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Immunity: Part IV 
Acquired Immunity
Remember: Types of Immunity 
• Innate 
• Acquired 
– Is the body’s second major kind of defense 
– Involves the activity o...
• A summary of innate and acquired immunity 
INNATE IMMUNITY 
Rapid responses to a 
broad range of microbes 
Copyright © 2...
Notes Handout
Types of Immunity
Properties of Immunity 
1.Specificity 
2.Versatility 
3.Memory 
4.Tolerance
Notes Handout
Figure 14.16
Notes Handout
Figure 14.12
T Cells & Cell-Mediated Immunity 
• T Cells must be activated by exposure to 
antigen 
• T Cells recognize antigens when t...
T Cells & Cell-Mediated Immunity 
• MHC Proteins 
• Class I 
– Found on the surface of all nucleated cells 
– Peptides pro...
Types of T Cells 
1. Cytotoxic T Cells 
2. Helper T Cells 
3. Memory T Cells 
4. Suppressor T Cells
Notes Handout
Activation of Cytotoxic T Cells 
MHC Class I clip
Helper T Cells 
• Activated by exposure to antigens presented by 
Class II MHC proteins 
• Activated helper T cells perfor...
Memory T Cells 
• Produced upon initial exposure to antigen, but 
do not respond to the antigen at that time. 
• Provide a...
Suppressor T Cells 
• Activated suppressor T cells dampen the 
responses of other T cells and B cells 
– Secrete suppressi...
Notes Handout
Sensitization & 
Activation of B 
Cells
Sensitization & 
Activation of B 
Cells
Sensitization & 
Activation of B 
Cells
Sensitization & Activation of B Cells
Notes Handout
Antibody Structure
Antigen-antibody binding
antibody clip
Antibody (IgG) Function 
• Neutralization 
• Agglutination and precipitation 
• Activation of complement 
• Attraction of ...
Notes Handout
Summary of the 
Immune 
Response and 
Its Relationship 
to Nonspecific 
Defenses
Notes Handout
Integration of the Lymphatic System with Other Systems
Immunity part iv acquired immunity
Immunity part iv acquired immunity
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Immunity part iv acquired immunity

  1. 1. Immunity: Part IV Acquired Immunity
  2. 2. Remember: Types of Immunity • Innate • Acquired – Is the body’s second major kind of defense – Involves the activity of lymphocytes Copyright © 2005 Pearson Education, Inc. publishing as Benjamin Cummings
  3. 3. • A summary of innate and acquired immunity INNATE IMMUNITY Rapid responses to a broad range of microbes Copyright © 2005 Pearson Education, Inc. publishing as Benjamin Cummings ACQUIRED IMMUNITY Slower responses to specific microbes External defenses Internal defenses Skin Mucous membranes Secretions Phagocytic cells Antimicrobial proteins Inflammatory response Natural killer cells Humoral response (antibodies) Cell-mediated response (cytotoxic lymphocytes) Invading microbes (pathogens)
  4. 4. Notes Handout
  5. 5. Types of Immunity
  6. 6. Properties of Immunity 1.Specificity 2.Versatility 3.Memory 4.Tolerance
  7. 7. Notes Handout
  8. 8. Figure 14.16
  9. 9. Notes Handout
  10. 10. Figure 14.12
  11. 11. T Cells & Cell-Mediated Immunity • T Cells must be activated by exposure to antigen • T Cells recognize antigens when they are bound to membrane receptors of other cells • Antigen membrane receptors are called – MAJOR HISTOCOMPATIBILITY COMPLEX PROTEINS • Class I MHC • Class II MHC
  12. 12. T Cells & Cell-Mediated Immunity • MHC Proteins • Class I – Found on the surface of all nucleated cells – Peptides produced inside the cell are displayed on the surface by Class I MHC proteins. • Class II – Found on the surface of lymphocytes & phagocytes • Called ANTIGEN-PRESENTING CELLS (APCs)
  13. 13. Types of T Cells 1. Cytotoxic T Cells 2. Helper T Cells 3. Memory T Cells 4. Suppressor T Cells
  14. 14. Notes Handout
  15. 15. Activation of Cytotoxic T Cells MHC Class I clip
  16. 16. Helper T Cells • Activated by exposure to antigens presented by Class II MHC proteins • Activated helper T cells perform two functions: 1. Coordinate specific & nonspecific defenses 2. Stimulate both cell-mediated & antibody-mediated immunity • Activated helper T cells divide to produce: – More activated helper T cells – Memory T cells • helper T cells clip
  17. 17. Memory T Cells • Produced upon initial exposure to antigen, but do not respond to the antigen at that time. • Provide a no-delay response to any FUTURE exposure to the same antigen – Immediate differentiation into cytotoxic T cells and helper T cells
  18. 18. Suppressor T Cells • Activated suppressor T cells dampen the responses of other T cells and B cells – Secrete suppression factors • Act after the initial immune response
  19. 19. Notes Handout
  20. 20. Sensitization & Activation of B Cells
  21. 21. Sensitization & Activation of B Cells
  22. 22. Sensitization & Activation of B Cells
  23. 23. Sensitization & Activation of B Cells
  24. 24. Notes Handout
  25. 25. Antibody Structure
  26. 26. Antigen-antibody binding
  27. 27. antibody clip
  28. 28. Antibody (IgG) Function • Neutralization • Agglutination and precipitation • Activation of complement • Attraction of phagocytes • Enhancement of phagocytes • Stimulation of inflammation
  29. 29. Notes Handout
  30. 30. Summary of the Immune Response and Its Relationship to Nonspecific Defenses
  31. 31. Notes Handout
  32. 32. Integration of the Lymphatic System with Other Systems

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