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UNDER THE SKIN: GENETIC
DIFFERENCES IN IDENTICAL TWINS
By: Brittany Lynch
THESIS
 The distinct differences found at the genetic level in
twins are causing scientists to question the idea of
“identical”.
TYPES OF IDENTICAL TWINS
 Dichorionic, Diamniotic
 Monochorionic, Diamniotic
 Monochorionic, Monoamniotic
DICHORIONIC, DIAMNIOTIC TWINS
 Zygote split in the first two days after fertilization
 Develop in different placentas and amniotic sacs
 Only occur 20-30% of the time
MONOCHORIONIC, DIAMNIOTIC TWINS
 Zygote splits after the first two days of fertilization
 Grow in the same placenta and different amniotic sacs
 Occur most often
MONOCHORIONIC, MONOAMNIOTIC TWINS
 Grow in the same placenta and amniotic sac
 Only occur about 1% of the time
WHAT IS IDENTICAL?
 To be considered an identical twin:
 have to come from the same zygote
 have same blood type
 have to be the same sex
 have the same hair color
JONATHAN MILL
 Study was used to determine how genes are activated
differently in identical twins
 studied the genome of 22 pairs of identical twins
 did have identical DNA, but they had certain differences in chemical
markings
 chemical markings do not alter the DNA sequence, but they do
leave marks on genes
NATURE VS. NURTURE
 Genes = Nature
 Environment = Nurture
 Manel Esteller
 studied 49 pairs of identical twins
 determine that epigenetic analysis could differentiate between
twins in a criminal case
EVERY BRAIN IS UNIQUE
 Life experience influences brain differences
 change the strength of connections between certain neurons
 Jumping Genes
 genes that paste copies of themselves into the genome
 causes cells to act differently
 can lead to differences in cognitive abilities, personality
traits, and susceptibility to neurological problems
TESTS USED TO IDENTIFY DIFFERENCES
 High resolution cameras
 Fingerprinting
 Iris scanners
DIFFERENCES DISCOVERED
 Gene Expression
 Environmental Factors
GENE EXPRESSION
 Although they did possess nearly identical genomes,
closer study revealed they often differed in the number of
copies of individual gene segments. For instance, one
twin might be missing a segment, or possess more copies
of that segment than the other twin
 They can develop different disorders and illnesses
ENVIRONMENTAL FACTORS
 Fingerprints
 caused by the different conditions experienced by the fetuses
in the womb
 Smoking, drugs, and alcohol
 Sun
 Personality Differences
 caused by different chemicals in the body that are affected by
a person’s lifestyle choices
WORKS CITED
 http://www.featureshoot.com/wp-content/uploads/2012/01/Eva_Johanna_Gill_0213_F.jpg
 http://api.ning.com/files/w3vIIvgIdO5AAeFt7G93WcNrsN5nS2fCi-74WFDZbP5tfmnnCp5AOx4IDrKz5bPa1B-
QrgSHX25vpBlYsrqHgzYzdm1lzSz4/natgeotwins01.jpg
 http://en.es-static.us/upl/2011/07/twins_twin.jpg
 http://questional.com/images/uploads/34/Identical-Twins-in-the-Womb.jpg
 http://medind.nic.in/ibn/t09/i1/IndianJRadiolImaging_2009_19_1_81_45352_u1.jpg
 http://radiographics.rsna.org/content/29/5/1371/F16.expansion.html
 http://1.bp.blogspot.com/_29vlt4MXQ-
A/S5Z3oYGfMhI/AAAAAAAAB2U/52NonF1w66Q/s400/DichorionicDiamniotic.jpg
 http://static.ddmcdn.com/gif/dna-ch150.jpg
 http://www.genengnews.com/media/images/GENHighlight/April4_2011_3769185_BlueBrainDNA_FiveNewAlzh
eimerGenes2689161031.jpg
 http://www.infobarrel.com/media/image/33385.png
 http://ribomed.com/wp-content/uploads/2011/12/methylmagnetslidev4-copy.jpg
 http://myidentico.com/wordpress/wp-content/uploads/2011/06/10598078-fbi-fd258-fingerprinting.jpg
 http://i.i.com.com/cnwk.1d/i/tim/2011/03/09/helmet_brain_540x405.jpg
 http://scientopia.org/blogs/scicurious/files/2011/05/neurons4.jpg
 http://truthsquad.tv/wp-content/uploads/2010/12/art_illu_biometrics1.jpg
 http://www.buzzle.com/img/articleImages/365107-57010-11.jpg
 http://www.techshout.com/images/nikon-d40x-camera.jpg
 http://upload.wikimedia.org/wikipedia/commons/thumb/0/07/Gene.png/270px-Gene.png
 http://www.bayareaalliance.org/images/e-Environment.jpg
 http://www.broadinstitute.org/files/news/images/2011/chromosome.jpg
 http://topnews.in/health/files/Gene_2.jpg
 http://abcnews.go.com/blogs/headlines/2012/01/a-thing-or-two-about-twins/

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Identical Twins

  • 1. UNDER THE SKIN: GENETIC DIFFERENCES IN IDENTICAL TWINS By: Brittany Lynch
  • 2. THESIS  The distinct differences found at the genetic level in twins are causing scientists to question the idea of “identical”.
