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Scientific supervisor :  Prof Dr. B.I.Polyakov   Dr . A.F. Marebuch Presented by  Dr. Khant Zaw Aung Gemcitabine/Cisplatin  And Paclitexal/Carboplatin Combinations In  Treatment Of Non-small Cell Lung Cancer Stage IIIB  And IV As First Line Of Treatment (ECOG PS <2) M.V. Lomonosov Moscow State University Faculty of Basic Medicine
[object Object],[object Object],[object Object]
[object Object],[object Object]
[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],53 Patients Gemcitabine 1,000-1,2500  mg/m2 IV over 30 minutes on day 1 and 8 + Cisplatin 50-80 mg/m2 IV over  1 hr on day 1 Paclitexal 175-200mg/m2 IV over 3 hrs on  day 1 + Carboplatin (AUC  5 or 6)  IV over  30 minutes on day 1 29 patients 24 patients Proper premdications, antiemetic therapy and prehydration therapy before treatment. Proper premdications  and standard antiemetic therapy before treatment  Cycles are repeated at 3 weeks interval.
[object Object],[object Object],[object Object],[object Object]
Arm specific Demographic
Arm specific Demographic  (continued)
Arm-Specific Demographics With Response
Arm-Specific Demographics With Response (continued) Correlation with Staging %
Haematological toxicities GC  combination CbP combination
Non-haematological toxicities GC combination CbP combination Patients Patients Grade   I Grade II
Response Rate ,[object Object]
% Therapeutic  Outcome
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
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