3. QUESTION 1
• What is your diagnosis?
• Name 4 conditions in which it is seen.
• What is the underlying mechanism?
4. ANSWER 1
• Cherry Red spot
• Tay sachs disease, Sandhoff disease, Niemann pick
disease, central retinal artery occlusion.
• Due to loss of transparency of the retinal ganglion
cell layer secondary to lipid accumulation/edema.
Because ganglion cells are not present in the fovea,
the fovea transmits the underlying choroidal colour.
6. ANSWER
• 2.5cm above the medial end of clavicle.
• Sternoclavicular joint.
• 4th costal cartilage.
• Midclavicular line at 6th rib.
• Midaxillary line at 8th rib.
• Lateral border of erector spinae at 10th rib.
• Oblique fissure – line joining spine of T3 vertebra to 6 th
rib in midclavicular line.
• Horizontal fissure – horizontal line extending from 4th
costal cartilage continued to meet oblique fissure in
midaxillary line.
10. QUESTION 4
• You have done therapeutic aspiration of
pleural fluid from a child with empyema.
Mention how will you dispose the following
after the procedure.
• Gloves.
• 18 gauge needle.
• Disposable syringe.
• Cotton and gauze.
12. QUESTION 5
This is the MRI of an infant evaluated for
recurrent seizures with developmental delay
13. QUESTION 5
• What is your diagnosis?
• Mention 2 ocular abnormalities associated
with this condition.
• Name the syndrome associated with this
condition.
14. ANSWER 5
• Lissencephaly (absence of cerebral
convolution and poorly formed sylvian fissure)
• Hypoplasia of the optic nerve and
microphthalmia.
• Miller-Dieker syndrome.
19. ANSWER 7
• Nystagmus – gaze evoked nystagmus.
• Gait – unsteady and irregular with a wide base.
• Intention tremor.
• Dysdiadokokinesia.
• Past pointing.
• Coordination – finger nose and heel shin test.
• Reflexes – pendular knee jerk.
• Dysarthria – scanning and robotic with syllable
pronounced individually and slowly.
20. QUESTION 8
• Counsel a mother whose child has been
diagnosed to have Acute lymphoblastic
leukemia.
21. ANSWER 8
• Introduces self.
• Says that child has been diagnosed to have
leukemia which is a blood cancer of WBC’s.
• Shows sympathy and reassures that the
overall prognosis is excellent.
• Says that the etiology is not known.
• Says that treatment involves drugs (chemo)
and occasionally radiotherapy.
22. • Says that the duration of treatment will be 2 ½ to 3yrs.
• Says regarding side effects of chemo like hairfall,
infections, bleeding tendencies etc.
• Also mentions about long term complications like
decreased growth, repeat cancer.
• Stresses the need for neutropenic care – avoid giving
outside food, avoid overcrowded places, avoid
frequent visitors.
• Mention the risk of relapse – CNS, testicular, blood and
hence the need for regular followup after completion
of treatment.
• Mention about vaccination – to consult doctor before
giving regular vaccines.
23. QUESTION 9
• A 3 yr old child is brought with history of
sudden onset of difficulty in breathing. The
child was playing with toys and was found
drowsy by the mother.
• On arrival in the ER, the child is unresponsive,
tachypneic, cyanosed with good peripheral
pulses.
• Mention the steps in management of this
child.
24. ANSWER 9
• Open the victim’s airway using a tongue-jaw
lift and look for an object in the mouth and
pharynx. If an object is visible, remove it. Do
not perform blind finger sweeps.
• Open the airway with a head tilt-chin lift and
attempt to provide rescue breaths. If breaths
are not effective, reposition the head and
reattempt ventilation.
25. • If the breaths are still not effective, prepare
to perform abdominal thrusts (Heimlich’s
maneuver).
• Repeat the steps until the object is dislodged
and the airway is patent or until attempts
have lasted approximately 1 minute. If the
infant remains unresponsive after 1minute,
activate the EMS system.
26. QUESTION 10
• Elicit Moro’s reflex, rooting and sucking reflex,
palmar and plantar grasp in this neonate.
27. QUESTION 11
• This is the electrolyte report of a 1yr old infant
who was evaluated for failure to thrive,
recurrent vomiting and polyuria.
• Na – 134mEq/dl, K – 2.6mEq/dl, Cl 100mEq/dl,
HCO3 – 28mEq/dl.
28. QUESTION 11
• What is your diagnosis.
• Mode of inheritance?.
• What is the underlying defect.
• Treatment.
29. ANSWER 11
• Barrter syndrome.
• Autosomal recessive inheritance.
• Defect in sodium and chloride resorption in
the loop of henle.
• Oral potassium supplement, potassium
sparing diuretic, Indomethacin.
30. QUESTION 12
• While drawing blood sample from a patient,
whose HIV status is unknown, your hospital
nurse has an accidental needle stick injury
(non intact skin, small volume exposure).
• Mention the setps which should be taken in
such a situation with regards to the following.
31. QUESTION 12
• Care of the exposed site.
• Counselling of the health care personnel.
• Counselling of the source.
• Tests to be done and timing of the test.
• Drug therapy – duration and dose.
• Administrative action.
32. ANSWER 12
• Wash the exposed site thoroughly with running water.
Wash skin with soap.
• Reassure and inform about PEP.
• Counsel the source and obtain consent for testing –
determination of HIV,HBV,HCV status of the source.
• HIV,HBV,HCV testing of the health care personnel. HIV
testing at zero hour, 6wks, 12wks, 6months.