  • 3. TYPES OF IDENTICAL TWINS  Dichorionic, Diamniotic  Monochorionic, Diamniotic  Monochorionic, Monoamniotic
  • 4. DICHORIONIC, DIAMNIOTIC TWINS  Zygote split in the first two days after fertilization  Develop in different placentas and amniotic sacs  Only occur 20-30% of the time
  • 5. MONOCHORIONIC, DIAMNIOTIC TWINS  Zygote splits after the first two days of fertilization  Grow in the same placenta and different amniotic sacs  Occur most often
  • 6. MONOCHORIONIC, MONOAMNIOTIC TWINS  Grow in the same placenta and amniotic sac  Only occur about 1% of the time
  • 7. WHAT IS IDENTICAL?  To be considered an identical twin:  have to come from the same zygote  have same blood type  have to be the same sex  have the same hair color
  • 8. JONATHAN MILL  Study was used to determine how genes are activated differently in identical twins  studied the genome of 22 pairs of identical twins  did have identical DNA, but they had certain differences in chemical markings  chemical markings do not alter the DNA sequence, but they do leave marks on genes
  • 9. NATURE VS. NURTURE  Genes = Nature  Environment = Nurture  Manel Esteller  studied 49 pairs of identical twins  determine that epigenetic analysis could differentiate between twins in a criminal case
  • 10. EVERY BRAIN IS UNIQUE  Life experience influences brain differences  change the strength of connections between certain neurons  Jumping Genes  genes that paste copies of themselves into the genome  causes cells to act differently  can lead to differences in cognitive abilities, personality traits, and susceptibility to neurological problems
  • 11. TESTS USED TO IDENTIFY DIFFERENCES  High resolution cameras  Fingerprinting  Iris scanners
  • 12. DIFFERENCES DISCOVERED  Gene Expression  Environmental Factors
  • 13. GENE EXPRESSION  Although they did possess nearly identical genomes, closer study revealed they often differed in the number of copies of individual gene segments. For instance, one twin might be missing a segment, or possess more copies of that segment than the other twin  They can develop different disorders and illnesses
  • 14. ENVIRONMENTAL FACTORS  Fingerprints  caused by the different conditions experienced by the fetuses in the womb  Smoking, drugs, and alcohol  Sun  Personality Differences  caused by different chemicals in the body that are affected by a person’s lifestyle choices
  • 15.
  • 16.
  • 17. WORKS CITED  http://www.featureshoot.com/wp-content/uploads/2012/01/Eva_Johanna_Gill_0213_F.jpg  http://api.ning.com/files/w3vIIvgIdO5AAeFt7G93WcNrsN5nS2fCi-74WFDZbP5tfmnnCp5AOx4IDrKz5bPa1B- QrgSHX25vpBlYsrqHgzYzdm1lzSz4/natgeotwins01.jpg  http://en.es-static.us/upl/2011/07/twins_twin.jpg  http://questional.com/images/uploads/34/Identical-Twins-in-the-Womb.jpg  http://medind.nic.in/ibn/t09/i1/IndianJRadiolImaging_2009_19_1_81_45352_u1.jpg  http://radiographics.rsna.org/content/29/5/1371/F16.expansion.html  http://1.bp.blogspot.com/_29vlt4MXQ- A/S5Z3oYGfMhI/AAAAAAAAB2U/52NonF1w66Q/s400/DichorionicDiamniotic.jpg  http://static.ddmcdn.com/gif/dna-ch150.jpg  http://www.genengnews.com/media/images/GENHighlight/April4_2011_3769185_BlueBrainDNA_FiveNewAlzh eimerGenes2689161031.jpg  http://www.infobarrel.com/media/image/33385.png  http://ribomed.com/wp-content/uploads/2011/12/methylmagnetslidev4-copy.jpg  http://myidentico.com/wordpress/wp-content/uploads/2011/06/10598078-fbi-fd258-fingerprinting.jpg  http://i.i.com.com/cnwk.1d/i/tim/2011/03/09/helmet_brain_540x405.jpg  http://scientopia.org/blogs/scicurious/files/2011/05/neurons4.jpg  http://truthsquad.tv/wp-content/uploads/2010/12/art_illu_biometrics1.jpg  http://www.buzzle.com/img/articleImages/365107-57010-11.jpg  http://www.techshout.com/images/nikon-d40x-camera.jpg  http://upload.wikimedia.org/wikipedia/commons/thumb/0/07/Gene.png/270px-Gene.png  http://www.bayareaalliance.org/images/e-Environment.jpg  http://www.broadinstitute.org/files/news/images/2011/chromosome.jpg  http://topnews.in/health/files/Gene_2.jpg  http://abcnews.go.com/blogs/headlines/2012/01/a-thing-or-two-about-twins/