Vaginal and rectal     • Therapeutic vaccines
 prophylaxis (PrEP)       microbicides
                                                        ARV = antiretroviral
8
Advocacy
Advocacy priorities

             o Increase and diversify funding
             o Increase research activities
               o RM research, expand pipeline
               o Lubricant safety
             o Increase knowledge
               o Heterosexual anal sex
               o Anal sex behaviours and practices in
                 general
It’s about the money, honey
It’s about the money, honey
It’s about the money, honey




     2010 rectal microbicide specific
     funding - approx. $7.1 million
     www.hivresourcetracking.org
It’s about the money, honey

Increase and diversify funding




          Source: From Promise to Product: Advancing Rectal Microbicide Research and Advocacy
It’s about the money, honey

Projected funding needs




         Source: From Promise to Product: Advancing Rectal Microbicide Research and Advocacy
Advocacy priorities

• Recruit researchers, advocates
• Recognise anal intercourse as
  important driver in HIV epidemic
  among gay men, MSM, and
  heterosexuals
• Address burden of HIV among
  gay/MSM
• Promote anal health
Anal intercourse is a
 human behaviour.
20
Activities
Highly active
                           moderated listserv



                                                           Website
                                                           • Tons of resources




Materials
                                                        Blog, Facebook, Twitter
• Fact sheets, reports




                         Global teleconferences
                         • Recorded, materials posted



                                                                                 22
Highly active
               moderated
                 listserv



                           You haven’t
                          lived if you’re
                            not on the
                             IRMA list.


Linda-Gail Bekker, Desmond Tutu HIV Foundation
                                                 23
Survey in English, Spanish, French, Russian,
          Chinese, Portuguese, German and Thai
                      TAKE IT. PASS THE LINK ALONG!
rectalmicrobicides.org
                                                24
Special initiatives
Special initiatives




o Project ARM
o IRMA-ALC
o “The Rectal Revolution is Here”
o Lube Safety
27
28
29
• Issues/context
  – Stigma, criminalization, denial, homophobia
  – Until recently, vaginal-centric, hetero-centric
  – Africa needs RM research and advocacy strategy
    specific to the continent
  – Anal health, LGBT rights, current prevention
    gaps, other contextual issues
  – Organizing, capacity building
  – Need for educational, communication tools
                                                      30
at ICASA 2011

• Centerpiece activity
  – Working/strategy meeting
    before ICASA 2011
  – Addis, Ababa, Ethiopia
    December 2 – 3, 2011
  – 45 individuals:
  Africans/allies

                                  31
at ICASA 2011

– Invited: RSA, Malawi, Kenya, Uganda, Nigeria,
  Ethiopia, Zimbabwe, Canada, USA
– Scholarship program to support additional 16 Africans
  to attend
   • 145 Africans submitted scholarship applications
   • Represented: gay/MSM, female, trans, openly HIV+,
     researchers, advocates, NGOs
   • Cameroon, Uganda, Zimbabwe, Zambia, RSA, Kenya,
     Nigeria , UK, Rwanda
                                                     32
33
34
35
IRMA-ALC – South America




                           36
MTN 017 Consult – Lima




                         37
MTN 017 Consult – Bangkok




                            38
MTN 017 Consult – Chiang Mai




                               39
MTN 017 Consult – Cape Town




                              40
IRMA oughta be in pictures
IRMA oughta be in pictures

“The Rectal Revolution is Here: An Introduction to
            Rectal Microbicide Trials”

 Collaboration: IRMA, MTN, Population Council
 Funding: MAC AIDS, MTN, Population Council
 Objective: develop a “generic” video about rectal
 microbicide clinical trials to use for multiple trials/products
 Target audience: communities, potential
 participants, advocates, clinical trial staff
 English, with subtitles for Spanish, Thai                  42
IRMA oughta be in pictures




                             43
IRMA oughta be in pictures




                             44
IRMA oughta be in pictures




                             45
IRMA oughta be in pictures




                             46
47
Be a Rectal Rock Star
                   48
What you can do in 5 minutes

         • WEAR YOUR STICKER
         • Take the douche survey
         • Join IRMA - sign up for IRMA listserv
           through website
         • Read one fact sheet, news item
         • Friend and follow us on FB, Twitter
         • Share web address
                     www.rectalmicrobicides.org
                                                  49
What you can do in 30 - 60 minutes

• Join one of IRMA’s regular free
  teleconferences featuring world leaders
  in RM research, advocacy
• Read our reports
• Share your interest in rectal
  microbicides –
and end the silence on ANAL SEX
                                            50
Want to do more?