• Zidovudine 300mg BD & Lamivudine 150mg BD for 4
weeks.
• Recording and reporting of the even.t
33. QUESTION 13
• A 1-1/2 year old with VSD on antifailure drugs
develops illness suggestive of influenza.
• What Category does this child belong to as
per govt of India guidelines.
• Mention 2 appropriate steps recommended
for this category
• What is the correct dosage and duration of
oseltamivir in children?
34. ANSWER 13
• Category B
• Home isolation and oseltamivir therapy
• For weight 15kg 30mg BD for 5 days
35. QUESTION 14
• 16 year old girl presents with h/o passing red
coloured urine for the last few hours. There
was no h/o fever. There was h/o drug intake
for diarrheal illness 3 days ago.
O/E she had gross pallor and a tinge of scleral
icterus
• What is the provisional diagnosis?
• Describe the peripheral smear picture in this
girl.
• Immediate steps in management.
37. QUESTION 15
• Mention the duration and temperature at
which the following blood products can be
stored?
• 1.Red Blood Cells
• 2.Fresh Frozen Plasma
• 3.Platelet Concentrate
• 4.Cryoprecipitate
38. ANSWER 15
• Packed RBC – 42 days in the refrigerator or 10
years in the freezer.
• FFP - 1 year in the freezer
• Platelet Concentrate – 5 days at room
temperature
• Cryoprecipitate – 1 year in the freezer
40. QUESTION 16
• This is the karyotype obtained from the
bonemarrow of a 6 year old girl with a
hematological malignancy.
• Comment on the abnormality
• Mention 1 favourable and 1 unfavourable
translocation in ALL
48. QUESTION 19
• Define Polio eradication and elimination
• Mention core strategies for eradication of
polio.
49. • Eradication – No cases of paralytic polio by
wild polio virus in the last 3 calender years
• Elimination – No cases of paralytic
poliomyelitis by wild polio virus in 1 calender
year.
• CORE STRATEGIES:
• Maintaining high routine immunisation
coverage with 4 doses of OPV
• Mass campaign
• Sensitive Surveillence
• Mop up campaign
50. QUESTION 20
• HPV VACCINE
• What are the types of vaccine available?
Mention the serotypes covered by them.
• What is the recommended dose?
• What is the recommended age for
vaccination?
51. ANSWER 20
• Quadrivalent vaccine (gardasil) – serotypes 16,
18, 6, 11.
• Bivalent vaccine (cervarix) – serotypes 16, 18.
• 0.5ml intramuscular at deltoid.
3 doses - 0, 2, 6months – gardasil.
3 doses - 0, 1, 6months – cervarix.
• Initiation of vaccine 10-12years of age. Catch
up vaccination up to 26yrs of age.
53. QUESTION 21
• Identify this graph.
• What do the square and area of each square
represent?
• What do the horizontal and vertical line
represent?
• What does the diamond represent?
• What does the centre of diamond represent?
54. ANSWER 21
• Forest plot (forest plot shows information
from individual studies that went into meta-
analysis at a glance. They show the amount of
variation between the studies and an estimate
of the overall result.
• Each square symbol represents a study
contributing to metanalysis and the area of
square corresponds to the weight of the
corresponding study to the metaanalysis.
55. ANSWER 21
• The horizontal line through the square shows
the confidence interval. The solid vertical line
represents no effect.
• The diamond represents the overall estimate
from the meta-analysis.
• The centre of diamond represents the pooled
point estimate and the horizontal tips
represent the confidence interval.
57. QUESTION 22
• Identify this peripheral smear.
• What is the underlying defect?
• Confirmatory test for diagnosis?
• Treatment options?
58. ANSWER 22
• Hereditary spherocytosis.
• Defect in spectrin or ankyrin - results in
uncoupling in the vertical interactions of the
lipid bilayer skeleton and loss of membrane
microvesicles.
• Osmotic fragility test.
• Folic acid 1mg/day, splenectomy.
62. QUESTION 24
1 ½ yr old child with history of chronic diarrhea was
brought with complaints of perioral and perineal rash.
63. QUESTION 24
• What is your diagnosis?
• Mode of inheritance?
• Investigation used for diagnosis?
• Treatment of choice?
• Mention a few differential diagnosis.
64. ANSWER 24
• Acrodermatitis enteropathica.
• Autosomal recessive – defect in intestinal zinc
specific transporter gene.
• Low plasma zinc concentration.
• Zinc – 50mg/day for infants, upto 150mg/day
for children.
• MSUD, organic acidemia, methylmalonic
acidemia, biotidinase def, severe PEM.
78. ANSWER 29
• Dense bones suggestive of osteopetrosis
• Steroids,Interferon,Bone marrow
Transplantation
• Infections,Bleeds,Loss of vision
79. Question 30
A 1 month old child
was brought with pink
staining of the diapers
since birth. He also had
history of blisters on
sun exposed areas.
On examination the
color of the urine is as
shown.
80. 1. What is your diagnosis?
2. Name the deficient enzyme.
3. What are the other clinical manifestations?
4. Mention the diagnostic lab finding.
81. Answer:
1. Congenital Erythropoietic Porphyria (Gunther disease)
2. Uroporphyrinogen III synthase (UROS)
3. Bullous cutaneous photosensitivity– hydroa aestivale,
hypertrichosis,
erythrodontia,
hemolytic anemia,
bone abnormalities
4. Markedly elevated levels of uroporphyrin I and
coproporphyrin I in urine,stool and RBC’s.