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Biotechnolog y,
Chemistry, and the
  Nine Billion
      L. Val Giddings, Ph.D.
       Senior Fellow, ITIF
        20 September 2011

     Chemical Heritage Foundation
  315 Chestnut Street, Philadelphia, PA
“The greatest challenge of the 21st
century: feeding 9 billion people with
a sustainable agricultural production
system.”
                --Chrispeels, 2000
GLOBAL DEMOGRAPHY

1999 -- 70% of people grow what
they eat

2025 -- 50% will live in cities, will
need to be fed through market
channels.
“It took some 10,000 years to expand
food production to the current level
of about 5 billion tons per year.

By 2025, we will have to nearly
double current production again.”
                --Norman Borlaug, 2000
FAO Projections…
“…prices above historic equilibrium
levels during the next ten years…”
higher costs for animal feed

demand increase 100% over 40y
How can we
increase production
by 100% in 40 years?
To double production
FAO estimates
gains will come from:

   additional farmlands      20%
   increased intensity       10%
   innovative technologies   70%
20th Century ~ Chemistry
     fertilizers & pesticides (munitions…)

     green revolution saved billions
     through chemistry


21st Century ~ Biology
     nucleic acids

     greater challenges;
     require more complex solutions
     chemistry will remain indispensible
Where does chemistry fit in?
“The reports of my death are greatly
exaggerated…”

                 -- Mark Twain
…fertilizers, pesticides and
transgenes are the best possible
    protectors of the planet.

         -----The Economist, “Ears of Plenty:
            The story of man’s staple food”
                      24 December 2005.
“A truly extraordinary variety of
alternatives to the chemical control of
insects is available. All have this in
common: They are biological solutions,
based on understanding of the living
organisms they seek to control. …Some
of the most interesting of the recent
work is concerned with ways of forging
weapons from the insects’ own life
processes.”
“A truly extraordinary variety of
alternatives to the chemical control of
insects is available. All have this in
common: They are biological solutions,
based on understanding of the living
organisms they seek to control. …Some
of the most interesting of the recent
work is concerned with ways of forging
weapons from the insects’ own life
processes.”
                      --Rachel Carson,
                      Silent Spring, 1962
It’s ALL chemistry…

     chemistry is the keystone.
Where are we headed?
Green Revolution Solutions = external
involve topical applications of
pesticides/herbicides, external apps of
fertilizers

Doubly Green Revolution Solutions:
build on GR but add solutions from
work with internal chemistry

      Both are essential and indispensible
Products of agricultural
biotechnology are becoming the
new “conventional” standard
Global Area of Biotech Crops, 1996 to 2009:
 Industrial and Developing Countries (M Has, M Acres)
 M Acres
  346 140

  296 120              Total
                       Industrial
  247 100
                       Developing
  198 80

  148 60

    99 40

    49 20

     0     0
               1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009
Source: Clive James, 2010
Global Area of Biotech Crops, 1996 to 2009:
  By Crop (Million Hectares, Million Acres)
M Acres
198 80

173 70             Soybean

148 60             Maize
                   Cotton
124 50
                   Canola
 99 40
 74 30

 49 20

 25 10

  0   0
          1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009

Source: Clive James, 2010
Global Area of Biotech Crops, 1996 to 2009:
   By Trait (Million Hectares, Million Acres)

M Acres
 222      90

 198      80         Herbicide Tolerance

 173      70         Insect Resistance (Bt)

 148                 Herb Tolerance/Insect resistance
          60

 124      50
  99      40
  74      30

  49      20
  25      10

   0       0
               1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009

  Source: Clive James, 2010
Global Adoption Rates (%) for Principal
Biotech Crops (Million Hectares, Million Acres), 2009
  M Acres
   445      180
                                            158
   395      160    Conventional
   346             Biotech
            140
   296      120
                      90
   247      100
   198       80
   148       60
    99       40                    33                     31

    49       20
     0        0
                      77%           49%     26%           21%
                   Soybean        Cotton   Maize        Canola
Source: Clive James, 2010
Biotech Crop Countries and Mega-Countries, 2009
GLOBAL AREA OF BIOTECH CROPS
                                       Million Hectares (1996 to 2009)
 200
                 “Trait Hectares”
 180             Total Hectares                                        25 Biotech Crop Countries

                 Industrial
 160
                 Developing
 140
 120
 100
   80
   60
   40
   20
    0
         1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009
     A record 14 million farmers, in 25 countries, planted 134 million hectares (330 million acres) in 2009, a
                  sustained increase of 7% or 9 million hectares (22 million acres) over 2008.

Source: Clive James, 2009.
Over the next five years,
   we anticipate…
 17 new soybean events (currently ~5)
 From 9 maize events to 24
 From 4 canola to 8
 From 12 cotton to 27
 From 1* rice to 15
 From 1* or 2 potatoes to 8
 From 7 to 23 minor crops
 R&D on at least 57 crops in 63 countries
Technology source Commercialization    Regulatory Advanced   Projected
                                       approval    R&D       total by 2015
                   current   pending   pipeline

USA and EU            24          7       10         26           67


Asia                   9          0       11         34           54


Latin America          0          0        2         1             3
1st generation = agronomic traits

2nd gen = quality/consumer traits

3rd gen = GURTS/ inducible traits

4th gen = complex, polygenic traits: water
metabolism, customized biofuels, N2
fixation, etc.
“…Societies initially lacking an
advantage either acquire it from
societies possessing it or (if they fail
to do so) are replaced by those other
societies.”              --Jared Diamond
                    Guns, Germs and Steel;
                   W.W. Norton, 1998, p. 407

