6. Anti tussive– Coughsuppressant
Mucolytic- Reduceviscosity of mucus
Mucokinetic-Increase mobility of cough
Classificationof Drugsfor cough
Antihistamines
Bronchodilators
7. Antitussives
Ideally cough should not besuppressed
Treatment of underlyingcause
Drugs which suppresscough-Antitussives
Raise threshold of cough centre in medulla
In respiratory tract reduce tussalimpulse
Useful for drycough
8. Semisynthetic opioidanalgesic
Lesspotent than morphine
More selective for coughcentre
Potent coughsuppressantaction at low dose(10 mg)
Anti tussive action –blockedbyNaloxone
Haslessaddiction
S/E
Constipation,Drowsiness,Respiratorydepression
Contraindicated in bronchialasthma
Codeine
10. Mucolytics
Acetylcysteine
Reduceviscosity of sputum by opening disulfide bondof
mucoprotein
S/E
Nausea,vomiting,gastratitis,bronchospasm,rhinorrhea
Administer directly to respiratorytract
12. Antihistamines
Added to antitussives/expectorantformulation
Relief in coughdue to sedative & anticholinergicactions
Lack selectivity for coughcentre
No expectorantaction
↓Secretions (anticholinergiceffect)
Suitable for allergic cough but not for asthma
Ex., diphenhydramine, promethazine
13. Bronchodilators
Bronchospasm induce or aggravate cough
↑Surface velocity of air flow during cough
Clear secretions of airway
Not used routinely for every type of cough
present ( Bronchial Use only when bronchoconstriction is
asthma)
Ex. β2-agonist (salbutamol,terbutaline)
14. Localanesthetic
Lignocaine
For intractable cough of Bronchialcarcinoma
Administer by nebulizer
Toprevent cough during endoscopy
Instill topically inairway
15. Roleof hydration in cough
Dehydration increase viscosity of secretion
Adequate fluid –decreaseviscosity
Highly effective Roleof
steaminhalation
Useful for liquefaction of tenacioussputum
Roleof other agents
16. Summary
Cough-protective reflex
Treat underlying cause
Provides symptomatic treatment
Antitussive –Suppresscough centre
Opioid&non opiod
Mucolytic-Lysis
Adjuvants-Anti-histamine,Bronchodilator