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Correlation of alpha-fetoprotein & LFTs in liver diseases By Zahoor Ahmed B .S MLT 06
Alpha Fetoprotein ,[object Object],[object Object],[object Object]
Structure of AFP ,[object Object],[object Object],[object Object]
Sites of synthesis ,[object Object],[object Object],[object Object]
Physiological role of AFP:   ,[object Object],[object Object],[object Object],[object Object],[object Object]
AFP TESTING ,[object Object],[object Object],[object Object],[object Object],[object Object]
Importance of AFP in lab diagnosis: ,[object Object],[object Object]
ELEVATED LEVEL ,[object Object],[object Object],[object Object],[object Object],[object Object]
LFT’S ,[object Object],[object Object]
Tests involved in LFT’s ,[object Object],[object Object],[object Object],[object Object],[object Object]
Normal Range  =  20 - 125 U/L Bile duct obstruction, liver injury,  and  some cancers . An enzyme produced in the liver, bone, and placenta that is released into the blood during injury or during such normal activities as bone growth or pregnancy . Alkaline phosphatase  What it Tells Us?  What is it ? TEST
Normal Range  =   0 - 48 U/L Liver cell injury (as in hepatitis ) An enzyme produced in the liver that is released into the blood when liver cells are injured.   Alanine transaminase (ALT)  What it Tells Us? What is it   ? TEST
Normal Range  =  M  = 50 U/L  F  = 35 U/L Injury to liver, heart, muscles, or brain. An enzyme released into the blood when the liver, heart, muscle, or brain is injured.  Aspartate transaminase (AST)  What it Tells Us? What is it   ? TEST
Normal Range  M=< 32 U/L  F= < 49 U/L Organ damage, drug toxicity, alcohol abuse, disease of the pancreas . An enzyme produced by the liver, pancreas, and kidneys and released into the blood when these organs are injured . Gamma-glutamyl transpeptidase   What it Tells Us? What is it?   TEST
NORMAL RANGE: TOTAL BILI  =  < 1.0 Mg/dl Direct bili  =  < 0. 3 Mg/dl   Obstruction to bile outflow, liver damage, excessive breakdown of red blood cells (from which bilirubin is made) . A component of the digestive juice (bile) produced by the liver.  Bilirubin  What it Tells Us? What is it   ? TEST
LIVER DISEASES ,[object Object],[object Object],[object Object]
CORRELETION
LIVER CARCINOMAS ,[object Object],[object Object],NORMAL BILI: GGT ALP ALT AST AFP
HEPATITIS ,[object Object],[object Object],[object Object],BILI: GGT ALP ALT AST AFP
LIVER CIRRHISIS ,[object Object],[object Object],BILI: GGT ALP ALT AST AFP
CONCLUSION ,[object Object],[object Object],[object Object],[object Object]
 

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Correlation Of Alpha Fetoprotein & Lf Ts In Liver

  • 1. Correlation of alpha-fetoprotein & LFTs in liver diseases By Zahoor Ahmed B .S MLT 06
  • 2.
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  • 11. Normal Range = 20 - 125 U/L Bile duct obstruction, liver injury, and some cancers . An enzyme produced in the liver, bone, and placenta that is released into the blood during injury or during such normal activities as bone growth or pregnancy . Alkaline phosphatase What it Tells Us? What is it ? TEST
  • 12. Normal Range = 0 - 48 U/L Liver cell injury (as in hepatitis ) An enzyme produced in the liver that is released into the blood when liver cells are injured. Alanine transaminase (ALT) What it Tells Us? What is it ? TEST
  • 13. Normal Range = M = 50 U/L F = 35 U/L Injury to liver, heart, muscles, or brain. An enzyme released into the blood when the liver, heart, muscle, or brain is injured. Aspartate transaminase (AST) What it Tells Us? What is it ? TEST
  • 14. Normal Range M=< 32 U/L F= < 49 U/L Organ damage, drug toxicity, alcohol abuse, disease of the pancreas . An enzyme produced by the liver, pancreas, and kidneys and released into the blood when these organs are injured . Gamma-glutamyl transpeptidase What it Tells Us? What is it? TEST
  • 15. NORMAL RANGE: TOTAL BILI = < 1.0 Mg/dl Direct bili = < 0. 3 Mg/dl Obstruction to bile outflow, liver damage, excessive breakdown of red blood cells (from which bilirubin is made) . A component of the digestive juice (bile) produced by the liver. Bilirubin What it Tells Us? What is it ? TEST
  • 16.
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