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Biotechnology, Chemistry, and the Nine Billion

  • 1. Biotechnolog y, Chemistry, and the Nine Billion L. Val Giddings, Ph.D. Senior Fellow, ITIF 20 September 2011 Chemical Heritage Foundation 315 Chestnut Street, Philadelphia, PA
  • 2. “The greatest challenge of the 21st century: feeding 9 billion people with a sustainable agricultural production system.” --Chrispeels, 2000
  • 3. GLOBAL DEMOGRAPHY 1999 -- 70% of people grow what they eat 2025 -- 50% will live in cities, will need to be fed through market channels.
  • 4. “It took some 10,000 years to expand food production to the current level of about 5 billion tons per year. By 2025, we will have to nearly double current production again.” --Norman Borlaug, 2000
  • 5. FAO Projections… “…prices above historic equilibrium levels during the next ten years…” higher costs for animal feed demand increase 100% over 40y
  • 6. How can we increase production by 100% in 40 years?
  • 7. To double production FAO estimates gains will come from: additional farmlands 20% increased intensity 10% innovative technologies 70%
  • 8. 20th Century ~ Chemistry fertilizers & pesticides (munitions…) green revolution saved billions through chemistry 21st Century ~ Biology nucleic acids greater challenges; require more complex solutions chemistry will remain indispensible
  • 10. “The reports of my death are greatly exaggerated…” -- Mark Twain
  • 11. …fertilizers, pesticides and transgenes are the best possible protectors of the planet. -----The Economist, “Ears of Plenty: The story of man’s staple food” 24 December 2005.
  • 12. “A truly extraordinary variety of alternatives to the chemical control of insects is available. All have this in common: They are biological solutions, based on understanding of the living organisms they seek to control. …Some of the most interesting of the recent work is concerned with ways of forging weapons from the insects’ own life processes.”
  • 13. “A truly extraordinary variety of alternatives to the chemical control of insects is available. All have this in common: They are biological solutions, based on understanding of the living organisms they seek to control. …Some of the most interesting of the recent work is concerned with ways of forging weapons from the insects’ own life processes.” --Rachel Carson, Silent Spring, 1962
  • 14. It’s ALL chemistry… chemistry is the keystone.
  • 15. Where are we headed?
  • 16. Green Revolution Solutions = external involve topical applications of pesticides/herbicides, external apps of fertilizers Doubly Green Revolution Solutions: build on GR but add solutions from work with internal chemistry Both are essential and indispensible
  • 17. Products of agricultural biotechnology are becoming the new “conventional” standard
  • 18. Global Area of Biotech Crops, 1996 to 2009: Industrial and Developing Countries (M Has, M Acres) M Acres 346 140 296 120 Total Industrial 247 100 Developing 198 80 148 60 99 40 49 20 0 0 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 Source: Clive James, 2010
  • 19. Global Area of Biotech Crops, 1996 to 2009: By Crop (Million Hectares, Million Acres) M Acres 198 80 173 70 Soybean 148 60 Maize Cotton 124 50 Canola 99 40 74 30 49 20 25 10 0 0 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 Source: Clive James, 2010
  • 20. Global Area of Biotech Crops, 1996 to 2009: By Trait (Million Hectares, Million Acres) M Acres 222 90 198 80 Herbicide Tolerance 173 70 Insect Resistance (Bt) 148 Herb Tolerance/Insect resistance 60 124 50 99 40 74 30 49 20 25 10 0 0 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 Source: Clive James, 2010
  • 21. Global Adoption Rates (%) for Principal Biotech Crops (Million Hectares, Million Acres), 2009 M Acres 445 180 158 395 160 Conventional 346 Biotech 140 296 120 90 247 100 198 80 148 60 99 40 33 31 49 20 0 0 77% 49% 26% 21% Soybean Cotton Maize Canola Source: Clive James, 2010
  • 22. Biotech Crop Countries and Mega-Countries, 2009
  • 23. GLOBAL AREA OF BIOTECH CROPS Million Hectares (1996 to 2009) 200 “Trait Hectares” 180 Total Hectares 25 Biotech Crop Countries Industrial 160 Developing 140 120 100 80 60 40 20 0 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 A record 14 million farmers, in 25 countries, planted 134 million hectares (330 million acres) in 2009, a sustained increase of 7% or 9 million hectares (22 million acres) over 2008. Source: Clive James, 2009.
  • 24. Over the next five years, we anticipate… 17 new soybean events (currently ~5) From 9 maize events to 24 From 4 canola to 8 From 12 cotton to 27 From 1* rice to 15 From 1* or 2 potatoes to 8 From 7 to 23 minor crops R&D on at least 57 crops in 63 countries
  • 25. Technology source Commercialization Regulatory Advanced Projected approval R&D total by 2015 current pending pipeline USA and EU 24 7 10 26 67 Asia 9 0 11 34 54 Latin America 0 0 2 1 3
  • 26. 1st generation = agronomic traits 2nd gen = quality/consumer traits 3rd gen = GURTS/ inducible traits 4th gen = complex, polygenic traits: water metabolism, customized biofuels, N2 fixation, etc.
  • 27. “…Societies initially lacking an advantage either acquire it from societies possessing it or (if they fail to do so) are replaced by those other societies.” --Jared Diamond Guns, Germs and Steel; W.W. Norton, 1998, p. 407