            • Become your community’s rectal
          microbicide expert and spokesperson
                  – Recruit new members, enlist
                organisational support for RMs
    – Conduct presentations in your community
          – Write an article, a blog or Facebook
          update on RMs - IRMA-ALC will help!
            – Join a Community Advisory Board
                  – Join Project ARM, IRMA-ALC 51
Or how about…




           Join a trial
                          52
53
http://irma-
 rectalmicrobicides.blog
spot.com/2009/04/putt
          ing-my-ass-on-
        lineliterally.html
Special thanks to IRMA supporters




                                    55
And, thank YOU




                 56
“IF YOU THINK YOU’RE TOO SMALL
TO MAKE A DIFFERENCE, YOU’VE
NEVER SPENT THE NIGHT WITH A
MOSQUITO.”
Questions?
             58
Don’t be a stranger.
jpickett@aidschicago.org
                           59

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Around the World with IRMA - Global Rectal Microbicide Advocacy Priorities, Opportunities and Challenges

  • 1. Ready, Set, Rectal Microbicides – A Multinational Update on Rectal Microbicide Research and Advocacy Around the World with IRMA Global Rectal Microbicide Advocacy Priorities, Opportunities, and Challenges Jim Pickett, IRMA chair Sydney, Australia – 16.4.12
  • 2. Today • Who is IRMA and what does she do? • Advocacy –Priorities, Opportunities, Challenges –Activities • Be a Rectal Rock Star
  • 4. IRMA, b.2005 4 people, 4 agencies, 2 countries 4
  • 5. 1100+ Mission: support advocates, scientists, development of funders, policymaker safe, effective, accepta s from 6 continents – ble, and accessible S. America/Latin rectal microbicides America and Nigeria for all chapters them that need 5
  • 6. Balls (and rectums) are fragile… -Betty White, American television star
  • 7. This is what a complete prevention toolkit looks like Prior to exposure Point of transmission Treatment •Rights-focused •Male and female • Improved, expanded ARV behaviour change condoms and lube therapy •Voluntary counselling •ARV treatment to • Treatment for and testing prevent vertical opportunistic infections •STI screening and transmission (PMTCT) • Basic care/nutrition treatment •Clean injecting •Male medical equipment • Prevention for positives circumcision •Post-exposure • Education & rights-focused •Preventive Vaccines prophylaxis (PEP) behaviour change •Pre-exposure •Vaginal and rectal • Therapeutic vaccines prophylaxis (PrEP) microbicides ARV = antiretroviral
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  • 11. Advocacy priorities o Increase and diversify funding o Increase research activities o RM research, expand pipeline o Lubricant safety o Increase knowledge o Heterosexual anal sex o Anal sex behaviours and practices in general
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  • 13. It’s about the money, honey
  • 14. It’s about the money, honey
  • 15. It’s about the money, honey 2010 rectal microbicide specific funding - approx. $7.1 million www.hivresourcetracking.org
  • 16. It’s about the money, honey Increase and diversify funding Source: From Promise to Product: Advancing Rectal Microbicide Research and Advocacy
  • 17. It’s about the money, honey Projected funding needs Source: From Promise to Product: Advancing Rectal Microbicide Research and Advocacy
  • 18. Advocacy priorities • Recruit researchers, advocates • Recognise anal intercourse as important driver in HIV epidemic among gay men, MSM, and heterosexuals • Address burden of HIV among gay/MSM • Promote anal health
  • 19. Anal intercourse is a human behaviour.
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  • 22. Highly active moderated listserv Website • Tons of resources Materials Blog, Facebook, Twitter • Fact sheets, reports Global teleconferences • Recorded, materials posted 22
  • 23. Highly active moderated listserv You haven’t lived if you’re not on the IRMA list. Linda-Gail Bekker, Desmond Tutu HIV Foundation 23
  • 24. Survey in English, Spanish, French, Russian, Chinese, Portuguese, German and Thai TAKE IT. PASS THE LINK ALONG! rectalmicrobicides.org 24
  • 26. Special initiatives o Project ARM o IRMA-ALC o “The Rectal Revolution is Here” o Lube Safety
