Introduction Causative agent : Treponema pallidium Transmission : Abraded skin / mucosal surface. Spreads through direct contact. Incubation period : 9 -90 days. Clinical features Phases of syphilis : Primary syphilis Lesion / Chancre : Single/ Multiple Site : Labia, fourchette, anus, cervix or nipples. Small papule gets eroded into an ulcer. The margins of ulcer are raised and floor is smooth and shiny. Healing of primary chancre takes place in 1-8 weeks. Secondary Syphilis Secondary syphilis is evident in form of Condyloma lata in vulva. Condyloma lata : coarse, flat topped, moist, necrotic lesions. Maculopapular rashes : Palms and soles. Alopecia, lymphadenopathy, mucosal ulcers. Latent Syphilis Quiescence phase. Duration : 2 -20 years. Tertiary Syphilis Progression of tertiary syphilis occurs only in condition of untreated syphilis. Damages CNS, CVS, Musculoskeletal system. Cranial nerve palsies III, VI, VII and VIII. Gummatous ulcer : deep punched ulcer with rolled out margins. Painless with moist leather base. Diagnosis History of exposure. Identification of organism. Serological test VDRL (Venereal disease research laboratory) TPHA (Treponoma pallidum haemagglutination) EIA (Enzyme immunoassay) FTA (Fluorescent treponomal Antibody) TPI (Treponoma pallidum immobilisation) Treatment Benzathine penicillin IM Tetracycline 500 mg Doxycycline 100 mg Serological test should be performed 1, 3, 6 and 12 month after treatment of syphilis.

1. Syphillis
Dr. Yashika

2. Introduction
• Causative agent : Treponema pallidium
• Transmission : Abraded skin / mucosal surface.
• Spreads through direct contact.
• Incubation period : 9 -90 days.

3. Clinical features
Phases of syphilis :
1. Primary syphilis
2. Secondary syphilis
3. Tertiary syphilis

4. Primary syphilis
• Lesion / Chancre : Single/ Multiple
Site : Labia, fourchette, anus, cervix or
nipples.
• Small papule gets eroded into an ulcer.
The margins of ulcer are raised and floor
is smooth and shiny.
• Healing of primary chancre takes place in
1-8 weeks.

5. Secondary Syphilis
• Secondary syphilis is evident in form of
Condyloma lata in vulva.
• Condyloma lata : coarse, flat topped,
moist, necrotic lesions.
• Maculopapular rashes : Palms and soles.
• Alopecia, lymphadenopathy, mucosal
ulcers.

6. Latent Syphilis
• Quiescence phase.
• Duration : 2 -20 years.

7. Tertiary Syphilis
• Progression of tertiary syphilis occurs
only in condition of untreated syphilis.
• Damages CNS, CVS, Musculoskeletal
system.
• Cranial nerve palsies III, VI, VII and
VIII.
• Gummatous ulcer : deep punched ulcer
with rolled out margins. Painless with
moist leather base.

8. Diagnosis
• History of exposure.
• Identification of organism.

9. Serological test
• VDRL (Venereal disease research laboratory)
• TPHA (Treponoma pallidum haemagglutination)
• EIA (Enzyme immunoassay)
• FTA (Fluorescent treponomal Antibody)
• TPI (Treponoma pallidum immobilisation)

10. Treatment
• Benzathine penicillin IM
• Tetracycline 500 mg
• Doxycycline 100 mg
Serological test should be performed 1, 3, 6 and 12
month after treatment of syphilis.