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  • 30. • Issues/context – Stigma, criminalization, denial, homophobia – Until recently, vaginal-centric, hetero-centric – Africa needs RM research and advocacy strategy specific to the continent – Anal health, LGBT rights, current prevention gaps, other contextual issues – Organizing, capacity building – Need for educational, communication tools 30
  • 31. at ICASA 2011 • Centerpiece activity – Working/strategy meeting before ICASA 2011 – Addis, Ababa, Ethiopia December 2 – 3, 2011 – 45 individuals: Africans/allies 31
  • 32. at ICASA 2011 – Invited: RSA, Malawi, Kenya, Uganda, Nigeria, Ethiopia, Zimbabwe, Canada, USA – Scholarship program to support additional 16 Africans to attend • 145 Africans submitted scholarship applications • Represented: gay/MSM, female, trans, openly HIV+, researchers, advocates, NGOs • Cameroon, Uganda, Zimbabwe, Zambia, RSA, Kenya, Nigeria , UK, Rwanda 32
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  • 36. IRMA-ALC – South America 36
  • 37. MTN 017 Consult – Lima 37
  • 38. MTN 017 Consult – Bangkok 38
  • 39. MTN 017 Consult – Chiang Mai 39
  • 40. MTN 017 Consult – Cape Town 40
  • 41. IRMA oughta be in pictures
  • 42. IRMA oughta be in pictures “The Rectal Revolution is Here: An Introduction to Rectal Microbicide Trials” Collaboration: IRMA, MTN, Population Council Funding: MAC AIDS, MTN, Population Council Objective: develop a “generic” video about rectal microbicide clinical trials to use for multiple trials/products Target audience: communities, potential participants, advocates, clinical trial staff English, with subtitles for Spanish, Thai 42
  • 43. IRMA oughta be in pictures 43
  • 44. IRMA oughta be in pictures 44
  • 45. IRMA oughta be in pictures 45
  • 46. IRMA oughta be in pictures 46
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  • 48. Be a Rectal Rock Star 48
  • 49. What you can do in 5 minutes • WEAR YOUR STICKER • Take the douche survey • Join IRMA - sign up for IRMA listserv through website • Read one fact sheet, news item • Friend and follow us on FB, Twitter • Share web address www.rectalmicrobicides.org 49
  • 50. What you can do in 30 - 60 minutes • Join one of IRMA’s regular free teleconferences featuring world leaders in RM research, advocacy • Read our reports • Share your interest in rectal microbicides – and end the silence on ANAL SEX 50
  • 51. Want to do more? • Become your community’s rectal microbicide expert and spokesperson – Recruit new members, enlist organisational support for RMs – Conduct presentations in your community – Write an article, a blog or Facebook update on RMs - IRMA-ALC will help! – Join a Community Advisory Board – Join Project ARM, IRMA-ALC 51
  • 52. Or how about… Join a trial 52
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  • 55. Special thanks to IRMA supporters 55
  • 57. “IF YOU THINK YOU’RE TOO SMALL TO MAKE A DIFFERENCE, YOU’VE NEVER SPENT THE NIGHT WITH A MOSQUITO.”
  • 59. Don’t be a stranger. jpickett@aidschicago.org 59

Hinweis der Redaktion

  1. Here is one way to think about what an expanded toolkit of HIV prevention and treatment options would look like. A comprehensive approach to HIV prevention should have many elements.Having a complete HIV prevention toolkit would mean we would have access to all these different strategies – both tools we have currently and new ones that are still being developed. No single tool or strategy will be the silver bullet. Ideally we will use these different tools and strategies in various combinations with one another.We can think about prevention in a similar way we do with HIV/AIDS treatment. People who have HIV/AIDS take a number of different medications – Combination Therapy. In the same way, we should think of prevention as Combination Prevention. Right now, we have many tools that people can use before exposure, right at the point of HIV transmission, and after being infected. We already agree that we need to improve people’s access to the existing tools, shown here in black.Advocates and researchers around the world are also working to see what new options could be added to this toolkit in the near future. These are shown here in red.As we will see, antiretroviral (ARV)-based prevention options could exist at all of these points.
  2. Now we’re going to talk more specifically about rectal microbicides. First, we need to acknowledge that anal intercourse is a common, human behavior, practiced by gay men, men who have sex with men, and between men and women. Following are some statistics.